Storage of vitamin A in extrahepatic stellate cells in normal rat

Journal of Lipid Research

Volumn 38, Issue 4, 1997, Pages 645-658

  Nagy, Nina E ^a   Holven, Kirsten B ^a   Roos, Norbert ^a   Senoo, Haruki ^b   Kojima, Naosuke ^b   Norum, Kaare R ^a   Blomhoff, Rune ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

electron microscopy; fluorescence; gold chloride; retinol; retinyl esters; stellate cells; vitamin A

Indexed keywords

ALPHA ACTIN; DESMIN; FAT DROPLET; GOLD CHLORIDE; RETINOL; RETINOL ESTER; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; FEEDING; FLUORESCENCE MICROSCOPY; GROWTH RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOCYTOCHEMISTRY; LIPID ANALYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STAINING; STELLATE CELL; TISSUE HOMOGENATE; VITAMIN INTAKE; VITAMIN METABOLISM;

ACTINS; ANIMALS; DESMIN; IMMUNOHISTOCHEMISTRY; INTESTINE, SMALL; KIDNEY; LIVER; LUNG; MALE; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; RATS; RATS, WISTAR; TRIGLYCERIDES; VITAMIN A;

EID: 0030984648     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Blomhoff, R., M. H. Green, T. Berg, and K. R. Norum. 1990. Transport and storage of vitamin A. Science. 250: 399-404.
2. Blomhoff, R. 1987. Hepatic retinol metabolism: role of various cell types. Nutr. Res. 45: 257-263.
3. Blomhoff, R., and K. Wake. 1991. Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J. 5: 271-277.
4. Wake, K. 1980. Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. Int. Rev. Cytol. 66: 303-353.
5. Moriwaki, H., W. S. Blaner, R. Piantedosi, and D. S. Goodman. 1988. Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and cell lipid droplets. J. Lipid Res. 29: 1523-1534.
6. Yamada, E., and K. Hirosawa. 1976. The possible existence of a vitamin A-storing cell system. Cell Struct. Funct. 1: 201-204.
7. Kusumoto, Y., and T. Fujita. 1977. Vitamin A uptake in cells distributed in the liver and other organs of the rat. Arch. Histol. Jpn. 40: 121-136.
8. Hirosawa, K., Y. Kokubo, M. Kitamura, and T. Shiraishi. 1988. Fine structure of intestinal fibroblasts: autoradiographic and three-dimensional studies. J. Electron Microsc. 37: 219-228.
9. Wake, K., K. Motomatsu, H. Senoo, A. Masuda, and E. Adachi. 1986. Improved Kupffer's gold chloride method for demonstrating the stellate cells storing retinol (vitamin A) in the liver and extrahepatic organs of vertebrates. Stain. Tech. 61: 193-200.
10. Napoli, J. L. 1986. Quantification of physiological levels of retinoic acid. Methods Enzymol. 123: 112-124.
11. Blomhoff, R., M. Rasmussen, A. Nilsson, K. R. Norum, T. Berg, W. S. Blaner, M. Kato, J. Mertz, D. S. Goodman, U. Eriksson, and P. A. Peterson. 1985. Hepatic retinol metabolism: distribution of retinoids, enzymes and binding proteins in isolated rat liver cells. J. Biol. Chem. 260: 13560-13565.
12. Popper, H., and R. Greenberg. 1941. Visualization of vitamin A in rat organs by fluorescence microscopy. Arch. Pathol. 32: 11-32.
13. Hayat, M. A., editor. 1970. Principles and Techniques of Electron Microscopy. Van Nostrand Reinhold Company, New York.
14. Weibel, E. R., G. S. Kistler, and W. F. Scherle. 1966. Practical stereological methods for morphometric cytology. J. Cell. Biol. 30: 23-38.
15. Loud, A. V. 1968. A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. J. Cell. Biol. 37: 27-46.
16. Zackman, R. D., B. Kakkad, and F. Chytil. 1984. Perinatal rat lung retinol (vitamin A) and retinyl palmitate. Pediatr. Res. 18: 1297-1299.
17. Shenai, J. P., and F. Chytil. 1990. Vitamin A storage in lungs during perinatal development in the rat. Biol. Neonate. 57: 126-132.
18. Okabe, T., H. Yorifuji, E. Yamada, and F. Takaku. 1984. Isolation and characterization of vitamin A-storing lung cells. Exp. Cell Res. 154: 125-135.
19. Chytil, F. 1992. The lungs and vitamin A. Am. J. Physiol. 262: L517-L527.
20. Zile, M. H., E. C. Bunge, and H. F. deLuca. 1977. Effect of vitamin A deficiency on intestinal cell proliferation in the rat. J. Nutr. 107: 552-560.
21. Takahashi, Y., T. Miura, and K. Takahashi. 1993. Vitamin A is involved in maintenance of epithelial cells on the bronchioles and cells in the alveoli of rats. J. Nutr. 123: 634-641.