Inhibition of the Na+/H+ exchanger reduces rat hepatic stellate cell activity and liver fibrosis: An in vitro and in vivo study

Gastroenterology

Volumn 120, Issue 2, 2001, Pages 545-556

  Benedetti, Antonio ^a   Di Sario, Antonio ^a   Casini, Alessandro ^a   Ridolfi, Francesco ^a   Bendia, Emanuele ^a   Pigini, Paola ^a   Tonnini, Cecilia ^a   D'ambrosio, Letizia ^a   Feliciangeli, Giuseppe ^a   Macarri, Giampiero ^a   Svegliati Baroni, Gianluca ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; AMILORIDE; COLLAGEN TYPE 1; DIMETHYLNITROSAMINE; FERROUS ASCORBATE; MESSENGER RNA; PROCOLLAGEN; RECOMBINANT PLATELET DERIVED GROWTH FACTOR BB; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; CELL PH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; IMMUNOHISTOCHEMISTRY; ION EXCHANGE; LIVER CELL; LIVER DISEASE; LIVER FIBROSIS; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; STELLATE CELL;

EID: 0035128122     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.21203     Document Type: Article

References (42)

1. Molecular regulation of hepatic fibrogenesis
2. Collagen types in normal and cirrhotic liver
3. Structure of the extracellutar matrix in normal and fibrotic liver: Collagen and glycoproteins
4. New insights into hepatic stellate cell activation: The simple becomes complex
5. Hepatic lipocytes: The principal collagen producing cells of normal rat liver
6. Immunocytochemical detection of desmin in fat-storing cells (Ito cells)
7. Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis
8. Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon-tetrachloride-injured rat liver
9. Alcoholic liver injury in baboons: Transformation of lipocytes to transitional cells
10. Vitamin A-containing lipocytes and formation of type III collagen in liver injury
11. Cellular localization of type I, III and IV procollagen gene transcripts in normal and fibrotic human liver
12. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix
13. Activation of hepatic stellate cells by TGF-β and collagen type I is mediated by oxidative stress through c-myb expression
14. + exchanger modulates the fibrogenic effect of oxidative stress in hepatic stellate cells
15. Fibrogenic effect of oxidative stress on rat hepatic stellate cells
16. Hepatic stellate cell activation and liver fibrosis are associated with necroinflammatory injury and Th1-like response in chronic hepatitis C
17. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
18. Insulin and IGF-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways
19. Amiloride and its analogs as tools in the study of ion transport
20. Characterization of ion transport mechanisms regulating intracellular pH in hepatic stellate cells
21. + activation by platelet-derived growth factor in rat hepatic stellate cells
22. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation
23. Expression of activin A is increased in cirrhotic and fibrotic rat livers
24. Cell proliferation following extrahepatic biliary obstruction. Evaluation by immunohistochemical methods
25. Regulation of extracellular matrix synthesis by transforming growth factor beta 1 in human fat-storing cells
26. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha1(I) gene expression in human liver fat-storing cells
27. Neutrophil-derived superoxide anions induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells
28. Single step-method of RNA isolation by acid guanidium thyocianate-phenol-chloroform extraction
29. P1B15: A cDNA clone of the rat mRNA encoding cyclophilin
30. Histological grading and staging of chronic hepatitis
31. Immunohistochemical analysis of S-phase cells in normal human and rat liver by PC10 monoclonal antibody
32. Construction of DNA sequences complementary to rat 1 and 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D
33. Simple high-performance liquid chromatographic method for the measurement of amiloride in body fluids
34. Myocardial fibrosis in the rat with mineral corticoid excess. Prevention of scarring by amiloride
35. Quantitative analysis of proliferating sinusoidal cells in dimethylnitrosamine-induced cirrhosis. An immunohistochemical study
36. Increased sodium influx is necessary to initiate rat hepatocyte proliferation
37. Myocardial fibrosis and the concepts of cardioprotection and cardioreparation
38. Determination and pharmacokinetics of a furosemide-amiloride drug combination
39. Effects of growth factors on intracellular pH regulation
40. + antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH
41. + antiport inhibitors
42. + exchange involvement in colony-stimulating factor-1-stimulated macrophage proliferation