Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

Nature Medicine

Volumn 11, Issue 2, 2005, Pages 138-145

  Lang, Karl S ^a   Recher, Mike ^a   Junt, Tobias ^a   Navarini, Alexander A ^a   Harris, Nicola L ^a   Freigang, Stefan ^a   Odermatt, Bernhard ^a   Conrad, Curdin ^b   Ittner, Lars M ^c   Bauer, Stefan ^d   Luther, Sanjiv A ^e   Uematsu, Satoshi ^f   Akira, Shizuo ^f   Hengartner, Hans ^a   Zinkernagel, Rolf M ^a  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF LAUSANNE   (Switzerland)

^f OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GLYCOPROTEIN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL DESTRUCTION; CONTROLLED STUDY; DIABETES MELLITUS; IMMUNIZATION; INFLAMMATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSGENE; UPREGULATION;

ANIMALS; AUTOIMMUNE DISEASES; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; GENES, MHC CLASS I; HUMANS; INTERFERON-ALPHA; ISLETS OF LANGERHANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; RATS; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTORS; TRANSGENES; VIRAL PROTEINS;

EID: 20044385554     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1176     Document Type: Article

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