RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 2, 1999, Pages 680-687

  Wadsworth, Scott A ^a   Cavender, Druie E ^a   Beers, Scott A ^a   Lalan, Praful ^a   Schafer, Peter H ^a   Malloy, Elizabeth A ^a   Wu, Wei ^a   Fahmy, Bohumila ^a   Olini, Gilbert C ^a   Davis, Janet E ^a   Pellegrino Gensey, J Lee ^a   Wachter, Michael P ^a   Siekierka, John J ^a,b  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b Drug Discovery Raritan   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (4 FLUOROPHENYL) 1 (3 PHENYLPROPYL) 5 (4 PYRIDINYL) 1H IMIDAZOL 2 YL] 3 BUTYN 1 OL; CYCLOOXYGENASE 1; ENTEROTOXIN; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; STAPHYLOCOCCUS TOXIN; SUPERANTIGEN; THROMBOXANE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

ANIMALS; ANTIGENS; CELL DIVISION; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROTOXINS; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; INTERFERON TYPE II; INTERLEUKIN-2; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; PROTEIN KINASES; PYRIDINES; RATS; RATS, INBRED LEW; STAPHYLOCOCCUS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032745423     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

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