Dendritic cell biology

Advances in Immunology

Volumn 88, Issue , 2005, Pages 193-233

  Granucci, Francesca ^a   Foti, Maria ^a   Ricciardi Castagnoli, Paola ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TOLL LIKE RECEPTOR;

ANTIGEN PRESENTATION; CELL FUNCTION; CELL INTERACTION; CELL MATURATION; CYTOLOGY; DENDRITIC CELL; DNA VIRUS; GENE TARGETING; GENOMICS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; IMMUNE SYSTEM; INNATE IMMUNITY; LEUKOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR DYNAMICS; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; REVIEW; RNA VIRUS;

ANIMALS; BACTERIAL INFECTIONS; DENDRITIC CELLS; GENE EXPRESSION REGULATION; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE TOLERANCE; IMMUNITY; LECTINS, C-TYPE; MICE; TOLL-LIKE RECEPTORS; VIRUS DISEASES;

EID: 26444502196     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(05)88006-X     Document Type: Review

References (239)

1. Aebischer T., Bennett C.L., Pelizzola M., Vizzardelli C., Pavelka N., Urbano M., Capozzoli M., Luchini A., Ilg T., Granucci F., Blackburn C.C., and Ricciardi-Castagnoli P. A critical role for lipophosphoglycan in proinflammatory responses of dendritic cells to Leishmania mexicana Eur. J. Immunol. 35 2005 476 486
2. Agnese D.M., Calvano J.E., Hahm S.J., Coyle S.M., Corbett S.A., Calvano S.E., and Lowry S.F. Human Toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections J. Infect. Dis. 186 2002 1522 1525
3. Agrawal S., Agrawal A., Doughty B., Gerwitz A., Blenis J., Van Dyke T., and Pulendran B. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos J. Immunol. 171 2003 4984 4989
4. Ahmad-Nejad P., Hacker H., Rutz M., Bauer S., Vabulas R.M., and Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments Eur. J. Immunol. 32 2002 1958 1968
5. Akiba H., Miyahira Y., Atsuta M., Takeda K., Nohara C., Futagawa T., Matsuda H., Aoki T., Yagita H., and Okumura K. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis J. Exp. Med. 191 2000 375 380
6. Akira S., and Takeda K. Toll-like receptor signalling Nat. Rev. Immunol. 4 2004 499 511
7. Akira S., Takeda K., and Kaisho T. Toll-like receptors: Critical proteins linking innate and acquired immunity Nat. Immunol. 2 2001 675 680
8. Aksoy E., Zouain C.S., Vanhoutte F., Fontaine J., Pavelka N., Thieblemont N., Willems F., Ricciardi-Castagnoli P., Goldman M., Capron M., Ryffel B., and Trottein F. Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells J. Biol. Chem. 280 2005 277 283
9. Allavena P., Chieppa M., Monti P., and Piemonti L. From pattern recognition receptor to regulator of homeostasis: The double-faced macrophage mannose receptor Crit. Rev. Immunol. 24 2004 179 192
10. An H., Yu Y., Zhang M., Xu H., Qi R., Yan X., Liu S., Wang W., Guo Z., Guo J., Qin Z., and Cao X. Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells Immunology 106 2002 38 45
11. Anderson D.C., Miller L.J., Schmalstieg F.C., Rothlein R., and Springer T.A. Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: Structure-function assessments employing subunit-specific monoclonal antibodies J. Immunol. 137 1986 15 27
12. Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., von Boehmer H., Bronson R., Dierich A., Benoist C., and Mathis D. Projection of an immunological self shadow within the thymus by the aire protein Science 298 2002 1395 1401
13. Andrews D.M., Andoniou C.E., Granucci F., Ricciardi-Castagnoli P., and Degli-Esposti M.A. Infection of dendritic cells by murine cytomegalovirus induces functional paralysis Nat. Immunol. 2 2001 1077 1084
14. Andrews D.M., Scalzo A.A., Yokoyama W.M., Smyth M.J., and Degli-Esposti M.A. Functional interactions between dendritic cells and NK cells during viral infection Nat. Immunol. 4 2003 175 181
15. Anjuere F., Martin P., Ferrero I., Fraga M.L., del Hoyo G.M., Wright N., and Ardavin C. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse Blood 93 1999 590 598
16. Ardavin C. Origin, precursors and differentiation of mouse dendritic cells Nat. Rev. Immunol. 3 2003 582 590
17. Ardavin C., Martinez del Hoyo G., Martin P., Anjuere F., Arias C.F., Marin A.R., Ruiz S., Parrillas V., and Hernandez H. Origin and differentiation of dendritic cells Trends Immunol. 22 2001 691 700
18. Asselin-Paturel C., Boonstra A., Dalod M., Durand I., Yessaad N., Dezutter-Dambuyant C., Vicari A., O'Garra A., Biron C., Briere F., and Trinchieri G. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology Nat. Immunol. 2 2001 1144 1150
19. Austyn J.M. New insights into the mobilization and phagocytic activity of dendritic cells J. Exp. Med. 183 1996 1287 1292
20. Avery A.C., Zhao Z.S., Rodriguez A., Bikoff E.K., Soheilian M., Foster C.S., and Cantor H. Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide Nature 376 1995 431 434
21. Azuma I., and Seya T. Development of immunoadjuvants for immunotherapy of cancer Int. Immunopharmacol. 1 2001 1249 1259
22. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J., Pulendran B., and Palucka K. Immunobiology of dendritic cells Annu. Rev. Immunol. 18 2000 767 811
23. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity Nature 392 1998 245 252
24. Bartz H., Turkel O., Hoffjan S., Rothoeft T., Gonschorek A., and Schauer U. Respiratory syncytial virus decreases the capacity of myeloid dendritic cells to induce interferon-gamma in naive T cells Immunology 109 2003 49 57
25. Bendelac A., and Medzhitov R. Adjuvants of immunity: Harnessing innate immunity to promote adaptive immunity J. Exp. Med. 195 2002 F19 F23
26. Bergelson J., Kreitman M., Stahl E.A., and Tian D. Evolutionary dynamics of plant R-genes Science 292 2001 2281 2285
27. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling Nature 430 2004 257 263
28. Bjorck P., Flores-Romo L., and Liu Y.J. Human interdigitating dendritic cells directly stimulate CD40-activated naive B cells Eur. J. Immunol. 27 1997 1266 1274
29. Blander J.M., and Medzhitov R. Regulation of phagosome maturation by signals from Toll-like receptors Science 304 2004 1014 1018
30. Blank C., Fuchs H., Rappersberger K., Rollinghoff M., and Moll H. Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major J. Infect. Dis. 167 1993 418 425
31. Boehm U., Klamp T., Groot M., and Howard J.C. Cellular responses to interferon-gamma Annu. Rev. Immunol. 15 1997 749 795
32. Bonifaz L., Bonnyay D., Mahnke K., Rivera M., Nussenzweig M.C., and Steinman R.M. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance J. Exp. Med. 196 2002 1627 1638
33. Borg C., Jalil A., Laderach D., Maruyama K., Wakasugi H., Charrier S., Ryffel B., Cambi A., Figdor C., Vainchenker W., Galy A., Caignard A., and Zitvogel L. NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs Blood 104 2004 3267 3275
34. Bowie A., Kiss-Toth E., Symons J.A., Smith G.L., Dower S.K., and O'Neill L.A. A46R and A52R from vaccinia virus are antagonists of host IL-1 and Toll-like receptor signaling Proc. Natl. Acad. Sci. USA 97 2000 10162 10167
35. Bretscher P., and Cohn M. A theory of self-nonself discrimination Science 169 1970 1042 1049
36. Bretscher P.A. A two-step, two-signal model for the primary activation of precursor helper T cells Proc. Natl. Acad. Sci. USA 96 1999 185 190
37. Brocker T., Riedinger M., and Karjalainen K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo J. Exp. Med. 185 1997 541 550
38. Bromley S.K., Iaboni A., Davis S.J., Whitty A., Green J.M., Shaw A.S., Weiss A., and Dustin M.L. The immunological synapse and CD28-CD80 interactions Nat. Immunol. 2 2001 1159 1166
39. Burkly L.C., Lo D., and Flavell R.A. Tolerance in transgenic mice expressing major histocompatibility molecules extrathymically on pancreatic cells Science 248 1990 1364 1368
40. Burley S.K., and Bonanno J.B. Structuring the universe of proteins Annu. Rev. Genomics Hum. Genet. 3 2002 243 262
41. Cannarile M.A., Decanis N., van Meerwijk J.P., and Brocker T. The role of dendritic cells in selection of classical and nonclassical CD8+ T cells in vivo J. Immunol. 173 2004 4799 4805
42. Capone M., Romagnoli P., Beermann F., Mac Donald H.R., and van Meerwijk J.P. Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells Blood 97 2001 1336 1342
43. Cavanagh L.L., and Von Andrian U.H. Travellers in many guises: The origins and destinations of dendritic cells Immunol. Cell Biol. 80 2002 448 462
44. Cella M., Engering A., Pinet V., Pieters J., and Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells Nature 388 1997 782 787
45. Chensue S.W., Warmington K.S., Ruth J.H., Sanghi P.S., Lincoln P., and Kunkel S.L. Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: Relationship to local inflammation, Th cell expression, and IL-12 production J. Immunol. 157 1996 4602 4608
46. Chieppa M., Bianchi G., Doni A., Del Prete A., Sironi M., Laskarin G., Monti P., Piemonti L., Biondi A., Mantovani A., Introna M., and Allavena P. Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program J. Immunol. 171 2003 4552 4560
47. Corinti S., Medaglini D., Cavani A., Rescigno M., Pozzi G., Ricciardi-Castagnoli P., and Girolomoni G. Human dendritic cells very efficiently present a heterologous antigen expressed on the surface of recombinant gram-positive bacteria to CD4+ T lymphocytes J. Immunol. 163 1999 3029 3036
48. Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M., Lira S.A., Gorman D., Kastelein R.A., and Sedgwick J.D. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 2003 744 748
49. De Smedt T., Pajak B., Klaus G.G., Noelle R.J., Urbain J., Leo O., and Moser M. Antigen-specific T lymphocytes regulate lipopolysaccharide-induced apoptosis of dendritic cells in vivo J. Immunol. 161 1998 4476 4479
50. Degli-Esposti M.A., and Smyth M.J. Close encounters of different kinds: dendritic cells and NK cells take centre stage Nat. Rev. Immunol. 5 2005 112 124
51. Demangel C., Bean A.G., Martin E., Feng C.G., Kamath A.T., and Britton W.J. Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guerin-infected dendritic cells Eur. J. Immunol. 29 1999 1972 1979
52. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., and Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells J. Exp. Med. 193 2001 233 238
53. Diebold S.S., Kaisho T., Hemmi H., Akira S., and Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA Science 303 2004 1529 1531
54. Diebold S.S., Montoya M., Unger H., Alexopoulou L., Roy P., Haswell L.E., Al-Shamkhani A., Flavell R., Borrow P., and Reis e Sousa C. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers Nature 424 2003 324 328
55. Doni A., Peri G., Chieppa M., Allavena P., Pasqualini F., Vago L., Romani L., Garlanda C., and Mantovani A. Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells Eur. J. Immunol. 33 2003 2886 2893
56. Doyle S.E., O'Connell R.M., Miranda G.A., Vaidya S.A., Chow E.K., Liu P.T., Suzuki S., Suzuki N., Modlin R.L., Yeh W.C., Lane T.F., and Cheng G. Toll-like receptors induce a phagocytic gene program through p38 J. Exp. Med. 199 2004 81 90
57. Dubois B., Bridon J.M., Fayette J., Barthelemy C., Banchereau J., Caux C., and Briere F. Dendritic cells directly modulate B cell growth and differentiation J. Leukoc. Biol. 66 1999 224 230
58. Dubois B., Massacrier C., Vanbervliet B., Fayette J., Briere F., Banchereau J., and Caux C. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes J. Immunol. 161 1998 2223 2231
59. Dubois B., Vanbervliet B., Fayette J., Massacrier C., Van Kooten C., Briere F., Banchereau J., and Caux C. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes J. Exp. Med. 185 1997 941 951
60. Feau S., Facchinetti V., Granucci F., Citterio S., Jarrossay D., Seresini S., Protti M.P., Lanzavecchia A., and Ricciardi-Castagnoli P. Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice Blood 105 2005 697 702
61. Ferlazzo G., Morandi B., D'Agostino A., Meazza R., Melioli G., Moretta A., and Moretta L. The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells Eur. J. Immunol. 33 2003 306 313
62. Ferlazzo G., Pack M., Thomas D., Paludan C., Schmid D., Strowig T., Bougras G., Muller W.A., Moretta L., and Munz C. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs Proc. Natl. Acad. Sci. USA 101 2004 16606 16611
63. Ferlazzo G., Tsang M.L., Moretta L., Melioli G., Steinman R.M., and Munz C. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells J. Exp. Med. 195 2002 343 351
64. Fernandez N.C., Lozier A., Flament C., Ricciardi-Castagnoli P., Bellet D., Suter M., Perricaudet M., Tursz T., Maraskovsky E., and Zitvogel L. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo Nat. Med. 5 1999 405 411
65. Fieschi C., and Casanova J.L. The role of interleukin-12 in human infectious diseases: Only a faint signature Eur. J. Immunol. 33 2003 1461 1464
66. Filgueira L., Nestle F.O., Rittig M., Joller H.I., and Groscurth P. Human dendritic cells phagocytose and process Borrelia burgdorferi J. Immunol. 157 1996 2998 3005
67. Foti M., Granucci F., Aggujaro D., Liboi E., Luini W., Minardi S., Mantovani A., Sozzani S., and Ricciardi-Castagnoli P. Upon dendritic cell (DC) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of DC at the inflammatory site Int. Immunol. 11 1999 979 986
68. Friedl P., and Storim J. Diversity in immune-cell interactions: states and functions of the immunological synapse Trends Cell Biol. 14 2004 557 567
69. Fugier-Vivier I., Servet-Delprat C., Rivailler P., Rissoan M.C., Liu Y.J., and Rabourdin-Combe C. Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells J. Exp. Med. 186 1997 813 823
70. Gantner B.N., Simmons R.M., Canavera S.J., Akira S., and Underhill D.M. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2 J. Exp. Med. 197 2003 1107 1117
71. Garlanda C., Hirsch E., Bozza S., Salustri A., De Acetis M., Nota R., Maccagno A., Riva F., Bottazzi B., Peri G., Doni A., Vago L., Botto M., De Santis R., Carminati P., Siracusa G., Altruda F., Vecchi A., Romani L., and Mantovani A. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response Nature 420 2002 182 186
72. Geijtenbeek T.B., Kwon D.S., Torensma R., van Vliet S.J., van Duijnhoven G.C., Middel J., Cornelissen I.L., Nottet H.S., Kewal Ramani V.N., Littman D.R., Figdor C.G., and van Kooyk Y. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells Cell 100 2000 587 597
73. Geijtenbeek T.B., Torensma R., van Vliet S.J., van Duijnhoven G.C., Adema G.J., van Kooyk Y., and Figdor C.G. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses Cell 100 2000 575 585
74. Geijtenbeek T.B., van Vliet S.J., Engering A., t Hart B.A., and van Kooyk Y. Self- and nonself-recognition by C-type lectins on dendritic cells Annu. Rev. Immunol. 22 2004 33 54
75. Gerosa F., Baldani-Guerra B., Nisii C., Marchesini V., Carra G., and Trinchieri G. Reciprocal activating interaction between natural killer cells and dendritic cells J. Exp. Med. 195 2002 327 333
76. Girardin S.E., Boneca I.G., Viala J., Chamaillard M., Labigne A., Thomas G., Philpott D.J., and Sansonetti P.J. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection J. Biol. Chem. 278 2003 8869 8872
77. Gotter J., and Kyewski B. Regulating self-tolerance by deregulating gene expression Curr. Opin. Immunol. 16 2004 741 745
78. Grakoui A., Bromley S.K., Sumen C., Davis M.M., Shaw A.S., Allen P.M., and Dustin M.L. The immunological synapse: a molecular machine controlling T-cell activation Science 285 1999 221 227
79. Granucci F., Feau S., Angeli V., Trottein F., and Ricciardi-Castagnoli P. Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming J. Immunol. 170 2003 5075 5081
80. Granucci F., Petralia F., Urbano M., Citterio S., Di Tota F., Santambrogio L., and Ricciardi-Castagnoli P. The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia Blood 102 2003 2940 2947
81. Granucci F., Vizzardelli C., Pavelka N., Feau S., Persico M., Virzi E., Rescigno M., Moro G., and Ricciardi-Castagnoli P. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis Nat. Immunol. 2 2001 882 888
82. Granucci F., Vizzardelli C., Virzi E., Rescigno M., and Ricciardi-Castagnoli P. Transcriptional reprogramming of dendritic cells by differentiation stimuli Eur. J. Immunol. 31 2001 2539 2546
83. Granucci F., Zanoni I., Pavelka N., Van Dommelen S.L., Andoniou C.E., Belardelli F., Degli Esposti M.A., and Ricciardi-Castagnoli P. A contribution of mouse dendritic cell-derived IL-2 for NK cell activation J. Exp. Med. 200 2004 287 295
84. Gredmark S., and Soderberg-Naucler C. Human cytomegalovirus inhibits differentiation of monocytes into dendritic cells with the consequence of depressed immunological functions J. Virol. 77 2003 10943 10956
85. Guermonprez P., Saveanu L., Kleijmeer M., Davoust J., Van Endert P., and Amigorena S. ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells Nature 425 2003 397 402
86. Guerreiro-Cacais A.O., Li L., Donati D., Bejarano M.T., Morgan A., Masucci M.G., Hutt-Fletcher L., and Levitsky V. Capacity of Epstein-Barr virus to infect monocytes and inhibit their development into dendritic cells is affected by the cell type supporting virus replication J. Gen. Virol. 85 2004 2767 2778
87. Guiducci C., Valzasina B., Dislich H., and Colombo M.P. CD40/CD40L interaction regulates CD4(+)CD25(+) T reg homeostasis through dendritic cell-produced IL-2 Eur. J. Immunol. 35 2005 557 567
88. Hahn G., Jores R., and Mocarski E.S. Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells Proc. Natl. Acad. Sc.i USA 95 1998 3937 3942
89. Halary F., Amara A., Lortat-Jacob H., Messerle M., Delaunay T., Houles C., Fieschi F., Arenzana-Seisdedos F., Moreau J.F., and Dechanet-Merville J. Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection Immunity 17 2002 653 664
90. Harte M.T., Haga I.R., Maloney G., Gray P., Reading P.C., Bartlett N.W., Smith G.L., Bowie A., and O'Neill L.A. The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense J. Exp. Med. 197 2003 343 351
91. Hawiger D., Inaba K., Dorsett Y., Guo M., Mahnke K., Rivera M., Ravetch J.V., Steinman R.M., and Nussenzweig M.C. Dendritic cells induce peripheral T-cell unresponsiveness under steady state conditions in vivo J. Exp. Med. 194 2001 769 779
92. Hawn T.R., Verbon A., Lettinga K.D., Zhao L.P., Li S.S., Laws R.J., Skerrett S.J., Beutler B., Schroeder L., Nachman A., Ozinsky A., Smith K.D., and Aderem A. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease J. Exp. Med. 198 2003 1563 1572
93. Heil F., Ahmad-Nejad P., Hemmi H., Hochrein H., Ampenberger F., Gellert T., Dietrich H., Lipford G., Takeda K., Akira S., Wagner H., and Bauer S. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily Eur. J. Immunol. 33 2003 2987 2997
94. Henderson R.A., Watkins S.C., and Flynn J.L. Activation of human dendritic cells following infection with Mycobacterium tuberculosis J. Immunol. 159 1997 635 643
95. Henri S., Vremec D., Kamath A., Waithman J., Williams S., Benoist C., Burnham K., Saeland S., Handman E., and Shortman K. The dendritic cell populations of mouse lymph nodes J. Immunol. 167 2001 741 748
96. Hernandez J., Aung S., Redmond W.L., and Sherman L.A. Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen J. Exp. Med. 194 2001 707 717
97. Hirschfeld M., Kirschning C.J., Schwandner R., Wesche H., Weis J.H., Wooten R.M., and Weis J.J. Cutting edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by Toll-like receptor 2 J. Immunol. 163 1999 2382 2386
98. Hosoi J., Murphy G.F., Egan C.L., Lerner E.A., Grabbe S., Asahina A., and Granstein R.D. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide Nature 363 1993 159 163
99. Huang Q., Liu D., Majewski P., Schulte L.C., Korn J.M., Young R.A., Lander E.S., and Hacohen N. The plasticity of dendritic cell responses to pathogens and their components Science 294 2001 870 875
100. Hugues S., Fetler L., Bonifaz L., Helft J., Amblard F., and Amigorena S. Distinct T-cell dynamics in lymph nodes during the induction of tolerance and immunity Nat. Immunol. 5 2004 1235 1242
101. Ibrahim M.A., Chain B.M., and Katz D.R. The injured cell: The role of the dendritic cell system as a sentinel receptor pathway Immunol. Today 16 1995 181 186
102. Inaba K., Inaba M., Naito M., and Steinman R.M. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo J. Exp. Med. 178 1993 479 488
103. Inohara N., and Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis Nat. Rev. Immunol. 3 2003 371 382
104. Janeway C.A. Jr. The immune system evolved to discriminate infectious nonself from noninfectious self Immunol. Today. 13 1992 11 16
105. Janeway C.A. Jr., and Medzhitov R. Innate immune recognition Annu. Rev. Immunol. 20 2002 197 216
106. Jones C. Herpes simplex virus type 1 and bovine herpesvirus 1 latency Clin. Microbiol. Rev. 16 2003 79 95
107. Jonuleit H., Schmitt E., Schuler G., Knop J., and Enk A.H. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells J. Exp. Med. 192 2000 1213 1222
108. Jung S., Unutmaz D., Wong P., Sano G., De los Santos K., Sparwasser T., Wu S., Vuthoori S., Ko K., Zavala F., Pamer E.G., Littman D.R., and Lang R.A. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens Immunity 17 2002 211 220
109. Kadowaki N., and Liu Y.J. Natural type I interferon-producing cells as a link between innate and adaptive immunity Hum. Immunol. 63 2002 1126 1132
110. Kahn R.A., Fu H., and Roy C.R. Cellular hijacking: a common strategy for microbial infection Trends Biochem. Sci. 27 2002 308 314
111. Kakimoto M., Hasegawa A., Fujita S., and Yasukawa M. Phenotypic and functional alterations of dendritic cells induced by human herpesvirus 6 infection J. Virol. 76 2002 10338 10345
112. Klagge I.M., ter Meulen V., and Schneider-Schaulies S. Measles virus-induced promotion of dendritic cell maturation by soluble mediators does not overcome the immunosuppressive activity of viral glycoproteins on the cell surface Eur. J. Immunol. 30 2000 2741 2750
113. Kleijmeer M., Ramm G., Schuurhuis D., Griffith J., Rescigno M., Ricciardi-Castagnoli P., Rudensky A.Y., Ossendorp F., Melief C.J., Stoorvogel W., and Geuze H.J. Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells J. Cell Biol. 155 2001 53 63
114. Krieg A.M. The role of CpG motifs in innate immunity Curr. Opin. Immunol. 12 2000 35 43
115. Kushnir N., Liu L., and Mac Pherson G.G. Dendritic cells and resting B cells form clusters in vitro and in vivo: T-cell independence, partial LFA-1 dependence, and regulation by cross-linking surface molecules J. Immunol. 160 1998 1774 1781
116. Kyewski B., and Derbinski J. Self-representation in the thymus: An extended view Nat. Rev. Immunol. 4 2004 688 698
117. Lafaille J.J., Nagashima K., Katsuki M., and Tonegawa S. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient antimyelin basic protein T-cell receptor transgenic mice Cell 78 1994 399 408
118. Latz E., Schoenemeyer A., Visintin A., Fitzgerald K.A., Monks B.G., Knetter C.F., Lien E., Nilsen N.J., Espevik T., and Golenbock D.T. TLR9 signals after translocating from the ER to CpG DNA in the lysosome Nat. Immunol. 5 2004 190 198
119. Laufer T.M., De Koning J., Markowitz J.S., Lo D., and Glimcher L.H. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex Nature 383 1996 81 85
120. Laufer T.M., Glimcher L.H., and Lo D. Using thymus anatomy to dissect T cell repertoire selection Semin. Immunol. 11 1999 65 70
121. Le Bon A., Schiavoni G., D'Agostino G., Gresser I., Belardelli F., and Tough D.F. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo Immunity 14 2001 461 470
122. Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., and Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults Cell 86 1996 973 983
123. Levings M.K., Gregori S., Tresoldi E., Cazzaniga S., Bonini C., and Roncarolo M.G. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells Blood 105 2005 1162 1169
124. Li L., Liu D., Hutt-Fletcher L., Morgan A., Masucci M.G., and Levitsky V. Epstein-Barr virus inhibits the development of dendritic cells by promoting apoptosis of their monocyte precursors in the presence of granulocyte macrophage-colony-stimulating factor and interleukin-4 Blood 99 2002 3725 3734
125. Lipford G.B., Heeg K., and Wagner H. Bacterial DNA as immune cell activator Trends Microbiol. 6 1998 496 500
126. Liston A., Lesage S., Wilson J., Peltonen L., and Goodnow C.C. Aire regulates negative selection of organ-specific T cells Nat. Immunol. 4 2003 350 354
127. Litinskiy M.B., Nardelli B., Hilbert D.M., He B., Schaffer A., Casali P., and Cerutti A. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL Nat. Immunol. 3 2002 822 829
128. Luft T., Pang K.C., Thomas E., Hertzog P., Hart D.N., Trapani J., and Cebon J. Type I IFNs enhance the terminal differentiation of dendritic cells J. Immunol. 161 1998 1947 1953
129. Lutz M.B., Rovere P., Kleijmeer M.J., Rescigno M., Assmann C.U., Oorschot V.M., Geuze H.J., Trucy J., Demandolx D., Davoust J., and Ricciardi-Castagnoli P. Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC class II-positive vesicles in immature dendritic cells J. Immunol. 159 1997 3707 3716
130. Lutz M.B., and Schuler G. Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity? Trends Immunol. 23 2002 445 449
131. Macatonia S.E., Hosken N.A., Litton M., Vieira P., Hsieh C.S., Culpepper J.A., Wysocka M., Trinchieri G., Murphy K.M., and O'Garra A. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells J. Immunol. 154 1995 5071 5079
132. Malek T.R., and Bayer A.L. Tolerance, not immunity, crucially depends on IL-2 Nat. Rev. Immunol. 4 2004 665 674
133. Marie J.C., Kehren J., Trescol-Biemont M.C., Evlashev A., Valentin H., Walzer T., Tedone R., Loveland B., Nicolas J.F., Rabourdin-Combe C., and Horvat B. Mechanism of measles virus-induced suppression of inflammatory immune responses Immunity 14 2001 69 79
134. Marrack P., Lo D., Brinster R., Palmiter R., Burkly L., Flavell R.H., and Kappler J. The effect of thymus environment on T-cell development and tolerance Cell 53 1988 627 634
135. Marrack P., Mitchell T., Hildeman D., Kedl R., Teague T.K., Bender J., Rees W., Schaefer B.C., and Kappler J. Genomic-scale analysis of gene expression in resting and activated T cells Curr. Opin. Immunol. 12 2000 206 209
136. Martin-Fontecha A., Thomsen L.L., Brett S., Gerard C., Lipp M., Lanzavecchia A., and Sallusto F. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming Nat. Immunol. 5 2004 1260 1265
137. Massari P., Henneke P., Ho Y., Latz E., Golenbock D.T., and Wetzler L.M. Cutting edge: Immune stimulation by neisserial porins is Toll-like receptor 2 and MyD88 dependent J. Immunol. 168 2002 1533 1537
138. Matsukawa A., Lukacs N.W., Standiford T.J., Chensue S.W., and Kunkel S.L. Adenoviral-mediated overexpression of monocyte chemoattractant protein-1 differentially alters the development of Th1 and Th2 type responses in vivo J. Immunol. 164 2000 1699 1704
139. Matsumoto M., Funami K., Tanabe M., Oshiumi H., Shingai M., Seto Y., Yamamoto A., and Seya T. Subcellular localization of Toll-like receptor 3 in human dendritic cells J. Immunol. 171 2003 3154 3162
140. Matsuno K., Ezaki T., Kudo S., and Uehara Y. A life stage of particle-laden rat dendritic cells in vivo: Their terminal division, active phagocytosis, and translocation from the liver to the draining lymph J. Exp. Med. 183 1996 1865 1878
141. Matzinger P. Tolerance, danger, and the extended family Annu. Rev. Immunol. 12 1994 991 1045
142. Matzinger P. An innate sense of danger Ann. NY Acad. Sci. 961 2002 341 342
143. Mbow M.L., Zeidner N., Panella N., Titus R.G., and Piesman J. Borrelia burgdorferi-pulsed dendritic cells induce a protective immune response against tick-transmitted spirochetes Infect. Immun. 65 1997 3386 3390
144. McCaffrey R.L., Fawcett P., O' Riordan M., Lee K.D., Havell E.A., Brown P.O., and Portnoy D.A. A specific gene expression program triggered by Gram-positive bacteria in the cytosol Proc. Natl. Acad. Sci. USA 101 2004 11386 11391
145. Medzhitov R., and Janeway C.A. Jr. Innate immunity: The virtues of a nonclonal system of recognition Cell 91 1997 295 298
146. Medzhitov R., and Janeway C.A. Jr. How does the immune system distinguish self from nonself? Semin. Immunol. 12 2000 185 188, discussion 257-344.
147. Medzhitov R., Preston-Hurlburt P., and Janeway C.A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 1997 394 397
148. Mempel T.R., Henrickson S.E., and Von Andrian U.H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases Nature 427 2004 154 159
149. Menges M., Rossner S., Voigtlander C., Schindler H., Kukutsch N.A., Bogdan C., Erb K., Schuler G., and Lutz M.B. Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity J. Exp. Med. 195 2002 15 21
150. Mikloska Z., Kesson A.M., Penfold M.E., and Cunningham A.L. Herpes simplex virus protein targets for CD4 and CD8 lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with interferon-gamma J. Infect. Dis. 173 1996 7 17
151. Miller L.J., Bainton D.F., Borregaard N., and Springer T.A. Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface J. Clin. Invest. 80 1987 535 544
152. Milone M.C., and Fitzgerald-Bocarsly P. The mannose receptor mediates induction of IFN-alpha in peripheral blood dendritic cells by enveloped RNA and DNA viruses J. Immunol. 161 1998 2391 2399
153. Moretta A. Natural killer cells and dendritic cells: Rendezvous in abused tissues Nat. Rev. Immunol. 2 2002 957 964
154. Morrow G., Slobedman B., Cunningham A.L., and Abendroth A. Varicella-zoster virus productively infects mature dendritic cells and alters their immune function J. Virol. 77 2003 4950 4959
155. Moutaftsi M., Mehl A.M., Borysiewicz L.K., and Tabi Z. Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells Blood 99 2002 2913 2921
156. Mueller D.L., Jenkins M.K., and Schwartz R.H. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T-cell antigen receptor occupancy Annu. Rev. Immunol. 7 1989 445 480
157. Mueller S.N., Jones C.M., Smith C.M., Heath W.R., and Carbone F.R. Rapid
158. Muller D.B., Raftery M.J., Kather A., Giese T., and Schonrich G. Frontline: Induction of apoptosis and modulation of c-FLIPL and p53 in immature dendritic cells infected with herpes simplex virus Eur. J. Immunol. 34 2004 941 951
159. Murphy C.A., Langrish C.L., Chen Y., Blumenschein W., McClanahan T., Kastelein R.A., Sedgwick J.D., and Cua D.J. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J. Exp. Med. 198 2003 1951 1957
160. Murphy K.M., Heimberger A.B., and Loh D.Y. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo Science 250 1990 1720 1723
161. Mushegian A., and Medzhitov R. Evolutionary perspective on innate immune recognition J. Cell Biol. 155 2001 705 710
162. Nelson D.J., McMenamin C., McWilliam A.S., Brenan M., and Holt P.G. Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: Differential regulation of Ia expression at different levels of the respiratory tract J. Exp. Med. 179 1994 203 212
163. Nestle F.O., Zheng X.G., Thompson C.B., Turka L.A., and Nickoloff B.J. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets J. Immunol. 151 1993 6535 6545
164. Nigou J., Zelle-Rieser C., Gilleron M., Thurnher M., and Puzo G. Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: Evidence for a negative signal delivered through the mannose receptor J. Immunol. 166 2001 7477 7485
165. Nilsen N., Nonstad U., Khan N., Knetter C.F., Akira S., Sundan A., Espevik T., and Lien E. Lipopolysaccharide and double-stranded RNA upregulate Toll-like receptor 2 independently of myeloid differentiation factor 88 J. Biol. Chem. 279 2004 39727 39735
166. Oxenius A., Karrer U., Zinkernagel R.M., and Hengartner H. IL-12 is not required for induction of type 1 cytokine responses in viral infections J. Immunol. 162 1999 965 973
167. Parr M.B., Kepple L., and Parr E.L. Langerhans cells phagocytose vaginal epithelial cells undergoing apoptosis during the murine estrous cycle Biol. Reprod. 45 1991 252 260
168. Piccioli D., Sbrana S., Melandri E., and Valiante N.M. Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells J. Exp. Med. 195 2002 335 341
169. Pierre P., Turley S.J., Gatti E., Hull M., Meltzer J., Mirza A., Inaba K., Steinman R.M., and Mellman I. Developmental regulation of MHC class II transport in mouse dendritic cells Nature 388 1997 787 792
170. Plotnicky-Gilquin H., Cyblat D., Aubry J.P., Delneste Y., Blaecke A., Bonnefoy J.Y., Corvaia N., and Jeannin P. Differential effects of parainfluenza virus type 3 on human monocytes and dendritic cells Virology 285 2001 82 90
171. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
172. Probst H.C., Lagnel J., Kollias G., and van den Broek M. Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance Immunity 18 2003 713 720
173. Probst H.C., McCoy K., Okazaki T., Honjo T., and van den Broek M. Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4 Nat. Immunol. 6 2005 280 286
174. Probst H.C., and van den Broek M. Priming of CTLs by Lymphocytic Choriomeningitis Virus Depends on Dendritic Cells J. Immunol. 174 2005 3920 3924
175. Reading P.C., Miller J.L., and Anders E.M. Involvement of the mannose receptor in infection of macrophages by influenza virus J. Virol. 74 2000 5190 5197
176. Reinhart T.A. Chemokine induction by HIV-1: Recruitment to the cause Trends Immunol. 24 2003 351 353
177. Reis e Sousa C., Stahl P.D., and Austyn J.M. Phagocytosis of antigens by Langerhans cells in vitro J. Exp. Med. 178 1993 509 519
178. Rescigno M., Citterio S., Thery C., Rittig M., Medaglini D., Pozzi G., Amigorena S., and Ricciardi-Castagnoli P. Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells Proc. Natl. Acad. Sci. USA 95 1998 5229 5234
179. Rescigno M., Urbano M., Rimoldi M., Valzasina B., Rotta G., Granucci F., and Ricciardi-Castagnoli P. Toll-like receptor 4 is not required for the full maturation of dendritic cells or for the degradation of Gram-negative bacteria Eur. J. Immunol. 32 2002 2800 2806
180. Rescigno M., Urbano M., Valzasina B., Francolini M., Rotta G., Bonasio R., Granucci F., Kraehenbuhl J.P., and Ricciardi-Castagnoli P. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria Nat. Immunol. 2 2001 361 367
181. Robbins P.A., and McMichael A.J. Immune recognition of HLA molecules downmodulates CD8 expression on cytotoxic T lymphocytes J. Exp. Med. 173 1991 221 230
182. Rodriguez A., Regnault A., Kleijmeer M., Ricciardi-Castagnoli P., and Amigorena S. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells Nat. Cell Biol. 1 1999 362 368
183. Roncarolo M.G., Gregori S., and Levings M. Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells Novartis Found. Symp. 252 2003 115 127 discussion 127-131, 203-210.
184. Roncarolo M.G., and Levings M.K. The role of different subsets of T regulatory cells in controlling autoimmunity Curr. Opin. Immunol. 12 2000 676 683
185. Rong Q., Alexander T.S., Koski G.K., and Rosenthal K.S. Multiple mechanisms for HSV-1 induction of interferon alpha production by peripheral blood mononuclear cells Arch. Virol. 148 2003 329 344
186. Sakaguchi S. Regulatory T cells: Key controllers of immunologic self-tolerance Cell 101 2000 455 458
187. Salio M., Cella M., Suter M., and Lanzavecchia A. Inhibition of dendritic cell maturation by herpes simplex virus Eur. J. Immunol. 29 1999 3245 3253
188. Sallusto F., and Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha J. Exp. Med. 179 1994 1109 1118
189. Schnare M., Barton G.M., Holt A.C., Takeda K., Akira S., and Medzhitov R. Toll-like receptors control activation of adaptive immune responses Nat. Immunol. 2 2001 947 950
190. Schonrich G., Kalinke U., Momburg F., Malissen M., Schmitt-Verhulst A.M., Malissen B., Hammerling G.J., and Arnold B. Downregulation of T-cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction Cell 65 1991 293 304
191. Schwartz R.H. T cell anergy Annu. Rev. Immunol. 21 2003 305 334
192. Sertl K., Takemura T., Tschachler E., Ferrans V.J., Kaliner M.A., and Shevach E.M. Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura J. Exp. Med. 163 1986 436 451
193. Sevilla N., Kunz S., McGavern D., and Oldstone M.B. Infection of dendritic cells by lymphocytic choriomeningitis virus Curr. Top. Microbiol. Immunol. 276 2003 125 144
194. Shortman K., and Liu Y.J. Mouse and human dendritic cell subtypes Nat. Rev. Immunol. 2 2002 151 161
195. Sing A., Rost D., Tvardovskaia N., Roggenkamp A., Wiedemann A., Kirschning C.J., Aepfelbacher M., and Heesemann J. Yersinia V-antigen exploits Toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression J. Exp. Med. 196 2002 1017 1024
196. Smyth M.J., Hayakawa Y., Takeda K., and Yagita H. New aspects of natural-killer-cell surveillance and therapy of cancer Nat. Rev. Cancer 2 2002 850 861
197. Sporri R., and Reis e Sousa C. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function Nat. Immunol. 6 2005 163 170
198. Steinman R.M. The dendritic cell system and its role in immunogenicity Annu. Rev. Immunol. 9 1991 271 296
199. Steinman R.M. DC-SIGN: A guide to some mysteries of dendritic cells Cell 100 2000 491 494
200. Steinman R.M. Dendritic cells and the control of immunity: Enhancing the efficiency of antigen presentation Mt Sinai J. Med. 68 2001 106 166
201. Steinman R.M., Hawiger D., and Nussenzweig M.C. Tolerogenic dendritic cells Annu. Rev. Immunol. 21 2003 685 711
202. Stockinger B. T lymphocyte tolerance: From thymic deletion to peripheral control mechanisms Adv. Immunol. 71 1999 229 265
203. Su H., Messer R., Whitmire W., Fischer E., Portis J.C., and Caldwell H.D. Vaccination against chlamydial genital tract infection after immunization with dendritic cells pulsed ex vivo with nonviable Chlamydiae J. Exp. Med. 188 1998 809 818
204. Sumen C., Mempel T.R., Mazo I.B., and von Andrian U.H. Intravital microscopy: Visualizing immunity in context Immunity 21 2004 315 329
205. Surh C.D., and Sprent J. T-cell apoptosis detected in situ during positive and negative selection in the thymus Nature 372 1994 100 103
206. Svensson M., Stockinger B., and Wick M.J. Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells J. Immunol. 158 1997 4229 4236
207. Takeda K., and Akira S. TLR signaling pathways Semin. Immunol. 16 2004 3 9
208. Takeda K., Kaisho T., and Akira S. Toll-like receptors Annu. Rev. Immunol. 21 2003 335 376
209. Takeuchi O., Hoshino K., and Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection J. Immunol. 165 2000 5392 5396
210. Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K., and Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components Immunity 11 1999 443 451
211. Tal G., Mandelberg A., Dalal I., Cesar K., Somekh E., Tal A., Oron A., Itskovich S., Ballin A., Houri S., Beigelman A., Lider O., Rechavi G., and Amariglio N. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease J. Infect. Dis. 189 2004 2057 2063
212. Tang Z., and Saltzman A. Understanding human dendritic cell biology through gene profiling Inflamm. Res. 53 2004 424 441
213. Taniguchi T., and Takaoka A. The interferon-alpha/beta system in antiviral responses: A multimodal machinery of gene regulation by the IRF family of transcription factors Curr. Opin. Immunol. 14 2002 111 116
214. Tarbell K.V., Yamazaki S., Olson K., Toy P., and Steinman R.M. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes J. Exp. Med. 199 2004 1467 1477
215. Terme M., Tomasello E., Maruyama K., Crepineau F., Chaput N., Flament C., Marolleau J.P., Angevin E., Wagner E.F., Salomon B., Lemonnier F.A., Wakasugi H., Colonna M., Vivier E., and Zitvogel L. IL-4 confers NK stimulatory capacity to murine dendritic cells: A signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules J. Immunol. 172 2004 5957 5966
216. Thurnher M., Ramoner R., Gastl G., Radmayr C., Bock G., Herold M., Klocker H., and Bartsch G. Bacillus Calmette-Guerin mycobacteria stimulate human blood dendritic cells Int. J. Cancer 70 1997 128 134
217. Trinchieri G., Pflanz S., and Kastelein R.A. The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses Immunity 19 2003 641 644
218. Trottein F., Pavelka N., Vizzardelli C., Angeli V., Zouain C.S., Pelizzola M., Capozzoli M., Urbano M., Capron M., Belardelli F., Granucci F., and Ricciardi-Castagnoli P. A type I IFN-dependent pathway induced by Schistosoma mansoni eggs in mouse myeloid dendritic cells generates an inflammatory signature J. Immunol. 172 2004 3011 3017
219. Tsuji S., Matsumoto M., Takeuchi O., Akira S., Azuma I., Hayashi A., Toyoshima K., and Seya T. Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: Involvement of Toll-like receptors Infect. Immun. 68 2000 6883 6890
220. Underhill D.M., Ozinsky A., Hajjar A.M., Stevens A., Wilson C.B., Bassetti M., and Aderem A. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens Nature 401 1999 811 815
221. Van Den Broeke L.T., Daschbach E., Thomas E.K., Andringa G., and Berzofsky J.A. Dendritic Cell-Induced Activation of Adaptive and Innate Antitumor Immunity J. Immunol. 171 2003 5842 5852
222. van Kooyk Y., and Geijtenbeek T.B. DC-SIGN: escape mechanism for pathogens Nat. Rev. Immunol. 3 2003 697 709
223. van Lint A., Ayers M., Brooks A.G., Coles R.M., Heath W.R., and Carbone F.R. Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation J. Immunol. 172 2004 392 397
224. Vidalain P.O., Azocar O., Lamouille B., Astier A., Rabourdin-Combe C., and Servet-Delprat C. Measles virus induces functional TRAIL production by human dendritic cells J. Virol. 74 2000 556 559
225. Visintin A., Mazzoni A., Spitzer J.H., Wyllie D.H., Dower S.K., and Segal D.M. Regulation of Toll-like receptors in human monocytes and dendritic cells J. Immunol. 166 2001 249 255
226. Volkmann A., Zal T., and Stockinger B. Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen J. Immunol. 158 1997 693 706
227. Weninger W., and von Andrian U.H. Chemokine regulation of naive T-cell traffic in health and disease Semin. Immunol. 15 2003 257 270
228. Wilflingseder D., Banki Z., Dierich M.P., and Stoiber H. Mechanisms promoting dendritic cell-mediated transmission of HIV Mol. Immunol. 42 2005 229 237
229. Winzler C., Rovere P., Rescigno M., Granucci F., Penna G., Adorini L., Zimmermann V.S., Davoust J., and Ricciardi-Castagnoli P. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures J. Exp. Med. 185 1997 317 328
230. Woolhouse M.E., Webster J.P., Domingo E., Charlesworth B., and Levin B.R. Biological and biomedical implications of the co-evolution of pathogens and their hosts Nat. Genet. 32 2002 569 577
231. Wooten R.M., Ma Y., Yoder R.A., Brown J.P., Weis J.H., Zachary J.F., Kirschning C.J., and Weis J.J. Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi J. Immunol. 168 2002 348 355
232. Wu M.T., and Hwang S.T. CXCR5-transduced bone marrow-derived dendritic cells traffic to B cell zones of lymph nodes and modify antigen-specific immune responses J. Immunol. 168 2002 5096 5102
233. Wykes M., Pombo A., Jenkins C., and Mac Pherson G.G. Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response J. Immunol. 161 1998 1313 1319
234. Yamazaki S., Iyoda T., Tarbell K., Olson K., Velinzon K., Inaba K., and Steinman R.M. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells J. Exp. Med. 198 2003 235 247
235. Yoshimura A., Lien E., Ingalls R.R., Tuomanen E., Dziarski R., and Golenbock D. Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2 J. Immunol. 163 1999 1 5
236. Zal T., Volkmann A., and Stockinger B. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen J. Exp. Med. 180 1994 2089 2099
237. Zanoni I., Foti M., Ricciardi-Castagnoli P., and Granucci F. TLR-dependent activation stimuli associated with Th1 responses confer NK-cell stimulatory capacity to mouse dendritic cells J. Immunol. 175 2005 286 292
238. Zhang G.X., Gran B., Yu S., Li J., Siglienti I., Chen X., Kamoun M., and Rostami A. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system J. Immunol. 170 2003 2153 2160
239. Zitvogel L. Dendritic and natural killer cells cooperate in the control/switch of innate immunity J. Exp. Med. 195 2002 F9 F14