-
1
-
-
0036217332
-
Proteasome inhibition: A novel approach to cancer therapy
-
Adams, J., 2002. Proteasome inhibition: a novel approach to cancer therapy. Trends Mol. Med. 8, S49-S54
-
(2002)
Trends Mol. Med
, vol.8
, pp. S49-S54
-
-
Adams, J.1
-
2
-
-
0037189519
-
The NEDD8 pathway is essential for SCF(beta-TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor
-
Amir, R.E., Iwai, K., Ciechanover, A., 2002. The NEDD8 pathway is essential for SCF(beta-TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor. J. Biol. Chem. 277, 23253-23259
-
(2002)
J. Biol. Chem
, vol.277
, pp. 23253-23259
-
-
Amir, R.E.1
Iwai, K.2
Ciechanover, A.3
-
3
-
-
0036467574
-
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
-
Baer, R., Ludwig, T., 2002. The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity. Curr. Opin. Genet. Dev. 12, 86-91
-
(2002)
Curr. Opin. Genet. Dev
, vol.12
, pp. 86-91
-
-
Baer, R.1
Ludwig, T.2
-
4
-
-
0026728171
-
Inhibition of ubiquitin-protein ligase (E3) by mono- and bifunctional phenylarsenoxides. Evidence for essential vicinal thiols and a proximal nucleophile
-
Berleth, E.S., Kasperek, E.M., Grill, S.P., Braunscheidel, J.A., Graziani, L.A., Pickart, C.M., 1992. Inhibition of ubiquitin-protein ligase (E3) by mono- and bifunctional phenylarsenoxides. Evidence for essential vicinal thiols and a proximal nucleophile. J. Biol. Chem. 267, 16403-16411
-
(1992)
J. Biol. Chem
, vol.267
, pp. 16403-16411
-
-
Berleth, E.S.1
Kasperek, E.M.2
Grill, S.P.3
Braunscheidel, J.A.4
Graziani, L.A.5
Pickart, C.M.6
-
5
-
-
0036340096
-
Hypophosphorylation of Mdm2 augments p53 stability
-
Blattner, C., Hay, T., Meek, D.W., Lane, D.P., 2002. Hypophosphorylation of Mdm2 augments p53 stability. Mol. Cell Biol. 22, 6170-6182
-
(2002)
Mol. Cell Biol
, vol.22
, pp. 6170-6182
-
-
Blattner, C.1
Hay, T.2
Meek, D.W.3
Lane, D.P.4
-
6
-
-
0034282102
-
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
-
Boyd, S.D., Tsai, K.Y., Jacs, T., 2000. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat. Cell Biol. 2, 563-568
-
(2000)
Nat. Cell Biol
, vol.2
, pp. 563-568
-
-
Boyd, S.D.1
Tsai, K.Y.2
Jacs, T.3
-
7
-
-
0037086283
-
Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity
-
Chaturvedi, P., Sudakin, V., Bobiak, M.L., Fisher, P.W., Mattem, M.R., Jablonski, S.A., Hurle, M.R., Zhu, Y., Yen, T.J., Zhou, B.B., 2002. Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. Cancer Res. 62, 1797-1801
-
(2002)
Cancer Res
, vol.62
, pp. 1797-1801
-
-
Chaturvedi, P.1
Sudakin, V.2
Bobiak, M.L.3
Fisher, P.W.4
Mattem, M.R.5
Jablonski, S.A.6
Hurle, M.R.7
Zhu, Y.8
Yen, T.J.9
Zhou, B.B.10
-
8
-
-
0036619301
-
Role of X-linked inhibitor of apoptosis protein in chemoresistance in ovarian cancer: Possible involvement of the phosphoinositide-3 kinase/Akt pathway
-
Cheng, J.Q., Jiang, X., Fraser, M., Li, M., Dan, H.C., Sun, M., Tsang, B.K., 2002. Role of X-linked inhibitor of apoptosis protein in chemoresistance in ovarian cancer: possible involvement of the phosphoinositide-3 kinase/Akt pathway. Drug Resist. Updates 5, 131-146
-
(2002)
Drug Resist. Updates
, vol.5
, pp. 131-146
-
-
Cheng, J.Q.1
Jiang, X.2
Fraser, M.3
Li, M.4
Dan, H.C.5
Sun, M.6
Tsang, B.K.7
-
9
-
-
0034963935
-
Von Hippel-Lindau disease: Clinical and molecular perspectives
-
Clifford, S.C., Maher, E.R., 2001. Von Hippel-Lindau disease: clinical and molecular perspectives. Adv. Cancer Res. 82, 85-105
-
(2001)
Adv. Cancer Res
, vol.82
, pp. 85-105
-
-
Clifford, S.C.1
Maher, E.R.2
-
10
-
-
0026653834
-
Three-dimensional structure of a ubiquitin-conjugating enzyme (E2)
-
Cook, W.J., Jeffrey, L.C., Sullivan, M.L., Vierstra, R.D., 1992. Three-dimensional structure of a ubiquitin-conjugating enzyme (E2). J. Biol. Chem. 267, 15116-15121
-
(1992)
J. Biol. Chem
, vol.267
, pp. 15116-15121
-
-
Cook, W.J.1
Jeffrey, L.C.2
Sullivan, M.L.3
Vierstra, R.D.4
-
11
-
-
0035945349
-
A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition
-
Coscoy, L., Sanchez, D.J., Ganem, D., 2001. A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. J. Cell Biol. 155, 1265-1273
-
(2001)
J. Cell Biol
, vol.155
, pp. 1265-1273
-
-
Coscoy, L.1
Sanchez, D.J.2
Ganem, D.3
-
12
-
-
0033279836
-
SCF and cullin/ring H2-based ubiquitin ligases
-
Deshaies, R.J., 1999. SCF and cullin/ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15, 435-467
-
(1999)
Annu. Rev. Cell Dev. Biol
, vol.15
, pp. 435-467
-
-
Deshaies, R.J.1
-
13
-
-
0033178142
-
Proteasome inhibitors as potential novel anticancer agents
-
Dou, Q.P., Li, B., 1999. Proteasome inhibitors as potential novel anticancer agents. Drug Resist. Updates 2, 215-223
-
(1999)
Drug Resist. Updates
, vol.2
, pp. 215-223
-
-
Dou, Q.P.1
Li, B.2
-
14
-
-
0025853776
-
Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
-
Fakharzadeh, S.S., Trusko, S.P., George, D.L., 2001. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 10, 1565-1569
-
(2001)
EMBO J
, vol.10
, pp. 1565-1569
-
-
Fakharzadeh, S.S.1
Trusko, S.P.2
George, D.L.3
-
15
-
-
0034708458
-
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
Fang, S., Jensen, J.P., Ludwig, R.L., Vousden, K.H., Weissman, A.M., 2000. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem. 275, 8945-8951
-
(2000)
J. Biol. Chem
, vol.275
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
Vousden, K.H.4
Weissman, A.M.5
-
16
-
-
0034282220
-
The MDM2 RING-finger domain is required to promote p53 nuclear export
-
Geyer, R.K., Yu, Z.K., Maki, C.G., 2000, The MDM2 RING-finger domain is required to promote p53 nuclear export. Nat. Cell Biol. 2, 569-573
-
(2000)
Nat. Cell Biol
, vol.2
, pp. 569-573
-
-
Geyer, R.K.1
Yu, Z.K.2
Maki, C.G.3
-
17
-
-
0026089183
-
Cyclin is degraded by the ubiquitin pathway
-
Glotzer, M., Murray, A.W., Kirschner, M.W., 1991. Cyclin is degraded by the ubiquitin pathway, Nature 349, 132-138
-
(1991)
Nature
, vol.349
, pp. 132-138
-
-
Glotzer, M.1
Murray, A.W.2
Kirschner, M.W.3
-
18
-
-
0034255264
-
The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
-
Gmachl, M., Gieffers, C., Podtelejnikov, A.V., Mann, M., Peters, J.M., 2000. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. Proc. Natl. Acad. Sci. U.S.A. 97, 8973-8978
-
(2000)
Proc. Natl. Acad. Sci. U.S.A
, vol.97
, pp. 8973-8978
-
-
Gmachl, M.1
Gieffers, C.2
Podtelejnikov, A.V.3
Mann, M.4
Peters, J.M.5
-
19
-
-
0035942224
-
Skp2 is oncogenic and overexpressed in human cancers
-
Gstaiger, M., Jordan, R., Lim, M., Catzavelos, C., Mestan, J., Slingerland, J., Krek, W., 2001. Skp2 is oncogenic and overexpressed in human cancers. Proc. Natl. Acad. Sci. U.S.A. 98, 5043-5048
-
(2001)
Proc. Natl. Acad. Sci. U.S.A
, vol.98
, pp. 5043-5048
-
-
Gstaiger, M.1
Jordan, R.2
Lim, M.3
Catzavelos, C.4
Mestan, J.5
Slingerland, J.6
Krek, W.7
-
20
-
-
0036713310
-
The anaphase-promoting complex: It's not just for mitosis any more
-
Harper, J.W., Burton, J.L., Solomon, M.J., 2002, The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 16, 2179-2206
-
(2002)
Genes Dev
, vol.16
, pp. 2179-2206
-
-
Harper, J.W.1
Burton, J.L.2
Solomon, M.J.3
-
21
-
-
0344625381
-
TGF-beta signaling and cancer: Structural and functional consequences of mutations in Smads
-
Hata, A., Shi, Y., Massague, J., 1998, TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. Mol. Med. Today 4, 257-262
-
(1998)
Mol. Med. Today
, vol.4
, pp. 257-262
-
-
Hata, A.1
Shi, Y.2
Massague, J.3
-
22
-
-
0035980094
-
U box proteins as a new family of ubiquitin-protein ligases
-
Hatakeyama, S., Yada, M., Matsumoto, M., Ishida, N., Nakayama, K.I., 2001. U box proteins as a new family of ubiquitin-protein ligases. J. Biol. Chem. 276, 33111-33120
-
(2001)
J. Biol. Chem
, vol.276
, pp. 33111-33120
-
-
Hatakeyama, S.1
Yada, M.2
Matsumoto, M.3
Ishida, N.4
Nakayama, K.I.5
-
23
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt, Y., Maya, R., Kazaz, A., Oren, M., 1997. Mdm2 promotes the rapid degradation of p53. Nature 387, 296-299
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
24
-
-
0037068455
-
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
-
Hoege, C., Pfander, B., Moldovan, G.L., Pyrowolakis, G., Jentsch, S., 2002. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-141
-
(2002)
Nature
, vol.419
, pp. 135-141
-
-
Hoege, C.1
Pfander, B.2
Moldovan, G.L.3
Pyrowolakis, G.4
Jentsch, S.5
-
25
-
-
0033521621
-
Association of pl9(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
-
Honda, R., Yasuda, H., 1999. Association of pl9(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J. 18, 22-27
-
(1999)
EMBO J
, vol.18
, pp. 22-27
-
-
Honda, R.1
Yasuda, H.2
-
26
-
-
0032741446
-
Structure of an E6AP-UbcH7 complex: Insights into ubiquitination by the E2-E3 enzyme cascade
-
Huang, L., Kinnucan, E., Wang, G., Beaudenon, S., Howley, P.M., Huibregtse, J.M., Pavletich, N.P., 1999. Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science 286, 1321-1326
-
(1999)
Science
, vol.286
, pp. 1321-1326
-
-
Huang, L.1
Kinnucan, E.2
Wang, G.3
Beaudenon, S.4
Howley, P.M.5
Huibregtse, J.M.6
Pavletich, N.P.7
-
27
-
-
0033963335
-
MdmX protects p53 from Mdm2-mediated degradation
-
Jackson, M.W., Berberich, S.J., 2000. MdmX protects p53 from Mdm2-mediated degradation. Mol. Cell Biol. 20, 1001-1007
-
(2000)
Mol. Cell Biol
, vol.20
, pp. 1001-1007
-
-
Jackson, M.W.1
Berberich, S.J.2
-
28
-
-
0036282703
-
The SCF ubiquitin ligase: An extended look
-
Jackson, P.K., Eldridge, A.G., 2002. The SCF ubiquitin ligase: an extended look. Mol. Cell 9, 923-925
-
(2002)
Mol. Cell
, vol.9
, pp. 923-925
-
-
Jackson, P.K.1
Eldridge, A.G.2
-
29
-
-
0034308251
-
The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
-
Jackson, P.K., Eldridge, A.G., Freed, E., Furstenthal, L., Hsu, J.Y., Kaiser, B.K., Reimann, J.D., 2000. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol. 10, 429-439
-
(2000)
Trends Cell Biol
, vol.10
, pp. 429-439
-
-
Jackson, P.K.1
Eldridge, A.G.2
Freed, E.3
Furstenthal, L.4
Hsu, J.Y.5
Kaiser, B.K.6
Reimann, J.D.7
-
30
-
-
0033545694
-
Inhibitory phosphorylation of the APC regulator Hctl is controlled by the kinase Cdc28 and the phosphatase Cdcl4
-
Jaspersen, S.L., Charles, J.F., Morgan, D.O., 1999. Inhibitory phosphorylation of the APC regulator Hctl is controlled by the kinase Cdc28 and the phosphatase Cdcl4. Curr. Biol. 9, 227-236
-
(1999)
Curr. Biol
, vol.9
, pp. 227-236
-
-
Jaspersen, S.L.1
Charles, J.F.2
Morgan, D.O.3
-
31
-
-
0033580653
-
Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 Å resolution
-
Jiang, F., Basavappa, R., 1999. Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 Å resolution. Biochemistry 38, 6471-6478
-
(1999)
Biochemistry
, vol.38
, pp. 6471-6478
-
-
Jiang, F.1
Basavappa, R.2
-
32
-
-
0037148527
-
The checkpoint protein Chfr is a ligase that ubiquitinates Plkl and inhibits Cdc2 at the G2 to M transition
-
Kang, D., Chen, J., Wong, J., Fang, G., 2002. The checkpoint protein Chfr is a ligase that ubiquitinates Plkl and inhibits Cdc2 at the G2 to M transition. J. Cell Biol. 156, 249-259
-
(2002)
J. Cell Biol
, vol.156
, pp. 249-259
-
-
Kang, D.1
Chen, J.2
Wong, J.3
Fang, G.4
-
33
-
-
0036546501
-
NF-kappaB in cancer: From innocent bystander to major culprit
-
Karin, M., Cao, Y., Greten, F.R., Li, Z.W., 2002. NF-kappaB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2, 301-310
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 301-310
-
-
Karin, M.1
Cao, Y.2
Greten, F.R.3
Li, Z.W.4
-
34
-
-
0029787091
-
Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates
-
King, R.W., Glotzer, M., Kirschner, M.W., 1996. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Mol. Biol. Cell 7, 1343-1357
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 1343-1357
-
-
King, R.W.1
Glotzer, M.2
Kirschner, M.W.3
-
35
-
-
0034568688
-
The F-box protein family
-
reviews
-
Kipreos, E.T., Pagano, M., 2000. The F-box protein family, Genome Biol. 1, 3002.1-3002.7 (reviews)
-
(2000)
Genome Biol
, vol.1
, pp. 30021-30027
-
-
Kipreos, E.T.1
Pagano, M.2
-
36
-
-
0033598127
-
Regulation of APC activity by phosphorylation and regulatory factors
-
Kotani, S., Tanaka, H., Yasuda, H., Todokoro, K., 1999. Regulation of APC activity by phosphorylation and regulatory factors. J. Cell Biol. 146, 791-800
-
(1999)
J. Cell Biol
, vol.146
, pp. 791-800
-
-
Kotani, S.1
Tanaka, H.2
Yasuda, H.3
Todokoro, K.4
-
37
-
-
0031991880
-
PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression
-
Kotani, S., Tugendreich, S., Fujii, M., Jorgensen, P.M., Watanabe, N., Hoog, C., Hieter, P., Todokoro, K., 1998. PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression. Mol. Cell. 1, 371-380
-
(1998)
Mol. Cell
, vol.1
, pp. 371-380
-
-
Kotani, S.1
Tugendreich, S.2
Fujii, M.3
Jorgensen, P.M.4
Watanabe, N.5
Hoog, C.6
Hieter, P.7
Todokoro, K.8
-
38
-
-
0035903157
-
Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization
-
Lai, Z., Ferry, K.V., Diamond, M.A., Wee, K.E., Kim, Y.B., Ma, J., Yang, T., Benfield, P.A., Copeland, R.A., Auger, K.R., 2001. Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization. J. Biol. Chem. 276, 31357-31367
-
(2001)
J. Biol. Chem
, vol.276
, pp. 31357-31367
-
-
Lai, Z.1
Ferry, K.V.2
Diamond, M.A.3
Wee, K.E.4
Kim, Y.B.5
Ma, J.6
Yang, T.7
Benfield, P.A.8
Copeland, R.A.9
Auger, K.R.10
-
39
-
-
0035891318
-
Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex
-
Lake, M.W., Wuebbens, M.M., Rajagopalan, K.V., Schindelin, H., 2001. Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex. Nature 414, 325-329
-
(2001)
Nature
, vol.414
, pp. 325-329
-
-
Lake, M.W.1
Wuebbens, M.M.2
Rajagopalan, K.V.3
Schindelin, H.4
-
40
-
-
0033930277
-
The APC11 RING-H2 finger mediates E2-dependent ubiquitination
-
Leverson, J.D., Joazeiro, C.A., Page, A.M., Huang, H., Hieter, P., Hunter, T., 2000. The APC11 RING-H2 finger mediates E2-dependent ubiquitination. Mol. Biol. Cell 11, 2315-2325
-
(2000)
Mol. Biol. Cell
, vol.11
, pp. 2315-2325
-
-
Leverson, J.D.1
Joazeiro, C.A.2
Page, A.M.3
Huang, H.4
Hieter, P.5
Hunter, T.6
-
41
-
-
0037077232
-
Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10
-
Lin, Y., Hwang, W.C., Basavappa, R., 2002, Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. J. Biol. Chem. 277, 21913-21921
-
(2002)
J. Biol. Chem
, vol.277
, pp. 21913-21921
-
-
Lin, Y.1
Hwang, W.C.2
Basavappa, R.3
-
42
-
-
0037188903
-
Destabilizing influences in apoptosis: Sowing the seeds of IAP destruction
-
Martin, S.J., 2002. Destabilizing influences in apoptosis: sowing the seeds of IAP destruction. Cell 109, 793-796
-
(2002)
Cell
, vol.109
, pp. 793-796
-
-
Martin, S.J.1
-
43
-
-
0036645405
-
Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: Modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis
-
Masuda, T.A., Inoue, H., Sonoda, H., Mine, S., Yoshikawa, Y., Nakayama, K., Nakayama, K., Mori, M., 2002. Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis. Cancer Res. 62, 3819-3825
-
(2002)
Cancer Res
, vol.62
, pp. 3819-3825
-
-
Masuda, T.A.1
Inoue, H.2
Sonoda, H.3
Mine, S.4
Yoshikawa, Y.5
Nakayama, K.6
Nakayama, K.7
Mori, M.8
-
44
-
-
0035573882
-
The pVHL-hlF-1 system. A key mediator of oxygen homeostasis
-
Maxwell, P.H., Pugh, C.W., Ratcliffe, P.J., 2001. The pVHL-hlF-1 system. A key mediator of oxygen homeostasis. Adv. Exp. Med. Biol. 502, 365-376
-
(2001)
Adv. Exp. Med. Biol
, vol.502
, pp. 365-376
-
-
Maxwell, P.H.1
Pugh, C.W.2
Ratcliffe, P.J.3
-
45
-
-
0034603897
-
An N-terminal pl4ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo
-
Midgley, C.A., Desterro, J.M., Saville, M.K., Howard, S., Sparks, A., Hay, R.T., Lane, D.P., 2000. An N-terminal pl4ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene 19, 2312-2323
-
(2000)
Oncogene
, vol.19
, pp. 2312-2323
-
-
Midgley, C.A.1
Desterro, J.M.2
Saville, M.K.3
Howard, S.4
Sparks, A.5
Hay, R.T.6
Lane, D.P.7
-
46
-
-
0032145989
-
The MDM2 gene amplification database
-
Momand, J., Jung, D., Wilczynski, S., Niland, J., 1998. The MDM2 gene amplification database. Nucleic Acids Res. 26, 3453-3459
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 3453-3459
-
-
Momand, J.1
Jung, D.2
Wilczynski, S.3
Niland, J.4
-
47
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand, J., Zambetti, G.P., Olson, D.C., George, D., Levine, A.J., 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69, 1237-1245
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
48
-
-
0034881624
-
Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13
-
Moraes, T.F., Edwards, R.A., McKenna, S., Pastushok, L., Xiao, W., Glover, J.N., Ellison, M.J., 2001. Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. Nat. Struct. Biol. 8, 669-673
-
(2001)
Nat. Struct. Biol
, vol.8
, pp. 669-673
-
-
Moraes, T.F.1
Edwards, R.A.2
McKenna, S.3
Pastushok, L.4
Xiao, W.5
Glover, J.N.6
Ellison, M.J.7
-
49
-
-
0036195134
-
An intact NEDD8 pathway is required for cullin-dependent ubiquitylation in mammalian cells
-
Ohh, M., Kim, W.Y., Moslehi, J.J., Chen, Y., Chau, V., Read, M.A., Kaelin, Jr., W.G., 2002. An intact NEDD8 pathway is required for cullin-dependent ubiquitylation in mammalian cells. EMBO Rep. 3, 177-182
-
(2002)
EMBO Rep
, vol.3
, pp. 177-182
-
-
Ohh, M.1
Kim, W.Y.2
Moslehi, J.J.3
Chen, Y.4
Chau, V.5
Read, M.A.6
Kaelin, W.G.7
-
50
-
-
0027325132
-
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
-
Oliner, J.D., Pietenpol, J.A., Thiagalingam, S., Gyuris, J., Kinzler, K.W., Vogelstein, B., 1993. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 362, 857-860
-
(1993)
Nature
, vol.362
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
Gyuris, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
51
-
-
0032529162
-
Xe-p9, a Xenopus Sucl/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase-promoting complex at mitosis
-
Patra, D., Dunphy, W.G., 1998. Xe-p9, a Xenopus Sucl/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase-promoting complex at mitosis. Genes Dev. 12, 2549-2559
-
(1998)
Genes Dev
, vol.12
, pp. 2549-2559
-
-
Patra, D.1
Dunphy, W.G.2
-
52
-
-
0029909251
-
Identification of BIME as a subunit of the anaphase-promoting complex
-
Peters, J.M., King, R.W., Hoog, C., Kirschner, M.W., 1996. Identification of BIME as a subunit of the anaphase-promoting complex. Science 274, 1199-1201
-
(1996)
Science
, vol.274
, pp. 1199-1201
-
-
Peters, J.M.1
King, R.W.2
Hoog, C.3
Kirschner, M.W.4
-
53
-
-
0034654399
-
The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1
-
Pfleger, C.M., Kirschner, M.W., 2000. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14, 655-665
-
(2000)
Genes Dev
, vol.14
, pp. 655-665
-
-
Pfleger, C.M.1
Kirschner, M.W.2
-
54
-
-
0034915764
-
Mechanisms underlying ubiquitination
-
Pickart, C.M., 2001. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533
-
(2001)
Annu. Rev. Biochem
, vol.70
, pp. 503-533
-
-
Pickart, C.M.1
-
55
-
-
0032543552
-
The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis
-
Prinz, S., Hwang, E.S., Visintin, R., Amon, A., 1998. The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis. Curr. Biol. 8, 750-760
-
(1998)
Curr. Biol
, vol.8
, pp. 750-760
-
-
Prinz, S.1
Hwang, E.S.2
Visintin, R.3
Amon, A.4
-
56
-
-
0035370009
-
Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase-promoting complex
-
Reimann, J.D., Freed, E., Hsu, J.Y., Kramer, E.R., Peters, J.M., Jackson, P.K., 2001. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase-promoting complex. Cell 105, 645-655
-
(2001)
Cell
, vol.105
, pp. 645-655
-
-
Reimann, J.D.1
Freed, E.2
Hsu, J.Y.3
Kramer, E.R.4
Peters, J.M.5
Jackson, P.K.6
-
57
-
-
0027358723
-
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
-
Scheffner, M., Huibregtse, J.M., Vierstra, R.D., Howley, P.M., 1993. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75, 495-505
-
(1993)
Cell
, vol.75
, pp. 495-505
-
-
Scheffner, M.1
Huibregtse, J.M.2
Vierstra, R.D.3
Howley, P.M.4
-
58
-
-
0025639158
-
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
-
Scheffner, M., Wemess, B.A., Huibregtse, J.M., Levine, A.J., Howley, P.M., 1990, The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63, 1129-1136
-
(1990)
Cell
, vol.63
, pp. 1129-1136
-
-
Scheffner, M.1
Wemess, B.A.2
Huibregtse, J.M.3
Levine, A.J.4
Howley, P.M.5
-
59
-
-
0034707053
-
In search of the tumour-suppressor functions of BRCA1 and BRCA2
-
Scully, R., Livingston, D.M., 2000. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429-432
-
(2000)
Nature
, vol.408
, pp. 429-432
-
-
Scully, R.1
Livingston, D.M.2
-
60
-
-
0036773256
-
Panepophenanthrin, from a mushroom strain, a novel inhibitor of the ubiquitin-activating enzyme
-
Sekizawa, R., Ikeno, S., Nakamura, H., Naganawa, H., Matsui, S., Iinuma, H., Takeuchi, T., 2002. Panepophenanthrin, from a mushroom strain, a novel inhibitor of the ubiquitin-activating enzyme. J. Nat. Products 65, 1491-1493
-
(2002)
J. Nat. Products
, vol.65
, pp. 1491-1493
-
-
Sekizawa, R.1
Ikeno, S.2
Nakamura, H.3
Naganawa, H.4
Matsui, S.5
Iinuma, H.6
Takeuchi, T.7
-
61
-
-
0034704182
-
Waiting for anaphase: Mad2 and the spindle assembly checkpoint
-
Shah, J.V., Cleveland, D.W., 2000. Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Cell 103, 997-1000
-
(2000)
Cell
, vol.103
, pp. 997-1000
-
-
Shah, J.V.1
Cleveland, D.W.2
-
62
-
-
0033621415
-
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
-
Sharp, D.A., Kratowicz, S.A., Sank, M.J., George, D.L., 1999. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J. Biol. Chem. 274, 38189-38196
-
(1999)
J. Biol. Chem
, vol.274
, pp. 38189-38196
-
-
Sharp, D.A.1
Kratowicz, S.A.2
Sank, M.J.3
George, D.L.4
-
63
-
-
0032473568
-
The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
-
Shirayama, M., Zachariae, W., Ciosk, R., Nasmyth, K., 1998. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17, 1336-1349
-
(1998)
EMBO J
, vol.17
, pp. 1336-1349
-
-
Shirayama, M.1
Zachariae, W.2
Ciosk, R.3
Nasmyth, K.4
-
64
-
-
0037189502
-
A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats
-
Swinney, D.C., Xu, Y.Z., Scarafia, L.E., Lee, I., Mak, A.Y., Gan, Q.F., Ramesha, C.S., Mulkins, M.A., Dunn, J., So, O.Y., Biegel, T., Dinh, M., Volkel, P., Barnett, J., Dalrymple, S.A., Lee, S., Huber, M., 2002. A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats. J. Biol. Chem. 277, 23573-23581
-
(2002)
J. Biol. Chem
, vol.277
, pp. 23573-23581
-
-
Swinney, D.C.1
Xu, Y.Z.2
Scarafia, L.E.3
Lee, I.4
Mak, A.Y.5
Gan, Q.F.6
Ramesha, C.S.7
Mulkins, M.A.8
Dunn, J.9
So, O.Y.10
Biegel, T.11
Dinh, M.12
Volkel, P.13
Barnett, J.14
Dalrymple, S.A.15
Lee, S.16
Huber, M.17
-
65
-
-
0035661566
-
APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex
-
Tang, Z., Li, B., Bharadwaj, R., Zhu, H., Ozkan, E., Hakala, K., Deisenhofer, J., Yu, H., 2001. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol. Biol. Cell 12, 3839-3851
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 3839-3851
-
-
Tang, Z.1
Li, B.2
Bharadwaj, R.3
Zhu, H.4
Ozkan, E.5
Hakala, K.6
Deisenhofer, J.7
Yu, H.8
-
66
-
-
0028922929
-
p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60
-
Thut, C.J., Chen, J.L., Klemm, R., Tjian, R., 1995. p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science 267, 100-104
-
(1995)
Science
, vol.267
, pp. 100-104
-
-
Thut, C.J.1
Chen, J.L.2
Klemm, R.3
Tjian, R.4
-
67
-
-
0037142070
-
Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth
-
Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., Inoue, S., 2002. Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Nature 417, 871-875
-
(2002)
Nature
, vol.417
, pp. 871-875
-
-
Urano, T.1
Saito, T.2
Tsukui, T.3
Fujita, M.4
Hosoi, T.5
Muramatsu, M.6
Ouchi, Y.7
Inoue, S.8
-
68
-
-
0035875079
-
Molecular insights into polyubiquitin chain assembly: Crystal structure of the Mms2/Ubc13 heterodimer
-
VanDemark, A.P., Hofmann, R.M., Tsui, C., Pickart, C.M., Wolberger, C., 2001. Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer. Cell 105, 711-720
-
(2001)
Cell
, vol.105
, pp. 711-720
-
-
VanDemark, A.P.1
Hofmann, R.M.2
Tsui, C.3
Pickart, C.M.4
Wolberger, C.5
-
69
-
-
0035736265
-
Clinical cancer research 2001: New agents and therapies
-
Verweij, J., de Vries, E.G.E., 2001. Clinical cancer research 2001: new agents and therapies. Drug Resist. Updates 4, 217-223
-
(2001)
Drug Resist. Updates
, vol.4
, pp. 217-223
-
-
Verweij, J.1
De Vries, E.G.E.2
-
70
-
-
0032513037
-
Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 Å resolution
-
Worthylake, D.K., Prakash, S., Prakash, L., Hill, C.P., 1998. Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 Å resolution. J. Biol. Chem. 273, 6271-6276
-
(1998)
J. Biol. Chem
, vol.273
, pp. 6271-6276
-
-
Worthylake, D.K.1
Prakash, S.2
Prakash, L.3
Hill, C.P.4
-
71
-
-
0035899468
-
Different effects of pl4ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
-
Xirodimas, D., Saville, M.K., Edling, C., Lane, D.P., Lain, S., 2001. Different effects of pl4ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene 20, 4972-4983
-
(2001)
Oncogene
, vol.20
, pp. 4972-4983
-
-
Xirodimas, D.1
Saville, M.K.2
Edling, C.3
Lane, D.P.4
Lain, S.5
-
72
-
-
0034712832
-
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting. Smads to the ubiquitin-proteasome pathway
-
Xu, J., Attisano, L., 2000. Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting. Smads to the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. U.S.A. 97, 4820-4825
-
(2000)
Proc. Natl. Acad. Sci. U.S.A
, vol.97
, pp. 4820-4825
-
-
Xu, J.1
Attisano, L.2
-
73
-
-
0030857274
-
Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast
-
Yamada, H., Kumada, K., Yanagida, M., 1997. Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast. J. Cell Sci. 110, 1793-1804
-
(1997)
J. Cell Sci
, vol.110
, pp. 1793-1804
-
-
Yamada, H.1
Kumada, K.2
Yanagida, M.3
-
74
-
-
0034607655
-
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
-
Yang, Y., Fang, S., Jensen, J.P., Weissman, A.M., Ashwell, J.D., 2000. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288, 874-877
-
(2000)
Science
, vol.288
, pp. 874-877
-
-
Yang, Y.1
Fang, S.2
Jensen, J.P.3
Weissman, A.M.4
Ashwell, J.D.5
-
75
-
-
0033567387
-
Whose end is destruction: Cell division and the anaphase-promoting complex
-
Zachariae, W., Nasmyth, K., 1999. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13, 2039-2058
-
(1999)
Genes Dev
, vol.13
, pp. 2039-2058
-
-
Zachariae, W.1
Nasmyth, K.2
-
76
-
-
0032573374
-
Control of cyclin ubiquitination by CDK-regulated binding of Hctl to the anaphase promoting complex
-
Zachariae, W., Schwab, M., Nasmyth, K., Seufert, W., 1998. Control of cyclin ubiquitination by CDK-regulated binding of Hctl to the anaphase promoting complex. Science 282, 1721-1724
-
(1998)
Science
, vol.282
, pp. 1721-1724
-
-
Zachariae, W.1
Schwab, M.2
Nasmyth, K.3
Seufert, W.4
-
77
-
-
0035970096
-
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
-
Zhang, Y., Chang, C., Gehling, D.J., Hemmati-Brivanlou, A., Derynck, R., 2001. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A. 98, 974-979
-
(2001)
Proc. Natl. Acad. Sci. U.S.A
, vol.98
, pp. 974-979
-
-
Zhang, Y.1
Chang, C.2
Gehling, D.J.3
Hemmati-Brivanlou, A.4
Derynck, R.5
-
78
-
-
0034915032
-
Control of p53 ubiquitination and nuclear export by MDM2 and ARF
-
Zhang, Y., Xiong, Y., 2001. Control of p53 ubiquitination and nuclear export by MDM2 and ARF. Cell Growth Differ. 12, 175-186
-
(2001)
Cell Growth Differ
, vol.12
, pp. 175-186
-
-
Zhang, Y.1
Xiong, Y.2
-
79
-
-
18344391432
-
Structure of the Cu11-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex
-
Zheng, N., Schulman, B.A., Song, L., Miller, J.J., Jeffrey, P.D., Wang, P., Chu, C., Koepp, D.M., Elledge, S.J., Pagano, M., Conaway, R.C., Conaway, J.W., Harper, J.W., Pavletich, N.P., 2002. Structure of the Cu11-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex. Nature 416, 703-709
-
(2002)
Nature
, vol.416
, pp. 703-709
-
-
Zheng, N.1
Schulman, B.A.2
Song, L.3
Miller, J.J.4
Jeffrey, P.D.5
Wang, P.6
Chu, C.7
Koepp, D.M.8
Elledge, S.J.9
Pagano, M.10
Conaway, R.C.11
Conaway, J.W.12
Harper, J.W.13
Pavletich, N.P.14
-
80
-
-
0034682718
-
Structure of a c-Cb1-UbcH7 complex: RING domain function in ubiquitin-protein ligases
-
Zheng, N., Wang, P., Jeffrey, P.D., Pavletich, N.P., 2000. Structure of a c-Cb1-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell 102, 533-539
-
(2000)
Cell
, vol.102
, pp. 533-539
-
-
Zheng, N.1
Wang, P.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
81
-
-
0033549789
-
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
-
Zhu, H., Kavsak, P., Abdollah, S., Wrana, J.L., Thomsen, G.H., 1999. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400, 687-693
-
(1999)
Nature
, vol.400
, pp. 687-693
-
-
Zhu, H.1
Kavsak, P.2
Abdollah, S.3
Wrana, J.L.4
Thomsen, G.H.5
|