Proteasome-mediated Glucocorticoid Receptor Degradation Restricts Transcriptional Signaling by Glucocorticoids

Journal of Biological Chemistry

Volumn 276, Issue 46, 2001, Pages 42714-42721

  Wallace, Andrew D ^a   Cidlowski, John A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; ENZYME INHIBITION; GENES; HORMONES; PROTEINS;

GENE EXPRESSION; TRANSCRIPTIONAL ACTIVATION;

BIOCHEMISTRY;

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; LACTONE DERIVATIVE; LIGAND; LYSINE; MUTANT PROTEIN; PHOSPHOPROTEIN; PROTEASOME; PROTEASOME INHIBITOR; RECEPTOR PROTEIN; UBIQUITIN; CHLORAMPHENICOL ACETYLTRANSFERASE; CYSTEINE PROTEINASE; LUCIFERASE; MULTIENZYME COMPLEX;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME DEGRADATION; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HORMONE RESPONSE; IMMUNOPRECIPITATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WILD TYPE; ANIMAL; CELL STRAIN COS1; CHEMISTRY; DOWN REGULATION; GENETIC TRANSFECTION; HELA CELL; HUMAN; METABOLISM; MUTATION; PHOSPHORYLATION; PLASMID; SERODIAGNOSIS; SITE DIRECTED MUTAGENESIS; TIME; TRANSACTIVATION; WESTERN BLOTTING;

ANIMALIA;

AMINO ACID MOTIFS; ANIMALS; BLOTTING, WESTERN; CHLORAMPHENICOL O-ACETYLTRANSFERASE; COS CELLS; CYSTEINE ENDOPEPTIDASES; DEXAMETHASONE; DOWN-REGULATION; GLUCOCORTICOIDS; HELA CELLS; HUMANS; LIGANDS; LUCIFERASES; LYSINE; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0035900780     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106033200     Document Type: Article

References (68)

1. Barnes, P. J. (1998) Clin. Sci. 94, 557-572
2. Mendel, D. B., Bodwell, J. E., and Munck, A. (1986) Nature 324, 478-480
3. Sapolsky, R. M., Romero, L. M., and Munck, A. U. (2000) Endocr. Rev. 21, 55-89
4. Kumar, R., and Thompson, E. B. (1999) Steroids 64, 310-319
5. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., and Chambon, P. (1995) Cell 83, 835-839
6. Bamberger, C. M., Schulte, H. M., and Chrousos, G. P. (1996) Endocr. Rev. 17, 245-261
7. McKay, L. I., and Cidlowski, J. A. (1999) Endocr. Rev. 20, 435-459
8. Webster, J. C., and Cidlowski, J. A. (1999) Trends Endocrinol Metab. 10, 396-402
9. Cidlowski, J. A., and Cidlowski, N. B. (1981) Endocrinology 109, 1975-1982
10. Hoeck, W., Rusconi, S., and Groner, B. (1989) J. Biol. Chem. 264, 14396-14402
11. Silva, C. M., Powell-Oliver, F. E., Jewell, C. M., Sar, M., Allgood, V. E., and Cidlowski, J. A. (1994) Steroids 59, 436-442
12. McIntyre, W. R., and Samuels, H. H. (1985) J. Biol. Chem. 260, 418-427
13. Burnstein, K. L., Jewell, C. M., and Cidlowski, J. A. (1990) J. Biol. Chem. 265, 7284-7291
14. Burnstein, K. L., Bellingham, D. L., Jewell, C. M., Powell-Oliver, F. E., and Cidlowski, J. A. (1991) Steroids 56, 52-58
15. Bellingham, D. L., Sar, M., and Cidlowski, J. A. (1992) Mol. Endocrinol. 6, 2090-2102
16. Oakley, R. H., and Cidlowski, J. A. (1993) Crit. Rev. Eukaryotic Gene Expr. 3, 63-88
17. Schmidt, T. J., and Meyer, A. S. (1994) Receptor 4, 229-257
18. Okret, S., Poellinger, L., Dong, Y., and Gustafsson, J. A. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 5899-5903
19. Dong, Y., Poellinger, L., Gustafsson, J. A., and Okret, S. (1988) Mol. Endocrinol. 2, 1256-1264
20. Burnstein, K. L., Jewell, C. M., Sar, M., and Cidlowski, J. A. (1994) Mol. Endocrinol. 8, 1764-1773
21. Webster, J. C., Jewell, C. M., Bodwell, J. E., Munck, A., Sar, M., and Cidlowski, J. A. (1997) J. Biol. Chem. 272, 9287-9293
22. Fuchs, S. Y., Fried, V. A., and Ronai, Z. (1998) Oncogene 17, 1483-1490
23. Hershko, A., and Ciechanover, A. (1998) Annu. Rev. Biochem. 67, 425-479
24. Laney, J. D., and Hochstrasser, M. (1999) Cell 97, 427-430
25. Kornitzer, D., and Ciechanover, A. (2000) J. Cell. Physiol. 182, 1-11
26. Chen, Z., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D., Ballard, D., and Maniatis, T. (1995) Genes Dev. 9, 1586-1597
27. Tsurumi, C., Ishida, N., Tamura, T., Kakizuka, A., Nishida, E., Okumura, E., Kishimoto, T., Inagaki, M., Okazaki, K., and Sagata, N. (1995) Mol. Cell. Biol. 15, 5682-5687
28. Talis, A. L., Huibregtse, J. M., and Howley, P. M. (1998) J. Biol. Chem. 273, 6439-6445
29. Baldi, L., Brown, K., Franzoso, G., and Siebenlist, U. (1996) J. Biol. Chem. 271, 376-379
30. Skowyra, D., Koepp, D. M., Kamura, T., Conrad, M. N., Conaway, R. C., Conaway, J. W., Elledge, S. J., and Harper, J. W. (1999) Science 284, 662-665
31. Coux, O., Tanaka, K., and Goldberg, A. L. (1996) Annu. Rev. Biochem. 65, 801-847
32. Lee, D. H., and Goldberg, A. L. (1998) Trends Cell Biol. 8, 397-403
33. Driscoll, J., and Goldberg, A. L. (1990) J. Biol. Chem. 265, 4789-4792
34. DeMartino, G. N., and Slaughter, C. A. (1999) J. Biol. Chem. 274, 22123-22126
35. Danielsen, M., Hinck, L., and Ringold, G. M. (1989) Cancer Res. 49, 2286-2291
36. Tilley, W. D., Marcelli, M., Wilson, J. D., and McPhaul, M. J. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 327-331
37. Allgood, V. E., Powell-Oliver, F. E., and Cidlowski, J. A. (1990) J. Biol. Chem. 265, 12424-12433
38. Allgood, V. E., Oakley, R. H., and Cidlowski, J. A. (1993) J. Biol. Chem. 268, 20870-20876
39. Ward, C. L., Omura, S., and Kopito, R. R. (1995) Cell 83, 121-127
40. Scheible, P. P., DeLorenzo, T. M., and Cidlowski, J. A. (1987) J. Steroid Biochem. 26, 181-187
41. McKay, L. I., and Cidlowski, J. A. (2000) Mol. Endocrinol. 14, 1222-1234
42. Cidlowski, J. A., Bellingham, D. L., Powell-Oliver, F. E., Lubahn, D. B., and Sar, M. (1990) Mol. Endocrinol. 4, 1427-1437
43. Haas, A. L., and Bright, P. M. (1985) J. Biol. Chem. 260, 12464-12473
44. Whitesell, L., and Cook, P. (1996) Mol. Endocrinol. 10, 705-712
45. Nirmala, P. B., and Thampan, R. V. (1995) Biochem. Biophys. Res. Commun. 213, 24-31
46. Syvala, H., Vienonen, A., Zhuang, Y. H., Kivineva, M., Ylikomi, T., and Tuohimaa, P. (1998) Life Sci. 63, 1505-1512
47. Rogers, S., Wells, R., and Rechsteiner, M. (1986) Science 234, 364-368
48. Rechsteiner, M., and Rogers, S. W. (1996) Trends Biochem. Sci. 21, 267-271
49. Ernst, M. K., Dunn, L. L., and Rice, N. R. (1995) Mol. Cell. Biol. 15, 872-882
50. Lin, R., Beauparlant, P., Makris, C., Meloche, S., and Hiscott, J. (1996) Mol. Cell. Biol. 16, 1401-1409
51. Roth, A. F., and Davis, N. G. (2000) J. Biol. Chem. 275, 8143-8153
52. Svec, F., and Rudis, M. (1981) J. Biol. Chem. 256, 5984-5987
53. Vedeckis, W. V., Ali, M., and Allen, H. R. (1989) Cancer Res. 49, 2295-2302
54. Nawaz, Z., Lonard, D. M., Dennis, A. P., Smith, C. L., and O'Malley, B. W. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1858-1862
55. Alarid, E. T., Bakopoulos, N., and Solodin, N. (1999) Mol. Endocrinol. 13, 1522-1534
56. Lonard, D. M., Nawaz, Z., Smith, C. L., and O'Malley, B. W. (2000) Mol. Cell 5, 939-948
57. Roberts, B. J., and Whitelaw, M. L. (1999) J. Biol. Chem. 274, 36351-36356
58. Davarinos, N. A., and Pollenz, R. S. (1999) J. Biol. Chem. 274, 28708-28715
59. Dace, A., Zhao, L., Park, K. S., Furuno, T., Takamura, N., Nakanishi, M., West, B. L., Hanover, J. A., and Cheng, S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 8985-8990
60. Lange, C. A., Shen, T., and Horwitz, K. B. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1032-1037
61. Nawaz, Z., Stancel, G. M., and Hyder, S. M. (1999) Cancer Res. 59, 372-376
62. Van Antwerp, D. J., and Verma, I. M. (1996) Mol. Cell. Biol. 16, 6037-6045
63. Yaglom, J., Linskens, M. H., Sadis, S., Rubin, D. M., Futcher, B., and Finley, D. (1995) Mol. Cell. Biol. 15, 731-741
64. McKinsey, T. A., Chu, Z. L., and Ballard, D. W. (1997) J. Biol. Chem. 272, 22377-22380
65. Bodwell, J. E., Orti, E., Coull, J. M., Pappin, D. J., Smith, L. I., and Swift, F. (1991) J. Biol. Chem. 266, 7549-7555
66. Bodwell, J. E., Webster, J. C., Jewell, C. M., Cidlowski, J. A., Hu, J. M., and Munck, A. (1998) J. Steroid Biochem. Mol. Biol. 65, 91-99
67. Bodwell, J. E., Hu, J. M., Orti, E., and Munck, A. (1995) J. Steroid Biochem. Mol. Biol. 52, 135-140
68. Shao, D., and Lazar, M. A. (1999) J. Clin. Invest. 103, 1617-1618