Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 3, 1996, Pages 1453-1461

  Badger, Alison M ^a   Bradbeer, Jeremy N ^a   Votta, Bart ^a   Lee, John C ^a   Adams, Jerry L ^a   Griswold, Don E ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIINFLAMMATORY AGENT; ANTIRHEUMATIC AGENT; ARACHIDONIC ACID; BACTERIUM LIPOPOLYSACCHARIDE; BINDING PROTEIN; CALCIUM 45; COLLAGEN TYPE 2; CYTOKINE; ENDOTOXIN; INTERLEUKIN 6; RAPAMYCIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BONE DENSITY; BONE MINERAL; CHRONIC DISEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME INHIBITION; IMMUNE FUNCTION TEST; INFLAMMATORY DISEASE; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOLYSIS; PAW EDEMA; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 0030426902     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. AARDEN, L. A., LANSDORP, P., AND DE GROOT, E.: A growth factor for B-cell hybridomas produced by human monocytes. Lymphokines 10: 175-185, 1985.
2. AREND, W. P. AND DAYER, J.-M.: Inhibition of the production and effects of interleukin-1 and tumor necrosis factor a in rheumatoid arthritis. Arthritis Rheum. 38: 151-160, 1995.
3. BADGER, A. M., OLIVERA, D., TALMADGE, J. E. AND HANNA, N.: Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: Inhibition of tumor necrosis factor as a possible mechanism of action. Circ. Shock 27: 51-61, 1989.
4. BERTOLINI, D. R., NEDWIN, G. E., BRINGMAN, T. S., SMITH, D. D. AND MUNDY, G. R.: Stimulation of bone resorption and inhibition of bone formation in vitro by human necrosis factors. Nature (Lond.) 319: 515-518, 1986.
5. BEYAERT, R., CUENDA, A., BERGHE, W. V., PLAISANCE, S., LEE, J. C., HAEGEMAN, G., COHEN, P. AND FIERS, W.: The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor. EMBO J. 15: 1914-1923, 1996.
6. BRADBEER, J. N., KAPADIA, R. S., SARKAR, S. K., ZHAO, H., STROUP, G. B., SWIFT, B. A., RIEMAN, D. J. AND BADGER, A. M.: Disease-modifying activity of SK&F 106615 in rat adjuvant-induced arthritis. Arthritis Rheum. 39: 504-514, 1996.
7. BRENNAN, F. M., COPE, A. P., KATSIKIS, P., GIBBONS, D. L., MAINI, R. N. AND FELDMANN, M.: Selective immunosuppression of tumour necrosis factor-alpha in rhuematoid arthritis. In Selective Immunosuppression: Basic Concepts and Clinical Applications, ed. by L. Adorini, pp. 48-60, S. Karger, Basel, 1995.
8. CUENDA, A., ROUSE, J., DOZA, Y. N., MEIER, R., COHEN, P., GALLAGHER, T. F., YOUNG, P. R. AND LEE, J. C.: SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364: 229-233, 1995.
9. DIMARTINO, M., SLIVJAK, M., ESSER, K., WOLFF, C., SMITH, E. AND GAGNON, R.: Adjuvant arthritic (AA) rats exhibit enhanced endotoxin-induced plasma TNF (EIPT) levels. Agents Actions 39: C58-C60, 1993.
10. DINARELLO, C. A.: Inflammatory cytokines: Interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases. Curr. Opin. Immunol. 3: 941-948, 1991.
11. ELLIOTT, M. J. AND MAINI, R. N.: Anticytokine Therapy in Rheumatoid Arthritis. In Bailliere's Clinical Rheumatology, Vol. 9 (issue 4), pp. 633-652, editors: P. M. Brooks and D. E. Furst, 1995.
12. ELLIOTT, M. J., MAINI, R. N., FELDMANN, M., LONG-FOX, A., CHARLES, P., KATSIKIS, P., BRENNAN, F. M., WALKER, J., BIJL, H., GHRAYEB, J. AND WOODY, J. N.: Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum. 36: 1681-1690, 1993.
13. FELDMANN, M., BRENNAN, F. M., ELLIOTT, M., KATSIKIS, P. AND MAINI, R. N.: TNFα as a therapeutic target in rheumatoid arthritis. Circ. Shock 43: 179-184, 1994.
14. GALLAGHER, T. F., FIER-THOMPSON, S. M., GARIGIPATI, R. S., SORENSON, M. E., SMIETANA, J. M., LEE, D., BENDER, P. E., LEE, J. C., LAYDON, J. T., GRISWOLD, D. E., CHABOT-FLETCHER, M. D., BRETON, J. J. AND ADAMS, J. L.: 2,4,5-Triarylimidazole inhibitors of IL-1 biosynthesis. Bioorg. Med. Chem. Lett. 5: 1171-1176, 1995.
15. GALLAGHER, T. F. et al.: Regulation of stress induced cytokine production by pyridinylimidazoles: Inhibition of CSBP kinase. In Press: Bioorganic and Medicinal Chemistry, 1996.
16. GOWEN, M. AND MUNDY, G. R.: Action of recombinant interleukin-1, interleukin-2 and interferon gamma on bone resorption in vitro. J. Immunol. 136: 2478-2482, 1986.
17. GRISWOLD, D. E., MARSHALL, P. J., WEBB, E. F., GODFREY, R., DIMARTINO, M. J., SARAU, H. M., NEWTON, J., JR., GLEASON, J. G., POSTE, G. AND HANNA, N.: SK&F 86002: A structurally novel antiinflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem. Pharmacol. 36: 3463-3470, 1987.
18. GRISWOLD, D. E., HILLEGASS, L. M., MEUNIER, P. C., DIMARTINO, M. J. AND HANNA, N.: Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis. Arthritis Rheum. 31: 1406-1412, 1988.
19. HAN, J., LEE, J. D., BIBB, S. L. AND ULEVITCH, R. J.: A MAP kinase targeted by endotoxin and in mammalian cells. Science (Wash. DC) 265: 808-811, 1994.
20. HIRANO, T., MATSUDA, T. AND TURNER, M.: Excessive production of IL-6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18: 1797-1802, 1988.
21. HOUSSIAU, F. A., DEVOGELAER, J.-P., VAN DAMME, J., NAGANT DE DEUXCHAISNES, D. AND VAN SNICK, J.: Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 31: 784-788, 1988.
22. KEFFER, J., PROBERT, L., CAZLARIS, H., GEORGOPOULOS, S., KASLARIS, E., KROUSSIS, D. AND KOLLIAS, G.: Transgenic mice expressing human tumor necrosis factor: A predictive genetic model of arthritis. EMBO J. 10: 4025-4031, 1991.
23. KRAMER, R. M., ROBERTS, E. F., STRIFLER, B. A. AND JOHNSTONE, E. M.: Thrombin induces activation of p38 MAP kinase in human platelets. J Biol. Chem. 270: 27395-27398, 1995.
24. LEE, J. C., BADGER, A. M., GRISWOLD, D. E., DUNNINGTON, D., THUNEH, A., VOTTA, B., WHITE, J. R., YOUNG, P. R. AND BENDER, P. E.: Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. Ann. N.Y. Acad. Sci. 696: 149-170, 1993.
25. LEE, J. C., BLUMENTHAL, M. J., LAYDON, J. T., TAN, K. B. AND DEWITT, D. L.: Translational Regulation of Prostaglandin Endoperoxide Synthase-2 Expression in Human Monocytes, Presented at the 7th International Conference of the Inflammatory Research Association, Poconos, PA. 1994a.
26. LEE, J. C., LAYDON, J. T., MCDONNELL, P. C., GALLAGHER, T. F., KUMAR, S., GREEN, D., MCNULTY, D., BLUMENTHAL, M. J., HEYS, J. R., LANDVATTER, S. W., STRICKLER, J. E., MCLAUGHLIN, M. M., SIEMENS, I. R., FISHER, S. M., LIVI, G. P., WHITE, J. R., ADAMS, J. L. AND YOUNG, P. R.: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature (Lond.) 372: 739-746, 1994b.
27. LEE, J. C., VOTTA, B., DALTON, B. J., GRISWOLD, D. E., BENDER, P. E. AND HANNA, N.: Inhibition of human monocyte IL-1 production by SK&F 86002. Int. J. Immunother. 6: 1-12, 1990.
28. LEE, J. C. AND YOUNG, P. R.: Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms. J. Leukocyte Biol. 59: 152-157, 1996.
29. MAINI, R. N., ELLIOTT, M. J., BRENNAN, F. M. AND FELDMANN, M.: Beneficial effects of tumour necrosis factor-alpha (TNF-α) blockade in rheumatoid arthritis (RA). Clin. Exp. Immunol. 101: 207-212, 1995.
30. OLIVERA, D. L., ESSER, K. M., LEE, J. C., GREIG, R. G. AND BADGER, A. M.: Beneficial effects of SK&F 105809, a novel cytokine-suppressive agent, in murine models of endotoxin shock. Circ. Shock 37: 301-306, 1992.
31. PIGUET, P. F., GRAU, G. E., VESIN, C., LOETSCHER, H., GENTZ, R. AND LESSLAUER, W.: Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor. Immunology 77: 510-514, 1992.
32. PRICHETT, W., HAND, A., SHEILDS, J. AND DUNNINGTON, D.: Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway of tumor necrosis factor α. J. Inflamm. 45: 97-105, 1995.
33. RAISZ, L. G.: Bone resorption in tissue culture. Factors influencing the response to parathyroid hormone. J. Clin. Invest. 44: 103-116, 1965.
34. REDDY, M. P., WEBB, E. F., CASSATT, D., MALEY, D., LEE, J. C., GRISWOLD, D. E. AND TRUNEH, A.: Pyridinyl imidazoles inhibit the inflammatory phase of delayed type hypersensitivity reactions without affecting T-dependent immune responses. Int. J. Immunopharmacol. 16: 795-804, 1994.
35. ROUSE, J., COHEN, P., TRIGON, S., MORANGE, M., ALONSO-LLAMAZARES, A., ZAMANILLO, D., HUNT, T. AND NEBREDA, A. R.: Identification of a novel protein kinase cascade stimulated by chemical stress and heat shock which activates MAP kinase-activated protein MAPKAP kinase-2 and induces phosphorylation of the small heat shock proteins. Cell 78: 1027-1037, 1994.
36. SABATINI, M., BOYCE, B., AUFDERMORTE, T., BONEWALD, L. AND MUNDY, G. R.: Infusion of interleukin-1α and β causes hypercalcemia in normal mice. Proc. Natl. Acad. Sci. U.S.A. 83: 5235-5239, 1988.
37. SMITH-OLIVER, T., NOEL, L. S., STIMPSON, S. S., YARNALL, D. P. AND CONNOLLY, K. M.: Elevated levels of TNF in the joints of adjuvant arthritic rats. Cytokine 5: 298-304, 1993.
38. STERN P. H. AND RAISZ L. G.: Organ cultures of bone. In Skeletal Research: An Experimental Approach, pp. 21-59, editors: D. J. Simmons, and A. S. Kunin, Academic Press, New York, 1979.
39. SWAAK, A. J. G., ROOYEN, A., VAN NIEUWENHUIS, E. AND AARDEN, L. A.: Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases. Scand. J. Rheumatol. 17: 469-474, 1988.
40. TASHIJIAN, A. H., VOEKEL, E. F., LAZZARO, M., GOAD, D., BOSMA, T. AND LEVINE, L.: Tumor necrosis factor α (cachectin) stimulates bone resorption in mouse calvaria via a prostaglandin-mediated mechanism. Endocrinology 120: 2029-2036, 1987.
41. THORBECKE, G. J., SHAH, R., LEU, C. H., KURUVILLA, A. P., HARDISON, A. M. AND PALLADINO, M. A.: Involvement of endogenous tumor necrosis factor α and transforming growth factor β during induction of collagen type II arthritis in mice. Proc. Natl. Acad. Sci. U.S.A. 89: 7375-7379, 1992.
42. VOTTA, B. J. AND BERTOLINI, D. R.: Cytokine suppressive antiinflammatory compounds inhibit bone resorption in vitro. Bone 15: 533-538, 1994.
43. WILLIAMS, R. O., FELDMANN, M. AND MAINI, R. N.: Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. U.S.A. 89: 9784-9788, 1992.
44. WOOLEY, P. H.: Collagen-induced arthritis in the mouse. Methods Enzymol. 162: 361-373, 1988.
45. YOUNG, P. R., MCDONNELL, P., DUNNINGTON, D., HAND, A., LAYDON, J. AND LEE, J. C.: Bicyclic imidazoles inhibit IL-1 and TNF production at the protein level. Agents Actions 39: C67-C69, 1993.