Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis

Journal of Gastroenterology and Hepatology (Australia)

Volumn 21, Issue SUPPL. 3, 2006, Pages

  Bachem, Max G ^a   Zhou, Zhengfei ^c   Zhou, Shaoxia ^a   Siech, Marco ^b  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b Ostalb Klinikum Aalen   (Germany)

^c PEKING UNIVERSITY   (China)

Author keywords

Chronic pancreatitis; Pancreas fibrosis; Pancreatic stellate cells

Indexed keywords

ACETALDEHYDE; ACTIVIN A; ALCOHOL; ALCOHOL DEHYDROGENASE; ALPHA SMOOTH MUSCLE ACTIN; ALPHA TOCOPHEROL; CERULETIDE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; DEFEROXAMINE MESYLATE; DIBUTYLTIN DICHLORIDE; ENDOTHELIN 1; FATTY ACID ESTER; FIBROBLAST GROWTH FACTOR 1; FIBRONECTIN; INTERLEUKIN 1; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; MEVINOLIN; PLATELET DERIVED GROWTH FACTOR; PROBUCOL; RETINOIC ACID; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; TRAPIDIL; TRINITROBENZENESULFONIC ACID; TROGLITAZONE; TROLOX C; TUMOR NECROSIS FACTOR ALPHA;

ACINAR CELL; ACUTE PANCREATITIS; ALCOHOL METABOLISM; AUTOCRINE EFFECT; CELL ACTIVATION; CELL DAMAGE; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CHRONIC PANCREATITIS; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CONFERENCE PAPER; CYSTIC FIBROSIS; DENSITY GRADIENT CENTRIFUGATION; FIBROGENESIS; HUMAN; LIPID PEROXIDATION; MYOFIBROBLAST; NONHUMAN; OXIDATIVE STRESS; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; STELLATE CELL; SYSTEMATIC REVIEW;

EID: 33747588068     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04592.x     Document Type: Conference Paper

References (43)

1. Buchholz M, Kestler HA, Holzmann K et al. Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype. J. Mol. Med. 2005; 83: 795-805.
2. Apte MV, Haber PS, Applegate TL et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 1998; 43: 128-33.
3. Bachem. MG, Schneider E, Gross H et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998; 115: 421-32.
4. Shinji T, Ujike K, Ochi K et al. Establishment of a novel collagenase perfusion method to isolate rat pancreatic stellate cells and investigation of their gene expression of TGF-beta1, type I collagen, and CTGF in primary culture or freshly isolated cells. Acta Med. Okayama 2002; 56: 2G8.
5. Kruse ML, Hildebrand PB, Timke C et al. Isolation, long-term culture, and characterization of rat pancreatic fibroblastoid/stellate cells. Pancreas 2001; 23: 49-54.
6. Schneider E, Schmid-Kotsas A, Zhao J et al. Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells. Am. J. Physiol. Cell Physiol. 2001; 281: C532-43.
7. Nakamura F, Shintani Y, Saotome T et al. Effects of synthetic serine protease inhibitors on proliferation and collagen synthesis of human pancreatic periacinar fibroblast-like cells. Pancreas 2001; 22: 317-25.
8. Satoh M, Masamune A, Sakai Y et al. Establishment and characterization of a simian virus 40-immortalized rat pancreatic stellate cell line. Tohoku J. Exp. Med. 2002; 198: 55-69.
9. Sparmann G, Hohenadl C, Tornoe J et al. Generation and characterization of immortalized rat pancreatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2004; 287: G2G9.
10. Jesnowski R, Furst D, Ringel J et al. Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteine. Lab. Invest. 2005; 85: 1276-91.
11. Phillips PA, Wu MJ, Kumar RK et al. Cell migration: a novel aspect of pancreatic stellate cell biology. Gut 2003; 52: 677-82.
12. McCarroll JA, Phillips PA, Kumar RK et al. Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase (PI3-kinase) pathway. Biochem. Pharmacol. 2004; 67: 1215-25.
13. Masamune A, Satoh M, Kikuta K et al. Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells. World J. Gastroenterol. 2005; 11: 6144-51.
14. Apte MV, Haber PS, Darby SJ et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999; 44: 534-41.
15. Apte MV, Wilson JS. Stellate cell activation in alcoholic pancreatitis. Pancreas 2003; 27: 316-20.
16. Yokota T, Denham W, Murayama K et al. Pancreatic stellate cell activation and MMP production in experimental pancreatic fibrosis. J. Surg. Res. 2002; 104: 106-11.
17. Neuschwander-Tetri BA, Burton FR, Presti ME et al. Repetitive self-limited acute pancreatitis induces pancreatic fibrogenesis in the mouse. Dig. Dis. Sci. 2000; 45: 665-74.
18. Emmerich J, Weber I, Nausch M et al. Immunohistochemical characterization of the pancreatic cellular infiltrate in normal pancreas, chronic pancreatitis and pancreatic carcinoma. Digestion 1998; 59: 192-8.
19. Neuschwander-Tetri BA, Bridle KR, Wells LD et al. Repetitive acute pancreatic injury in the mouse induces procollagen alpha1(I) expression colocalized to pancreatic stellate cells. Lab. Invest. 2000; 80: 143-50.
20. Vogelmann R, Ruf D, Wagner M et al. Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model. Am. J. Physiol. Gastrointest. Liver Physiol. 2001; 280: G164-72.
21. Haber PS, Keogh GW, Apte MV et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am. J. Pathol. 1999; 155: 1087-95.
22. Casini A, Galli A, Pignalosa P et al. Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis. J. Pathol. 2000; 192: 81-9.
23. Schmid-Kotsas A, Gross HJ, Menke A et al. Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and C-fibronectin in cultured pancreatic stellate cells. Am. J. Pathol. 1999; 155: 1749-58.
24. Luttenberger T, Schmid-Kotsas A, Menke A et al. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis. Lab. Invest. 2000; 80: 47-55.
25. Apte MV, Phillips PA, Fahmy RG et al. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 2000; 118: 780-94.
26. Fantone JD, Ward PA. Role of oxygen-derived free radicals and metabolites in leucocyte-dependent inflammatory reactions. Am. J. Pathol. 1982; 107: 397-403.
27. Weiss SJ, LoBuglio AF. Biology of disease: phagocyte-generated oxygen metabolites and cellular injury. Lab. Invest. 1982; 47: 5-11.
28. Mylonas C, Kouretas D. Lipid peroxidation and tissue damage. In Vivo 1999; 13: 295-309.
29. Girotti AW. Lipid hydroperoxide generation, turnover, and effector action in biological systems. J. Lipid Res. 1998; 39: 1529-42.
30. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. Oxford: Clarendon Press, 1989.
31. - with unsaturated fatty acids. J. Biol. Chem. 1983; 258: 4759-61.
32. Masamune A, Sakai Y, Kikuta K et al. Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM-1) in vitro. Pancreas 2002; 25: 78-85.
33. Bachem. MG, Schmid-Kotsas A, Siech M et al. Pancreatic stellate cells and their role in fibrogenesis. In: Johnson CD, Imrie, CW, eds. Pancreatic Disease. Basic Science and Clinical Management. Berlin: Springer, 2004; 227-39.
34. Mews P, Phillips P, Fahmy R et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut 2002; 50: 535-41.
35. Shek FW, Benyon RC, Walker FM et al. Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am. J. Pathol. 2002; 160: 1787-98.
36. Gao R, Brigstock DR. Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor. Gastroenterology 2005; 129: 1019-30.
37. Greten FR, Wagner M, Weber CK et al. TGF alpha transgenic mice. A model of pancreatic cancer development. Pancreatology 2001; 1: 363-8.
38. Klöppel G, Detlefsen S, Feyerabend B. Fibrosis of the pancreas: the initial tissue damage and the resulting pattern. Virchows Arch. 2004; 445: 1-8.
39. Masamune A, Kikuta K, Satoh M et al. Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells. J. Pharmacol. Exp. Ther. 2002; 302: 36-42.
40. Jaster R, Sparmann G, Emmrich J et al. Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells. Gut 2002; 51: 579-84.
41. Aoki H, Ohnishi H, Hama K et al. Autocrine loop between transforming growth factor-β1 and interleukin-1β through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. Am. J. Physiol. Cell Physiol. 2006; 290: C1100-8.
42. Ohnishi N, Miyata T, Ohnishi H et al. Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis. Gut 2003; 52: 1487-93.
43. Klonowski-Stumpe H, Reinehr R, Fischer R et al. Production and effects of endothelin-1 in rat pancreatic stellate cells. Pancreas 2003; 27: 67-74.