Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 290, Issue 6, 2006, Pages

  Gewirtz, Andrew T ^a,e   Vijay Kumar, Matam ^a   Brant, Steven R ^c   Duerr, Richard H ^d   Nicolae, Dan L ^b   Cho, Judy H ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e EMORY UNIVERSITY   (United States)

Author keywords

Inflammatory bowel disease; Lipopolysacharride; Serum immunoglobulins

Indexed keywords

FLAGELLIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 5;

ARTICLE; CONTROLLED STUDY; CROHN DISEASE; GENETIC POLYMORPHISM; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREACTIVITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADAPTATION, PHYSIOLOGICAL; CROHN DISEASE; FLAGELLIN; GENES, DOMINANT; GENES, MHC CLASS II; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, NATURAL; INFLAMMATORY BOWEL DISEASES; POLYMORPHISM, GENETIC; TOLL-LIKE RECEPTOR 5;

EID: 33646866567     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00544.2005     Document Type: Article

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