-
2
-
-
3142779901
-
Therapeutics targeting the innate immune system
-
Ulevitch, R. J. 2004. Therapeutics targeting the innate immune system. Nat. Rev. Immunol. 4:512.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 512
-
-
Ulevitch, R.J.1
-
3
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 499
-
-
Akira, S.1
Takeda, K.2
-
4
-
-
0036219195
-
CpG motifs in bacterial DNA and their immune effects
-
Krieg, A. M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:709.
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 709
-
-
Krieg, A.M.1
-
5
-
-
0347480224
-
Activation of autoreactive B cells by CpG dsDNA
-
Viglianti, G. A., C. M. Lau, T. M. Hanley, B. A. Miko, M. J. Shlomchik, and A. Marshak-Rothstein. 2003. Activation of autoreactive B cells by CpG dsDNA. Immunity 19:837.
-
(2003)
Immunity
, vol.19
, pp. 837
-
-
Viglianti, G.A.1
Lau, C.M.2
Hanley, T.M.3
Miko, B.A.4
Shlomchik, M.J.5
Marshak-Rothstein, A.6
-
6
-
-
0038639795
-
Systemic lupus erythematosus and the type I interferon system
-
Ronnblom, L., and G. V. Alm. 2003. Systemic lupus erythematosus and the type I interferon system. Arthritis Res. Ther. 5:68.
-
(2003)
Arthritis Res. Ther.
, vol.5
, pp. 68
-
-
Ronnblom, L.1
Alm, G.V.2
-
7
-
-
0032514616
-
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
-
Krieg, A. M., T. Wu, R. Weeratna, S. M. Efler, L. Love-Homan, L. Yang, A. K. Yi, D. Short, and H. L. Davis. 1998. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc. Natl. Acad. Sci. USA 95:12631.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 12631
-
-
Krieg, A.M.1
Wu, T.2
Weeratna, R.3
Efler, S.M.4
Love-Homan, L.5
Yang, L.6
Yi, A.K.7
Short, D.8
Davis, H.L.9
-
8
-
-
0037111465
-
Effect of suppressive DNA on CpG-induced immune activation
-
Yamada, H., I. Gursel, F. Takeshita, J. Conover, K. J. Ishii, M. Gursel, S. Takeshita, and D. M. Klinman. 2002. Effect of suppressive DNA on CpG-induced immune activation. J. Immunol. 169:5590.
-
(2002)
J. Immunol.
, vol.169
, pp. 5590
-
-
Yamada, H.1
Gursel, I.2
Takeshita, F.3
Conover, J.4
Ishii, K.J.5
Gursel, M.6
Takeshita, S.7
Klinman, D.M.8
-
9
-
-
0036913736
-
Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides
-
Zhu, F. G., C. F. Reich, and D. S. Pisetsky. 2002. Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides. J. Leukocyte Biol. 72:1154.
-
(2002)
J. Leukocyte Biol.
, vol.72
, pp. 1154
-
-
Zhu, F.G.1
Reich, C.F.2
Pisetsky, D.S.3
-
10
-
-
0036107449
-
Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells
-
Stunz, L. L., P. Lenert, D. Peckham, A. K. Yi, S. Haxhinasto, M. Chang, A. M. Krieg, and R. F. Ashman. 2002. Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells. Eur. J. Immunol. 32:1212.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 1212
-
-
Stunz, L.L.1
Lenert, P.2
Peckham, D.3
Yi, A.K.4
Haxhinasto, S.5
Chang, M.6
Krieg, A.M.7
Ashman, R.F.8
-
11
-
-
0142210343
-
An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems
-
Ho, P. P., P. Fontoura, P. J. Ruiz, L. Steinman, and H. Garren. 2003. An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems. J. Immunol. 171:4920.
-
(2003)
J. Immunol.
, vol.171
, pp. 4920
-
-
Ho, P.P.1
Fontoura, P.2
Ruiz, P.J.3
Steinman, L.4
Garren, H.5
-
12
-
-
0042346153
-
Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation
-
Gursel, I., M. Gursel, H. Yamada, K. J. Ishii, F. Takeshita, and D. M. Klinman. 2003. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J. Immunol. 171:1393.
-
(2003)
J. Immunol.
, vol.171
, pp. 1393
-
-
Gursel, I.1
Gursel, M.2
Yamada, H.3
Ishii, K.J.4
Takeshita, F.5
Klinman, D.M.6
-
13
-
-
6344262317
-
Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-γ- and IL-12-mediated signaling
-
Shirota, H., M. Gursel, and D. M. Klinman. 2004. Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-γ- and IL-12-mediated signaling. J. Immunol. 173:5002.
-
(2004)
J. Immunol.
, vol.173
, pp. 5002
-
-
Shirota, H.1
Gursel, M.2
Klinman, D.M.3
-
14
-
-
0036674998
-
Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides
-
Zeuner, R. A., K. J. Ishii, M. J. Lizak, I. Gursel, H. Yamada, D. M. Klinman, and D. Verthelyi. 2002. Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides. Arthritis Rheum. 46:2219.
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 2219
-
-
Zeuner, R.A.1
Ishii, K.J.2
Lizak, M.J.3
Gursel, I.4
Yamada, H.5
Klinman, D.M.6
Verthelyi, D.7
-
15
-
-
2342491490
-
Suppressive oligonucleotides protect against collagen-induced arthritis in mice
-
Dong, L., S. Ito, K. J. Ishii, and D. M. Klinman. 2004. Suppressive oligonucleotides protect against collagen-induced arthritis in mice. Arthritis Rheum. 50:1686.
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1686
-
-
Dong, L.1
Ito, S.2
Ishii, K.J.3
Klinman, D.M.4
-
16
-
-
0038341916
-
Identification of a novel CpG DNA class and motif which optimally stimulate B cell and plasmacytoid dendritic cell functions
-
Marshall, J. D., K. Fearon, C. Abbate, S. Subramanian, P. Yee, J. Gregorio, R. L. Coffman, and G. Van Nest. 2003. Identification of a novel CpG DNA class and motif which optimally stimulate B cell and plasmacytoid dendritic cell functions. J. Leucocyte Biol. 73:781.
-
(2003)
J. Leucocyte Biol.
, vol.73
, pp. 781
-
-
Marshall, J.D.1
Fearon, K.2
Abbate, C.3
Subramanian, S.4
Yee, P.5
Gregorio, J.6
Coffman, R.L.7
Van Nest, G.8
-
17
-
-
0344737658
-
IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences
-
Duramad, O., K. L. Fearon, J. H. Chan, H. Kanzler, J. D. Marshall, R. L. Coffman, and F. J. Barrat. 2003. IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences. Blood 102:4487.
-
(2003)
Blood
, vol.102
, pp. 4487
-
-
Duramad, O.1
Fearon, K.L.2
Chan, J.H.3
Kanzler, H.4
Marshall, J.D.5
Coffman, R.L.6
Barrat, F.J.7
-
18
-
-
0023788886
-
Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis
-
Sen, D., and W. Gilbert. 1988. Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature 334:364.
-
(1988)
Nature
, vol.334
, pp. 364
-
-
Sen, D.1
Gilbert, W.2
-
19
-
-
0025269255
-
A sodium-potassium switch in the formation of four-stranded G4-DNA
-
Sen, D., and W. Gilbert. 1990. A sodium-potassium switch in the formation of four-stranded G4-DNA. Nature 344:410.
-
(1990)
Nature
, vol.344
, pp. 410
-
-
Sen, D.1
Gilbert, W.2
-
20
-
-
0025896273
-
Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediates
-
Hardin, C. C., E. Henderson, T. Watson, and J. K. Prosser. 1991. Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediates. Biochemistry 30:4460.
-
(1991)
Biochemistry
, vol.30
, pp. 4460
-
-
Hardin, C.C.1
Henderson, E.2
Watson, T.3
Prosser, J.K.4
-
21
-
-
0033528756
-
Determinants of DNA quadruplex structural type: Sequence and potassium binding
-
Marathias, V. M., and P. H. Bolton. 1999. Determinants of DNA quadruplex structural type: sequence and potassium binding. Biochemistry 38:4355.
-
(1999)
Biochemistry
, vol.38
, pp. 4355
-
-
Marathias, V.M.1
Bolton, P.H.2
-
22
-
-
0027983025
-
Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion
-
Wyatt, J. R., T. A. Vickers, J. L. Roberson, R. W. Buckheit, Jr., T. Klimkait, E. DeBaets, P. W. Davis, B. Rayner, J. L. Imbach, and D. J. Ecker. 1994. Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion. Proc. Natl. Acad. Sci. USA 91:1356.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1356
-
-
Wyatt, J.R.1
Vickers, T.A.2
Roberson, J.L.3
Buckheit Jr., R.W.4
Klimkait, T.5
DeBaets, E.6
Davis, P.W.7
Rayner, B.8
Imbach, J.L.9
Ecker, D.J.10
-
23
-
-
0030015009
-
Kinetics of G-quartet-mediated tetramer formation
-
Wyatt, J. R., P. W. Davis, and S. M. Freier. 1996. Kinetics of G-quartet-mediated tetramer formation. Biochemistry 35:8002.
-
(1996)
Biochemistry
, vol.35
, pp. 8002
-
-
Wyatt, J.R.1
Davis, P.W.2
Freier, S.M.3
-
24
-
-
0034650517
-
Mechanism and function of a newly identified CpG DNA motif in human primary B cells
-
Hartmann, G., and A. M. Krieg. 2000. Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol. 164:944.
-
(2000)
J. Immunol.
, vol.164
, pp. 944
-
-
Hartmann, G.1
Krieg, A.M.2
-
25
-
-
0034777579
-
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
-
Krug, A., A. Towarowski, S. Britsch, S. Rothenfusser, V. Hornung, R. Bals, T. Giese, H. Engelmann, S. Endres, A. M. Krieg, et al. 2001. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31:3026.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 3026
-
-
Krug, A.1
Towarowski, A.2
Britsch, S.3
Rothenfusser, S.4
Hornung, V.5
Bals, R.6
Giese, T.7
Engelmann, H.8
Endres, S.9
Krieg, A.M.10
-
26
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, et al. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740.
-
(2000)
Nature
, vol.408
, pp. 740
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
-
27
-
-
0030764558
-
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
-
Roman, M., E. Martin-Orozco, J. S. Goodman, M. D. Nguyen, Y. Sato, A. Ronaghy, R. S. Kornbluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3:849.
-
(1997)
Nat. Med.
, vol.3
, pp. 849
-
-
Roman, M.1
Martin-Orozco, E.2
Goodman, J.S.3
Nguyen, M.D.4
Sato, Y.5
Ronaghy, A.6
Kornbluth, R.S.7
Richman, D.D.8
Carson, D.A.9
Raz, E.10
-
28
-
-
0033397574
-
Oligodeoxyribonucleotides with 5′-ACGT-3′ or 5′-TCGA-3′ sequence induce production of interferons
-
Yamamoto, S., T. Yamamoto, and T. Tokunaga. 2000. Oligodeoxyribonucleotides with 5′-ACGT-3′ or 5′-TCGA-3′ sequence induce production of interferons. Curr. Top. Microbiol. Immunol. 247:23.
-
(2000)
Curr. Top. Microbiol. Immunol.
, vol.247
, pp. 23
-
-
Yamamoto, S.1
Yamamoto, T.2
Tokunaga, T.3
-
29
-
-
0034073872
-
Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism
-
Cho, H. J., K. Takabayashi, P. M. Cheng, M. D. Nguyen, M. Corr, S. Tuck, and E. Raz. 2000. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism. Nat. Biotechnol. 18:509.
-
(2000)
Nat. Biotechnol.
, vol.18
, pp. 509
-
-
Cho, H.J.1
Takabayashi, K.2
Cheng, P.M.3
Nguyen, M.D.4
Corr, M.5
Tuck, S.6
Raz, E.7
-
30
-
-
0033950421
-
CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-γ production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type 1 and interleukin-12
-
Kranzer, K., M. Bauer, G. B. Lipford, K. Heeg, H. Wagner, and R. Lang. 2000. CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-γ production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type 1 and interleukin-12. Immunology 99:170.
-
(2000)
Immunology
, vol.99
, pp. 170
-
-
Kranzer, K.1
Bauer, M.2
Lipford, G.B.3
Heeg, K.4
Wagner, H.5
Lang, R.6
-
31
-
-
0035979192
-
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
-
Bauer, S., C. J. Kirschning, H. Hacker, V. Redecke, S. Hausmann, S. Akira, H. Wagner, and G. B. Lipford. 2001. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98:9237.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9237
-
-
Bauer, S.1
Kirschning, C.J.2
Hacker, H.3
Redecke, V.4
Hausmann, S.5
Akira, S.6
Wagner, H.7
Lipford, G.B.8
-
32
-
-
0344012220
-
Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells
-
Marshall, J. D., E. M. Hessel, J. Gregorio, C. Abbate, P. Yee, M. Chu, G. Van Nest, R. L. Coffman, and K. L. Fearon. 2003. Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells. Nucleic Acids Res. 31:5122.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 5122
-
-
Marshall, J.D.1
Hessel, E.M.2
Gregorio, J.3
Abbate, C.4
Yee, P.5
Chu, M.6
Van Nest, G.7
Coffman, R.L.8
Fearon, K.L.9
|