Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-α (TNF-α) mRNA induction: Evidence for selective destabilization of TNF-α transcripts

Journal of Biological Chemistry

Volumn 276, Issue 9, 2001, Pages 6666-6674

  Rutault, Karine ^a   Hazzalin, Catherine A ^a   Mahadevan, Louis C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; ENZYMES; PATHOLOGY; PROTEINS; RNA; TUMORS;

PURIFIED HUMAN MONOCYTES;

BIOCHEMISTRY;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COMPLEMENTARY DNA; CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA; UO 126; CD14 ANTIGEN; FLAVONOID; IMIDAZOLE DERIVATIVE; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; PYRIDINE DERIVATIVE;

ANTIGEN EXPRESSION; ARTICLE; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; MONOCYTE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN ANALYSIS; WESTERN BLOTTING; CELL CULTURE; CELL DIFFERENTIATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY;

ESCHERICHIA COLI;

ANTIGENS, CD14; CELL DIFFERENTIATION; CELLS, CULTURED; FLAVONOIDS; HUMANS; IMIDAZOLES; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-JUN; PYRIDINES; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035794225     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M005486200     Document Type: Article

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