The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction

Molecular Cell

Volumn 8, Issue 5, 2001, Pages 1027-1039

  Wan, Yong ^a   Liu, Xuedong ^b   Kirschner, Marc W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; PROTEIN; PROTEIN SNON; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GROWTH REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSACTIVATION;

EID: 0035930333     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00382-3     Document Type: Article

References (27)

1. TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
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4. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
5. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
6. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
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16. Cell cycle extracts
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