Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance

Journal of Experimental Medicine

Volumn 196, Issue 12, 2002, Pages 1627-1638

  Bonifaz, Laura ^a   Bonnyay, David ^a   Mahnke, Karsten ^a   Rivera, Miguel ^a   Nussenzweig, Michel C ^a,b   Steinman, Ralph M ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

CD8 T cell; DEC 205 receptor; Dendritic cells; MHC class I; Tolerance

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; CELL RECEPTOR; FREUND ADJUVANT; GAMMA INTERFERON; GLYCOPROTEIN P 15095; HLA ANTIGEN CLASS 1; INTERLEUKIN 2; MONOCLONAL ANTIBODY; OVALBUMIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGENICITY; ARTICLE; CELL DIVISION; CELL MATURATION; CELL MIGRATION; CELLULAR IMMUNITY; CONJUGATION; CONTROLLED STUDY; CYTOLYSIS; DENDRITIC CELL; ENDOSOME; FEMALE; GENE DELETION; INJECTION; INJECTION SITE; LUNG; LYMPH NODE; LYMPHATIC DRAINAGE; LYMPHOID TISSUE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEIN TRANSPORT; PROVOCATION TEST; SOLUBILITY; STEADY STATE; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; ANTIGENS; ANTIGENS, CD; ANTIGENS, CD11C; ANTIGENS, CD40; CARRIER PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNE TOLERANCE; LECTINS, C-TYPE; LYMPH NODES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN; RECEPTORS, CELL SURFACE;

EID: 0037122011     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021598     Document Type: Article

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