Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression

Journal of Hepatology

Volumn 42, Issue 4, 2005, Pages 548-556

  Bansal, Meena B ^a   Kovalovich, Kellen ^b   Gupta, Ritu ^a   Li, Wei ^b   Agarwal, Akansha ^a   Radbill, Brian ^a   Alvarez, Carlos E ^a   Safadi, Rifaat ^a   Fiel, M Isabel ^a   Friedman, Scott L ^a   Taub, Rebecca A ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Fibrosis; Interleukin 6; Liver injury; Matrix degradation; Matrix metalloproteinase 2; Stellate cells

Indexed keywords

CARBON TETRACHLORIDE; GELATINASE A; RECOMBINANT INTERLEUKIN 6;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; LIVER CELL; LIVER HISTOLOGY; LIVER INJURY; LIVER REGENERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 20044396720     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2004.11.043     Document Type: Article

References (20)

1. Y. Sun, K. Tokushige, E. Isano, K. Yamauchi, and H. Ohata Elevated serum interleukin-6 levels in patients with acute hepatitis J Clin Immunol 12 1992 192 200
2. D. Hill, L. Marsano, D. Cohen, J. Allen, S. Shedlofsky, and C. McClain Increased plasma interleukin-6 concentrations in alcoholic hepatitis J Clin Immunol 119 1992 547 552
3. R. Taub Hepatoprotection via the IL-6/stat 3 pathway J Clin Investig 112 2003 978 980
4. D. Cressman, L. Greenbaum, R. DeAngelis, G. Cilberto, E. Furth, and V. Poli Liver failure and defective hepatocyte regeneration in interleukin-6 deficient mice Science 274 1996 1379 1383
5. K. Kovalovich, W. Li, R. DeAngelis, L. Greenbaum, G. Cilberto, and R. Taub Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-XL J Biol Chem 276 2001 26605 26613
6. M. Czaja, J. Xu, and E. Alt Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor Gastroenterology 108 1995 1849 1854
7. S. Friedman Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury J Biol Chem 275 2000 2247 2250
8. B. Wielockx, K. Lannoy, S. Shapiro, T. Itoh, S. Itohara, and J. Vanderkerckhove Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy Nat Med 7 2001 1202 1208
9. H. Nagase, and J. Woessner Matrix metalloproteinases J Biol Chem 1999 1999 21491 21494
10. V. Poli, R. Balena, E. Fattori, A. Markatos, M. Yamamoto, and H. Tanaka Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion Eur Mol Biol Org J 13 1994 1189 1196
11. K. Kovalovich, R.D. Angelis, W. Li, E. Furth, G. Cilberto, and R. Taub Increased toxin-induced liver injury and fibrosi in IL-6 deficient mice Hepatology 31 2000 149 159
12. E. Koivunen, W. Arap, H. Valtanen, A. Rainisalo, O. Medina, P. Heikkila, and C. Kantor Tumor targeting with a selective gelatinase inhibitor Nat Biotech 17 1999 768 774
13. Safadi R, Ohta M, Alvarez C, Fiel MI, Bansal M, Mehal W, et al. Immune stimulation of hepatic fibrogenesis by CD8 Cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology 2004;127:870-882.
14. J. Le, P. Dauchot, J. Perrot, F. Cambazard, J. Frey, and A. Chamson Quantitative zymography of matrix metalloproteinases by measuring hydroxyproline: application to gelatinases A and B Electrophoresis 20 1999 2824 2829
15. S. Vogel, R. Piantedosi, J. Frank, A. Lalazar, D. Rockey, and S. Friedman An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro J Lipid Res 41 2000 882 893
16. J. Leu, M. Crissey, J. Leu, G. Ciliberto, and R. Taub Interleukin-6 induced stat-3 and AP-1 amplify hepatocyte nuclear factor-1 mediated transactivation of hepatic genes, an adaptive response to liver injury Mol Cell Biol 21 2001 414 424
17. C. Overall, E. Tam, G. McQuibban, C. Morrison, U. Wallon, and H. Bigg Domain interactions in the gelatinase A/TIMP-2/MT1-MMP activation complex J Biol Chem 2000 2000 39497 39506
18. J. Keski-Oja, J. Lohi, K. Tuuttila, K. Tryggvaso, and T. Vartio Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator Exp Cell Res 202 1992 471 476
19. N. Theret, O. Musso, A. L'Helgoualch, and B. Clement Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes Am J Pathol 150 1997 51 58
20. D. Schuppan, M. Ruehl, R. Somasundarum, and E. Hahn Matrix as a modulator of hepatic fibrogenesis Semin Liver Dis 21 2001 351 372