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Volumn 2, Issue 4, 2006, Pages 585-599

Toll-like receptors: A new target in rheumatoid arthritis?

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (4 FLUOROPHENYL) 1 (3 PHENYLPROPYL) 5 (4 PYRIDINYL) 1H IMIDAZOL 2 YL] 3 BUTYN 1 OL; 5 (2 AMINO 4 PYRIMIDINYL) 4 (4 FLUOROPHENYL) 1 (4 PIPERIDINYL)IMIDAZOLE; ADALIMUMAB; BORTEZOMIB; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; GLUCOCORTICOID; GOLD DERIVATIVE; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 6 ANTIBODY; MATRIX METALLOPROTEINASE; METHOTREXATE; MYELOID DIFFERENTIATION FACTOR 88; NONSTEROID ANTIINFLAMMATORY AGENT; PENICILLIN G; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RHEUMATOID FACTOR; SALAZOSULFAPYRIDINE; SCLEROPROTEIN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; TUMOR NECROSIS FACTOR ANTIBODY; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNINDEXED DRUG;

EID: 33748480691     PISSN: 1744666X     EISSN: None     Source Type: Journal    
DOI: 10.1586/1744666X.2.4.585     Document Type: Review
Times cited : (22)

References (218)
  • 1
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N. Engl. J. Med. 344(12), 907-916 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , Issue.12 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 3
    • 0029053188 scopus 로고
    • The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The arthritis and rheumatism council low-dose glucocorticoid study group
    • Kirwan JR. The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The arthritis and rheumatism council low-dose glucocorticoid study group. N. Engl. J. Med. 333(3), 142-146 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , Issue.3 , pp. 142-146
    • Kirwan, J.R.1
  • 4
    • 0032603379 scopus 로고    scopus 로고
    • The combination of methotrexate, sulfasalazine and hydroxychloroquine is highly effective in rheumatoid arthritis
    • Furst DE. The combination of methotrexate, sulfasalazine and hydroxychloroquine is highly effective in rheumatoid arthritis. Clin. Exp. Rheumatol. 17(1), 39-40 (1999).
    • (1999) Clin. Exp. Rheumatol. , vol.17 , Issue.1 , pp. 39-40
    • Furst, D.E.1
  • 5
    • 0028143211 scopus 로고
    • Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis
    • Elliott MJ, Maini RN, Feldmann M et al. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 344(8930), 1105-1110. (1994).
    • (1994) Lancet , vol.344 , Issue.8930 , pp. 1105-1110
    • Elliott, M.J.1    Maini, R.N.2    Feldmann, M.3
  • 6
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF-α therapy of rheumatoid arthritis: What have we learned?
    • Feldmann M, Maini RN. Anti-TNF-α therapy of rheumatoid arthritis: what have we learned? Ann. Rev. Immunol. 19, 163-196 (2001).
    • (2001) Ann. Rev. Immunol. , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 7
    • 0033574147 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial
    • Moreland LW, Schiff MH, Baumgartner SW et al. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann. Intern. Med. 130(6), 478-486 (1999).
    • (1999) Ann. Intern. Med. , vol.130 , Issue.6 , pp. 478-486
    • Moreland, L.W.1    Schiff, M.H.2    Baumgartner, S.W.3
  • 8
    • 0037231533 scopus 로고    scopus 로고
    • Adalimumab, a fully human anti-tumor necrosis factor α monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial
    • Weinblatt ME, Keystone EC, Furst DE et al. Adalimumab, a fully human anti-tumor necrosis factor α monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial. Arthritis Rheum. 48(1), 35-45 (2003).
    • (2003) Arthritis Rheum. , vol.48 , Issue.1 , pp. 35-45
    • Weinblatt, M.E.1    Keystone, E.C.2    Furst, D.E.3
  • 9
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • Bresnihan B, Alvaro-Gracia JM, Cobby M et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum. 41(12), 2196-2204 (1998).
    • (1998) Arthritis Rheum. , vol.41 , Issue.12 , pp. 2196-2204
    • Bresnihan, B.1    Alvaro-Gracia, J.M.2    Cobby, M.3
  • 10
    • 0029943271 scopus 로고    scopus 로고
    • Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis
    • The IL-1Ra Arthritis Study Group
    • Campion Gv, Lebsack ME, Lookabaugh J, Gordon G, Catalano M. Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group. Arthritis Rheum. 39(7), 1092-1101 (1996).
    • (1996) Arthritis Rheum. , vol.39 , Issue.7 , pp. 1092-1101
    • Campion, Gv.1    Lebsack, M.E.2    Lookabaugh, J.3    Gordon, G.4    Catalano, M.5
  • 11
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial
    • Nishimoto N, Yoshizaki K, Miyasaka N et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 50(6), 1761-1769 (2004).
    • (2004) Arthritis Rheum. , vol.50 , Issue.6 , pp. 1761-1769
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3
  • 12
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller DL, Jenkins MK, Schwartz RH. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Ann. Rev. Immunol. 7, 445-480 (1989).
    • (1989) Ann. Rev. Immunol. , vol.7 , pp. 445-480
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 14
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • Kremer JM, Westhovens R, Leon M et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N. Engl. J. Med. 349(20), 1907-1915 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , Issue.20 , pp. 1907-1915
    • Kremer, J.M.1    Westhovens, R.2    Leon, M.3
  • 15
    • 23644455857 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial
    • Kremer JM, Dougados M, Emery P et al. Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial. Arthritis Rheum. 52(8), 2263-2271 (2005).
    • (2005) Arthritis Rheum. , vol.52 , Issue.8 , pp. 2263-2271
    • Kremer, J.M.1    Dougados, M.2    Emery, P.3
  • 16
    • 21644468434 scopus 로고    scopus 로고
    • The evolving clinical profile of abatacept (CTLA4-Ig): A novel co-stimulatory modulator for the treatment of rheumatoid arthritis
    • Ruderman EM, Pope RM. The evolving clinical profile of abatacept (CTLA4-Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis. Arthritis Res. Ther. 7(Suppl. 2), S21-S25 (2005).
    • (2005) Arthritis Res. Ther. , vol.7 , Issue.SUPPL. 2
    • Ruderman, E.M.1    Pope, R.M.2
  • 17
    • 0035846326 scopus 로고    scopus 로고
    • Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent
    • Keane J, Gershon S, Wise RP et al. Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent. N. Engl. J. Med. 345(15), 1098-1104. (2001).
    • (2001) N. Engl. J. Med. , vol.345 , Issue.15 , pp. 1098-1104
    • Keane, J.1    Gershon, S.2    Wise, R.P.3
  • 18
    • 0029877828 scopus 로고    scopus 로고
    • Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins
    • Silman AJ, Newman J, MacGregor AJ. Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins. Arthritis Rheum. 39(5), 732-735 (1996).
    • (1996) Arthritis Rheum. , vol.39 , Issue.5 , pp. 732-735
    • Silman, A.J.1    Newman, J.2    MacGregor, A.J.3
  • 19
    • 0029900167 scopus 로고    scopus 로고
    • Potential infectious agents in the induction of arthritides
    • Krause A, Kamradt T, Burmester GR. Potential infectious agents in the induction of arthritides. Curr. Opin. Rheumatol. 8(3), 203-209 (1996).
    • (1996) Curr. Opin. Rheumatol. , vol.8 , Issue.3 , pp. 203-209
    • Krause, A.1    Kamradt, T.2    Burmester, G.R.3
  • 20
    • 0027375302 scopus 로고
    • Twin concordance rates for rheumatoid arthritis: Results from a nationwide study
    • Silman AJ, MacGregor AJ, Thomson W et al. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br. J. Rheumatol. 32(10), 903-907 (1993).
    • (1993) Br. J. Rheumatol. , vol.32 , Issue.10 , pp. 903-907
    • Silman, A.J.1    MacGregor, A.J.2    Thomson, W.3
  • 21
    • 0017878054 scopus 로고
    • Association of the B-cell alloantigen DRw4 with rheumatoid arthritis
    • Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N. Engl. J. Med. 298(16), 869-871 (1978).
    • (1978) N. Engl. J. Med. , vol.298 , Issue.16 , pp. 869-871
    • Stastny, P.1
  • 22
    • 0036962313 scopus 로고    scopus 로고
    • Autoantigens and immune pathways in rheumatoid arthritis
    • Corrigall VM, Panayi GS. Autoantigens and immune pathways in rheumatoid arthritis. Crit. Rev. Immunol. 22(4), 281-293 (2002).
    • (2002) Crit. Rev. Immunol. , vol.22 , Issue.4 , pp. 281-293
    • Corrigall, V.M.1    Panayi, G.S.2
  • 23
    • 0033947786 scopus 로고    scopus 로고
    • Raised human cartilage glycoprotein-39 plasma levels in patients with rheumatoid arthritis and other inflammatory conditions
    • Vos K, Steenbakkers P, Miltenburg AM et al. Raised human cartilage glycoprotein-39 plasma levels in patients with rheumatoid arthritis and other inflammatory conditions. Ann. Rheum. Dis. 59(7), 544-548 (2000).
    • (2000) Ann. Rheum. Dis. , vol.59 , Issue.7 , pp. 544-548
    • Vos, K.1    Steenbakkers, P.2    Miltenburg, A.M.3
  • 25
    • 0032126846 scopus 로고    scopus 로고
    • The Toll pathway is required in the epidermis for muscle development in the Drosophila embryo
    • Halfon MS, Keshishian H. The Toll pathway is required in the epidermis for muscle development in the Drosophila embryo. Dev. Biol. 199(1), 164-174 (1998).
    • (1998) Dev. Biol. , vol.199 , Issue.1 , pp. 164-174
    • Halfon, M.S.1    Keshishian, H.2
  • 26
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86(6), 973-983 (1996).
    • (1996) Cell , vol.86 , Issue.6 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 27
    • 10444278132 scopus 로고    scopus 로고
    • Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-γ
    • Radstake TR, Roelofs MF, Jenniskens YM et al. Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-γ. Arthritis Rheum. 50(12), 3856-3865 (2004).
    • (2004) Arthritis Rheum. , vol.50 , Issue.12 , pp. 3856-3865
    • Radstake, T.R.1    Roelofs, M.F.2    Jenniskens, Y.M.3
  • 28
    • 0037378466 scopus 로고    scopus 로고
    • Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium
    • Seibl R, Birchler T, Loeliger S et al. Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium. Am. J. Pathol. 162(4), 1221-1227 (2003).
    • (2003) Am. J. Pathol. , vol.162 , Issue.4 , pp. 1221-1227
    • Seibl, R.1    Birchler, T.2    Loeliger, S.3
  • 29
    • 2342604896 scopus 로고    scopus 로고
    • + blood monocytes and synovial tissue macrophages in rheumatoid arthritis
    • + blood monocytes and synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum. 50(5), 1457-1467 (2004).
    • (2004) Arthritis Rheum. , vol.50 , Issue.5 , pp. 1457-1467
    • Iwahashi, M.1    Yamamura, M.2    Aita, T.3
  • 31
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. Toll-like receptors in innate immunity. Int. Immunol. 17(1), 1-14 (2005).
    • (2005) Int. Immunol. , vol.17 , Issue.1 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 32
    • 0031423761 scopus 로고    scopus 로고
    • MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
    • Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7(6), 837-847 (1997).
    • (1997) Immunity , vol.7 , Issue.6 , pp. 837-847
    • Wesche, H.1    Henzel, W.J.2    Shillinglaw, W.3    Li, S.4    Cao, Z.5
  • 33
    • 0032524335 scopus 로고    scopus 로고
    • MyD88, an adapter protein involved in interleukin-1 signaling
    • Burns K, Martinon F, Esslinger C et al. MyD88, an adapter protein involved in interleukin-1 signaling. J. Biol. Chem. 273(20), 12203-12209 (1998).
    • (1998) J. Biol. Chem. , vol.273 , Issue.20 , pp. 12203-12209
    • Burns, K.1    Martinon, F.2    Esslinger, C.3
  • 34
    • 0033583034 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
    • Zhang FX, Kirschning CJ, Mancinelli R et al. Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274(12), 7611-7614 (1999).
    • (1999) J. Biol. Chem. , vol.274 , Issue.12 , pp. 611-7614
    • Zhang, F.X.1    Kirschning, C.J.2    Mancinelli, R.3
  • 35
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278(5343), 1612-1615 (1997).
    • (1997) Science , vol.278 , Issue.5343 , pp. 1612-1615
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 37
    • 0032428729 scopus 로고    scopus 로고
    • AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis
    • Han Z, Boyle DL, Manning AM, Firestein GS. AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 28(4), 197-208 (1998).
    • (1998) Autoimmunity , vol.28 , Issue.4 , pp. 197-208
    • Han, Z.1    Boyle, D.L.2    Manning, A.M.3    Firestein, G.S.4
  • 38
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11(1), 115-122 (1999).
    • (1999) Immunity , vol.11 , Issue.1 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 39
    • 0035817925 scopus 로고    scopus 로고
    • Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
    • Fitzgerald KA, Palsson-McDermott EM, Bowie AG et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413(6851), 78-83 (2001).
    • (2001) Nature , vol.413 , Issue.6851 , pp. 78-83
    • Fitzgerald, K.A.1    Palsson-McDermott, E.M.2    Bowie, A.G.3
  • 40
    • 0035555301 scopus 로고    scopus 로고
    • TIRAP: An adapter molecule in the Toll signaling pathway
    • Horng T, Barton GM, Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2(9), 835-841 (2001).
    • (2001) Nat. Immunol. , vol.2 , Issue.9 , pp. 835-841
    • Horng, T.1    Barton, G.M.2    Medzhitov, R.3
  • 41
    • 0037114185 scopus 로고    scopus 로고
    • Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling
    • Yamamoto M, Sato S, Mori K et al. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J. Immunol. 169(12), 6668-6672 (2002).
    • (2002) J. Immunol. , vol.169 , Issue.12 , pp. 6668-6672
    • Yamamoto, M.1    Sato, S.2    Mori, K.3
  • 42
    • 0037320451 scopus 로고    scopus 로고
    • TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction
    • Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction. Nat. Immunol. 4(2), 161-167 (2003).
    • (2003) Nat. Immunol. , vol.4 , Issue.2 , pp. 161-167
    • Oshiumi, H.1    Matsumoto, M.2    Funami, K.3    Akazawa, T.4    Seya, T.5
  • 43
    • 0141959224 scopus 로고    scopus 로고
    • LPS-TLR4 signaling to IRF-3/7 and NF-{kappa}B involves the Toll adapters TRAM and TRIF
    • Fitzgerald KA, Rowe DC, Barnes BJ et al. LPS-TLR4 signaling to IRF-3/7 and NF-{kappa}B involves the Toll adapters TRAM and TRIF. J. Exp. Med. 198(7), 1043-1055 (2003).
    • (2003) J. Exp. Med. , vol.198 , Issue.7 , pp. 1043-1055
    • Fitzgerald, K.A.1    Rowe, D.C.2    Barnes, B.J.3
  • 44
    • 0345991221 scopus 로고    scopus 로고
    • TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β
    • Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β. J. Biol. Chem. 278(50), 49751-49762 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.50 , pp. 49751-49762
    • Oshiumi, H.1    Sasai, M.2    Shida, K.3    Fujita, T.4    Matsumoto, M.5    Seya, T.6
  • 45
    • 30544451546 scopus 로고    scopus 로고
    • Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    • Hacker H, Redecke V, Blagoev B et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439(7073), 204-207 (2006).
    • (2006) Nature , vol.439 , Issue.7073 , pp. 204-207
    • Hacker, H.1    Redecke, V.2    Blagoev, B.3
  • 46
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4(7), 499-511 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 47
    • 0035889228 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    • Kawai T, Takeuchi O, Fujita T et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167(10), 5887-5894 (2001).
    • (2001) J. Immunol. , vol.167 , Issue.10 , pp. 5887-5894
    • Kawai, T.1    Takeuchi, O.2    Fujita, T.3
  • 48
    • 15044345461 scopus 로고    scopus 로고
    • Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    • Takaoka A, Yanai H, Kondo S et al. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434(7030), 243-249 (2005).
    • (2005) Nature , vol.434 , Issue.7030 , pp. 43-249
    • Takaoka, A.1    Yanai, H.2    Kondo, S.3
  • 49
    • 27744561393 scopus 로고    scopus 로고
    • Rip1 mediates the Trif-dependent Toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
    • Cusson-Hermance N, Khurana S, Lee TH, Fitzgerald KA, Kelliher MA. Rip1 mediates the Trif-dependent Toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. J. Biol. Chem. 280(44), 36560-36566 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.44 , pp. 36560-36566
    • Cusson-Hermance, N.1    Khurana, S.2    Lee, T.H.3    Fitzgerald, K.A.4    Kelliher, M.A.5
  • 50
    • 24944586285 scopus 로고    scopus 로고
    • Achieving stability of lipopolysaccharide-induced NF-κB activation
    • Covert MW, Leung TH, Gaston JE, Baltimore D. Achieving stability of lipopolysaccharide-induced NF-κB activation. Science 309(5742), 1854-1857 (2005).
    • (2005) Science , vol.309 , Issue.5742 , pp. 854-1857
    • Covert, M.W.1    Leung, T.H.2    Gaston, J.E.3    Baltimore, D.4
  • 51
    • 4344627821 scopus 로고    scopus 로고
    • Endogenous ligands of Toll-like receptors
    • Tsan MF, Gao B. Endogenous ligands of Toll-like receptors. J. Leukoc. Biol. 76(3), 514-519 (2004).
    • (2004) J. Leukoc. Biol. , vol.76 , Issue.3 , pp. 514-519
    • Tsan, M.F.1    Gao, B.2
  • 53
    • 33748510244 scopus 로고    scopus 로고
    • Toll-like receptors and rheumatoid arthritis: Is there a connection?
    • In: O'Neill LAJ, Brint E (Eds), Birkhauser, Basel, Switzerland
    • Sacre SM, Drexler SK, Foxwell BM. Toll-like receptors and rheumatoid arthritis: is there a connection? In: Toll-like Receptors in Inflammation. O'Neill LAJ, Brint E (Eds), Birkhauser, Basel, Switzerland, 19-40 (2005).
    • (2005) Toll-like Receptors in Inflammation , pp. 19-40
    • Sacre, S.M.1    Drexler, S.K.2    Foxwell, B.M.3
  • 54
    • 23044494509 scopus 로고    scopus 로고
    • The role of Toll-like receptor signalling in the pathogenesis of arthritis
    • Brentano F, Kyburz D, Schorr O, Gay R, Gay S. The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol. 233(2), 90-96 (2005).
    • (2005) Cell Immunol. , vol.233 , Issue.2 , pp. 90-96
    • Brentano, F.1    Kyburz, D.2    Schorr, O.3    Gay, R.4    Gay, S.5
  • 55
    • 0020405571 scopus 로고
    • Necrosis and apoptosis: Distinct modes of cell death with fundamentally different significance
    • Searle J, Kerr JF, Bishop CJ. Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance. Pathol. Ann. 17(Pt 2), 229-259 (1982).
    • (1982) Pathol. Ann. , vol.17 , Issue.PART 2 , pp. 229-259
    • Searle, J.1    Kerr, J.F.2    Bishop, C.J.3
  • 56
    • 7744235672 scopus 로고    scopus 로고
    • Death by design: Apoptosis, necrosis and autophagy
    • Edinger AL, Thompson CB. Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell. Biol. 16(6), 663-669 (2004).
    • (2004) Curr. Opin. Cell. Biol. , vol.16 , Issue.6 , pp. 663-669
    • Edinger, A.L.1    Thompson, C.B.2
  • 57
    • 0032169220 scopus 로고    scopus 로고
    • Recognizing death: The phagocytosis of apoptotic cells
    • Platt N, da Silva RP, Gordon S. Recognizing death: the phagocytosis of apoptotic cells. Trends Cell Biol. 8(9), 365-372 (1998).
    • (1998) Trends Cell Biol. , vol.8 , Issue.9 , pp. 365-372
    • Platt, N.1    da Silva, R.P.2    Gordon, S.3
  • 58
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
    • Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191(3), 423-434 (2000).
    • (2000) J. Exp. Med. , vol.191 , Issue.3 , pp. 423-434
    • Sauter, B.1    Albert, M.L.2    Francisco, L.3    Larsson, M.4    Somersan, S.5    Bhardwaj, N.6
  • 59
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci S, Lolkema M, Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5(11), 1249-1255 (1999).
    • (1999) Nat. Med. , vol.5 , Issue.11 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 60
    • 28544449709 scopus 로고    scopus 로고
    • Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
    • Vollmer J, Tluk S, Schmitz C et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J. Exp. Med. 202(11), 1575-1585 (2005).
    • (2005) J. Exp. Med. , vol.202 , Issue.11 , pp. 1575-1585
    • Vollmer, J.1    Tluk, S.2    Schmitz, C.3
  • 61
    • 0035903158 scopus 로고    scopus 로고
    • Endocytosed HSP60s use Toll-like receptor 2 (TLR2) and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immune cells
    • Vabulas RM, Ahmad-Nejad P, da Costa C et al. Endocytosed HSP60s use Toll-like receptor 2 (TLR2) and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immune cells. J. Biol. Chem. 276(33), 31332-31339 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.33 , pp. 31332-31339
    • Vabulas, R.M.1    Ahmad-Nejad, P.2    da Costa, C.3
  • 63
    • 0037036369 scopus 로고    scopus 로고
    • The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway
    • Vabulas RM, Braedel S, Hilf N et al. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J. Biol. Chem. 277(23), 20847-20853 (2002).
    • (2002) J. Biol. Chem. , vol.277 , Issue.23 , pp. 0847-20853
    • Vabulas, R.M.1    Braedel, S.2    Hilf, N.3
  • 64
    • 33646882893 scopus 로고    scopus 로고
    • Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
    • Roelofs MF, Boelens WC, Joosten LA et al. Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J. Immunol. 176(11), 7021-7027 (2006).
    • (2006) J. Immunol. , vol.176 , Issue.11 , pp. 7021-7027
    • Roelofs, M.F.1    Boelens, W.C.2    Joosten, L.A.3
  • 66
    • 0037414787 scopus 로고    scopus 로고
    • Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor α release by murine macrophages
    • Gao B, Tsan MF. Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor α release by murine macrophages. J. Biol. Chem. 278(1), 174-179 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.1 , pp. 174-179
    • Gao, B.1    Tsan, M.F.2
  • 67
    • 0036919852 scopus 로고    scopus 로고
    • Endotoxin-free heat-shock protein 70 fails to induce APC activation. Eur
    • Bausinger H, Lipsker D, Ziylan U et al. Endotoxin-free heat-shock protein 70 fails to induce APC activation. Eur. J. Immunol. 32(12), 3708-3713 (2002).
    • (2002) J. Immunol. , vol.32 , Issue.12 , pp. 3708-3713
    • Bausinger, H.1    Lipsker, D.2    Ziylan, U.3
  • 68
    • 0042357122 scopus 로고    scopus 로고
    • GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-κB activation and nitric oxide production
    • Reed RC, Berwin B, Baker JP, Nicchitta CV. GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-κB activation and nitric oxide production. J. Biol. Chem. 278(34), 31853-31860 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.34 , pp. 31853-31860
    • Reed, R.C.1    Berwin, B.2    Baker, J.P.3    Nicchitta, C.V.4
  • 69
    • 0346734122 scopus 로고    scopus 로고
    • Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases
    • Liu B, Dai J, Zheng H, Stoilova D, Sun S, Li Z. Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases. Proc. Natl Acad. Sci. USA 100(26), 15824-15829 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.26 , pp. 15824-15829
    • Liu, B.1    Dai, J.2    Zheng, H.3    Stoilova, D.4    Sun, S.5    Li, Z.6
  • 71
    • 0034698830 scopus 로고    scopus 로고
    • High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
    • Andersson U, Wang H, Palmblad K et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J. Exp. Med. 192(4), 565-570 (2000).
    • (2000) J. Exp. Med. , vol.192 , Issue.4 , pp. 565-570
    • Andersson, U.1    Wang, H.2    Palmblad, K.3
  • 72
    • 0037769813 scopus 로고    scopus 로고
    • Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells
    • Fiuza C, Bustin M, Talwar S et al. Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. Blood 101(7), 2652-2660 (2003).
    • (2003) Blood , vol.101 , Issue.7 , pp. 2652-2660
    • Fiuza, C.1    Bustin, M.2    Talwar, S.3
  • 73
    • 0037376222 scopus 로고    scopus 로고
    • Activation of gene expression in human neutrophils by high mobility group box 1 protein
    • Park JS, Arcaroli J, Yum HK et al. Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am. J. Physiol. Cell Physiol. 284(4), C870-C879 (2003).
    • (2003) Am. J. Physiol. Cell Physiol. , vol.284 , Issue.4
    • Park, J.S.1    Arcaroli, J.2    Yum, H.K.3
  • 74
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of Toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, Svetkauskaite D, He Q et al. Involvement of Toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J. Biol. Chem. 279(9), 7370-7377 (2004).
    • (2004) J. Biol. Chem. , vol.279 , Issue.9 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3
  • 75
    • 33645461206 scopus 로고    scopus 로고
    • High mobility group box 1 protein interacts with multiple Toll-like receptors
    • Park JS, Gamboni-Robertson F, He Q et al. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am. J. Physiol. Cell Physiol. 290(3), C917-C924 (2006).
    • (2006) Am. J. Physiol. Cell Physiol. , vol.290 , Issue.3
    • Park, J.S.1    Gamboni-Robertson, F.2    He, Q.3
  • 76
    • 0026744148 scopus 로고
    • Cell surface heparan sulfate proteoglycans
    • Yanagishita M, Hascall VC. Cell surface heparan sulfate proteoglycans. J. Biol. Chem. 267(14), 9451-9454 (1992).
    • (1992) J. Biol. Chem. , vol.267 , Issue.14 , pp. 9451-9454
    • Yanagishita, M.1    Hascall, V.C.2
  • 77
    • 0032496145 scopus 로고    scopus 로고
    • Syndecans, heparan sulfate proteoglycans maintain the proteolytic balance of acute wound fluids
    • Kainulainen V, Wang H, Schick C, Bernfield M. Syndecans, heparan sulfate proteoglycans maintain the proteolytic balance of acute wound fluids. J. Biol. Chem. 273(19), 11563-11569 (1998).
    • (1998) J. Biol. Chem. , vol.273 , Issue.19 , pp. 11563-11569
    • Kainulainen, V.1    Wang, H.2    Schick, C.3    Bernfield, M.4
  • 78
    • 0024352667 scopus 로고
    • Increased levels of proteoglycan fragments in knee joint fluid after injury
    • Lohmander LS, Dahlberg L, Ryd L, Heinegard D. Increased levels of proteoglycan fragments in knee joint fluid after injury. Arthritis Rheum. 32(11), 1434-1442 (1989).
    • (1989) Arthritis Rheum. , vol.32 , Issue.11 , pp. 1434-1442
    • Lohmander, L.S.1    Dahlberg, L.2    Ryd, L.3    Heinegard, D.4
  • 79
    • 0033847652 scopus 로고    scopus 로고
    • Increased excretion of urinary glycosaminoglycans in meningococcal septicemia and their relationship to proteinuria
    • Oragui EE, Nadel S, Kyd P, Levin M. Increased excretion of urinary glycosaminoglycans in meningococcal septicemia and their relationship to proteinuria. Crit. Care Med. 28(8), 3002-3008 (2000).
    • (2000) Crit. Care Med. , vol.28 , Issue.8 , pp. 3002-3008
    • Oragui, E.E.1    Nadel, S.2    Kyd, P.3    Levin, M.4
  • 80
    • 0022572291 scopus 로고
    • A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healing
    • Weigel PH, Fuller GM, LeBoeuf RD. A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healing. J. Theor. Biol. 119(2), 219-234 (1986).
    • (1986) J. Theor. Biol. , vol.119 , Issue.2 , pp. 219-234
    • Weigel, P.H.1    Fuller, G.M.2    LeBoeuf, R.D.3
  • 81
    • 0037094084 scopus 로고    scopus 로고
    • Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
    • Johnson GB, Brunn GJ, Kodaira Y, Platt JL. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J. Immunol. 168(10), 5233-5239 (2002).
    • (2002) J. Immunol. , vol.168 , Issue.10 , pp. 5233-5239
    • Johnson, G.B.1    Brunn, G.J.2    Kodaira, Y.3    Platt, J.L.4
  • 82
    • 0037033364 scopus 로고    scopus 로고
    • Oligosaccharides of hyaluronan activate dendritic cells via Toll-like receptor 4
    • Termeer C, Benedix F, Sleeman J et al. Oligosaccharides of hyaluronan activate dendritic cells via Toll-like receptor 4. J. Exp. Med. 195(1), 99-111 (2002).
    • (2002) J. Exp. Med. , vol.195 , Issue.1 , pp. 99-111
    • Termeer, C.1    Benedix, F.2    Sleeman, J.3
  • 84
    • 23644456849 scopus 로고    scopus 로고
    • The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages
    • Schaefer L, Babelova A, Kiss E et al. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J. Clin. Invest. 115(8), 2223-2233 (2005).
    • (2005) J. Clin. Invest. , vol.115 , Issue.8 , pp. 2223-2233
    • Schaefer, L.1    Babelova, A.2    Kiss, E.3
  • 85
    • 0028596335 scopus 로고
    • Expression of variant fibronectins in wound healing: Cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis
    • Jarnagin WR, Rockey DC, Koteliansky VE, Wang SS, Bissell DM. Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J. Cell Biol. 127(6 Pt 2), 2037-2048 (1994).
    • (1994) J. Cell Biol. , vol.127 , Issue.6 PART 2 , pp. 2037-2048
    • Jarnagin, W.R.1    Rockey, D.C.2    Koteliansky, V.E.3    Wang, S.S.4    Bissell, D.M.5
  • 86
    • 0033874135 scopus 로고    scopus 로고
    • Transforming growth factor-β initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform
    • George J, Wang SS, Sevcsik AM et al. Transforming growth factor-β initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform. Am. J. Pathol. 156(1), 115-124 (2000).
    • (2000) Am. J. Pathol. , vol.156 , Issue.1 , pp. 115-124
    • George, J.1    Wang, S.S.2    Sevcsik, A.M.3
  • 87
    • 0032697555 scopus 로고    scopus 로고
    • The fibronectin extra domain A activates matrix metalloproteinase gene expression by an interleukin-1-dependent mechanism
    • Saito S, Yamaji N, Yasunaga K et al. The fibronectin extra domain A activates matrix metalloproteinase gene expression by an interleukin-1-dependent mechanism. J. Biol. Chem. 274(43), 30756-30763 (1999).
    • (1999) J. Biol. Chem. , vol.274 , Issue.43 , pp. 30756-30763
    • Saito, S.1    Yamaji, N.2    Yasunaga, K.3
  • 88
    • 0028906093 scopus 로고
    • EDA-containing fibronectin is synthesized from rheumatoid synovial fibroblast-like cells
    • Hino K, Shiozawa S, Kuroki Y et al. EDA-containing fibronectin is synthesized from rheumatoid synovial fibroblast-like cells. Arthritis Rheum. 38(5), 678-683 (1995).
    • (1995) Arthritis Rheum. , vol.38 , Issue.5 , pp. 678-683
    • Hino, K.1    Shiozawa, S.2    Kuroki, Y.3
  • 89
    • 0035971217 scopus 로고    scopus 로고
    • The extra domain A of fibronectin activates Toll-like receptor 4
    • Okamura Y, Watari M, Jerud ES et al. The extra domain A of fibronectin activates Toll-like receptor 4. J. Biol. Chem. 276(13), 10229-10233 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.13 , pp. 10229-10233
    • Okamura, Y.1    Watari, M.2    Jerud, E.S.3
  • 90
    • 0021912846 scopus 로고
    • Regulation of extravascular coagulation by microvascular permeability
    • Dvorak HN, Senger DR, Dvorak AM, Harvey VS, McDonagh J. Regulation of extravascular coagulation by microvascular permeability. Science 227(4690), 1059-1061 (1985).
    • (1985) Science , vol.227 , Issue.4690 , pp. 1059-1061
    • Dvorak, H.N.1    Senger, D.R.2    Dvorak, A.M.3    Harvey, V.S.4    McDonagh, J.5
  • 91
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4
    • Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4. J. Immunol. 167(5), 2887-2894 (2001).
    • (2001) J. Immunol. , vol.167 , Issue.5 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 92
    • 0036829687 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2
    • Biragyn A, Ruffini PA, Leifer CA et al. Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2. Science 298(5595), 1025-1029 (2002).
    • (2002) Science , vol.298 , Issue.5595 , pp. 1025-1029
    • Biragyn, A.1    Ruffini, P.A.2    Leifer, C.A.3
  • 93
    • 0033569408 scopus 로고    scopus 로고
    • β-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
    • Yang D, Chertov O, Bykovskaia SN et al. β-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286(5439), 525-528 (1999).
    • (1999) Science , vol.286 , Issue.5439 , pp. 525-528
    • Yang, D.1    Chertov, O.2    Bykovskaia, S.N.3
  • 94
    • 0035576242 scopus 로고    scopus 로고
    • Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens
    • Biragyn A, Surenhu M, Yang D et al. Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens. J. Immunol. 167(11), 6644-6653 (2001).
    • (2001) J. Immunol. , vol.167 , Issue.11 , pp. 6644-6653
    • Biragyn, A.1    Surenhu, M.2    Yang, D.3
  • 95
    • 1842477469 scopus 로고    scopus 로고
    • mRNA is an endogenous ligand for Toll-like receptor 3
    • Kariko K, Ni H, Capodici J, Lamphier M, Weissman D. mRNA is an endogenous ligand for Toll-like receptor 3. J. Biol. Chem. 279(13), 12542-12550 (2004).
    • (2004) J. Biol. Chem. , vol.279 , Issue.13 , pp. 12542-12550
    • Kariko, K.1    Ni, H.2    Capodici, J.3    Lamphier, M.4    Weissman, D.5
  • 96
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
    • Heil F, Hemmi H, Hochrein H et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303(5663), 1526-1529 (2004).
    • (2004) Science , vol.303 , Issue.5663 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3
  • 97
    • 0020599402 scopus 로고
    • Regulation of the antiviral and anticellular activities of interferon by exogenous double-stranded RNA
    • Panet A. Regulation of the antiviral and anticellular activities of interferon by exogenous double-stranded RNA. Mol. Cell Biochem. 52(2), 153-160 (1983).
    • (1983) Mol. Cell Biochem. , vol.52 , Issue.2 , pp. 153-160
    • Panet, A.1
  • 98
    • 27744444832 scopus 로고    scopus 로고
    • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    • Lau CM, Broughton C, Tabor AS et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202(9), 1171-1177 (2005).
    • (2005) J. Exp. Med. , vol.202 , Issue.9 , pp. 1171-1177
    • Lau, C.M.1    Broughton, C.2    Tabor, A.S.3
  • 99
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • Krieg AM, Yi AK, Matson S et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374(6522), 546-549 (1995).
    • (1995) Nature , vol.374 , Issue.6522 , pp. 546-549
    • Krieg, A.M.1    Yi, A.K.2    Matson, S.3
  • 100
    • 0344321897 scopus 로고    scopus 로고
    • Impact of aging on DNA methylation
    • Richardson B. Impact of aging on DNA methylation. Ageing Res. Rev. 2(3), 245-261 (2003).
    • (2003) Ageing Res. Rev. , vol.2 , Issue.3 , pp. 245-261
    • Richardson, B.1
  • 101
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 33(11), 1665-1673 (1990).
    • (1990) Arthritis Rheum. , vol.33 , Issue.11 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3    Gross, L.4    Hanash, S.5    Johnson, M.6
  • 102
    • 0031252286 scopus 로고    scopus 로고
    • Mitogenicity of DNA from different organisms for murine B cells
    • Sun S, Beard C, Jaenisch R, Jones P, Sprent J. Mitogenicity of DNA from different organisms for murine B cells. J. Immunol. 159(7), 3119-3125 (1997).
    • (1997) J. Immunol. , vol.159 , Issue.7 , pp. 3119-3125
    • Sun, S.1    Beard, C.2    Jaenisch, R.3    Jones, P.4    Sprent, J.5
  • 103
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118(2), 229-241 (2004).
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 104
    • 30744462300 scopus 로고    scopus 로고
    • Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    • Jiang D, Liang J, Fan J et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med. 11(11), 1173-1179 (2005).
    • (2005) Nat. Med. , vol.11 , Issue.11 , pp. 1173-1179
    • Jiang, D.1    Liang, J.2    Fan, J.3
  • 105
    • 0034040746 scopus 로고    scopus 로고
    • Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides
    • van der Heijden IM, Wilbrink B, Tchetverikov I et al. Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthritis Rheum. 43(3), 593-598 (2000).
    • (2000) Arthritis Rheum. , vol.43 , Issue.3 , pp. 593-598
    • van der Heijden, I.M.1    Wilbrink, B.2    Tchetverikov, I.3
  • 106
    • 0344483894 scopus 로고    scopus 로고
    • Chlamydia trachomatis nucleic acids can be found in the synovium of some asymptomatic subjects
    • Schumacher HR Jr, Arayssi T, Crane M et al. Chlamydia trachomatis nucleic acids can be found in the synovium of some asymptomatic subjects. Arthritis Rheum. 42(6), 1281-1284 (1999).
    • (1999) Arthritis Rheum. , vol.42 , Issue.6 , pp. 1281-1284
    • Schumacher Jr., H.R.1    Arayssi, T.2    Crane, M.3
  • 107
    • 0034931802 scopus 로고    scopus 로고
    • Chromosomal DNA from a variety of bacterial species is present in synovial tissue from patients with various forms of arthritis
    • Gerard HC, Wang Z, Wang GF et al. Chromosomal DNA from a variety of bacterial species is present in synovial tissue from patients with various forms of arthritis. Arthritis Rheum. 44(7), 1689-1697 (2001).
    • (2001) Arthritis Rheum. , vol.44 , Issue.7 , pp. 1689-1697
    • Gerard, H.C.1    Wang, Z.2    Wang, G.F.3
  • 108
    • 0033806602 scopus 로고    scopus 로고
    • Reverse transcriptase-PCR analysis of bacterial rRNA for detection and characterization of bacterial species in arthritis synovial tissue
    • Kempsell KE, Cox CJ, Hurle M et al. Reverse transcriptase-PCR analysis of bacterial rRNA for detection and characterization of bacterial species in arthritis synovial tissue. Infect. Immun. 68(10), 6012-6026 (2000).
    • (2000) Infect. Immun. , vol.68 , Issue.10 , pp. 6012-6026
    • Kempsell, K.E.1    Cox, C.J.2    Hurle, M.3
  • 109
    • 0038651926 scopus 로고    scopus 로고
    • Bacterial components in the synovial tissue of patients with advanced rheumatoid arthritis or osteoarthritis: Analysis with gas chromatography-mass spectrometry and pan-bacterial polymerase chain reaction
    • Chen T, Rimpilainen M, Luukkainen R et al. Bacterial components in the synovial tissue of patients with advanced rheumatoid arthritis or osteoarthritis: analysis with gas chromatography-mass spectrometry and pan-bacterial polymerase chain reaction. Arthritis Rheum. 49(3), 328-334 (2003).
    • (2003) Arthritis Rheum. , vol.49 , Issue.3 , pp. 328-334
    • Chen, T.1    Rimpilainen, M.2    Luukkainen, R.3
  • 110
    • 0032528185 scopus 로고    scopus 로고
    • Enhanced expression of heat shock protein 70 (HSP70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of HSP70 expression and HSF1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs
    • Schett G, Redlich K, Xu Q et al. Enhanced expression of heat shock protein 70 (HSP70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of HSP70 expression and HSF1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J. Clin. Invest. 102(2), 302-311 (1998).
    • (1998) J. Clin. Invest. , vol.102 , Issue.2 , pp. 302-311
    • Schett, G.1    Redlich, K.2    Xu, Q.3
  • 111
    • 0019354902 scopus 로고
    • The distribution of fibronectin in the pannus in rheumatoid arthritis
    • Scott DL, Delamere JP, Walton KW. The distribution of fibronectin in the pannus in rheumatoid arthritis. Br. J. Exp. Pathol. 62(4), 362-368 (1981).
    • (1981) Br. J. Exp. Pathol. , vol.62 , Issue.4 , pp. 362-368
    • Scott, D.L.1    Delamere, J.P.2    Walton, K.W.3
  • 112
    • 0030987868 scopus 로고    scopus 로고
    • Soluble oligonucleosomal complexes in synovial fluid from inflamed joints
    • Yu D, Rumore PM, Liu Q, Steinman CR. Soluble oligonucleosomal complexes in synovial fluid from inflamed joints. Arthritis Rheum. 40(4), 648-654 (1997).
    • (1997) Arthritis Rheum. , vol.40 , Issue.4 , pp. 648-654
    • Yu, D.1    Rumore, P.M.2    Liu, Q.3    Steinman, C.R.4
  • 113
    • 0037386810 scopus 로고    scopus 로고
    • High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine
    • Taniguchi N, Kawahara K, Yone K et al. High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine. Arthritis Rheum. 48(4), 971-981 (2003).
    • (2003) Arthritis Rheum. , vol.48 , Issue.4 , pp. 971-981
    • Taniguchi, N.1    Kawahara, K.2    Yone, K.3
  • 114
    • 0017743014 scopus 로고
    • Arthritis in rats after systemic injection of streptococcal cells or cell walls
    • Cromartie WJ, Craddock JG, Schwab JH, Anderle SK, Yang CH. Arthritis in rats after systemic injection of streptococcal cells or cell walls. J. Exp. Med. 146(6), 1585-1602 (1977).
    • (1977) J. Exp. Med. , vol.146 , Issue.6 , pp. 1585-1602
    • Cromartie, W.J.1    Craddock, J.G.2    Schwab, J.H.3    Anderle, S.K.4    Yang, C.H.5
  • 115
    • 10744223444 scopus 로고    scopus 로고
    • Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: Critical role of myeloid differentiation factor 88
    • Joosten LA, Koenders MI, Smeets RL et al. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J. Immunol. 171(11), 6145-6153 (2003).
    • (2003) J. Immunol. , vol.171 , Issue.11 , pp. 6145-6153
    • Joosten, L.A.1    Koenders, M.I.2    Smeets, R.L.3
  • 116
    • 9144232901 scopus 로고    scopus 로고
    • Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands
    • Pieter M, Rethage J, Seibl R et al. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. J. Immunol. 172(2), 1256-1265 (2004).
    • (2004) J. Immunol. , vol.172 , Issue.2 , pp. 1256-1265
    • Pieter, M.1    Rethage, J.2    Seibl, R.3
  • 117
  • 118
    • 0037450737 scopus 로고    scopus 로고
    • Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by Toll-like receptor 4 signaling
    • Choe JY, Crann B, Wu SR, Corr M. Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by Toll-like receptor 4 signaling. J. Exp. Med. 197(4), 537-542 (2003).
    • (2003) J. Exp. Med. , vol.197 , Issue.4 , pp. 537-542
    • Choe, J.Y.1    Crann, B.2    Wu, S.R.3    Corr, M.4
  • 119
    • 25444443335 scopus 로고    scopus 로고
    • RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3
    • Brentano F, Schorr O, Gay RE, Gay S, Kyburz D. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum. 52(9), 2656-2665 (2005).
    • (2005) Arthritis Rheum. , vol.52 , Issue.9 , pp. 2656-2665
    • Brentano, F.1    Schorr, O.2    Gay, R.E.3    Gay, S.4    Kyburz, D.5
  • 120
    • 23644449245 scopus 로고    scopus 로고
    • The expression of Toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of Toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
    • Roelofs MF, Joosten LA, Abdollahi-Roodsaz S et al. The expression of Toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of Toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum. 52(8), 2313-2322 (2005).
    • (2005) Arthritis Rheum. , vol.52 , Issue.8 , pp. 2313-2322
    • Roelofs, M.F.1    Joosten, L.A.2    Abdollahi-Roodsaz, S.3
  • 121
    • 0037333990 scopus 로고    scopus 로고
    • Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by Toll-like receptor signaling
    • Kyburz D, Rethage J, Seibl R et al. Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by Toll-like receptor signaling. Arthritis Rheum. 48(3), 642-650 (2003).
    • (2003) Arthritis Rheum. , vol.48 , Issue.3 , pp. 642-650
    • Kyburz, D.1    Rethage, J.2    Seibl, R.3
  • 122
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H, Bloom O, Zhang M et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285(5425), 248-251 (1999).
    • (1999) Science , vol.285 , Issue.5425 , pp. 248-251
    • Wang, H.1    Bloom, O.2    Zhang, M.3
  • 123
    • 0036822347 scopus 로고    scopus 로고
    • High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis
    • Kokkola R, Sundberg E, Ulfgren AK et al. High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum. 46(10), 2598-2603 (2002).
    • (2002) Arthritis Rheum. , vol.46 , Issue.10 , pp. 2598-2603
    • Kokkola, R.1    Sundberg, E.2    Ulfgren, A.K.3
  • 124
    • 0037534428 scopus 로고    scopus 로고
    • A biologically important single nucleotide polymorphism within the Toll-like receptor-4 gene is not associated with rheumatoid arthritis
    • Kilding R, Akil M, Till S et al. A biologically important single nucleotide polymorphism within the Toll-like receptor-4 gene is not associated with rheumatoid arthritis. Clin. Exp. Rheumatol. 21(3), 340-342 (2003).
    • (2003) Clin. Exp. Rheumatol. , vol.21 , Issue.3 , pp. 340-342
    • Kilding, R.1    Akil, M.2    Till, S.3
  • 125
    • 17644423164 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4) gene polymorphisms and susceptibility to juvenile idiopathic arthritis
    • Lamb RM, Zeggini E, Thomson W, Donn R. Toll-like receptor 4 (TLR4) gene polymorphisms and susceptibility to juvenile idiopathic arthritis. Ann. Rheum. Dis. 64(5), 767-769 (2004).
    • (2004) Ann. Rheum. Dis. , vol.64 , Issue.5 , pp. 767-769
    • Lamb, R.M.1    Zeggini, E.2    Thomson, W.3    Donn, R.4
  • 126
    • 1642521633 scopus 로고    scopus 로고
    • Polymorphisms of Toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus
    • Sanchez E, Orozco G, Lopez-Nevot MA, Jimenez-Alonso J, Martin J. Polymorphisms of Toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus. Tissue Antigens 63(1), 54-57 (2004).
    • (2004) Tissue Antigens , vol.63 , Issue.1 , pp. 54-57
    • Sanchez, E.1    Orozco, G.2    Lopez-Nevot, M.A.3    Jimenez-Alonso, J.4    Martin, J.5
  • 127
    • 1542283740 scopus 로고    scopus 로고
    • The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome
    • Radstake TR, Franke B, Hanssen S et al. The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Arthritis Rheum. 50(3), 999-1001 (2004).
    • (2004) Arthritis Rheum. , vol.50 , Issue.3 , pp. 999-1001
    • Radstake, T.R.1    Franke, B.2    Hanssen, S.3
  • 128
    • 1542302690 scopus 로고    scopus 로고
    • Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release
    • Hong Z, Jiang Z, Liangxi W et al. Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release. Int. Immunopharmacol. 4(2), 223-234 (2004).
    • (2004) Int. Immunopharmacol. , vol.4 , Issue.2 , pp. 223-234
    • Hong, Z.1    Jiang, Z.2    Liangxi, W.3
  • 129
    • 33745634132 scopus 로고    scopus 로고
    • Chloroquine inhibits production of TNF-α, IL-1β and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes
    • Jang CH, Choi JH, Byun MS, Jue DM. Chloroquine inhibits production of TNF-α, IL-1β and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes. Rheumatology (Oxford) 45(6), 703-710 (2006).
    • (2006) Rheumatology (Oxford) , vol.45 , Issue.6 , pp. 703-710
    • Jang, C.H.1    Choi, J.H.2    Byun, M.S.3    Jue, D.M.4
  • 130
    • 24144465889 scopus 로고    scopus 로고
    • Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors
    • Ogawa S, Lozach J, Benner C et al. Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors. Cell 122(5), 707-721 (2005).
    • (2005) Cell , vol.122 , Issue.5 , pp. 707-721
    • Ogawa, S.1    Lozach, J.2    Benner, C.3
  • 131
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of Toll-like receptor-mediated immune responses
    • Liew FY, Xu D, Brint EK, O'Neill LA. Negative regulation of Toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5(6), 446-458 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , Issue.6 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.4
  • 132
    • 30044441094 scopus 로고    scopus 로고
    • Limiting inflammatory responses during activation of innate immunity
    • Han J, Ulevitch RJ. Limiting inflammatory responses during activation of innate immunity. Nat. Immunol. 6(12), 1198-1205 (2005).
    • (2005) Nat. Immunol. , vol.6 , Issue.12 , pp. 1198-1205
    • Han, J.1    Ulevitch, R.J.2
  • 133
    • 0033567388 scopus 로고    scopus 로고
    • ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
    • Kopp E, Medzhitov R, Carothers J et al. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 13(16), 2059-2071 (1999).
    • (1999) Genes Dev. , vol.13 , Issue.16 , pp. 2059-2071
    • Kopp, E.1    Medzhitov, R.2    Carothers, J.3
  • 136
    • 0034603036 scopus 로고    scopus 로고
    • Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-α
    • Murakami S, Lefebvre V, de Crombrugghe B. Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-α. J. Biol. Chem. 275(5), 3687-3692 (2000).
    • (2000) J. Biol. Chem. , vol.275 , Issue.5 , pp. 3687-3692
    • Murakami, S.1    Lefebvre, V.2    de Crombrugghe, B.3
  • 137
    • 0029552889 scopus 로고
    • High DNA-binding activity of transcription factor NF-κB in synovial membranes of patients with rheumatoid arthritis
    • Asahara H, Asanuma M, Ogawa N, Nishibayashi S, Inoue H. High DNA-binding activity of transcription factor NF-κB in synovial membranes of patients with rheumatoid arthritis. Biochem. Mol. Biol. Int. 37(5), 827-832 (1995).
    • (1995) Biochem. Mol. Biol. Int. , vol.37 , Issue.5 , pp. 827-832
    • Asahara, H.1    Asanuma, M.2    Ogawa, N.3    Nishibayashi, S.4    Inoue, H.5
  • 138
    • 0029563524 scopus 로고
    • Nuclear factor-κB in rheumatoid synovium. Localization of p50 and p65
    • Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-κB in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum. 38(12), 1762-1770 (1995).
    • (1995) Arthritis Rheum. , vol.38 , Issue.12 , pp. 1762-1770
    • Handel, M.L.1    McMorrow, L.B.2    Gravallese, E.M.3
  • 139
    • 15844384253 scopus 로고    scopus 로고
    • Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue
    • Marok R, Winyard PG, Coumbe A et al. Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue. Arthritis Rheum. 39(4), 583-591 (1996).
    • (1996) Arthritis Rheum. , vol.39 , Issue.4 , pp. 583-591
    • Marok, R.1    Winyard, P.G.2    Coumbe, A.3
  • 140
    • 0032493278 scopus 로고    scopus 로고
    • Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent
    • Foxwell B, Browne K, Bondeson J et al. Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent. Proc. Natl Acad. Sci. USA 95(14), 8211-8215 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , Issue.14 , pp. 8211-8215
    • Foxwell, B.1    Browne, K.2    Bondeson, J.3
  • 141
    • 0035889229 scopus 로고    scopus 로고
    • NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts
    • Smith C, Andreakos E, Crawley JB, Brennan FM, Feldmann M, Foxwell BM. NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts. J Immunol. 167(10), 5895-5903 (2001).
    • (2001) J Immunol. , vol.167 , Issue.10 , pp. 5895-5903
    • Smith, C.1    Andreakos, E.2    Crawley, J.B.3    Brennan, F.M.4    Feldmann, M.5    Foxwell, B.M.6
  • 142
    • 0033545863 scopus 로고    scopus 로고
    • Defining therapeutic targets by using adenovirus: Blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators
    • Bondeson J, Foxwell B, Brennan F, Feldmann M. Defining therapeutic targets by using adenovirus: blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators. Proc. Natl Acad. Sci. USA 96(10), 5668-5673 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.10 , pp. 5668-5673
    • Bondeson, J.1    Foxwell, B.2    Brennan, F.3    Feldmann, M.4
  • 143
    • 0032505870 scopus 로고    scopus 로고
    • NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
    • Miagkov AV, Kovalenko DV, Brown CE et al. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl Acad. Sci. USA 95(23), 13859-13864 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , Issue.23 , pp. 13859-13864
    • Miagkov, A.V.1    Kovalenko, D.V.2    Brown, C.E.3
  • 144
    • 13044316560 scopus 로고    scopus 로고
    • Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis
    • Palombella VJ, Conner EM, Fuseler JW et al. Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis. Proc. Natl Acad. Sci. USA 95(26), 15671-15676 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , Issue.26 , pp. 15671-15676
    • Palombella, V.J.1    Conner, E.M.2    Fuseler, J.W.3
  • 145
    • 0030907182 scopus 로고    scopus 로고
    • The effect of dexamethasone on the expression of activated NF-κB in adjuvant arthritis
    • Tsao PW, Suzuki T, Totsuka R et al. The effect of dexamethasone on the expression of activated NF-κB in adjuvant arthritis. Clin. Immunol. Immunopathol. 83(2), 173-178 (1997).
    • (1997) Clin. Immunol. Immunopathol. , vol.83 , Issue.2 , pp. 173-178
    • Tsao, P.W.1    Suzuki, T.2    Totsuka, R.3
  • 146
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: A treasure trove for drug development
    • Karin M, Yamamoto Y, Wang QM. The IKK NF-κB system: a treasure trove for drug development. Nature Rev. Drug Discov. 3(1), 17-26 (2004).
    • (2004) Nature Rev. Drug Discov. , vol.3 , Issue.1 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 148
    • 0033758633 scopus 로고    scopus 로고
    • Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis
    • Schett G, Tohidast-Akrad M, Smolen JS et al. Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. Arthritis Rheum. 43(11), 2501-2512 (2000).
    • (2000) Arthritis Rheum. , vol.43 , Issue.11 , pp. 2501-2512
    • Schett, G.1    Tohidast-Akrad, M.2    Smolen, J.S.3
  • 149
    • 0032951716 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
    • Dean JL, Brook M, Clark AR, Saklatvala J. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J. Biol. Chem. 274(1), 264-269 (1999).
    • (1999) J. Biol. Chem. , vol.274 , Issue.1 , pp. 264-269
    • Dean, J.L.1    Brook, M.2    Clark, A.R.3    Saklatvala, J.4
  • 150
    • 0032515186 scopus 로고    scopus 로고
    • A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA
    • Ridley SH, Dean JL, Sarsfield SJ, Brook M, Clark AR, Saklatvala J. A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett. 439(1-2), 75-80 (1998).
    • (1998) FEBS Lett. , vol.439 , Issue.1-2 , pp. 75-80
    • Ridley, S.H.1    Dean, J.L.2    Sarsfield, S.J.3    Brook, M.4    Clark, A.R.5    Saklatvala, J.6
  • 151
    • 0035794225 scopus 로고    scopus 로고
    • Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-α) mRNA induction. Evidence for selective destabilization of TNF-α transcripts
    • Rutault K, Hazzalin CA, Mahadevan LC. Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-α) mRNA induction. Evidence for selective destabilization of TNF-α transcripts. J. Biol. Chem. 276(9), 6666-6674. (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.9 , pp. 6666-6674
    • Rutault, K.1    Hazzalin, C.A.2    Mahadevan, L.C.3
  • 152
    • 9144251043 scopus 로고    scopus 로고
    • A novel mechanism for TNF-α regulation by p38 MAPK: Involvement of NF-κB with implications for therapy in rheumatoid arthritis
    • Campbell J, Ciesielski CJ, Hunt AE et al. A novel mechanism for TNF-α regulation by p38 MAPK: involvement of NF-κB with implications for therapy in rheumatoid arthritis. J. Immunol. 173(11), 6928-6937 (2004).
    • (2004) J. Immunol. , vol.173 , Issue.11 , pp. 6928-6937
    • Campbell, J.1    Ciesielski, C.J.2    Hunt, A.E.3
  • 153
    • 0030426902 scopus 로고    scopus 로고
    • Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
    • Badger AM, Bradbeer JN, Votta B, Lee JC, Adams JL, Griswold DE. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279(3), 1453-1461 (1996).
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , Issue.3 , pp. 1453-1461
    • Badger, A.M.1    Bradbeer, J.N.2    Votta, B.3    Lee, J.C.4    Adams, J.L.5    Griswold, D.E.6
  • 154
    • 0031934170 scopus 로고    scopus 로고
    • Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models
    • Jackson JR, Bolognese B, Hillegass L et al. Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models. J. Pharmacol. Exp. Ther. 284(2), 687-692 (1998).
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , Issue.2 , pp. 687-692
    • Jackson, J.R.1    Bolognese, B.2    Hillegass, L.3
  • 155
    • 0034121690 scopus 로고    scopus 로고
    • Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
    • Badger AM, Griswold DE, Kapadia R et al. Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Arthritis Rheum. 43(1), 175-183 (2000).
    • (2000) Arthritis Rheum. , vol.43 , Issue.1 , pp. 175-183
    • Badger, A.M.1    Griswold, D.E.2    Kapadia, R.3
  • 156
    • 0032745423 scopus 로고    scopus 로고
    • RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase
    • Wadsworth SA, Cavender DE, Beers SA et al. RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. J. Pharmacol. Exp. Ther. 291(2), 680-687 (1999).
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , Issue.2 , pp. 680-687
    • Wadsworth, S.A.1    Cavender, D.E.2    Beers, S.A.3
  • 157
    • 0035086636 scopus 로고    scopus 로고
    • The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy
    • McLay LM, Halley F, Souness JE et al. The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy. Bioorg. Med. Chem. 9(2), 537-554 (2001).
    • (2001) Bioorg. Med. Chem. , vol.9 , Issue.2 , pp. 537-554
    • McLay, L.M.1    Halley, F.2    Souness, J.E.3
  • 158
    • 0043281537 scopus 로고    scopus 로고
    • Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections
    • Medvedev AE, Lentschat A, Kuhns DB et al. Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. J. Exp. Med. 198(4), 521-531 (2003).
    • (2003) J. Exp. Med. , vol.198 , Issue.4 , pp. 521-531
    • Medvedev, A.E.1    Lentschat, A.2    Kuhns, D.B.3
  • 159
    • 0037471003 scopus 로고    scopus 로고
    • Pyogenic bacterial infections in humans with IRAK-4 deficiency
    • Picard C, Puel A, Bonnet M et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 299(5615), 2076-2079 (2003).
    • (2003) Science , vol.299 , Issue.5615 , pp. 2076-2079
    • Picard, C.1    Puel, A.2    Bonnet, M.3
  • 160
    • 0031569480 scopus 로고    scopus 로고
    • Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections
    • Kuhns DB, Long Priel DA, Gallin JI. Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections. J. Immunol. 158(8), 3959-3964 (1997).
    • (1997) J. Immunol. , vol.158 , Issue.8 , pp. 3959-3964
    • Kuhns, D.B.1    Long Priel, D.A.2    Gallin, J.I.3
  • 161
    • 0027341368 scopus 로고
    • Disease resistance results from foreign phytoalexin expression in a novel plant
    • Hain R, Reif HJ, Krause E et al. Disease resistance results from foreign phytoalexin expression in a novel plant. Nature 361(6408), 153-156 (1993).
    • (1993) Nature , vol.361 , Issue.6408 , pp. 153-156
    • Hain, R.1    Reif, H.J.2    Krause, E.3
  • 162
    • 0025476770 scopus 로고
    • Expression of a stilbene synthase gene in Nicotiana tabacum results in synthesis of the phytoalexin resveratrol
    • Hain R, Bieseler B, Kindl H, Schroder G, Stocker R. Expression of a stilbene synthase gene in Nicotiana tabacum results in synthesis of the phytoalexin resveratrol. Plant Mol. Biol. 15(2), 325-335 (1990).
    • (1990) Plant Mol. Biol. , vol.15 , Issue.2 , pp. 325-335
    • Hain, R.1    Bieseler, B.2    Kindl, H.3    Schroder, G.4    Stocker, R.5
  • 163
    • 0036297527 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of resveratrol
    • Bhat KP, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Ann. NY Acad. Sci 957, 210-229 (2002).
    • (2002) Ann. NY Acad. Sci , vol.957 , pp. 210-229
    • Bhat, K.P.1    Pezzuto, J.M.2
  • 164
    • 0242695672 scopus 로고    scopus 로고
    • Resveratrol: From grapevines to mammalian biology
    • Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J. 17(14), 1975-1985 (2003).
    • (2003) FASEB J. , vol.17 , Issue.14 , pp. 1975-1985
    • Pervaiz, S.1
  • 165
    • 23844478190 scopus 로고    scopus 로고
    • Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex
    • Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J. Immunol. 175(5), 3339-3346 (2005).
    • (2005) J. Immunol. , vol.175 , Issue.5 , pp. 3339-3346
    • Youn, H.S.1    Lee, J.Y.2    Fitzgerald, K.A.3    Young, H.A.4    Akira, S.5    Hwang, D.H.6
  • 166
    • 30944443792 scopus 로고    scopus 로고
    • The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals
    • Ahn JY, Choi IS, Shim JY et al. The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals. Eur. J. Immunol. 36(1), 37-45 (2006).
    • (2006) Eur. J. Immunol. , vol.36 , Issue.1 , pp. 37-45
    • Ahn, J.Y.1    Choi, I.S.2    Shim, J.Y.3
  • 167
    • 0020517536 scopus 로고
    • 1,25-dihydroxyvitamin D3 receptors in human leukocytes
    • Provvedini DM, Tsoukas CD, Deftos LJ, Manolagas SC. 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 221(4616), 1181-1183 (1983).
    • (1983) Science , vol.221 , Issue.4616 , pp. 1181-1183
    • Provvedini, D.M.1    Tsoukas, C.D.2    Deftos, L.J.3    Manolagas, S.C.4
  • 168
    • 0035125707 scopus 로고    scopus 로고
    • Beneficial effect of the active form of vitamin D3 against LPS-induced DIC but not against tissue-factor-induced DIC in rat models
    • Asakura H, Aoshima K, Suga Y et al. Beneficial effect of the active form of vitamin D3 against LPS-induced DIC but not against tissue-factor-induced DIC in rat models. Thromb. Haemost. 85(2), 287-290 (2001).
    • (2001) Thromb. Haemost. , vol.85 , Issue.2 , pp. 287-290
    • Asakura, H.1    Aoshima, K.2    Suga, Y.3
  • 169
    • 32944464959 scopus 로고    scopus 로고
    • Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns
    • Sadeghi K, Wessner B, Laggner U et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur. J. Immunol. 36(2), 361-370 (2006).
    • (2006) Eur. J. Immunol. , vol.36 , Issue.2 , pp. 361-370
    • Sadeghi, K.1    Wessner, B.2    Laggner, U.3
  • 170
    • 17844383756 scopus 로고    scopus 로고
    • Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation
    • Duramad O, Fearon KL, Chang B et al. Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from
    • (2005) J. Immunol. , vol.174 , Issue.9 , pp. 5193-5200
    • Duramad, O.1    Fearon, K.L.2    Chang, B.3
  • 171
    • 2342491490 scopus 로고    scopus 로고
    • Suppressive oligonucleotides protect against collagen-induced arthritis in mice
    • Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligonucleotides protect against collagen-induced arthritis in mice. Arthritis Rheum. 50(5), 1686-1689 (2004).
    • (2004) Arthritis Rheum. , vol.50 , Issue.5 , pp. 1686-1689
    • Dong, L.1    Ito, S.2    Ishii, K.J.3    Klinman, D.M.4
  • 172
    • 33645076274 scopus 로고    scopus 로고
    • TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
    • Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J. Exp. Med. 203(3), 553-561 (2006).
    • (2006) J. Exp. Med. , vol.203 , Issue.3 , pp. 553-561
    • Ehlers, M.1    Fukuyama, H.2    McGaha, T.L.3    Aderem, A.4    Ravetch, J.V.5
  • 173
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat FJ, Meeker T, Gregorio J et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J. Exp. Med. 202(8), 1131-1139 (2005).
    • (2005) J. Exp. Med. , vol.202 , Issue.8 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3
  • 174
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boule MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199(12), 1631-1640 (2004).
    • (2004) J. Exp. Med. , vol.199 , Issue.12 , pp. 1631-1640
    • Boule, M.W.1    Broughton, C.2    Mackay, F.3    Akira, S.4    Marshak-Rothstein, A.5    Rifkin, I.R.6
  • 175
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 420(6917), 868-874 (2002).
    • (2002) Nature , vol.420 , Issue.6917 , pp. 868-874
    • Libby, P.1
  • 176
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 276(20), 16683-16689 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.20 , pp. 6683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 177
    • 2342435824 scopus 로고    scopus 로고
    • Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
    • Lee JY, Zhao L, Youn HS et al. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J. Biol. Chem. 279(17), 16971-16979 (2004).
    • (2004) J. Biol. Chem. , vol.279 , Issue.17 , pp. 16971-16979
    • Lee, J.Y.1    Zhao, L.2    Youn, H.S.3
  • 178
    • 0037449723 scopus 로고    scopus 로고
    • Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells
    • Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J. Biol. Chem. 278(3), 1561-1568 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.3 , pp. 1561-1568
    • Miller, Y.I.1    Viriyakosol, S.2    Binder, C.J.3    Feramisco, J.R.4    Kirkland, T.N.5    Witztum, J.L.6
  • 179
    • 0042031044 scopus 로고    scopus 로고
    • Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein
    • Walton KA, Hsieh X, Gharavi N et al. Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein. J. Biol. Chem. 278(32), 29661-29666 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.32 , pp. 29661-29666
    • Walton, K.A.1    Hsieh, X.2    Gharavi, N.3
  • 180
    • 0027976942 scopus 로고
    • Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
    • Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler. Thromb. 14(1), 141-147 (1994).
    • (1994) Arterioscler. Thromb. , vol.14 , Issue.1 , pp. 141-147
    • Reddick, R.L.1    Zhang, S.H.2    Maeda, N.3
  • 181
    • 3242710174 scopus 로고    scopus 로고
    • Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
    • Michelsen KS, Wong MH, Shah PK et al. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc. Natl Acad. Sci. USA 101(29), 10679-10684 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.29 , pp. 10679-10684
    • Michelsen, K.S.1    Wong, M.H.2    Shah, P.K.3
  • 182
    • 0034678402 scopus 로고    scopus 로고
    • Infectious agents are not necessary for murine atherogenesis
    • Wright SD, Burton C, Hernandez M et al. Infectious agents are not necessary for murine atherogenesis. J. Exp. Med. 191(8), 1437-1442 (2000).
    • (2000) J. Exp. Med. , vol.191 , Issue.8 , pp. 1437-1442
    • Wright, S.D.1    Burton, C.2    Hernandez, M.3
  • 183
    • 3242728901 scopus 로고    scopus 로고
    • Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
    • Bjorkbacka H, Kunjathoor VV, Moore KJ et al. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat. Med. 10(4), 416-421 (2004).
    • (2004) Nat. Med. , vol.10 , Issue.4 , pp. 416-421
    • Bjorkbacka, H.1    Kunjathoor, V.V.2    Moore, K.J.3
  • 184
    • 0037388984 scopus 로고    scopus 로고
    • Lack of interleukin-1β decreases the severity of atherosclerosis in ApoE-deficient mice
    • Kirii H, Niwa T, Yamada Y et al. Lack of interleukin-1β decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 23(4), 656-660 (2003).
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , Issue.4 , pp. 656-660
    • Kirii, H.1    Niwa, T.2    Yamada, Y.3
  • 185
    • 0038094522 scopus 로고    scopus 로고
    • Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice
    • Elhage R, Jawien J, Rudling M et al. Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice. Cardiovasc. Res. 59(1), 234-240 (2003).
    • (2003) Cardiovasc. Res. , vol.59 , Issue.1 , pp. 234-240
    • Elhage, R.1    Jawien, J.2    Rudling, M.3
  • 186
    • 0027199742 scopus 로고
    • Atherosclerosis and plasma and liver lipids in nine inbred strains of mice
    • Nishina PM, Wang J, Toyofuku W, Kuypers FA, Ishida BY, Paigen B. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7), 599-605 (1993).
    • (1993) Lipids , vol.28 , Issue.7 , pp. 599-605
    • Nishina, P.M.1    Wang, J.2    Toyofuku, W.3    Kuypers, F.A.4    Ishida, B.Y.5    Paigen, B.6
  • 187
    • 0037130195 scopus 로고    scopus 로고
    • Toll-like receptor 4 polymorphisms and atherogenesis
    • Kiechl S, Lorenz E, Reindl M et al. Toll-like receptor 4 polymorphisms and atherogenesis. N. Engl. J. Med. 347(3), 185-192 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , Issue.3 , pp. 185-192
    • Kiechl, S.1    Lorenz, E.2    Reindl, M.3
  • 188
    • 1342278730 scopus 로고    scopus 로고
    • Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events
    • Ameziane N, Beillat T, Verpillat P et al. Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler. Thromb. Vasc. Biol. 23(12), e61-e64 (2003).
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , Issue.12
    • Ameziane, N.1    Beillat, T.2    Verpillat, P.3
  • 189
    • 0029837397 scopus 로고    scopus 로고
    • T-cell responses to autoantigens in IDDM. The search for the Holy Grail
    • Roep BO. T-cell responses to autoantigens in IDDM. The search for the Holy Grail. Diabetes 45(9), 1147-1156 (1996).
    • (1996) Diabetes , vol.45 , Issue.9 , pp. 1147-1156
    • Roep, B.O.1
  • 190
    • 20044385554 scopus 로고    scopus 로고
    • Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
    • Lang KS, Recher M, Junt T et al. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat. Med. 11(2), 138-145 (2005).
    • (2005) Nat. Med. , vol.11 , Issue.2 , pp. 138-145
    • Lang, K.S.1    Recher, M.2    Junt, T.3
  • 191
    • 3242805826 scopus 로고    scopus 로고
    • Type I IFN protects against murine lupus
    • Hron JD, Peng SL. Type I IFN protects against murine lupus. J. Immunol. 173(3), 2134-2142 (2004).
    • (2004) J. Immunol. , vol.173 , Issue.3 , pp. 2134-2142
    • Hron, J.D.1    Peng, S.L.2
  • 192
    • 0026641148 scopus 로고
    • Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity, and cytotoxicity
    • Jingwu Z, Medaer R, Hashim GA, Chin Y, van den Berg-Loonen E, Raus JC. Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicity. Ann. Neurol. 32(3), 330-338 (1992).
    • (1992) Ann. Neurol. , vol.32 , Issue.3 , pp. 330-338
    • Jingwu, Z.1    Medaer, R.2    Hashim, G.A.3    Chin, Y.4    van den Berg-Loonen, E.5    Raus, J.C.6
  • 193
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA, T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346(6280), 183-187 (1990).
    • (1990) Nature , vol.346 , Issue.6280 , pp. 183-187
    • Ota, K.1    Matsui, M.2    Milford, E.L.3    Mackin, G.A.4    Weiner, H.L.5    Hafler, D.A.6
  • 194
    • 0027486499 scopus 로고
    • Myelin basic protein-specific T-cell responses in identical twins discordant or concordant for multiple sclerosis
    • Martin R, Voskuhl R, Flerlage M, McFarlin DE, McFarland HF. Myelin basic protein-specific T-cell responses in identical twins discordant or concordant for multiple sclerosis. Ann. Neurol. 34(4), 524-535 (1993).
    • (1993) Ann. Neurol. , vol.34 , Issue.4 , pp. 524-535
    • Martin, R.1    Voskuhl, R.2    Flerlage, M.3    McFarlin, D.E.4    McFarland, H.F.5
  • 195
    • 0037029424 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet 359(9313), 1221-1231 (2002).
    • (2002) Lancet , vol.359 , Issue.9313 , pp. 1221-1231
    • Compston, A.1    Coles, A.2
  • 196
    • 0034566306 scopus 로고    scopus 로고
    • Prognosis of multiple sclerosis: Environmental factors
    • Casetta I, Granieri E. Prognosis of multiple sclerosis: environmental factors. Neurol. Sci. 21(4 Suppl. 2), S839-S842 (2000).
    • (2000) Neurol. Sci. , vol.21 , Issue.4 SUPPL. 2
    • Casetta, I.1    Granieri, E.2
  • 197
    • 0036237054 scopus 로고    scopus 로고
    • Prospective study on the relationship between infections and multiple sclerosis exacerbations
    • Buljevac D, Flach HZ, Hop WC et al. Prospective study on the relationship between infections and multiple sclerosis exacerbations. Brain 125(Pt 5), 952-960 (2002).
    • (2002) Brain , vol.125 , Issue.PART 5 , pp. 952-960
    • Buljevac, D.1    Flach, H.Z.2    Hop, W.C.3
  • 198
    • 2142821465 scopus 로고    scopus 로고
    • Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease
    • Waldner H, Collins M, Kuchroo VK. Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J. Clin. Invest. 113(7), 990-997 (2004).
    • (2004) J. Clin. Invest. , vol.113 , Issue.7 , pp. 990-997
    • Waldner, H.1    Collins, M.2    Kuchroo, V.K.3
  • 199
    • 9144247024 scopus 로고    scopus 로고
    • TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease
    • Kerfoot SM, Long EM, Hickey MJ et al. TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. J. Immunol. 173(11), 7070-7077 (2004).
    • (2004) J. Immunol. , vol.173 , Issue.11 , pp. 7070-7077
    • Kerfoot, S.M.1    Long, E.M.2    Hickey, M.J.3
  • 200
    • 0020001747 scopus 로고
    • Development of acute autoimmune encephalomyelitis in mice: Factors regulating the effector phase of the disease
    • Linthicum DS. Development of acute autoimmune encephalomyelitis in mice: factors regulating the effector phase of the disease. Immunobiology 162(3), 211-220 (1982).
    • (1982) Immunobiology , vol.162 , Issue.3 , pp. 211-220
    • Linthicum, D.S.1
  • 201
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411(6837), 599-603 (2001).
    • (2001) Nature , vol.411 , Issue.6837 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 202
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411(6837), 603-606 (2001).
    • (2001) Nature , vol.411 , Issue.6837 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 203
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • Inohara N, Ogura Y, Fontalba A et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 278(8), 5509-5512 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.8 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3
  • 204
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • Girardin SE, Boneca IG, Viala J et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278(11), 8869-8872 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.11 , pp. 8869-8872
    • Girardin, S.E.1    Boneca, I.G.2    Viala, J.3
  • 205
    • 23844508543 scopus 로고    scopus 로고
    • Synergistic enhancement of Toll-like receptor responses by NOD1 activation
    • van Heel DA, Ghosh S, Butler M et al. Synergistic enhancement of Toll-like receptor responses by NOD1 activation. Eur. J. Immunol. 35(8), 2471-2476 (2005).
    • (2005) Eur. J. Immunol. , vol.35 , Issue.8 , pp. 2471-2476
    • van Heel, D.A.1    Ghosh, S.2    Butler, M.3
  • 206
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    • Watanabe T, Kitani A, Murray PJ, Strober W. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5(8), 800-808 (2004).
    • (2004) Nat. Immunol. , vol.5 , Issue.8 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3    Strober, W.4
  • 207
    • 10744227704 scopus 로고    scopus 로고
    • Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia
    • Netea MG, Hijmans A, van Wissen S et al. Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia. Eur J. Clin. Invest. 34(2), 94-99 (2004).
    • (2004) Eur J. Clin. Invest. , vol.34 , Issue.2 , pp. 94-99
    • Netea, M.G.1    Hijmans, A.2    van Wissen, S.3
  • 210
    • 0028455802 scopus 로고
    • Crystals and arthritis
    • McCarty DJ. Crystals and arthritis. Dis. Mon. 40(6), 255-299 (1994).
    • (1994) Dis. Mon. , vol.40 , Issue.6 , pp. 255-299
    • McCarty, D.J.1
  • 211
    • 4043075471 scopus 로고    scopus 로고
    • Gout: On the brink of novel therapeutic options for an ancient disease
    • Bieber JD, Terkeltaub RA. Gout: on the brink of novel therapeutic options for an ancient disease. Arthritis Rheum. 50(8), 2400-2414 (2004).
    • (2004) Arthritis Rheum. , vol.50 , Issue.8 , pp. 2400-2414
    • Bieber, J.D.1    Terkeltaub, R.A.2
  • 212
    • 17144371314 scopus 로고    scopus 로고
    • TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation
    • Liu-Bryan R, Pritzker K, Firestein GS, Terkeltaub R. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J. Immunol. 174(8), 5016-5023 (2005).
    • (2005) J. Immunol. , vol.174 , Issue.8 , pp. 5016-5023
    • Liu-Bryan, R.1    Pritzker, K.2    Firestein, G.S.3    Terkeltaub, R.4
  • 213
    • 25444454295 scopus 로고    scopus 로고
    • Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation
    • Liu-Bryan R, Scott P, Sydlaske A, Rose DM, Terkeltaub R. Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum. 52(9), 2936-2946 (2005).
    • (2005) Arthritis Rheum. , vol.52 , Issue.9 , pp. 2936-2946
    • Liu-Bryan, R.1    Scott, P.2    Sydlaske, A.3    Rose, D.M.4    Terkeltaub, R.5
  • 214
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440(7081), 237-241 (2006).
    • (2006) Nature , vol.440 , Issue.7081 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 215
    • 33344476398 scopus 로고    scopus 로고
    • CATERPILLERs, pyrin and hereditary immunological disorders
    • Ting JP, Kastner DL, Hoffman HM. CATERPILLERs, pyrin and hereditary immunological disorders. Nat. Rev. Immunol. 6(3), 183-195 (2006).
    • (2006) Nat. Rev. Immunol. , vol.6 , Issue.3 , pp. 183-195
    • Ting, J.P.1    Kastner, D.L.2    Hoffman, H.M.3
  • 216
    • 7944232105 scopus 로고    scopus 로고
    • Identification of bacterial muramyl dipeptide as activator of the NALP3 /cryopyrin inflammasome
    • Martinon F, Agostini L, Meylan E, Tschopp J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 14(21), 1929-1934 (2004).
    • (2004) Curr. Biol. , vol.14 , Issue.21 , pp. 1929-1934
    • Martinon, F.1    Agostini, L.2    Meylan, E.3    Tschopp, J.4
  • 217
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10(2), 417-426 (2002).
    • (2002) Mol. Cell , vol.10 , Issue.2 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 218
    • 3142654767 scopus 로고    scopus 로고
    • Differential activation of the inflammasome by caspase-I adaptors ASC and Ipaf
    • Mariathasan S, Newton K, Monack DM et al. Differential activation of the inflammasome by caspase-I adaptors ASC and Ipaf. Nature 430(6996), 213-218 (2004).
    • (2004) Nature , vol.430 , Issue.6996 , pp. 213-218
    • Mariathasan, S.1    Newton, K.2    Monack, D.M.3


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