Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens

Journal of Immunology

Volumn 167, Issue 11, 2001, Pages 6644-6653

  Biragyn, A ^a   Surenhu, M ^a   Yang, D ^a   Ruffini, P A ^a   Haines, B A ^a   Klyushnenkova, E ^a   Oppenheim, J J ^a   Kwak, L W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; DEFENSIN; MACROPHAGE INFLAMMATORY PROTEIN; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOCOMPETENT CELL; IMMUNOGENICITY; LYMPHOID TISSUE; MEDIATOR RELEASE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; STROMA CELL; TUMOR IMMUNITY;

EID: 0035576242     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.11.6644     Document Type: Article

References (43)

1. Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma
2. Idiotype-cytokine fusion proteins as cancer vaccines: Relative efficacy of IL-2, IL-4, and granulocyte-macrophage colony-stimulating factor
3. A nine-amino acid peptide from IL-1β augments antitumor immune responses induced by protein and DNA vaccines
4. DNA vaccines with singlechain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma
5. Innate immunity
6. Innate immunity: Impact on the adaptive immune response
7. An innate sense of danger
8. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
9. The nature of the principal type I interferon-producing cells in human blood
10. The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity
11. Lymphocyte traffic control by chemokines
12. The instructive role of dendritic cells on T cell responses: Lineages, plasticity and kinetics
13. Distinct patterns and kinetics of chemokine production regulate dendritic cell function
14. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
15. Macrophage inflammatory protein 3α is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors
16. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
17. Idiotype vaccination against murine B cell lymphoma: Humoral and cellular requirements for the full expression of antitumor immunity
18. β-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
19. Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides
20. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins
21. Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity
22. Characterization of a carcinogen-induced murine B lymphocyte cell line of C3H/eb origin
23. Establishment and characterization of BALB/c lymphoma lines with B cell properties
24. A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies
25. Comparative analysis of murine dendritic cells derived from spleen and bone marrow
26. A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration
27. Differential regulation of responsiveness to fMLP and C5a upon dendritic cell maturation: Correlation with receptor expression
28. Cutting edge: Immature dendritic cells generated from monocytes in the presence of TGF-β1 express functional C-C chemokine receptor 6
29. Idiotypic DNA vaccines against B-cell lymphoma
30. Chemokines: Chemotactic cytokines that mediate inflammation
31. Chemokine receptor trafficking and viral replication
32. CXCR3 chemokine receptor distribution in normal and inflamed tissues: Expression on activated lymphocytes, endothelial cells, and dendritic cells
33. The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia
34. - T cells after gene gun immunization
35. Activation of human dendritic cells through CD40 cross-linking
36. Dendritic cells and the control of immunity
37. Enhanced activation of T cells by dendritic cells engineered to hyperexpress a triad of costimulatory molecules
38. Defensins: Key players or bystanders in infection, injury, and repair in the lung?
39. Differential CC chemokine-induced enhancement of T helper cell cytokine production
40. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1
41. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine
42. In vivo priming by DNA injection occurs predominantly by antigen transfer
43. Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response