Chemical Genetic Control of Protein Levels: Selective in Vivo Targeted Degradation

Journal of the American Chemical Society

Volumn 126, Issue 12, 2004, Pages 3748-3754

  Schneekloth Jr , John S ^a   Fonseca, Fabiana N ^a   Koldobskiy, Michael ^a   Mandal, Amit ^a   Deshaies, Raymond ^c,d   Sakamoto, Kathleen ^c,e   Crews, Craig M ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c California Institute of Technology HHMI   (United States)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^e MATTEL CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; FLUOROMETERS; MATHEMATICAL MODELS; PROTEINS;

GENETIC MODEL; GREEN FLUORESCENT PROTEIN (GFP);

GENETIC ENGINEERING;

ANDROGEN RECEPTOR; ANDROSTANOLONE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 12; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LIGAND; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CHIMERA; FLUOROMETRY; GENE CONTROL; GENE LOSS; IN VIVO STUDY; MOLECULE; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEOLYSIS TARGETING CHIMERIC MOLECULE; SYNTHESIS; WESTERN BLOTTING;

CELL LINE; CYSTEINE ENDOPEPTIDASES; DIHYDROTESTOSTERONE; GREEN FLUORESCENT PROTEINS; HUMANS; LIGANDS; LUMINESCENT PROTEINS; MULTIENZYME COMPLEXES; OLIGOPEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTORS, ANDROGEN; RECOMBINANT FUSION PROTEINS; TACROLIMUS BINDING PROTEIN 1A; UBIQUITINS;

EID: 1642343326     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja039025z     Document Type: Article

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