Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts

Mechanisms of Ageing and Development

Volumn 119, Issue 3, 2000, Pages 113-130

  Lim, In Kyoung ^a   Won Hong, Kwang ^a   Kwak, In Hae ^a   Yoon, Gyesoon ^a   Park, Sang Chul ^b  

^a Ajou University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

H rasV12C40; H rasV12G37; H rasV12S35; p Erk1 2 in cytoplasm, actin in nucleus; Racl in nucleus

Indexed keywords

ACTIN;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; CYTOSKELETON; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MORPHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENESCENCE; SIGNAL TRANSDUCTION;

UNIDENTIFIED RETROVIRUS;

EID: 0034669673     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(00)00167-6     Document Type: Article

References (30)

1. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
2. Transport into the cell nucleus of p42 and p44 isoforms of MAP kinase induced by epidermal growth factor requires the presence of intact active cytoskeleton
3. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
4. Interaction of MAP kinase with MAP kinase kinase; its possible role in the control of nucleocytoplasmic transport of MAP kinase
5. Abundance of plate let-derived growth factors (PDGFs), PDGF receptors and activation of mitogen-activated protein kinases in brain decline with age
6. The KKRKK sequence is involved in heat shock-induced nuclear translocation of the 18-kDa actin-binding protein, cofilin
7. Nuclear translocation of mitogen-activated protein kinase kinase (MEK) in response to mitogenic stimulation
8. Stimulation of membrane ruffling and MAP kinase activation by distinct effect of RAS
9. Akt protein kinase inhibits Racl-GTP binding through phosphorylation at serine 71 of Racl
10. Growth factor-induced p42/p44 MAPK nuclar translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins
11. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
12. Relationship between cell kinetic changes and metabolic events during cell senescense in vitro
13. Actin-based cell mobility and cell locomotion
14. ADF/cofilin porteins: Stimulus-responsive modulator of actin dynamics
15. Coflin, a protein in porcine brain that binds to actin filaments and inhibits their interactions with myosin and tropornyosin
16. Actin
17. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
18. Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments Listeria monocytogenes tails
19. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
20. RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts
21. The relationship between donor age and the growth characteristics of human smooth muscle cultures of aorta and stomach
22. On the crawling of animal cells
23. Activation induces dephosphorylation of cofilin and its translocation to plasma membranes in neutrophil-like differentiated HL-60 cells
24. Accelerating on a treadmill: ADF/cofilin promote rapid actin filament turnover in the dynamic cytoskeleton
25. Nuclear export of actin: A novel mechanism regulating the subcellular localization of a major cytoskeleton protein
26. Age-related reductions in the activation of mitogen-activated protein kinases p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex
27. Multiple Ras functions can contribute to mammalian cell transformation
28. CDC42 and FGDI cause distinct signaling and transforming activities
29. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
30. Rho family proteins and Ras transformation: The RHOad less traveled gets congested