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Volumn 5, Issue 8, 2004, Pages 800-808

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR;

EID: 4444253690     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1092     Document Type: Article
Times cited : (722)

References (49)
  • 1
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1
  • 2
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot, J.P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603 (2001).
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1
  • 3
    • 0036202885 scopus 로고    scopus 로고
    • The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    • Cuthbert, A.P. et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology 122, 867-874 (2002).
    • (2002) Gastroenterology , vol.122 , pp. 867-874
    • Cuthbert, A.P.1
  • 4
    • 0035897904 scopus 로고    scopus 로고
    • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
    • Hampe, J. et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 357, 1925-1928 (2001).
    • (2001) Lancet , vol.357 , pp. 1925-1928
    • Hampe, J.1
  • 5
    • 0038624558 scopus 로고    scopus 로고
    • NODs: Intracellular proteins involved in inflammation and apoptosis
    • Inohara, N. & Nunez, G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3, 371-382 (2003).
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 371-382
    • Inohara, N.1    Nunez, G.2
  • 6
    • 0041827164 scopus 로고    scopus 로고
    • Nods, Nalps and Naip: Intracellular regulators of bacterial-induced inflammation
    • Chamaillard, M., Girardin, S.E., Viala, J. & Philpott, D.J. Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell. Microbiol. 5, 581-592 (2003).
    • (2003) Cell Microbiol. , vol.5 , pp. 581-592
    • Chamaillard, M.1    Girardin, S.E.2    Viala, J.3    Philpott, D.J.4
  • 7
    • 0037108346 scopus 로고    scopus 로고
    • Cutting edge: CATERPILLER: A large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains
    • Harton, J.A., Linhoff, M.W., Zhang, J. & Ting, J.P. Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J. Immunol. 169, 4088-4093 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 4088-4093
    • Harton, J.A.1    Linhoff, M.W.2    Zhang, J.3    Ting, J.P.4
  • 8
    • 0036828844 scopus 로고    scopus 로고
    • Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-κB activation
    • Gutierrez, O. et al. Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-κB activation. J. Biol. Chem. 277, 41701-41705 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 41701-41705
    • Gutierrez, O.1
  • 9
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • Inohara, N. et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 278, 5509-5512 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 5509-5512
    • Inohara, N.1
  • 10
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • Girardin, S.E. et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278, 8869-8872 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 8869-8872
    • Girardin, S.E.1
  • 11
    • 0037075551 scopus 로고    scopus 로고
    • RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    • Kobayashi, K. et al. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416, 194-199 (2002).
    • (2002) Nature , vol.416 , pp. 194-199
    • Kobayashi, K.1
  • 12
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
    • Ogura, Y. et al. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem. 276, 4812-4818 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 4812-4818
    • Ogura, Y.1
  • 13
    • 0038615855 scopus 로고    scopus 로고
    • Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan
    • Girardin, S.E. et al. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300, 1584-1587 (2003).
    • (2003) Science , vol.300 , pp. 1584-1587
    • Girardin, S.E.1
  • 14
    • 0038824980 scopus 로고    scopus 로고
    • An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
    • Chamaillard, M. et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol. 4, 702-707 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 702-707
    • Chamaillard, M.1
  • 15
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S., Takeda, K. & Kaisho, T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2, 675-680 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 16
    • 0141532262 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira, S. Toll-like receptor signaling. J. Biol. Chem. 278, 38105-38108 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 38105-38108
    • Akira, S.1
  • 17
    • 0037452968 scopus 로고    scopus 로고
    • Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases
    • Chamaillard, M. et al. Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc. Natl. Acad. Sci. USA 100, 3455-3460 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 3455-3460
    • Chamaillard, M.1
  • 18
    • 0037221395 scopus 로고    scopus 로고
    • Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan
    • Bonen, D.K. et al. Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology 124, 140-146 (2003).
    • (2003) Gastroenterology , vol.124 , pp. 140-146
    • Bonen, D.K.1
  • 19
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • Bouma, G. & Strober, W. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3, 521-533 (2003).
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 20
    • 0036218221 scopus 로고    scopus 로고
    • The immunology of mucosal models of inflammation
    • Strober, W., Fuss, I.J. & Blumberg, R.S. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20, 495-549 (2002).
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 495-549
    • Strober, W.1    Fuss, I.J.2    Blumberg, R.S.3
  • 21
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • Monteleone, G. et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112, 1169-1178 (1997).
    • (1997) Gastroenterology , vol.112 , pp. 1169-1178
    • Monteleone, G.1
  • 22
    • 0034465943 scopus 로고    scopus 로고
    • Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease
    • Kanai, T. et al. Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease. Gastroenterology 119, 1514-1523 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 1514-1523
    • Kanai, T.1
  • 23
    • 0037029649 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    • Neurath, M.F. et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 195, 1129-1143 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1129-1143
    • Neurath, M.F.1
  • 24
    • 0030209985 scopus 로고    scopus 로고
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157, 1261-1270 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 1261-1270
    • Fuss, I.J.1
  • 25
    • 0031057872 scopus 로고    scopus 로고
    • Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
    • Parronchi, P. et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am. J. Pathol. 150, 823-832 (1997).
    • (1997) Am. J. Pathol. , vol.150 , pp. 823-832
    • Parronchi, P.1
  • 26
    • 0142123222 scopus 로고    scopus 로고
    • Role of nod2 in the response of macrophages to toll-like receptor agonists
    • Pauleau, A.L. & Murray, P.J. Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol. Cell. Biol. 23, 7531-7539 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7531-7539
    • Pauleau, A.L.1    Murray, P.J.2
  • 27
    • 10744223303 scopus 로고    scopus 로고
    • Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages
    • Nakayama, K. et al. Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages. J.Biol. Chem. 279, 6629-6634 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 6629-6634
    • Nakayama, K.1
  • 28
    • 0037408257 scopus 로고    scopus 로고
    • Distinct pathways for NF-κB regulation are associated with aberrant macrophage IL-12 production in lupus- and diabetes-prone mouse strains
    • Liu, J. & Beller, D.I. Distinct pathways for NF-κB regulation are associated with aberrant macrophage IL-12 production in lupus- and diabetes-prone mouse strains. J. Immunol. 170, 4489-4496 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 4489-4496
    • Liu, J.1    Beller, D.I.2
  • 29
    • 0036738421 scopus 로고    scopus 로고
    • Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
    • Hilliard, B.A. et al. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J. Clin. Invest. 110, 843-850 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 843-850
    • Hilliard, B.A.1
  • 30
    • 0037380969 scopus 로고    scopus 로고
    • CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells
    • Hisamatsu, T. et al. CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology 124, 993-1000 (2003).
    • (2003) Gastroenterology , vol.124 , pp. 993-1000
    • Hisamatsu, T.1
  • 31
    • 0034650930 scopus 로고    scopus 로고
    • Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors
    • Cario, E. et al. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J. Immunol. 164, 966-972 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 966-972
    • Cario, E.1
  • 32
    • 0042859750 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-κB activation and chemokine expression by epithelial cells
    • Smith, M.F., Jr. et al. Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-κB activation and chemokine expression by epithelial cells. J. Biol. Chem. 278, 32552-32560 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 32552-32560
    • Smith Jr., M.F.1
  • 33
    • 0344012591 scopus 로고    scopus 로고
    • The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-κB activation in epithelial cells in a Toll-like receptor 2-dependent manner
    • Fisette, P.L., Ram, S., Andersen, J.M., Guo, W. & Ingalls, R.R. The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-κB activation in epithelial cells in a Toll-like receptor 2-dependent manner. J. Biol. Chem. 278, 46252-46260 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 46252-46260
    • Fisette, P.L.1    Ram, S.2    Andersen, J.M.3    Guo, W.4    Ingalls, R.R.5
  • 34
    • 0033917674 scopus 로고    scopus 로고
    • Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis
    • Campbell, I.K., Gerondakis, S., O'Donnell, K. & Wicks, I.P. Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis. J. Clin. Invest. 105, 1799-1806 (2000 ).
    • (2000) J. Clin. Invest. , vol.105 , pp. 1799-1806
    • Campbell, I.K.1    Gerondakis, S.2    O'Donnell, K.3    Wicks, I.P.4
  • 36
    • 0035886848 scopus 로고    scopus 로고
    • + dendritic cells by specifically inducing p35 gene transcription
    • + dendritic cells by specifically inducing p35 gene transcription. J. Exp. Med. 194, 1021-1032 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 1021-1032
    • Grumont, R.1
  • 37
    • 0037799912 scopus 로고    scopus 로고
    • Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
    • Kobayashi, M. et al. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111, 1297-1308 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 1297-1308
    • Kobayashi, M.1
  • 38
    • 0036316394 scopus 로고    scopus 로고
    • CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice
    • Obermeier, F. et al. CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice. Eur. J. Immunol. 32, 2084-2092 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2084-2092
    • Obermeier, F.1
  • 39
    • 0035078190 scopus 로고    scopus 로고
    • Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture
    • Yang, S. et al. Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture. Infect. Immun. 69, 2045-2053 (2001).
    • (2001) Infect. Immun. , vol.69 , pp. 2045-2053
    • Yang, S.1
  • 40
    • 0036453023 scopus 로고    scopus 로고
    • Enhancement of endotoxin activity by muramyldipeptide
    • Takada, H., Yokoyama, S. & Yang, S. Enhancement of endotoxin activity by muramyldipeptide. J. Endotoxin. Res. 8, 337-342 (2002).
    • (2002) J. Endotoxin. Res. , vol.8 , pp. 337-342
    • Takada, H.1    Yokoyama, S.2    Yang, S.3
  • 41
    • 0037131232 scopus 로고    scopus 로고
    • The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan
    • Wolfert, M.A., Murray, T.F., Boons, G.J. & Moore, J.N. The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan. J. Biol. Chem. 277, 39179-39186 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 39179-39186
    • Wolfert, M.A.1    Murray, T.F.2    Boons, G.J.3    Moore, J.N.4
  • 42
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease
    • Crohn's Disease cA2 Study Group
    • Targan, S.R. et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. Crohn's Disease cA2 Study Group. N. Engl. J. Med. 337, 1029-1035 (1997).
    • (1997) N. Engl. J. Med. , vol.337 , pp. 1029-1035
    • Targan, S.R.1
  • 43
    • 0345303939 scopus 로고    scopus 로고
    • Lessons from Nod2 studies: Towards a link between Crohn's disease and bacterial sensing
    • Girardin, S.E., Hugot, J.P. & Sansonetti, P.J. Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing. Trends. Immunol. 24, 652-658 (2003).
    • (2003) Trends Immunol. , vol.24 , pp. 652-658
    • Girardin, S.E.1    Hugot, J.P.2    Sansonetti, P.J.3
  • 44
    • 0036498794 scopus 로고    scopus 로고
    • + T cells expressing CD95 ligand and secreting IL-4 in the liver
    • + T cells expressing CD95 ligand and secreting IL-4 in the liver. J. Immunol. 168, 2188-2199 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 2188-2199
    • Watanabe, T.1
  • 45
    • 0034610979 scopus 로고    scopus 로고
    • T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor β2 chain expression and signaling
    • Nishikomori, R., Ehrhardt, R.O. & Strober, W. T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor β2 chain expression and signaling. J. Exp. Med. 191, 847-858 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 847-858
    • Nishikomori, R.1    Ehrhardt, R.O.2    Strober, W.3
  • 46
    • 0036604277 scopus 로고    scopus 로고
    • CD40 ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-κB
    • O'Sullivan, B.J. & Thomas, R. CD40 ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-κB. J. Immunol. 168, 5491-5498 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 5491-5498
    • O'Sullivan, B.J.1    Thomas, R.2
  • 47
    • 0142219250 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis
    • Kitani, A. et al. Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis. J. Exp. Med. 198, 1179-1188 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1179-1188
    • Kitani, A.1
  • 48
    • 0037427491 scopus 로고    scopus 로고
    • HVJ-envelope vector for gene transfer into central nervous system
    • Shimamura, M. et al. HVJ-envelope vector for gene transfer into central nervous system. Biochem. Biophys. Res. Commun. 300, 464-471 (2003).
    • (2003) Biochem. Biophys. Res. Commun. , vol.300 , pp. 464-471
    • Shimamura, M.1
  • 49
    • 0037709366 scopus 로고    scopus 로고
    • Cloning, sequencing and expression analysis of the mouse NOD2/CARD15 gene
    • Iwanaga, Y. et al. Cloning, sequencing and expression analysis of the mouse NOD2/CARD15 gene. Inflamm. Res. 52, 272-276 (2003).
    • (2003) Inflamm. Res. , vol.52 , pp. 272-276
    • Iwanaga, Y.1


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