Nuclear factor-κB (NF-κB) regulates proliferation and branching in mouse mammary epithelium

Molecular Biology of the Cell

Volumn 12, Issue 5, 2001, Pages 1445-1455

  Brantley, D M ^a   Chen, C L ^a   Muraoka, R S ^a   Bushdid, P B ^a   Bradberry, J L ^a   Kittrell, F ^a   Medina, D ^a   Matrisian, L M ^a   Kerr, L D ^a   Yull, F E ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CANCER CELL CULTURE; CELL COUNT; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; GENETIC CODE; IN VIVO STUDY; MOUSE; MUTATION; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REGULATORY MECHANISM; TISSUE TRANSPLANTATION; ANIMAL; CELL CULTURE; CELL DIVISION; CYTOLOGY; DRUG ANTAGONISM; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FEMALE; GENETICS; HUMAN; METABOLISM; NICK END LABELING; PHYSIOLOGY; REPORTER GENE; TRANSGENIC MOUSE; TRANSPLANTATION; UDDER;

ANIMALIA; MURINAE; TRIXIS;

ANIMALS; APOPTOSIS; CELL DIVISION; CELLS, CULTURED; DNA-BINDING PROTEINS; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FEMALE; GENES, REPORTER; HUMANS; I-KAPPA B PROTEINS; IN SITU NICK-END LABELING; MAMMARY GLANDS, ANIMAL; MICE; MICE, TRANSGENIC; NF-KAPPA B; TRANSPLANTS;

EID: 0034740504     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.5.1445     Document Type: Article

References (59)

1. An essential role for NF-κB in preventing TNF-α-induced cell death
2. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
3. An intact NF-κB signaling pathway is required for maintenance of mature B cell subsets
4. Multi-organ nuclear factor κB activation in a transgenic mouse model of systemic inflammation
5. Nuclear factor κB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts
6. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB
7. Dynamic expression and activity of NF-κB during post-natal mammary gland morphogenesis
8. Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis
9. Lymphocytes lacking IκB-α develop normally, but have selective defects in proliferation and function
10. RAG2-/-, IκB-α-/- chimeras display a psoriasiform skin disease
11. NF-κB inhibits apoptosis in murine mammary epithelia
12. Selective activation of NF-κB subunits in human breast cancer: Potential roles for NF-κB2/p52 and for Bcl-3
13. Role of mesenchymal-epithelial interactions in mammary gland development
14. Highly-expressed p100/p52 (NFKB2) sequesters other NF-κB-related proteins in the cytoplasm of human breast cancer cells
15. Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female CH3 mice
16. The c-rel protooncogene product represses NF-κB p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus
17. Requirement for NF-κB in osteoclast and B-cell development
18. Introduction: Mammary gland involution and apoptosis of mammary epithelial cells
19. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
20. The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects
21. A novel complex between the p65 subunit of NF-κB and c-Rel binds to a DNA element involved in phorbol ester induction of the human urokinase gene
22. Dehydration activates an NF-κB driven, COX-2 dependent survival mechanism in renal medullary interstitial cells
23. Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells
24. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
25. Role of Rel/NF-κB transcription factors during the out-growth of the vertebrate limb
26. Activation of NF-κB/Rel occurs early during neoplastic transformation of mammary cells
27. IκBα deficiency results in a sustained NF-κB response and severe widespread dermatitis in mice
28. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
29. Transcriptional regulation of the HIV-1 promoter by NF-κB in vitro
30. IKK1-deficient mice exhibit abnormal development of skin and skeleton
31. Severe liver degeneration in mice lacking the IκB kinase 2 gene
32. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis
33. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death
34. Specific NF-κB subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription
35. Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt10 by fluorescence in situ hybridization
36. Signal transd uction through NF-κB
37. The mammary gland: A unique organ for the study of development and tumorigenesis
38. Gelatinase B/lacZ transgenic mice, a model for mapping gelatinase B expression during developmental and injury-related tissue remodeling
39. Altered expression of the p50 subunit of the NF-κB transcription factor complex in non-small cell lung carcinoma
40. Mesenchymal expression of nuclear factor-κB inhibits epithelial growth and branching in the embryonic chick lung
41. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth
42. Negative regulation of transactivation function but not DNA-binding of NF-κB and AP-1 by IκBβ1 in breast cancer cells
43. Regulation of mammary gland development by tissue interaction
44. Severe liver degeneration and lack of NF-κB activation in NEMO/IKKgamma-deficient mice
45. C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation ia the mouse mammary gland
46. Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB
47. TGF β1 inhibits branching morphogenesis and N-myc expression in lung bud organ cultures
48. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
49. The inhibitory effects of transforming growth factor β1 on breast cancer cell proliferation are mediated through regulation of aberrant nuclear factor-κB/Rel expression
50. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer
51. Limb and skin abnormalities in mice lacking IKKα
52. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β-deficient mice
53. Suppression of TNF-α-induced apoptosis by NF-κB
54. Rel/NF-κB/IκB family: Intimate tales of association and dissociation
55. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA
56. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
57. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
58. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family
59. KiSS-1 represses 92-kDa type IV. Collagenase expression by down-regulating NF-κB binding to the promoter as a consequence of IκBα-induced block of p65/p50 nuclear translocation