TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE

Journal of Experimental Medicine

Volumn 203, Issue 3, 2006, Pages 553-561

  Ehlers, Marc ^a   Fukuyama, Hidehiro ^a   McGaha, Tracy L ^a   Aderem, Alan ^b   Ravetch, Jeffrey V ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; FC GAMMA RECEPTOR 4; FC RECEPTOR; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN M; IMMUNOGLOBULIN SUBCLASS; MYELOID DIFFERENTIATION FACTOR 88; RECEPTOR SUBTYPE; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; IMMUNOCOMPETENT CELL; IMMUNOGLOBULIN PRODUCING CELL; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOREGULATION; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOANTIBODIES; B-LYMPHOCYTES; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN G; LUPUS ERYTHEMATOSUS, SYSTEMIC; MACROPHAGES; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, IGG; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9;

EID: 33645076274     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20052438     Document Type: Article

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