The Ubiquitin Ligase SCFFbw7 Antagonizes Apoptotic JNK Signaling

Science

Volumn 303, Issue 5662, 2004, Pages 1374-1378

  Nateri, Abdolrahman S ^a   Riera Sans, Lluís ^a   Da Costa, Clive ^a   Behrens, Axel ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLOGY; TOXICITY;

APOPTOSIS; NEUROTOXICITY;

ENZYMES;

ACTIVATING PROTEIN 1; PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; F BOX PROTEIN; FBXW7 PROTEIN, HUMAN; FBXW7 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; UBIQUITIN;

BIOLOGY;

APOPTOSIS; ARTICLE; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; NERVE CELL; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UBIQUITINATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL STRAIN; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL CYCLE PROTEINS; CELL LINE; F-BOX PROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; NEURONS; PC12 CELLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 1342275412     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092880     Document Type: Article

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26. We thank A. Aronheim for providing reagents and advice for the RRS; H. Naumann for primary neuron culture and transfection; M. Mitchell for rat Fbw7 exon prediction; L. Bakiri, A. Lin, and F. Uhlmann for essential reagents; and S. Sabapathy, M. Sibilia, and T. Toda for critical reading of the manuscript. L. R. acknowledges support from an EU Marie-Curie Fellowship. The London Research Institute is funded by Cancer Research UK.