Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo

Journal of Investigative Dermatology

Volumn 115, Issue 2, 2000, Pages 177-182

  Chung, J H ^a   Kang, S ^a   Varani, J ^a   Lin, J ^a   Fisher, G J ^a   Voorhees, J J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

C Fos; C Jun; Cyclin

Indexed keywords

AGING; ARTICLE; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN TISSUE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SKIN DISEASE; STRESS;

EID: 0033889654     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00009.x     Document Type: Article

References (46)

1. Transforming p21 ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
2. The jun proto-oncogene is positively autoregulated by its product
3. Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly hnmans stimulated by the TCR/CD3 complex and co-stimulatory signals
4. Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors
5. The role of cellular senescence in skin aging
6. UV irradiation activates JNK and increases alpha(I) collagen gene expression in rat hepatic stellate cells
7. Assembly of cyclin D-dependent kinase and titration of p27(Kipl) regulated by mitogen-activated protein kinase (MEK1)
8. An AP-1 binding sequence is essential for regulation of the human α2(1) collagen (COL1A2) promoter activity by transforming growth factor-β
9. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
10. The formation of all-trans-retinoic acid from all-trans-retinol in hairless mouse skin
11. Raf and nitrogen-activated protein kinase regulate stellate cell collagen gene expression
12. New JNK expands the group
13. Molecular mechanisms of retinoid actions in skin
14. Cellular, immunologic and biochemical characterization of topical retinoic-acid treated human skin
15. Molecular basis of sun-induced premature skin ageing and retinoid antagonism
16. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin invivo
17. Cyclins, cyclin-dependent kinases and differentiation
18. A review of skin ageing and its medical therapy
19. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid)
20. Regulation of 92 kDa type IV expression of the jun amino terminal kinase and the extracellular signal-regulated kinase-dependent signaling cascades
21. A c-Jun dominant negative murant protects sympathetic neurons against programmed cell death
22. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
23. An altered repertoire of fosjun (AP-1) at the onset of replicative senescence
24. Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus
25. An AP-1-like motif in the first intron of human Pro alpha 1(I) collagen gene is a critical determinant of its transcriptional activity
26. Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by the p38/HOG MAPK pathway
27. Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes
28. Nuclear factor binding to an AP-1 site is associated with the activation of pro-alpha 1(I)-collagen gene in dedifferentiating chondrocytes
29. Fibroblast changes in cutaneous aging
30. Effect of donor age on epidermal growth factor processing in man
31. Aging affects epidermal growth factor receptor phosphorylation and traffic kinetics
32. Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes
33. Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging
34. Mitogen-activated protein kinase pathways
35. Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors
36. Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
37. The influence of age on skin thickness, skin collagen and density
38. Reduced type I and type III procollagens in photodamaged adult human skin
39. Differential expression and regulation of cyclin D1 protein in normal and tumor human ells: Association with Cdk4 is required for cyclin D1 function in G1 progression
40. Retinol (vitamin A) stimulates collagen accumulation in chronologically-aged human skin in vivo
41. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
42. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
43. The cellular and molecular biology of skin aging
44. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
45. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
46. Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors