Mechanisms and implications of the age-associated decrease in DNA repair capacity

FASEB Journal

Volumn 14, Issue 10, 2000, Pages 1325-1334

  Goukassian, David ^a   Gad, Eaten ^a   Yaar, Mina ^a   Eller, Mark S ^a   Nehal, Umbereen S ^a   Gilchrest, Barbara A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; DNA damage repair; DNA photoproducts; Nucleotide excision repair

Indexed keywords

CYCLINE; DIMER; MESSENGER RNA; PROTEIN DERIVATIVE; PROTEIN P53; THYMINE;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; SKIN CANCER; ULTRAVIOLET IRRADIATION;

EID: 0033948285     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.10.1325     Document Type: Article

References (23)

1. Miller, D. L., and Weinstock, M. A. (1994) Nonmelanoma skin cancer in the United States. J. Am. Acad. Dermatol. 30, 774-778
2. Kochevar, I. E., Pathak, M. A., and Parrish, J. A. (1993) Photophysics, photochemistry and photobiology. In Dermatology in General Medicine, pp. 1627-1638, McGraw-Hill, Inc., New York
3. Scotto, J., Fears, T. R., and Fraumeni, J. F., Jr. (1981) U.S. Dept. of Health and Human Services Publication No. (NIH) 82-2433
4. Gilchrest, B. A. (1983) In vitro assessment of keratinocyte aging. J. Invest. Dermatol. 81, 184s-189s
5. Brash, D. E., Rudolph, J. A., Simon, J. A., Lin, A., McKenna, G. J., Baden, H. P., Halperin, A. J., and Ponten, J. (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl. Acad. Sci. USA 88, 10124-10128
6. Ziegler, A., Leffell, D. J., Kunala, S., Sharma, H. W., Gailani, M., Simon, J. A., Halperin, A. J., Baden, H. P., Shapiro, P. E., Bale, A. E., et al. (1993) Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc. Natl. Acad. Sci. USA 90, 4216-4220
7. Patrick, M. H. (1977) Studies on thymine-derived UV photoproducts in DNA. I. Formation and biological role of pyrimidine adducts in DNA. Photochem. Photobiol. 25, 357-372
8. Pfeifer, G. P., Steigerwald, S. D., Hansen, R. S., Gartler, S. M., and Riggs, A. D. (1990) Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance. CpG site autonomy, and an explanation of activity state stability. Proc. Natl. Acad. Sci. USA 87, 8252-8256
9. Mitchell, D. L., Jen, J., and Cleaver, J. E. (1992) Sequence specificity of cyclobutane pyrimidine dimers in DNA treated with solar (ultraviolet B) radiation. Nucleic Acids Res. 20, 225-229
10. Mitchell, D. L., and Karentz, D. (1993) Induction and repair of DNA photodamage in the environment. In Environmental UV Photobiology (Young, A. R., Moan, J., Bjorn, L. O., and Nultsch, W., eds) pp. 345-377, Plenum Press, New York
11. Sancar, G. B., Siede, W., and van Zeeland, A. A. (1996) Repair and processing of DNA damage: a summary of recent progress. Mutat. Res. 362, 127-146
12. Wood, R. D. (1996) DNA repair in eukaryotes. Annu. Rev. Biochem. 65, 135-167
13. He, Z., Hendricksen, L. A., Wold, M. S., and Ingles, C. J. (1995) RPA involvement in the damage recognition and incision steps of nucleotide excision repair. Nature (London) 374, 566-569
14. Li, L., Lu, X., Peterson, C. A., and Legerski, R. J. (1995) An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair. Mol. Cell. Biol. 15, 5396-5402
15. Kenny, M. K., Schlegel, U., Furneaux, H., and Hurwitz, J. (1990) The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication. J. Biol. Chem. 265, 7693-7700
16. Zernik-Kobak, M., Vasunia, K., Connelly, M., Anderson, C. W., and Dixon, K. (1997) Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. J. Biol. Chem. 272, 23896-23904
17. Nocentini, S., Coin, F., Saijo, M., Tanaka, K., and Egly, J. M. (1997) DNA damage recognition by XPA protein promotes efficient recruitment of transcription factor II H. J. Biol. Chem. 272, 22991-22994
18. Leveillard, M. L., Andera, L., Bissonnette, N., Schaeffer, L., Bracco, L., Egly, J. M., and Wasylyk, B. (1996) Functional interactions between p53 and the TF11H complex are affected by tumour-associated mutations. EMBO J. 15, 1615-1624
19. Carr, A. M., and Hoekstra, M. F. (1995) The cellular responses to DNA damage. Trends Cell Biol. 5, 32-40
20. Sancar, A. (1994) Mechanisms of DNA excision repair. Science 266, 1954-1956
21. Ko, L. J., and Prives, C. (1996) p53: puzzle and paradigm. Genes Dev. 10, 1054-1072
22. Hall, P. A., McKee, P. H., Menage, H. D., Dover, R., and Lane, D. P. (1993) High levels of p53 protein in UV-irradiated normal human skin. Oncogene 8, 203-207
23. Levine, A. J. (1997) p53, the cellular gatekeeper for growth and division. Cell 88, 323-331