Mediator complexes and transcription

Current Opinion in Cell Biology

Volumn 13, Issue 3, 2001, Pages 274-280

  Rachez, Christophe ^a,b   Freedman, Leonard P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EMBRYO DEVELOPMENT; GENE ACTIVATION; MEDIATOR; METAZOON; NOMENCLATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; REVIEW; TRANSCRIPTION REGULATION; YEAST;

EID: 0035371483     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00209-X     Document Type: Review

References (60)

1. Orchestrated response: A symphony of transcription factors for gene control
2. Transcription of eukaryotic protein-coding genes
3. The role of general initiation factors in transcription by RNA polymerase II
4. The general transcription factors of RNA polymerase II
5. Snapshots of RNA polymerase II transcription initiation
6. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
7. Activation of class II gene transcription by regulatory factors is potentiated by a novel activity
8. Isolation of coactivators associated with the TATA-binding protein that mediates transcriptional activation
9. TAFs mediate transcriptional activation and promoter selectivity
10. RNA polymerase II holoenzymes and subcomplexes
11. Mediator of transcriptional regulation
12. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
13. The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain
14. Regulatory targets in the RNA polymerase II holoenzyme
15. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
16. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex
17. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
18. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
19. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
20. Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro
21. Composite co-activator ARC mediates chromatin-directed transcriptional activation
22. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
23. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
24. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
25. RNA polymerase II cofactor PC2 facilitates activation of transcription by GAL4-AH in vitro
26. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs
27. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1
28. Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit srb7 in mice
29. Binding of liganded vitamin D receptor to the vitamin D receptor interacting protein coactivator complex induces interaction with RNA polymerase II holoenzyme
30. An activator target in the RNA polymerase II holoenzyme
31. TFIIH is negatively regulated by cdk8-containing mediator complexes
32. Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation
33. Control of elongation by RNA polymerase II
34. Reversible phosphorylation of the C-terminal domain of RNA polymerase II
35. Evidence for a mediator cycle at the initiation of transcription
36. A transcription reinitiation intermediate that is stabilized by activator
37. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter
38. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle and developmentally regulated promoter
39. Acetylation and chromosomal functions
40. Nuclear receptor cofactors as chromatin remodelers
41. What does 'chromatin remodeling' mean?
42. ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR in vitro
43. Mediator-nucleosome interaction
44. Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae
45. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes
46. Specific structural motifs determine TRAP220 interactions with nuclear hormone receptors
47. Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes
48. The coregulator exchange in transcriptional functions of nuclear receptors
49. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription
50. Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators
51. Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation
52. A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene
53. Association of an X-chromosome dodecamer insertional variant allele with mental retardation
54. sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction
55. Drosophila homologues of the transcriptional coactivation complex TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development
56. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification
57. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action
58. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
59. Yeast nuclear extract contains two major forms of RNA polymearase II mediator complexes
60. Drosophila mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters