Expression of mRNAs related to connective tissue metabolism in rat hepatic stellate cells and myofibroblasts

Experimental and Toxicologic Pathology

Volumn 58, Issue 4, 2007, Pages 263-273

  Jiroutova, Alena ^a   Slavkovsky, Rastislav ^a,b   Cermakova, Martina ^a   Majdiakova, Lenka ^a   Hanovcova, Irena ^a   Bolehovska, Radka ^a,c   Hajzlerova, Milena ^a   Radilova, Hana ^d   Ruszova, Ema ^b   Kanta, Jiri ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CPN ^*  (Czech Republic)

^c UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^d GENERI BIOTECH   (Czech Republic)

Author keywords

Connective tissue; Gene expression; Hepatic stellate cells; Liver cirrhosis; Liver myofibroblasts; Microarray analysis

Indexed keywords

MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DENSITY; CELL POPULATION; CELL SUSPENSION; CENTRIFUGATION; CONNECTIVE TISSUE; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCATION; LIVER PERFUSION; MALE; MYOFIBROBLAST; NONHUMAN; RAT; STELLATE CELL;

EID: 33845322662     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2006.06.005     Document Type: Article

References (45)

1. Abou-Shady M., Friess H., Zimmermann A., di Mola F.F., Guo X- Z., Baer H.U., et al. Connective tissue growth factor in human liver cirrhosis. Liver 20 (2000) 296-304
2. Annoni G., Weiner F.R., and Zern M.A. Increased transforming growth factor-β1 gene expression in human liver disease. J Hepatol 14 (1992) 259-264
3. Arthur M.J.P. Fibrosis and altered matrix degradation. Digestion 59 (1998) 376-380
4. Arthur M.J.P., Stanley A., Iredale J.P., Rafferty J.A., Hembry R.M., and Friedman S.L. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Biochem J 287 (1992) 701-707
5. Bissell D.M., Roulot D., and George J. Transforming growth factor and the liver. Hepatology 34 (2001) 859-867
6. Breitkopf K., Sawitza I., Westhof J.H., Wickert L., Dooley S., and Gressner A.M. Thrombospondin 1 acts as a strong promoter of transforming growth factor β effects via two distinct mechanisms in hepatic stellate cells. Gut 54 (2005) 673-681
7. Burton K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 62 (1956) 315-323
8. Cao Q., Mak K.M., and Lieber C.S. DLPC decreases TGF-β1-induced collagen mRNA by inhibiting MAPK in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 283 (2002) G1051-G1061
9. Chen H., Herndon M.E., and Lawler J. The cell biology of thrombospondin-1. Matrix Biol 19 (2000) 597-614
10. Cheng S., and Lovett D.H. Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am J Pathol 162 (2003) 1937-1949
11. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156-159
12. Denhardt D.T., Noda M., O'Regan A.W., Dubravko P., and Berman J.S. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 107 (2001) 1055-1061
13. Dubuisson L., Lepreux S., Bioulac-Sage P., Balabaud C., Costa A.M.A., Rosenbaum J., et al. Expression and cellular localization of fibrillin-1 in normal and pathological human liver. J Hepatol 34 (2001) 514-522
14. Friedman S.L., Roll F.J., Boyles J., and Bissell D.M. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 82 (1985) 8681-8685
15. Friedman S.L., Roll F.J., Boyles J., Arenson D.M., and Bisell D.M. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem 264 (1989) 10756-10762
16. Frizell E., Liu S.L., Abraham A., Ozaki I., Eghball M., Sage E.H., et al. Expression of SPARC in normal and fibrotic livers. Hepatology 21 (1995) 847-854
17. Graham J.M. Fractionation of hepatic nonparenchymal cells. Sci World J 2 (2002) 1347-1350
18. Greenwel P., Schwartz M., Rosas M., Peyrol S., Grimaud J.A., and Rojkind M. Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences and the production of interleukin-6. Lab Invest 65 (1991) 644-653
19. Gressner A.M., Weiskirchen R., Breitkopf K., and Dooley S. Role of TGF-β in hepatic fibrosis. Front Biosci 7 (2002) 793-807
20. Holmbeck K., Bianco P., Yamada S., and Birkedal-Hansen H. MT1-MMP: a tethered collagenase. J Cell Physiol 200 (2004) 11-19
21. Iozzo R.V., Cohen I.R., Grassel S., and Murdoch A.D. The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices. Biochem J 302 (1994) 625-639
22. Iredale J.P. Matrix turnover in fibrogenesis. Hepato-Gastroenterol 43 (1996) 56-61
23. Jiang Y., Liu J., Waalkes M., and Kang Y.J. Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing mice. Toxicol Sci 79 (2004) 404-410
24. Jiroutova A., Majdiakova L., Cermakova M., Köhlerova R., and Kanta J. Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic liver. Acta Med (Hradec Kralove) 48 (2005) 137-144
25. Kanta J., Dooley S., Delvoux B., Breuer S., D'Amico T., and Gressner A.M. Tropoelastin expression is upregulated during activation of hepatic stellate cells and in the livers of CCl4-cirrhotic rats. Liver 22 (2002) 220-227
26. Kim W.H., Matsumoto K., Bessho K., and Nakamura T. Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 166 (2005) 1017-1028
27. Kinnman N., Francoz C., Barbu V., Wendum D., Rey C., Hultcrantz R., et al. The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis. Lab Invest 83 (2003) 163-173
28. Knittel T., Kobold D., Saile B., Grundmann A., Neubauer K., Piscaglia F., et al. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 117 (1999) 1205-1221
29. Knittel T., Mehde M., Kobold D., Saile B., Dinter C., and Ramadori G. Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-α and TGF-β1. J Hepatol 30 (1999) 48-60
30. Laplante P., Raymond M.A., Gagnon G., Vigneault N., Sasseville A.M.J., Langelier Y., et al. Novel fibrogenic pathways are activated in response to endothelial apoptosis: implications in the pathophysiology of systemic sclerosis. J Immunol 174 (2005) 5740-5749
31. Lee S.H., Seo G.S., Park Y.N., Yoo T.M., and Sohn D.H. Effects and regulation of osteopontin in rat hepatic stellate cells. Biochem Pharmacol 68 (2004) 2367-2378
32. Li D., and Friedman S.L. Hepatic stellate cells: morphology, function, and regulation. In: Arias I.M., Boyer J.L., Chisari F.V., Fausto N., Schachter D., and Shafritz D.A. (Eds). The liver: biology and pathobiology (2001), Lippincott Williams & Wilkins, Philadelphia 455-468
33. Nagase H., and Woessner Jr. J.F. Matrix metalloproteinases. J Biol Chem 274 (1999) 21491-21494
34. Neubauer K., Krüger M., Quandamatteo F., Knittel T., Saile B., Ramadori G., et al. Transforming growth factor-β1 stimulates the synthesis of basement membrane proteins laminin, collagen type IV and entactin in rat liver sinusoidal endothelial cells. J Hepatol 31 (1999) 692-702
35. Ozaki S., Sato Y., Yasoshima Y., Harad K., and Nakanuma Y. Diffuse expression of heparan sulfate proteoglycan and connective tissue growth factor in fibrous septa with many mast cells relate to unresolving hepatic fibrosis of congenital hepatic fibrosis. Liver Int 25 (2005) 817-828
36. Paradis V., Dargere D., Bonvoust F., Vidaud M., Segarini P., and Bedossa P. Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest 82 (2002) 767-773
37. Rachfal A.W., and Brigstock D.R. Connective tissue factor (CTGF/CCN2) in hepatic fibrosis. Hepatol Res 26 (2003) 1-9
38. Ramadori G., and Saile B. Mesenchymal cell in the liver - one cell type or two?. Liver 22 (2002) 283-294
39. Schuppan D. Structure of the extracellular matrix in normal and fibrotic liver: collagens and glycoproteins. Semin Liver Dis 10 (1990) 1-10
40. Seomun Y., Kim J., Lee E.H., and Joo C.H. Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells. Biochem J 358 (2001) 41-48
41. Wells R.G., Kruglov E., and Dranoff J.A. Autocrine release of TGF-β by portal fibroblasts regulates cell growth. FEBS Lett 559 (2004) 107-110
42. Whitington P.F., Malladi P., Melin-Aldana H., Azzam R., Mack C.L., and Sahaj A. Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia. Ped Res 57 (2005) 837-844
43. Wickert L., Steinkrüger S., Abiaka M., Bolkenius U., Purps O., Schnabel C., et al. Quantitative monitoring of the mRNA expression pattern of the TGF-β-isoforms (β1, β2, β3) during transdifferentiation of hepatic stelate cells using a newly developed real-time SYBR Green PCR. Biochem Biophys Res Commun 295 (2002) 330-335
44. Worley J.R., Thompkins P.B., Meng H.L., Hutton M., Soloway P., Edwards D.R., et al. Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP). Biochem J 372 (2003) 799-809
45. Yata Y., Gotwals P., Koteliansky V., and Rockey D.C. Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-β soluble receptor: implications for antifibrotic therapy. Hepatology 35 (2002) 1022-1030