The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Nature

Volumn 396, Issue 6706, 1998, Pages 77-80

  Yin, Min Jean ^a   Yamamoto, Yumi ^a   Gaynor, Richard B ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOTRANSFERASE; SALICYLIC ACID;

ARTICLE; CYTOPLASM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BINDING, COMPETITIVE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; COS CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; I-KAPPA B KINASE; JURKAT CELLS; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SODIUM SALICYLATE; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032487857     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/23948     Document Type: Article

References (26)

1. Baeuerle, P. A. & Baltimore, D. NF-κB: Ten years after. Cell 87, 13-20 (1996).
2. Baldwin, J. A. S. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-681 (1996).
3. Brown, K., Gerstberger, S., Carlson, L., Franzoso, G. & Siebenlist, U. Control of IκBα proteolysis by site specific signal induced phosphorylation. Science 267, 1485-1488 (1995).
4. Chen, Z. et al. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev. 9, 1586-1597 (1995).
5. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. & Karin, M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388, 548-554 (1997).
6. Régnier, C. H. et al. Identification and characterization of an IκB kinase. Cell 90, 373-383 (1997).
7. Mercurio, F. et al. IKK-1 and IKK-2: cyotkine-activated IκB kinases essential for NT-κB activation. Science 278, 860-866 (1997).
8. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M. & Karin, M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91, 243-252 (1997).
9. Woronicz, J. D., Gao, X., Cao, Z., Rothe, M. & Goeddel, D. V. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278, 866-869 (1997).
10. Malinin, N. L., Boldin, M. P., Kovalenko, A. V. & Wallach, D. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385, 540-544 (1997).
11. Yin, M.-J. et al. HTLV-I Tax protein binds to MEKK1 to stimulate IκB kinase activity and NF-κB activation. Cell 93, 875-884 (1998).
12. Vane, J. R. Inhibition of prostaglandin synthesis as a mechanism of action of the aspirin-like drugs. Nature New Biol. 231, 232-235 (1971).
13. Vane, J. Towards a better aspirin. Nature 367, 215-216 (1994).
14. Kopp, E. & Ghosh, S. Inhibition of NF-κB by sodium salicylate and aspirin. Science 265, 956-959 (1994).
15. Grilli, M., Pizzi, M., Memo, M. & Spano, P. Neuroprotection by aspirin and sodium salicylate through blockade of NF-κB activation. Science 274, 1383-1385 (1996).
16. Rothe, M., Sarma, V., Dixit, V. M. & Goeddel, D. V. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269, 1424-1427 (1995).
17. Insel, P. The Pharmacological Basis of Therapeutics (eds Harman, J. G., Molinoff, P. B., Rudden, R. W. & Gilman, A. G.) (McGraw-Hill, New York, 1996).
18. Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A. & Karin, M. Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science 270, 286-290 (1995).
19. Scheinman, R. I., Cogswell, P. C., Lofquist, A. K. & Baldwin, A. S. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270, 283-286 (1995).
20. Tan, T. H., Jia, R. & Roeder, R. G. Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activator tax. J. Virol. 63, 3761-3768 (1989).
21. Boulton, T. G. et al. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorated in response to insulin and NGF. Cell, 663-675 (1991).
22. khokhlatchev, A. et al. Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. J. Biol. Chem. 272, 11057-11062 (1997).
23. Xu, S. & Cobb, M. H. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J. Biol. Chem. 272, 32056-32060 (1997).
24. Kyriakis, J. M. et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160 (1994).
25. Mitchell, J. A., Akarasereenont, P., Thiermermann, C., Flower, R. J. & Vane, J. R. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl Acad. Sci. USA 90, 11693-11697 (1994).
26. Kalgutkar, A. S. et al. Aspirin-like molecule that covalently inactivates cyclooxygenase-2. Science 280, 1268-1270 (1998).