Ethanol induces transforming growth factor-α expression in hepatocytes, leading to stimulation of collagen synthesis by hepatic stellate cells

Alcoholism: Clinical and Experimental Research

Volumn 27, Issue 8 SUPPL., 2003, Pages

  Kato, Junji ^a   Sato, Yasuhiro ^a   Inui, Noriaki ^a   Nakano, Yoichiro ^a   Takimoto, Rishu ^a   Takada, Kohich ^a   Kobune, Masayoshi ^a   Kuroiwa, Ganji ^a   Miyake, Sachie ^a   Kohgo, Yutaka ^b   Niitsu, Yoshiro ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Alcoholic Liver Disease; Hepatic Stellate Cells; Liver Fibrosis; Transforming Growth Factor

Indexed keywords

ALCOHOL; COLLAGEN TYPE 1; MESSENGER RNA; TRANSFORMING GROWTH FACTOR ALPHA;

ALCOHOL CONSUMPTION; ANIMAL CELL; COLLAGEN SYNTHESIS; CONFERENCE PAPER; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; LIVER CELL; LIVER DISEASE; LIVER FIBROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING;

BLOTTING, WESTERN; COLLAGEN; COLLAGEN TYPE I; CULTURE MEDIA, CONDITIONED; ETHANOL; GENE EXPRESSION; HEPATOBLASTOMA; HEPATOCYTES; HUMANS; LIVER CIRRHOSIS, ALCOHOLIC; LIVER NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR CELLS, CULTURED; UP-REGULATION;

ANIMALIA;

EID: 10744222325     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (38)

1. Arthur MJ (1998) Fibrosis and altered matrix degradation. Digestion 59:376-380.
2. Buniatian G, Gebhardt R, Schrenk D, Hamprecht B (1996) Colocalization of three types of intermediate filament proteins in perisinusoidal stellate cells: glial fibrillary acidic protein as a new cellular marker. Eur J Cell Biol 70:23-32.
3. Fausto N, Laird AD, Webber EM (1995) Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration. FASEB J 9:1527-1536.
4. Friedman SL (1993) The cellular basis of hepatic fibrosis: mechanisms and treatment strategies. N Engl J Med 328:1828-1835.
5. Friedman SL (1999a) Stellate cell activation in alcoholic fibrosis - an overview. Alcohol Clin Exp Res 23:904-910.
6. Friedman SL (1999b) Cytokines and fibrogenesis. Semin Liver Dis 19: 129-140.
7. Hamlyn AN, Brown AJ, Sherlock S, Baron DN (1975) Casual blood-ethanol estimations in patients with chronic liver disease. Lancet 2:345-347.
8. Inui N, Kato J, Kohgo Y, Katsuki S, Niitsu Y (1996) Detection of activity in the conditioned medium of ethanol-treated HepG2 cells which stimulates collagen synthesis in IMR-90 cells. Alcohol Clin Exp Res (Suppl) 20:63A-65A.
9. Israel Y, Britton RS, Orrego H (1982) Liver cell enlargement induced by chronic alcohol consumption: studies on its causes and consequences. Clin Biochem 15:189-192.
10. Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT (1990) TGF-α overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61:1137-1146.
11. Jokelainen K, Reinke LA, Nanji AA (2001) Nf-kappab activation is associated with free radical generation and endotoxemia and precedes pathological liver injury in experimental alcoholic liver disease. Cytokine 16:36-39.
12. Kato J, Wanebo H, Calabresi P, Clark JW (1992) Basic fibroblast growth factor production and growth factor receptors as potential targets for melanoma therapy. Melanoma Res 2:13-23.
13. Knittel T, Kobold D, Saile B, Grundmannm A, Neubauer K, Piscaglia F, Ramadpri G (1999) Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 117:1205-1221.
14. Knook DL, Seffelaar AM, de Leeuw AM (1982) Fat-storing cells of the rat liver. Their isolation and purification. Exp Cell Res 139:468-471.
15. Knowles BB, How CC, Aden DP (1980) Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science (Wash. DC) 209:497-499.
16. Kohgo Y, Mogi Y, Kato J, Nakaya R, Nakajima M, Katsuki S, Niitsu Y (1994) Ethanol inhibits asialoglycoprotein receptor synthesis but augments its mRNA expression in a human hepatoma cell line. J Gastroenterol 29:598-604.
17. Lee KS, Buck M, Houglum K, Chojkier M (1995) Activation of hepatic stellate cells by TGF-α and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96:2461-2468.
18. Lieber CS (1991) Alcohol and fibrogenesis. Alcohol Alcohol Suppl 1:339-344.
19. Lu SC, Huang ZZ, Yang JM, Tsukamoto H (1999) Effect of ethanol and high-fat feeding on hepatic gamma-glutamylcysteine synthetase subunit expression in the rat. Hepatology 30:209-214.
20. Malizia G, Brunt EM, Peters MG, Rizzo A, Broekelmann TJ, McDonald JA (1995) Growth factor and procollagen type I gene expression in human liver disease. Gastroenterology 108:145-156.
21. Moshage H, Casini A, Lieber CS (1990) Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes. Hepatology 12:511-518.
22. Nakano M, Worner TM, Lieber CS (1982) Perivenular fibrosis in alcoholic liver injury: ultrastructure and histologic progression. Gastroenterology 83:777-785.
23. Nichols WW, Murphy DG, Christofalo VJ, Toji LH, Greene AE, Dwight SA (1977) Characterization of a new human diploid cell strain, IMR-90. Science (Wash. DC) 196:60-63.
24. Niederau C, Fischer R, Sonnenberg A, Stremmel W, Trampisch HJ, Strohmeyer G (1985) Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med 313:1256-1262.
25. Niemela O, Blake JE, Orrego H (1992) Serum type I collagen propeptide and severity of alcoholic liver disease. Alcohol Clin Exp Res 16:1064-1067.
26. Peterson TC, Isbrucker RA (1992) Fibroproliferation in liver disease: role of monocyte factors. Hepatology 15:191-197.
27. Pinzani M, Gesualdo L, Sabbah GM, Abboud HE (1989) Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 84:1786-1793.
28. Popper H, Lieber CS (1980) Histogenesis of alcoholic fibrosis and cirrhosis in the baboon. Am J Pathol 98:695-716.
29. Savolainen ER, Leo MA, Timpl R, Lieber CS (1984) Acetaldehyde and lactate stimulate collagen synthesis of cultured baboon liver myofibroblasts. Gastroenterology 87:777-787.
30. Shiratori Y, Ichida T, Kawase T, Wisse E (1986) Effect of acetaldehyde on collagen synthesis by fat-storing cells isolated from rats treated with carbon tetrachloride. Liver 6:246-251.
31. Sternlieb I (1980) Copper and the liver. Gastroenterology 78:1615-1628.
32. Tahashi Y, Matsuzaki K, Date M, Yoshida K, Furukawa F, Sugano Y, Matsushita M, Himeno Y, Inagaki Y, Inoue K (2002) Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury. Hepatology 35:49-61.
33. Tsukamoto H (1999) Cytokine regulation of hepatic stellate cells in liver fibrosis. Alcohol Clin Exp Res 23:911-916.
34. Tsukamoto H, Gaal K, French SW (1990) Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology 12: 599-608.
35. Tsutsumi M, Takada A, Takase S, Shimanaka K, Enyama K (1989) Effect of ethanol and its metabolites on collagen synthesis by cultured rat liver cells. J Gastroenterol Hepatol 4:229-240.
36. Wang D, Kudlow JE (1999) Purification and characterization of TEF1, a transcription factor that controls the human transforming growth factor-α promoter. Biochim Biophys Acta 1449:50-62.
37. Wang D, Shin TH, Kudlow JE (1997) Transcription factor AP-2 controls transcription of the human transforming growth factor-α gene. J Biol Chem 272:14244-14250.
38. Webber EM, FitzGerald MJ, Brown PI, Bartlett MH, Fausto N (1993) Transforming growth factor-α expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor-α and hepatocyte growth factor. Hepatology 18:1422-3141.