메뉴 건너뛰기




Volumn 173, Issue 11, 2004, Pages 6928-6937

A novel mechanism for TNF-α regulation by p38 MAPK: Involvement of NF-κB with implications for therapy in rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; D 168A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 9144251043     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.11.6928     Document Type: Article
Times cited : (121)

References (45)
  • 1
    • 0142041982 scopus 로고    scopus 로고
    • Lasker Clinical Medical Research Award: TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
    • Feldmann, M., and R. N. Maini. 2003. Lasker Clinical Medical Research Award: TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat. Med. 9:1245.
    • (2003) Nat. Med. , vol.9 , pp. 1245
    • Feldmann, M.1    Maini, R.N.2
  • 2
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNFα therapy of rheumatoid arthritis: What have we learned?
    • Feldmann, M., and R. N. Maini. 2001. Anti-TNFα therapy of rheumatoid arthritis: what have we learned? Annu. Rev. Immunol. 19:163.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 163
    • Feldmann, M.1    Maini, R.N.2
  • 4
    • 0142218524 scopus 로고    scopus 로고
    • Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents
    • Foxwell, B., E. Andreakos, F. Brennan, M. Feldmann, C. Smith, and M. Conron. 2003. Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents. Ann. Rheum. Dis. (62 Suppl.)2:ii90.
    • (2003) Ann. Rheum. Dis. (62 Suppl.) , vol.2
    • Foxwell, B.1    Andreakos, E.2    Brennan, F.3    Feldmann, M.4    Smith, C.5    Conron, M.6
  • 5
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649
    • Baldwin Jr., A.S.1
  • 6
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes, P. J., and M. Karin. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 1066
    • Barnes, P.J.1    Karin, M.2
  • 7
    • 0032493278 scopus 로고    scopus 로고
    • Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor a production in rheumatoid arthritis is NF-κB dependent
    • Foxwell, B., K. Browne, J. Bondeson, C. Clarke, C. de Martin, F. Brennan, and M. Feldmann. 1998. Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor a production in rheumatoid arthritis is NF-κB dependent. Proc. Natl. Acad. Sci. USA 95:8211.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8211
    • Foxwell, B.1    Browne, K.2    Bondeson, J.3    Clarke, C.4    De Martin, C.5    Brennan, F.6    Feldmann, M.7
  • 8
    • 0033545863 scopus 로고    scopus 로고
    • Defining therapeutic targets by using adenovirus: Blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares antiinflammatory mediators
    • Bondeson, J., B. Foxwell, F. Brennan, and M. Feldmann. 1999. Defining therapeutic targets by using adenovirus: blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares antiinflammatory mediators. Proc. Natl. Acad. Sci. USA 96:5668.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 5668
    • Bondeson, J.1    Foxwell, B.2    Brennan, F.3    Feldmann, M.4
  • 10
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • Han, J., J. D. Lee, L. Bibbs, and R. J. Ulevitch. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808.
    • (1994) Science , vol.265 , pp. 808
    • Han, J.1    Lee, J.D.2    Bibbs, L.3    Ulevitch, R.J.4
  • 12
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
    • Kontoyiannis, D., M. Pasparakis, T. T. Pizarro, F. Cominelli, and G. Kollias. 1999. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10:387.
    • (1999) Immunity , vol.10 , pp. 387
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3    Cominelli, F.4    Kollias, G.5
  • 14
    • 0032588317 scopus 로고    scopus 로고
    • NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
    • Wang, C. Y., D. C. Guttridge, M. W. Mayo, and A. S. Baldwin, Jr. 1999. NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol. Cell. Biol. 19:5923.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5923
    • Wang, C.Y.1    Guttridge, D.C.2    Mayo, M.W.3    Baldwin Jr., A.S.4
  • 15
    • 0034644837 scopus 로고    scopus 로고
    • Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade
    • Brook, M., G. Sully, A. R. Clark, and J. Saklatvala. 2000. Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. FEBS Lett. 483:57.
    • (2000) FEBS Lett. , vol.483 , pp. 57
    • Brook, M.1    Sully, G.2    Clark, A.R.3    Saklatvala, J.4
  • 16
    • 0141960214 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation
    • Dean, J. L., S. J. Sarsfield, E. Tsounakou, and J. Saklatvala. 2003. p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. J. Biol. Chem. 278:39470.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39470
    • Dean, J.L.1    Sarsfield, S.J.2    Tsounakou, E.3    Saklatvala, J.4
  • 17
    • 0032951716 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
    • Dean, J. L., M. Brook. A. R. Clark, and J. Saklatvala. 1999. p38 Mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J. Biol. Chem. 274:264.
    • (1999) J. Biol. Chem. , vol.274 , pp. 264
    • Dean, J.L.1    Brook, M.2    Clark, A.R.3    Saklatvala, J.4
  • 18
    • 0034629345 scopus 로고    scopus 로고
    • The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide- dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
    • Lali, F. V., A. E. Hunt, S. J. Turner, and B. M. Foxwell. 2000. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J. Biol. Chem. 275:7395.
    • (2000) J. Biol. Chem. , vol.275 , pp. 7395
    • Lali, F.V.1    Hunt, A.E.2    Turner, S.J.3    Foxwell, B.M.4
  • 19
    • 0032544234 scopus 로고    scopus 로고
    • Regulation of interleukin-1β-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
    • Miyazawa, K., A. Mori, H. Miyata, M. Akahane, Y. Ajisawa, and H. Okudaira. 1998. Regulation of interleukin-1β-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase. J. Biol Chem. 273:24832.
    • (1998) J. Biol Chem. , vol.273 , pp. 24832
    • Miyazawa, K.1    Mori, A.2    Miyata, H.3    Akahane, M.4    Ajisawa, Y.5    Okudaira, H.6
  • 20
    • 0030872398 scopus 로고    scopus 로고
    • Modulation of the fate of cytoplasmic mRNA by AU-rich elements: Key sequence features controlling mRNA deadenylation and decay
    • Xu, N., C. Y. Chen, and A. B. Shyu. 1997. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay. Mol. Cell. Biol. 17:4611.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4611
    • Xu, N.1    Chen, C.Y.2    Shyu, A.B.3
  • 21
    • 0034077529 scopus 로고    scopus 로고
    • Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade
    • Lasa, M., K. R. Mahtani, A. Finch, G. Brewer, J. Saklatvala, and A. R. Clark. 2000. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol. Cell. Biol. 20:4265.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4265
    • Lasa, M.1    Mahtani, K.R.2    Finch, A.3    Brewer, G.4    Saklatvala, J.5    Clark, A.R.6
  • 22
    • 0033568608 scopus 로고    scopus 로고
    • The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
    • Winzen, R., M. Kracht, B. Ritter, A. Wilhelm, C. Y. Chen, A. B. Shyu, M. Muller, M. Gaestel, K. Resch, and H. Holtmann. 1999. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J. 18:4969.
    • (1999) EMBO J. , vol.18 , pp. 4969
    • Winzen, R.1    Kracht, M.2    Ritter, B.3    Wilhelm, A.4    Chen, C.Y.5    Shyu, A.B.6    Muller, M.7    Gaestel, M.8    Resch, K.9    Holtmann, H.10
  • 23
    • 0031964698 scopus 로고    scopus 로고
    • Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells
    • Chen, K. D., L. Y. Chen, H. L. Huang, C. H. Lieu, Y. N. Chang, M. D. Chang, and Y. K. Lai. 1998. Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells. J. Biol. Chem. 273:749.
    • (1998) J. Biol. Chem. , vol.273 , pp. 749
    • Chen, K.D.1    Chen, L.Y.2    Huang, H.L.3    Lieu, C.H.4    Chang, Y.N.5    Chang, M.D.6    Lai, Y.K.7
  • 24
    • 0030894683 scopus 로고    scopus 로고
    • Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
    • Han, J., Y. Jiang, Z. Li, V. V. Kravchenko, and R. J. Ulevitch. 1997. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386:296.
    • (1997) Nature , vol.386 , pp. 296
    • Han, J.1    Jiang, Y.2    Li, Z.3    Kravchenko, V.V.4    Ulevitch, R.J.5
  • 25
    • 0029938805 scopus 로고    scopus 로고
    • Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase
    • Wang, X. Z., and D. Ron. 1996. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 272:1347.
    • (1996) Science , vol.272 , pp. 1347
    • Wang, X.Z.1    Ron, D.2
  • 26
    • 0030051528 scopus 로고    scopus 로고
    • MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    • Raingeaud, J., A. J. Whitmarsh, T. Barrett, B. Derijard, and R. J. Davis. 1996. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16:1247.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1247
    • Raingeaud, J.1    Whitmarsh, A.J.2    Barrett, T.3    Derijard, B.4    Davis, R.J.5
  • 27
    • 0037451357 scopus 로고    scopus 로고
    • Transcriptional activation of the NF-κB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
    • Vermeulen, L., G. De Wilde, P. Van Damme, W. Vanden Berghe, and G. Haegeman. 2003. Transcriptional activation of the NF-κB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 22:1313.
    • (2003) EMBO J. , vol.22 , pp. 1313
    • Vermeulen, L.1    De Wilde, G.2    Van Damme, P.3    Vanden Berghe, W.4    Haegeman, G.5
  • 28
    • 0036143654 scopus 로고    scopus 로고
    • p38-Dependent marking of inflammatory genes for increased NF-κB recruitment
    • Saccani, S., S. Pantano, and G. Natoli. 2002. p38-Dependent marking of inflammatory genes for increased NF-κB recruitment. Nat. Immunol. 3:69.
    • (2002) Nat. Immunol. , vol.3 , pp. 69
    • Saccani, S.1    Pantano, S.2    Natoli, G.3
  • 29
    • 0034671636 scopus 로고    scopus 로고
    • Vitamin C inhibits NF-κB activation by TNF via the activation of p38 mitogen-activated protein kinase
    • Bowie, A. G., and L. A. O'Neill. 2000. Vitamin C inhibits NF-κB activation by TNF via the activation of p38 mitogen-activated protein kinase. J. Immunol. 165:7180.
    • (2000) J. Immunol. , vol.165 , pp. 7180
    • Bowie, A.G.1    O'Neill, L.A.2
  • 30
    • 0033529495 scopus 로고    scopus 로고
    • Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IκB phosphorylation and NF-κB activation
    • Alpert, D., P. Schwenger, J. Han, and J. Vilcek. 1999. Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IκB phosphorylation and NF-κB activation. J. Biol. Chem. 274:22176.
    • (1999) J. Biol. Chem. , vol.274 , pp. 22176
    • Alpert, D.1    Schwenger, P.2    Han, J.3    Vilcek, J.4
  • 31
    • 0023773031 scopus 로고
    • Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: Prolonged production of IL-1α
    • Buchan, G., K. Barrett, M. Turner, D. Chantry, R. N. Maini, and M. Feldmann. 1988. Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1α. Clin. Exp. Immunol. 73:449.
    • (1988) Clin. Exp. Immunol. , vol.73 , pp. 449
    • Buchan, G.1    Barrett, K.2    Turner, M.3    Chantry, D.4    Maini, R.N.5    Feldmann, M.6
  • 35
    • 0033812222 scopus 로고    scopus 로고
    • Effective adenoviral transfer of IκBα into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-κB dependent
    • Bondeson, J., F. Brennan, B. Foxwell, and M. Feldmann. 2000. Effective adenoviral transfer of IκBα into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-κB dependent. J. Rheumatol. 27:2078.
    • (2000) J. Rheumatol. , vol.27 , pp. 2078
    • Bondeson, J.1    Brennan, F.2    Foxwell, B.3    Feldmann, M.4
  • 36
    • 0033548678 scopus 로고    scopus 로고
    • Role of interleukin (IL)-2 receptor β-chain subdomains and Shc in p38 mitogen-activated protein (MAP) kinase and p54 MAP kinase (stress-activated protein kinase/c-Jun N-terminal kinase) activation: IL-2-driven proliferation is independent of p38 and p54 MAP kinase activation
    • Hunt, A. E., F. V. Lali, J. D. Lord, B. H. Nelson, T. Miyazaki, K. J. Tracey, and B. M. Foxwell. 1999. Role of interleukin (IL)-2 receptor β-chain subdomains and Shc in p38 mitogen-activated protein (MAP) kinase and p54 MAP kinase (stress-activated protein kinase/c-Jun N-terminal kinase) activation: IL-2-driven proliferation is independent of p38 and p54 MAP kinase activation. J. Biol. Chem. 274:7591.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7591
    • Hunt, A.E.1    Lali, F.V.2    Lord, J.D.3    Nelson, B.H.4    Miyazaki, T.5    Tracey, K.J.6    Foxwell, B.M.7
  • 37
    • 0033136947 scopus 로고    scopus 로고
    • The role of p38 mitogen-activated protein kinase in IL-1β transcription
    • Baldassare, J. J., Y. Bi, and C. J. Bellone. 1999. The role of p38 mitogen-activated protein kinase in IL-1β transcription. J. Immunol. 162:5367.
    • (1999) J. Immunol. , vol.162 , pp. 5367
    • Baldassare, J.J.1    Bi, Y.2    Bellone, C.J.3
  • 38
    • 0037093989 scopus 로고    scopus 로고
    • Evidence for a dual mechanism for IL-10 suppression of TNF-α production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-κB in primary human macrophages
    • Denys, A., I. A. Udalova, C. Smith, L. M. Williams, C. J. Ciesielski, J. Campbell, C. Andrews, D. Kwaitkowski, and B. M. Foxwell. 2002. Evidence for a dual mechanism for IL-10 suppression of TNF-α production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-κB in primary human macrophages. J. Immunol. 168:4837.
    • (2002) J. Immunol. , vol.168 , pp. 4837
    • Denys, A.1    Udalova, I.A.2    Smith, C.3    Williams, L.M.4    Ciesielski, C.J.5    Campbell, J.6    Andrews, C.7    Kwaitkowski, D.8    Foxwell, B.M.9
  • 40
    • 0142026209 scopus 로고    scopus 로고
    • p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
    • Kumar, S., J. Boehm, and J. C. Lee. 2003. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat. Rev. Drug. Discov. 2:717.
    • (2003) Nat. Rev. Drug. Discov. , vol.2 , pp. 717
    • Kumar, S.1    Boehm, J.2    Lee, J.C.3
  • 42
    • 0033120071 scopus 로고    scopus 로고
    • Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide
    • Kuprash, D. V., I. A. Udalova, R. L. Turetskaya, D. Kwiatkowski, N. R. Rice, and S. A. Nedospasov. 1999. Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide. J. Immunol. 162:4045.
    • (1999) J. Immunol. , vol.162 , pp. 4045
    • Kuprash, D.V.1    Udalova, I.A.2    Turetskaya, R.L.3    Kwiatkowski, D.4    Rice, N.R.5    Nedospasov, S.A.6
  • 43
    • 0032698069 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression: The role of TATA-binding protein (TBP)
    • Carter, A. B., K. L. Knudtson, M. M. Monick, and G. W. Hunninghake. 1999. The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression: the role of TATA-binding protein (TBP). J. Biol. Chem. 274:30858.
    • (1999) J. Biol. Chem. , vol.274 , pp. 30858
    • Carter, A.B.1    Knudtson, K.L.2    Monick, M.M.3    Hunninghake, G.W.4
  • 44
    • 0038575364 scopus 로고    scopus 로고
    • Heterogeneous requirement of IκB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: Implications for therapy
    • Andreakos, E., C. Smith, S. Kiriakidis, C. Monaco, R. de Martin, F. M. Brennan, E. Paleolog, M. Feldmann, and B. M. Foxwell. 2003. Heterogeneous requirement of IκB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy. Arthritis. Rheum. 48:1901.
    • (2003) Arthritis. Rheum. , vol.48 , pp. 1901
    • Andreakos, E.1    Smith, C.2    Kiriakidis, S.3    Monaco, C.4    De Martin, R.5    Brennan, F.M.6    Paleolog, E.7    Feldmann, M.8    Foxwell, B.M.9
  • 45
    • 0034935779 scopus 로고    scopus 로고
    • A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg
    • Brennan, F. M. 2001. A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg. Arthritis Res. 3:211.
    • (2001) Arthritis Res. , vol.3 , pp. 211
    • Brennan, F.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.