메뉴 건너뛰기




Volumn 71, Issue , 1998, Pages 229-265

T lymphocyte tolerance: From thymic deletion to peripheral control mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; T LYMPHOCYTE RECEPTOR;

EID: 0033491636     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review
Times cited : (134)

References (255)
  • 2
    • 0023108381 scopus 로고
    • Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells
    • Adams, T. E., Alpert, S., and Hanahan, D. (1987). Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature 325, 223-228.
    • (1987) Nature , vol.325 , pp. 223-228
    • Adams, T.E.1    Alpert, S.2    Hanahan, D.3
  • 3
    • 0030852519 scopus 로고    scopus 로고
    • A range of CD4 T cell tolerance: Partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis
    • Akkaraju, S., Ho, W. Y., Leong, D., Canaan, K., Davis, M. M., and Goodnow, C. C. (1997). A range of CD4 T cell tolerance: Partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity 7, 255-271.
    • (1997) Immunity , vol.7 , pp. 255-271
    • Akkaraju, S.1    Ho, W.Y.2    Leong, D.3    Canaan, K.4    Davis, M.M.5    Goodnow, C.C.6
  • 5
    • 0028859281 scopus 로고
    • Selective requirement for MAP kinase activation in thymocyte differentiation
    • Alberola, Ila, J., Forbush, K. A., Seger, R., Krebs, E. C., and Perlmutter, R. M. (1995). Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 335, 620-623.
    • (1995) Nature , vol.335 , pp. 620-623
    • Alberola, I.J.1    Forbush, K.A.2    Seger, R.3    Krebs, E.G.4    Perlmutter, R.M.5
  • 6
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
    • Albert, M. L., Sauter, B., and Bhardwaj, N. (1998). Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs Nature 392, 86-89.
    • (1998) Nature , vol.392 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 7
    • 0028921624 scopus 로고
    • Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance
    • Alferink, J., Schittek, B., Schonrich, G., Hammerling, G. J., and Arnold, B. (1995). Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance. Int. Immunol 7, 331-336.
    • (1995) Int. Immunol , vol.7 , pp. 331-336
    • Alferink, J.1    Schittek, B.2    Schönrich, G.3    Hämmerling, G.J.4    Arnold, B.5
  • 10
    • 0030472261 scopus 로고    scopus 로고
    • CD28-B7 interactions function to costimulate clonal deletion of double-positive thymocytes
    • Amsen, D., and Kruisbeek, A. M. (1996). CD28-B7 interactions function to costimulate clonal deletion of double-positive thymocytes. Int. Immunol. 8, 1927-1936.
    • (1996) Int. Immunol. , vol.8 , pp. 1927-1936
    • Amsen, D.1    Kruisbeek, A.M.2
  • 11
    • 84966146209 scopus 로고
    • The use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle
    • Anderson, D., Billingham, R. E., Lampkin, G. H., and Medawar, P. B. (1951). The use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle. Heredity 5, 379-397.
    • (1951) Heredity , vol.5 , pp. 379-397
    • Anderson, D.1    Billingham, R.E.2    Lampkin, G.H.3    Medawar, P.B.4
  • 12
    • 0029005494 scopus 로고
    • Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein
    • Antonia, S. J., Geiger, T., Miller, J., and Flavell, R. A. (1995). Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein. Int. Immunol. 7, 715-725.
    • (1995) Int. Immunol. , vol.7 , pp. 715-725
    • Antonia, S.J.1    Geiger, T.2    Miller, J.3    Flavell, R.A.4
  • 13
    • 0013801630 scopus 로고
    • Selective and specific inhibition of 24 hour skin reactions in the Guinea-pig. Immune deviation: Description of the phenomenon and the effect of splenectomy
    • Asherson, G. L., and Stone, S. H. (1965). Selective and specific inhibition of 24 hour skin reactions in the guinea-pig. Immune deviation: Description of the phenomenon and the effect of splenectomy. Immunology 9, 205-217.
    • (1965) Immunology , vol.9 , pp. 205-217
    • Asherson, G.L.1    Stone, S.H.2
  • 16
    • 0030844378 scopus 로고    scopus 로고
    • Differentiation of CD4(high) CD8(low) coreeeptor-skewed thymocytes into mature CDS single-positive cells independent of MHC class I recognition
    • Barthlott, T., Kohler, H., Pircher, H., and Eichmann, K. (1997). Differentiation of CD4(high) CD8(low) coreeeptor-skewed thymocytes into mature CDS single-positive cells independent of MHC class I recognition. Eur. J. Immunol. 27, 2024-2032.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2024-2032
    • Barthlott, T.1    Kohler, H.2    Pircher, H.3    Eichmann, K.4
  • 17
    • 0024428184 scopus 로고
    • Antigen/MHC specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
    • Berg, L. J., Pullen, A. M, Fazekas de St. Groth, B., Matins, D., Benoist, C., and Davis, M. M. (1989). Antigen/MHC specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58, 1035-1046.
    • (1989) Cell , vol.58 , pp. 1035-1046
    • Berg, L.J.1    Pullen, A.M.2    Fazekas de St Groth, B.3    Matins, D.4    Benoist, C.5    Davis, M.M.6
  • 18
    • 0017688347 scopus 로고
    • In a radiation chimera host H-2 antigens determine the immune responsiveness of donor cytotoxic cells
    • Bevan, M. J. (1977). In a radiation chimera host H-2 antigens determine the immune responsiveness of donor cytotoxic cells. Nature 269, 417-418.
    • (1977) Nature , vol.269 , pp. 417-418
    • Bevan, M.J.1
  • 19
    • 0026687519 scopus 로고
    • Reversal of in vitro T cell clonal anergy by IL-2 stimulation
    • Beverley, B., Kang, S. M., Lenardo, M. J., and Schwartz, R. H. (1992). Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 4, 661-671.
    • (1992) Int. Immunol. , vol.4 , pp. 661-671
    • Beverley, B.1    Kang, S.M.2    Lenardo, M.J.3    Schwartz, R.H.4
  • 20
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham, R. E., Brent, L., and Medawar, P. B. (1953). Actively acquired tolerance of foreign cells. Nature 172, 603-606.
    • (1953) Nature , vol.172 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 21
    • 0026688409 scopus 로고
    • Inefficient positive selection of T cells directed by hematopoietic cells
    • Bix, M., and Raulet, D. (1992). Inefficient positive selection of T cells directed by hematopoietic cells. Nature 359, 330-333.
    • (1992) Nature , vol.359 , pp. 330-333
    • Bix, M.1    Raulet, D.2
  • 22
    • 0029906983 scopus 로고    scopus 로고
    • + T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma
    • + T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma. Eur. J. Immunol. 26, 2671-2679.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2671-2679
    • Bogen, B.1
  • 23
    • 0027458694 scopus 로고
    • Clonal deletion of specific thymocytes by an immunoglobulin idiotype
    • Bogen, B., Dembic, Z., and Weiss, S. (1993). Clonal deletion of specific thymocytes by an immunoglobulin idiotype. EMBO J. 12, 357-363.
    • (1993) EMBO J , vol.12 , pp. 357-363
    • Bogen, B.1    Dembic, Z.2    Weiss, S.3
  • 24
    • 0025923302 scopus 로고
    • Transgenic mice with ectopic expression of alloantigenic MHC molecules: Why are they so different and of how much help are they?
    • Bölnne, J., and Pilstrom, B. (1991). Transgenic mice with ectopic expression of alloantigenic MHC molecules: Why are they so different and of how much help are they? Immunol. Rev. 122, 21-32.
    • (1991) Immunol. Rev. , vol.122 , pp. 21-32
    • Bölnne, J.1    Pilström, B.2
  • 25
    • 0027450835 scopus 로고
    • Thymus epithelium induces tissue-specific tolerance
    • Bonomo, A., and Matzinger, P. (1993). Thymus epithelium induces tissue-specific tolerance. J. Exp. Med. 177, 1153-1164.
    • (1993) J. Exp. Med. , vol.177 , pp. 1153-1164
    • Bonomo, A.1    Matzinger, P.2
  • 28
    • 0028102855 scopus 로고
    • Blockade of the CD28 co-stimulatory pathway: A means to induce tolerance
    • Boussiotis, V. A., Gribben, J. G., Freeman, G. J., and Nadler, L. M. (1994b). Blockade of the CD28 co-stimulatory pathway: A means to induce tolerance. Curr. Opin. Immunol. 6, 797-807.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 797-807
    • Boussiotis, V.A.1    Gribben, J.G.2    Freeman, G.J.3    Nadler, L.M.4
  • 29
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively
    • Bretscher, P., and Colin, M. (1970). A theory of self-nonself discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science 169, 1042-1049.
    • (1970) Science , vol.169 , pp. 1042-1049
    • Bretscher, P.1    Colin, M.2
  • 30
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • Brocker, T., Riedinger, M., and Karjalaine, K. (1997). Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 185, 541-550.
    • (1997) J. Exp. Med. , vol.185 , pp. 541-550
    • Brocker, T.1    Riedinger, M.2    Karjalaine, K.3
  • 31
    • 0023161452 scopus 로고
    • Distinction of virgin and memory T lymphocytes: Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation
    • Budd, R. C., Cerottini, J.-C, Horvath, C., Bron, C., Pedrazzini, T., Howe, R. C., and MacDonald, R. H. (1987). Distinction of virgin and memory T lymphocytes: Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation. J. Immunol. 138, 3120-3129.
    • (1987) J. Immunol. , vol.138 , pp. 3120-3129
    • Budd, R.C.1    Cerottini, J.-C.2    Horvath, C.3    Bron, C.4    Pedrazzini, T.5    Howe, R.C.6    MacDonald, R.H.7
  • 32
    • 0031964338 scopus 로고    scopus 로고
    • Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo
    • Buer, J., Lanoue, A., Franzke, A., Garcia, C., von Boehmer, H., and Sarukhan, A. (1998). Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J. Exp. Med. 187, 177-183.
    • (1998) J. Exp. Med. , vol.187 , pp. 177-183
    • Buer, J.1    Lanoue, A.2    Franzke, A.3    Garcia, C.4    von Boehmer, H.5    Sarukhan, A.6
  • 34
    • 0030001675 scopus 로고    scopus 로고
    • Lymphocyte homing and homeostasis
    • Butcher, E. C., and Picker, L. J. (1996). Lymphocyte homing and homeostasis. Science 272, 60-66.
    • (1996) Science , vol.272 , pp. 60-66
    • Butcher, E.G.1    Picker, L.J.2
  • 35
    • 0014252186 scopus 로고
    • The X-Y-Z scheme of immunocyte maturation. IV. The exhaustion of memory cells
    • Byers, V. S., and Sercarz, E. E. (1968). The X-Y-Z scheme of immunocyte maturation. IV. The exhaustion of memory cells. J. Exp. Med. 127, 307-325.
    • (1968) J. Exp. Med. , vol.127 , pp. 307-325
    • Byers, V.S.1    Sercarz, E.E.2
  • 36
    • 0028807837 scopus 로고
    • A role for the orphan steroid receptor Nur77 in apoptosi.s accompanying antigen-induced negative selection
    • Calnan, B. J., Szychowski, S., Chan, F. K., Cado, D., and Winoto, A. (1995). A role for the orphan steroid receptor Nur77 in apoptosi.s accompanying antigen-induced negative selection. Immunity 3, 273-282.
    • (1995) Immunity , vol.3 , pp. 273-282
    • Calnan, B.J.1    Szychowski, S.2    Chan, F.K.3    Cado, D.4    Winoto, A.5
  • 37
    • 0026574558 scopus 로고
    • Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions
    • Carlow, D. A., van, O. N., Teh, S. J., and Teh, II. S. (1992). Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions. J. Immunol. 148, 1595-1603.
    • (1992) J. Immunol. , vol.148 , pp. 1595-1603
    • Carlow, D.A.1    Van, O.N.2    Teh, S.J.3    Teh, I.I.S.4
  • 41
    • 0020062886 scopus 로고
    • Antigen presentation by normal B cells, B cell tumors and macrophages: Functional and biochemical comparison
    • Chesnut, R. W., Colon, S., and Crey, H. M. (1982). Antigen presentation by normal B cells, B cell tumors and macrophages: Functional and biochemical comparison. J. Immunol. 128, 1764-1768.
    • (1982) J. Immunol. , vol.128 , pp. 1764-1768
    • Chesnut, R.W.1    Colon, S.2    Crey, H.M.3
  • 42
    • 0015240716 scopus 로고
    • Kinetic differences in unresponsiveness of thymus and bone marrow cells
    • Chiller, J. M., Habicht, G. S., and Weigle, W. O. (1971). Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science 171, 813-815.
    • (1971) Science , vol.171 , pp. 813-815
    • Chiller, J.M.1    Habicht, G.S.2    Weigle, W.O.3
  • 43
    • 0015592448 scopus 로고
    • Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin)
    • Chiller, J. M., and Weigle, W. O. (1973). Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin). J. Exp. Med. 137, 740-750.
    • (1973) J. Exp. Med. , vol.137 , pp. 740-750
    • Chiller, J.M.1    Weigle, W.O.2
  • 44
    • 0017836055 scopus 로고
    • Immunological tolerance to lymphoytic choriomeningitis virus in neonatally infected virus carrier mice: Evidence supporting a clonal inactivation mechanism
    • Cihak, J., and Lehmann-Grube, F. (1978). Immunological tolerance to lymphoytic choriomeningitis virus in neonatally infected virus carrier mice: Evidence supporting a clonal inactivation mechanism. Immunology 34, 265-275.
    • (1978) Immunology , vol.34 , pp. 265-275
    • Cihak, J.1    Lehmann-Grube, F.2
  • 45
    • 0029659048 scopus 로고    scopus 로고
    • Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CDS
    • Cobbold, S. P., Adams, E., Marshall, S. E., Davies, J. D., and Waldmann, H. (1996). Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CDS. Immunol. Rev. 149, 5-33.
    • (1996) Immunol. Rev. , vol.149 , pp. 5-33
    • Cobbold, S.P.1    Adams, E.2    Marshall, S.E.3    Davies, J.D.4    Waldmann, H.5
  • 46
    • 0028127965 scopus 로고
    • Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells
    • Cooke, M. P., Heath, A. W., Shokat, K. M., Zeng, Y., Finkelman, F. D., Linsley, P. S., Howard, M., and Goodnow, C. C. (1994). Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J. Exp. Med. 179, 425-438.
    • (1994) J. Exp. Med. , vol.179 , pp. 425-438
    • Cooke, M.P.1    Heath, A.W.2    Shokat, K.M.3    Zeng, Y.4    Finkelman, F.D.5    Linsley, P.S.6    Howard, M.7    Goodnow, C.C.8
  • 48
    • 0028483671 scopus 로고
    • Fatal interactions: Fas-induced apoptosis of mature T cells
    • Crispe, I. N. (1994). Fatal interactions: Fas-induced apoptosis of mature T cells. Immunity 1, 347-349.
    • (1994) Immunity , vol.1 , pp. 347-349
    • Crispe, I.N.1
  • 50
    • 0031252579 scopus 로고    scopus 로고
    • Partial activation of naive CD4 T cells and tolerance induction in response to peptide presented by resting B cells
    • Croft, M., Joseph, S. B., and Miner, K. T. (1997). Partial activation of naive CD4 T cells and tolerance induction in response to peptide presented by resting B cells. J. Immunol. 159, 3257-3265.
    • (1997) J. Immunol. , vol.159 , pp. 3257-3265
    • Croft, M.1    Joseph, S.B.2    Miner, K.T.3
  • 51
    • 0028064578 scopus 로고
    • Competition for follicular niches excludes self-reactive B cells from the recirculating B-cell repertoire
    • Cyster, J. G., Hartley, S. B., and Goodnow, C. C. (1994). Competition for follicular niches excludes self-reactive B cells from the recirculating B-cell repertoire. Nature 371, 389-395.
    • (1994) Nature , vol.371 , pp. 389-395
    • Cyster, J.G.1    Hartley, S.B.2    Goodnow, C.C.3
  • 52
    • 0028582150 scopus 로고
    • On the various manifestations of spontaneous autoimmune diabetes in rodent models
    • Degermann, S., Reilly, C., Scott, B., Ogata, L., von Boehmer, H., and Lo, D. (1994). On the various manifestations of spontaneous autoimmune diabetes in rodent models. Eur. J. Immunol. 24, 3155-3160.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 3155-3160
    • Degermann, S.1    Reilly, C.2    Scott, B.3    Ogata, L.4    von Boehmer, H.5    Lo, D.6
  • 53
    • 0027232788 scopus 로고
    • + T cell clones and resting T cells: Specific inhibition of IL-2 production and proliferation
    • + T cell clones and resting T cells: Specific inhibition of IL-2 production and proliferation. J. Immunol. 150, 4754-4765.
    • (1993) J. Immunol. , vol.150 , pp. 4754-4765
    • de Waal Malefyt, R.1    Yssel, H.2    de Vries, J.E.3
  • 54
    • 0027239842 scopus 로고
    • IL-10 inhibits macrophage costimulatory activity by selectivity inhibiting the up-regulation of B7 expression
    • Ding, L., Linsley, P. S., Huang, L. Y., Germain, R. N., and Shevach, E. M. (1993). IL-10 inhibits macrophage costimulatory activity by selectivity inhibiting the up-regulation of B7 expression. J. Immunol. 151, 1224-1234.
    • (1993) J. Immunol. , vol.151 , pp. 1224-1234
    • Ding, L.1    Linsley, P.S.2    Huang, L.Y.3    Germain, R.N.4    Shevach, E.M.5
  • 55
    • 0342547306 scopus 로고    scopus 로고
    • The MHC class II-restricted T cell response of C57/B16 mice to human C-reactive protein: Homology to self and the selection of T cell epitopes and T cell receptors
    • Doffinger, R., Klein, T. C., Pepys, M. B., Casanova, J.-L., and Kyewski, B. A. (1997). The MHC class II-restricted T cell response of C57/B16 mice to human C-reactive protein: Homology to self and the selection of T cell epitopes and T cell receptors. Mol. Immunol. 34, 115-124.
    • (1997) Mol. Immunol. , vol.34 , pp. 115-124
    • Doffinger, R.1    Klein, T.C.2    Pepys, M.B.3    Casanova, J.-L.4    Kyewski, B.A.5
  • 56
    • 0021892860 scopus 로고
    • I-J as a restriction element in the suppressor T cell system
    • Dorf, M. E., and Benacerraf, B. (1985). I-J as a restriction element in the suppressor T cell system. Immunol. Rev. 83, 23-40.
    • (1985) Immunol. Rev. , vol.83 , pp. 23-40
    • Dorf, M.E.1    Benacerraf, B.2
  • 57
    • 0029790931 scopus 로고    scopus 로고
    • Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites
    • Douek, D. C, Corley, K. T. T., Zal, T., Mellor, A., Dyson, J., and Altmann, D. (1996). Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites. Int. Immunol. 8, 1413-1420.
    • (1996) Int. Immunol. , vol.8 , pp. 1413-1420
    • Douek, D.C.1    Corley, K.T.T.2    Zal, T.3    Mellor, A.4    Dyson, J.5    Altmann, D.6
  • 58
    • 36949064734 scopus 로고
    • Effectiveness of lipid and lipidophilic substances as adjuvants
    • Dresser, D. W. (1961). Effectiveness of lipid and lipidophilic substances as adjuvants. Nature 191, 1169-1171.
    • (1961) Nature , vol.191 , pp. 1169-1171
    • Dresser, D.W.1
  • 59
    • 0028947845 scopus 로고
    • + single-positive thymocytes requires the thymus to produce long-lived, functional T cells
    • + single-positive thymocytes requires the thymus to produce long-lived, functional T cells. J. Exp. Med. 181, 235-245.
    • (1995) J. Exp. Med. , vol.181 , pp. 235-245
    • Dyall, R.1    Nikolic Zugic, J.2
  • 61
    • 0026593440 scopus 로고
    • Small B cells as antigen presenting cells in the induction of tolerance to soluble protein antigen
    • Eynon, E. E., and Parker, D. C. (1992). Small B cells as antigen presenting cells in the induction of tolerance to soluble protein antigen. J. Exp. Med. 175, 131-138.
    • (1992) J. Exp. Med. , vol.175 , pp. 131-138
    • Eynon, E.E.1    Parker, D.C.2
  • 64
    • 0026904895 scopus 로고
    • + T lymphocytes in vivo: Importance for B lymphocyte and T lymphocyte activation
    • + T lymphocytes in vivo: Importance for B lymphocyte and T lymphocyte activation. Sem. Immunol. 4, 247-255.
    • (1992) Sem. Immunol. , vol.4 , pp. 247-255
    • Finkehnan, F.D.1    Lees, A.2    Morris, S.C.3
  • 66
    • 0029823232 scopus 로고    scopus 로고
    • Peripheral tolerance of CD4 T cells following local activation in adolescent mice
    • Förster, I., and Lieberman, I. (1996). Peripheral tolerance of CD4 T cells following local activation in adolescent mice. Eur. J. Immunol. 26, 3194-3202.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 3194-3202
    • Förster, I.1    Lieberman, I.2
  • 68
    • 0030589288 scopus 로고    scopus 로고
    • Thymic expression of myelin basic protein (MBP): Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP
    • Fritz, R. B., and Zhao, M. L. (1996). Thymic expression of myelin basic protein (MBP): Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP. J. Immunol. 157, 5249-5253.
    • (1996) J. Immunol. , vol.157 , pp. 5249-5253
    • Fritz, R.B.1    Zhao, M.L.2
  • 69
    • 0026451165 scopus 로고
    • B cells turn off virgin, but not memory T cells
    • Fuchs, E. J., and Matzinger, P. (1992). B cells turn off virgin, but not memory T cells. Science 258, 1156-1159.
    • (1992) Science , vol.258 , pp. 1156-1159
    • Fuchs, E.J.1    Matzinger, P.2
  • 70
    • 0028167459 scopus 로고
    • Anergy" of Th0 helper T lymphocytes induces downregulation of Th1 characteristics and a transition to a Th2-like phenotype
    • Gajewski, T. F., Lancki, D. W., Stack, R., and Fitch, F. W. (1994). "Anergy" of Th0 helper T lymphocytes induces downregulation of Th1 characteristics and a transition to a Th2-like phenotype. J. Exp. Med. 179, 481-491.
    • (1994) J. Exp. Med. , vol.179 , pp. 481-491
    • Gajewski, T.F.1    Lancki, D.W.2    Stack, R.3    Fitch, F.W.4
  • 71
    • 0025272416 scopus 로고
    • Strong T cell tolerance in parent-F1 bone marrow chimeras prepared with supralethal irradiation
    • Gao, E.-K., and Sprent, J. (1990). Strong T cell tolerance in parent-F1 bone marrow chimeras prepared with supralethal irradiation. J. Exp. Med. 171, 1101-1121.
    • (1990) J. Exp. Med. , vol.171 , pp. 1101-1121
    • Gao, E.-K.1    Sprent, J.2
  • 72
    • 0027499537 scopus 로고
    • Receptor editing: An approach by autoreactive B cells to escape tolerance
    • Gay, D., Saunders, T., Camper, S., and Weigert, M. (1993). Receptor editing: An approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177, 999-1008.
    • (1993) J. Exp. Med. , vol.177 , pp. 999-1008
    • Gay, D.1    Saunders, T.2    Camper, S.3    Weigert, M.4
  • 73
    • 0026594386 scopus 로고
    • T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice
    • Geiger, T., Gooding, L. R., and Flavell, R. A. (1992). T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice. Proc. Natl. Acad. Sci. USA 89, 2985-2989.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2985-2989
    • Geiger, T.1    Gooding, L.R.2    Flavell, R.A.3
  • 74
    • 0030846580 scopus 로고    scopus 로고
    • Double-positive T cell receptor (high) thymocytes are resistant to peptide/major histocompatibility complex ligand induced negative selection
    • Ghendler, Y., Hussey, R. E., Witte, T., Mizoguchi, E., Clayton, L. K., Bhan, A. K., Koyasu, S., Chang, H. C., and Reinherz, E. L. (1997). Double-positive T cell receptor (high) thymocytes are resistant to peptide/major histocompatibility complex ligand induced negative selection. Eur. J. Immunol. 27, 2279-2289.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2279-2289
    • Ghendler, Y.1    Hussey, R.E.2    Witte, T.3    Mizoguchi, E.4    Clayton, L.K.5    Bhan, A.K.6    Koyasu, S.7    Chang, H.C.8    Reinherz, E.L.9
  • 75
    • 0029659052 scopus 로고    scopus 로고
    • Organ-specific autoimmunity induced by lymphopenia
    • Gleeson, P. A., Toh, B.-H., and van Driel, I. R. (1996). Organ-specific autoimmunity induced by lymphopenia. Immunol. Rev. 149, 97-125.
    • (1996) Immunol. Rev. , vol.149 , pp. 97-125
    • Gleeson, P.A.1    Toh, B.-H.2    van Driel, I.R.3
  • 76
    • 0029097083 scopus 로고
    • Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice
    • Godfraind, C., Holmes, K. V., and Coutelier, J. P. (1995). Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice. J. Virol. 69, 6541-6547.
    • (1995) J. Virol. , vol.69 , pp. 6541-6547
    • Godfraind, C.1    Holmes, K.V.2    Coutelier, J.P.3
  • 78
    • 0027468174 scopus 로고
    • Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
    • Goverman, J., Woods, A., Larson, L., Weiner, L. P., Hood, L., and Zaller, D. M. (1993). Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72, 551-560.
    • (1993) Cell , vol.72 , pp. 551-560
    • Goverman, J.1    Woods, A.2    Larson, L.3    Weiner, L.P.4    Hood, L.5    Zaller, D.M.6
  • 79
    • 0030045373 scopus 로고    scopus 로고
    • Igspecific T cell receptor-transgenic T cells are not deleted in the thymus and are functional in vivo
    • Granueci, F., Rescigno, M., Marconi, G., Foti, M., and Ricciardi-Castagnoli, P. (1996). Igspecific T cell receptor-transgenic T cells are not deleted in the thymus and are functional in vivo. J. Exp. Med. 183, 203-213.
    • (1996) J. Exp. Med. , vol.183 , pp. 203-213
    • Granueci, F.1    Rescigno, M.2    Marconi, G.3    Foti, M.4    Ricciardi-Castagnoli, P.5
  • 82
    • 0030848546 scopus 로고    scopus 로고
    • Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
    • Grubin, C. E., Kovats, S., deRoos, P., and Rudensky, A. Y. (1997). Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7, 197-208.
    • (1997) Immunity , vol.7 , pp. 197-208
    • Grubin, C.E.1    Kovats, S.2    deRoos, P.3    Rudensky, A.Y.4
  • 83
    • 0026717868 scopus 로고
    • A tail-safe mechanism for maintaining self-tolerance
    • Guerder, S., and Matzinger, P. (1992). A tail-safe mechanism for maintaining self-tolerance. J. Exp. Med. 176, 553-564.
    • (1992) J. Exp. Med. , vol.176 , pp. 553-564
    • Guerder, S.1    Matzinger, P.2
  • 84
    • 0028428910 scopus 로고
    • The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen
    • Guerder, S., Meyerhoff, J., and Flavell, R. (1994). The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen. Immunity 1, 155-166.
    • (1994) Immunity , vol.1 , pp. 155-166
    • Guerder, S.1    Meyerhoff, J.2    Flavell, R.3
  • 85
    • 0025923305 scopus 로고
    • Non-deletional mechanisms of peripheral and central tolerance: Studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen
    • Hiimmerling, G. J., Schonrich, G., Momburg, F., Auphan, N., Malissen, M., Schmitt-Verhulst, A.-M., and Arnold, B. (1991). Non-deletional mechanisms of peripheral and central tolerance: Studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen. Immunol. Rev. 122, 47-68.
    • (1991) Immunol. Rev. , vol.122 , pp. 47-68
    • Hiimmerling, G.J.1    Schönrich, G.2    Momburg, F.3    Auphan, N.4    Malissen, M.5    Schmitt-Verhulst, A.-M.6    Arnold, B.7
  • 86
    • 0029658305 scopus 로고    scopus 로고
    • Requirement for p561ck tyrosine kinase activation in T cell receptor-mediated thymic selection
    • Hashimoto, K., Sohn, S. J., Levin, S. D., Tada, T., Perlmutter, R. M., and Nakayama, T. (1996). Requirement for p561ck tyrosine kinase activation in T cell receptor-mediated thymic selection. J. Exp. Med. 184, 931-941.
    • (1996) J. Exp. Med. , vol.184 , pp. 931-941
    • Hashimoto, K.1    Sohn, S.J.2    Levin, S.D.3    Tada, T.4    Perlmutter, R.M.5    Nakayama, T.6
  • 90
    • 0027716926 scopus 로고
    • T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model
    • Homer, R. J., Mamalaki, C., Kioussis, D., and Flavell, R. A. (1993). T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model. Int. Immunol. 5, 1495-1500.
    • (1993) Int. Immunol. , vol.5 , pp. 1495-1500
    • Homer, R.J.1    Mamalaki, C.2    Kioussis, D.3    Flavell, R.A.4
  • 91
    • 0028218815 scopus 로고
    • Thymic epithelial cell lines that mediate positive selection can also induce thymocyte clonal deletion
    • Hugo, P., Kappler, J. W., Godfrey, D. I., and Marrack, P. C. (1994). Thymic epithelial cell lines that mediate positive selection can also induce thymocyte clonal deletion. J. Immunol. 152, 1022-1031.
    • (1994) J. Immunol. , vol.152 , pp. 1022-1031
    • Hugo, P.1    Kappler, J.W.2    Godfrey, D.I.3    Marrack, P.C.4
  • 92
    • 0030134246 scopus 로고    scopus 로고
    • Danger: Pathogen on the premises! Immunological tolerance
    • Janeway, C. A., Jr., Goodnow, C. C., and Medzhitov, R. (1996). Danger: Pathogen on the premises! Immunological tolerance. Curr. Biol. 6, 519-522.
    • (1996) Curr. Biol. , vol.6 , pp. 519-522
    • Janeway, C.A.1    Goodnow, C.C.2    Medzhitov, R.3
  • 93
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins, M. K., and Schwartz, R. H. (1987). Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302-319.
    • (1987) J. Exp. Med. , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 94
    • 0028301977 scopus 로고
    • T cell tolerance toward a transgenic β cell antigen and transcription of endogenous pancreatic genes in the thymus
    • Jolicoeur, C., Hanahan, D., and Smith, K. M. (1994). T cell tolerance toward a transgenic β cell antigen and transcription of endogenous pancreatic genes in the thymus. Proc. Natl. Acad. Sci. USA 91, 6707-6711.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6707-6711
    • Jolicoeur, C.1    Hanahan, D.2    Smith, K.M.3
  • 95
    • 0025693909 scopus 로고
    • Peripheral clonal elimination of functional T cells
    • Jones, L. A., Chin, L. T., Longo, D. L., and Kruisbeek, A. M. (1990). Peripheral clonal elimination of functional T cells. Science 250, 1726-1729.
    • (1990) Science , vol.250 , pp. 1726-1729
    • Jones, L.A.1    Chin, L.T.2    Longo, D.L.3    Kruisbeek, A.M.4
  • 96
  • 98
    • 0026667860 scopus 로고
    • Transactivation by AP-1 is a molecular target of T cell clonal anergy
    • Kang, S. M., Beverly, B., Tran, A. C, Brorson, K., Schwartz, R. H., and Lenardo, M. J. (1992). Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science 257, 1134-1138.
    • (1992) Science , vol.257 , pp. 1134-1138
    • Kang, S.M.1    Beverly, B.2    Tran, A.C.3    Brorson, K.4    Schwartz, R.H.5    Lenardo, M.J.6
  • 99
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • Kappler, J. W., Roehm, N., and Marrack, P. C. (1987). T cell tolerance by clonal elimination in the thymus. Cell 49, 273-280.
    • (1987) Cell , vol.49 , pp. 273-280
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.C.3
  • 100
    • 0029030964 scopus 로고
    • T helper cell subsets in insulin dependent diabetes
    • Katz, J. D., Benoist, C., and Mathis, D. (1995). T helper cell subsets in insulin dependent diabetes. Science 268, 1185-1189.
    • (1995) Science , vol.268 , pp. 1185-1189
    • Katz, J.D.1    Benoist, C.2    Mathis, D.3
  • 101
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz, J. D., Wang, B., Haskins, K., Benoist, C., and Mathis, D. (1993). Following a diabetogenic T cell from genesis through pathogenesis. Cell 74, 1098-1100.
    • (1993) Cell , vol.74 , pp. 1098-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 102
    • 0026068601 scopus 로고
    • + T cells in mice tolerant to staphylococcus aureus enterotoxin B
    • + T cells in mice tolerant to staphylococcus aureus enterotoxin B. Nature 349, 245-248.
    • (1991) Nature , vol.349 , pp. 245-248
    • Kawabe, Y.1    Ochi, A.2
  • 104
    • 0028466130 scopus 로고
    • Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
    • Kearney, E. R., Pape, K. A., Loh, D. Y., and Jenkins, M. K. (1994). Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327-339.
    • (1994) Immunity , vol.1 , pp. 327-339
    • Kearney, E.R.1    Pape, K.A.2    Loh, D.Y.3    Jenkins, M.K.4
  • 105
    • 0028824265 scopus 로고
    • Virgin alpha beta and gamma delta T cells recirculate extensively through peripheral tissues and skin during normal development of the fetal immune system
    • Kimpton, W. G., Washington, E. A., and Cahill, R. N. (1995). Virgin alpha beta and gamma delta T cells recirculate extensively through peripheral tissues and skin during normal development of the fetal immune system. Int. Immunol. 7, 1567-1577.
    • (1995) Int. Immunol. , vol.7 , pp. 1567-1577
    • Kimpton, W.G.1    Washington, E.A.2    Cahill, R.N.3
  • 108
    • 0029831662 scopus 로고    scopus 로고
    • Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes
    • Kishimoto, H., Cai, Z., Brunmark, A., Jackson, M. R., Peterson, P. A., and Sprent, J. (1996). Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes. J. Exp. Med. 184, 531-537.
    • (1996) J. Exp. Med. , vol.184 , pp. 531-537
    • Kishimoto, H.1    Cai, Z.2    Brunmark, A.3    Jackson, M.R.4    Peterson, P.A.5    Sprent, J.6
  • 109
    • 0031054632 scopus 로고    scopus 로고
    • Negative selection in the thymus includes semimature T cells
    • Kishimoto, H., and Sprent, J. (1997). Negative selection in the thymus includes semimature T cells. J. Exp. Med. 185, 263-271.
    • (1997) J. Exp. Med. , vol.185 , pp. 263-271
    • Kishimoto, H.1    Sprent, J.2
  • 111
    • 0032490563 scopus 로고
    • CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by thymic epithelium
    • Klein, L., Klein, T., Riither, U., and Kyewski, B. (1988). CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by thymic epithelium. J. Exp. Med. 188, 5-16.
    • (1988) J. Exp. Med. , vol.188 , pp. 5-16
    • Klein, L.1    Klein, T.2    Riither, U.3    Kyewski, B.4
  • 112
    • 0342770172 scopus 로고
    • RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatiblity complex
    • Kronenberg, M., Steinmetz, M., and Kobori, J. (1983). RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatiblity complex. Proc. Nail. Acad. Sci. USA 80, 5704-5708.
    • (1983) Proc. Nail. Acad. Sci. USA , vol.80 , pp. 5704-5708
    • Kronenberg, M.1    Steinmetz, M.2    Kobori, J.3
  • 113
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • Krummel, M. F., and Allison, J. P. (1996). CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183, 2533-2540.
    • (1996) J. Exp. Med. , vol.183 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 114
    • 0028261549 scopus 로고
    • Regulation of the immune response within privileged sites
    • Ksander, B. R., and Streilein, J. W. (1994). Regulation of the immune response within privileged sites. Chem. Immunol. 58, 117-145.
    • (1994) Chem. Immunol. , vol.58 , pp. 117-145
    • Ksander, B.R.1    Streilein, J.W.2
  • 118
    • 0027183157 scopus 로고
    • T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides
    • Kyburz, D., Aichele, P., Speiser, D. E., Hengartner, H., Zinkernagel, R. M., and Pircher, H. (1993). T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides. Eur. J. Immunol. 23, 1956-1962.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1956-1962
    • Kyburz, D.1    Aichele, P.2    Speiser, D.E.3    Hengartner, H.4    Zinkernagel, R.M.5    Pircher, H.6
  • 119
    • 0028102655 scopus 로고
    • High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
    • Lafaille, J. J., Nagashima, K., Katsuki, M., and Tonegawa, S. (1994). High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78, 399-408.
    • (1994) Cell , vol.78 , pp. 399-408
    • Lafaille, J.J.1    Nagashima, K.2    Katsuki, M.3    Tonegawa, S.4
  • 120
    • 0020977018 scopus 로고
    • Immunobiology of tissue transplantation: A return to the passenger leukocyte concept
    • Lafferty, K. J., Prowse, S. J., and Simeonovic, C. J. (1983). Immunobiology of tissue transplantation: A return to the passenger leukocyte concept. Annu. Rev. Immunol. 1, 143-173.
    • (1983) Annu. Rev. Immunol. , vol.1 , pp. 143-173
    • Lafferty, K.J.1    Prowse, S.J.2    Simeonovic, C.J.3
  • 122
    • 0025240576 scopus 로고
    • Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes
    • Lanzavecchia, A. (1990). Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu. Rev. Immunol. 8, 773-793.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 773-793
    • Lanzavecchia, A.1
  • 123
    • 0023676055 scopus 로고
    • Can B cells turn on virgin T cells?
    • Lassila, O., Vainio, O., and Matzinger, P. (1988). Can B cells turn on virgin T cells? Nature 344, 253-255.
    • (1988) Nature , vol.344 , pp. 253-255
    • Lassila, O.1    Vainio, O.2    Matzinger, P.3
  • 124
    • 0029835390 scopus 로고    scopus 로고
    • Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
    • Laufer, T. M., DeKoning, J., Markowitz, J. S., Lo, D., and Glimcher, L. (1996). Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383, 81-85.
    • (1996) Nature , vol.383 , pp. 81-85
    • Laufer, T.M.1    DeKoning, J.2    Markowitz, J.S.3    Lo, D.4    Glimcher, L.5
  • 125
    • 0029659049 scopus 로고    scopus 로고
    • Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells
    • Le Douarin, N., Corbel, C., Bandeira, A., Thomas-Vaslin, V., Modigliani, Y., Coutinho, A., and Salaiin, J. (1996). Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells. Immunol. Rev. 149, 35-53.
    • (1996) Immunol. Rev. , vol.149 , pp. 35-53
    • Le Douarin, N.1    Corbel, C.2    Bandeira, A.3    Thomas-Vaslin, V.4    Modigliani, Y.5    Coutinho, A.6    Salaiin, J.7
  • 126
    • 0026607073 scopus 로고
    • CDS surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice
    • Lee, N. A., Loh, D. Y., and Lacy, E. (1992). CDS surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice. J. Exp. Med. 175, 1013-1025.
    • (1992) J. Exp. Med. , vol.175 , pp. 1013-1025
    • Lee, N.A.1    Loh, D.Y.2    Lacy, E.3
  • 128
    • 0029907408 scopus 로고    scopus 로고
    • Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death
    • Lerner, A., Clayton, L. K., Mizoguchi, E., Ghendler, Y., van Ewijk, W., Koyasu, S., Bhan, A. K., and Reinherz, E. L. (1996). Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death. EMBO J. 15, 5876-5887.
    • (1996) EMBO J , vol.15 , pp. 5876-5887
    • Lerner, A.1    Clayton, L.K.2    Mizoguchi, E.3    Ghendler, Y.4    van Ewijk, W.5    Koyasu, S.6    Bhan, A.K.7    Reinherz, E.L.8
  • 131
    • 0028824098 scopus 로고
    • Low avidity recognition of self-antigen by T cells permits escape from central tolerance
    • Liu, G. Y., Fairchild, P. J., Smith, R. M., Prowle, J. R., Kioussis, D., and Wraith, D. C. (1995). Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3, 407-415.
    • (1995) Immunity , vol.3 , pp. 407-415
    • Liu, G.Y.1    Fairchild, P.J.2    Smith, R.M.3    Prowle, J.R.4    Kioussis, D.5    Wraith, D.C.6
  • 132
    • 0025923307 scopus 로고
    • Peripheral tolerance in transgenic mice: Tolerance to class II MHC and non-MHC transgene antigens
    • Lo, D., Freedman, J., Hesse, S., Brinster, R. L., and Sherman, L. (1991). Peripheral tolerance in transgenic mice: Tolerance to class II MHC and non-MHC transgene antigens. Immunol. Rev. 122, 87-102.
    • (1991) Immunol. Rev. , vol.122 , pp. 87-102
    • Lo, D.1    Freedman, J.2    Hesse, S.3    Brinster, R.L.4    Sherman, L.5
  • 134
    • 0022597528 scopus 로고
    • Identity of cells that imprint H-2 restricted T-cell specificity in the thymus
    • Lo, D., and Sprent, J. (1986). Identity of cells that imprint H-2 restricted T-cell specificity in the thymus. Nature 319, 672-675.
    • (1986) Nature , vol.319 , pp. 672-675
    • Lo, D.1    Sprent, J.2
  • 135
    • 2642655282 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
    • Lühder, F., Hoglund, P., Allison, J. P., Benoist, C., and Mathis, D. (1998). Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187, 427-432.
    • (1998) J. Exp. Med. , vol.187 , pp. 427-432
    • Lühder, F.1    Hoglund, P.2    Allison, J.P.3    Benoist, C.4    Mathis, D.5
  • 136
    • 0027276423 scopus 로고
    • Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production
    • Macatonia, S. E., Doherty, T. M., Knight, S. C, and O'Garra, A. (1993). Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production. J. Immunol. 150, 3755-3765.
    • (1993) J. Immunol. , vol.150 , pp. 3755-3765
    • Macatonia, S.E.1    Doherty, T.M.2    Knight, S.C.3    O'Garra, A.4
  • 137
    • 0025767045 scopus 로고
    • + peripheral T cells responding to staphylococcal enterotoxin B in vivo
    • + peripheral T cells responding to staphylococcal enterotoxin B in vivo. Eur. J. Immunol. 21, 1963-1966.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1963-1966
    • MacDonald, H.R.1    Baschieri, S.2    Lees, R.K.3
  • 139
    • 0027299866 scopus 로고
    • Homing of naive, memory and effector lymphocytes
    • Mackay, C. R. (1993). Homing of naive, memory and effector lymphocytes. Curr. Opin. Immunol. 5, 423-427.
    • (1993) Curr. Opin. Immunol. , vol.5 , pp. 423-427
    • Mackay, C.R.1
  • 140
    • 0029878314 scopus 로고
    • Tolerance in TCR/cognate antigen double-transgenic mice mediated by incomplete thymic deletion and peripheral receptor downregulation
    • Mamalaki, C., Murdjeva, M., Tolaini, M., Norton, T., Chandler, P., Townsend, A., Simpson, E., and Kioussis, D. (1995). Tolerance in TCR/cognate antigen double-transgenic mice mediated by incomplete thymic deletion and peripheral receptor downregulation. Dev. Immunol. 4, 299-315.
    • (1995) Dev. Immunol. , vol.4 , pp. 299-315
    • Mamalaki, C.1    Murdjeva, M.2    Tolaini, M.3    Norton, T.4    Chandler, P.5    Townsend, A.6    Simpson, E.7    Kioussis, D.8
  • 141
    • 0026468228 scopus 로고
    • Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice
    • Mamalaki, C., Norton, T., Tanaka, Y., Townsend, A. R., Chandler, P., Simpson, E., and Kioussis, D. (1992). Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 89, 11342-11346.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11342-11346
    • Mamalaki, C.1    Norton, T.2    Tanaka, Y.3    Townsend, A.R.4    Chandler, P.5    Simpson, E.6    Kioussis, D.7
  • 147
    • 0030659110 scopus 로고    scopus 로고
    • Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection
    • Martin, S., and Bevan, M. J. (1997). Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection. Eur. J. Immunol. 27, 2726-2736.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2726-2736
    • Martin, S.1    Bevan, M.J.2
  • 148
    • 0027486298 scopus 로고
    • Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo
    • Mathisen, P. M., Pease, S., Garvey, J., Hood, L., and Readhead, C. (1993). Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo. Proc. Natl. Acad. Sci. USA 90, 10125-10129.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10125-10129
    • Mathisen, P.M.1    Pease, S.2    Garvey, J.3    Hood, L.4    Readhead, C.5
  • 149
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger, P. (1994). Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 150
    • 0030815504 scopus 로고    scopus 로고
    • Immunological tolerance to a pancreatic antigen as a result of local expression of TNFα by islet β cells
    • McSorley, S. J., S. Soldera, L. Malherbe, C. Carnaud, Locksley, R. M., R. A. Flavell, and N. Glaichenhaus (1997). Immunological tolerance to a pancreatic antigen as a result of local expression of TNFα by islet β cells. Immunity 7, 401-409.
    • (1997) Immunity , vol.7 , pp. 401-409
    • McSorley, S.J.1    Soldera, S.2    Malherbe, L.3    Carnaud, C.4    Locksley, R.M.5    Flavell, R.A.6    Glaichenhaus, N.7
  • 151
    • 0029744338 scopus 로고    scopus 로고
    • A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- Cells to colonize lymph nodes
    • Mebius, R. E., Streeter, P. R., Michie, S., Butcher, E. C, and Weissman, I. L. (1996). A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes. Proc. Natl. Acad. Sci. USA 93, 11019-11024.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11019-11024
    • Mebius, R.E.1    Streeter, P.R.2    Michie, S.3    Butcher, E.G.4    Weissman, I.L.5
  • 152
    • 0024477132 scopus 로고
    • T-cell tolerance in transgenic mice expressing major histocompatibility class I molecules in defined tissues
    • Miller, J. F., Morahan, G., Allison, J., Bhathal, P. S., and Cox, K. O. (1989). T-cell tolerance in transgenic mice expressing major histocompatibility class I molecules in defined tissues. Immunol. Rev. 107, 109-123.
    • (1989) Immunol. Rev. , vol.107 , pp. 109-123
    • Miller, J.F.1    Morahan, G.2    Allison, J.3    Bhathal, P.S.4    Cox, K.O.5
  • 153
    • 0002384347 scopus 로고
    • Induction of immunological paralysis in two zones of dosage
    • Mitchison, N. A. (1964). Induction of immunological paralysis in two zones of dosage. Proc. Roy. Soc. 161, 275-290.
    • (1964) Proc. Roy. Soc. , vol.161 , pp. 275-290
    • Mitchison, N.A.1
  • 154
    • 0027493158 scopus 로고
    • The role of macrophages in antigen presentation and T cell tolerance
    • Miyazaka, T., Suzuki, G., and Yamamura, K. (1993). The role of macrophages in antigen presentation and T cell tolerance. Int. Immunol. 5, 1023-1033.
    • (1993) Int. Immunol. , vol.5 , pp. 1023-1033
    • Miyazaka, T.1    Suzuki, G.2    Yamamura, K.3
  • 155
    • 0030073402 scopus 로고    scopus 로고
    • A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens
    • Modigliani, Y., Bandeira, A., and Coutinho, A. (1996). A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens. Immunol. Rev. 149, 155-220.
    • (1996) Immunol. Rev. , vol.149 , pp. 155-220
    • Modigliani, Y.1    Bandeira, A.2    Coutinho, A.3
  • 157
    • 0030239829 scopus 로고    scopus 로고
    • Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells
    • Mondino, A., Whaley, C. D., DeSilva, D. R., Li, W., Jenkins, M. K., and Mueller, D. L. (1996). Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells. J. Immunol. 157, 2048-2057.
    • (1996) J. Immunol. , vol.157 , pp. 2048-2057
    • Mondino, A.1    Whaley, C.D.2    DeSilva, D.R.3    Li, W.4    Jenkins, M.K.5    Mueller, D.L.6
  • 158
    • 0026334630 scopus 로고
    • A nondeletional mechanism of peripheral tolerance in T cell receptor transgenic mice
    • Morahan, G., Hoffmann, M. W., and Miller, J. F. (1991). A nondeletional mechanism of peripheral tolerance in T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 88, 11421-11425.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 11421-11425
    • Morahan, G.1    Hoffmann, M.W.2    Miller, J.F.3
  • 161
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatorv signaling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller, D. L., [enkins, M. K., and Shcwartz, R. H. (1989). Clonal expansion versus functional clonal inactivation: A costimulatorv signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7, 445-480.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 445-480
    • Mueller, D.L.1    Enkins, M.K.2    Shcwartz, R.H.3
  • 163
    • 0024835848 scopus 로고
    • Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: Evidence against a clonal deletion mechanism
    • Murphy, K. M., Weaver, C. T., Elish, M., Allen, P. M., and Loh, D. Y. (1989). Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: Evidence against a clonal deletion mechanism. Proc. Natl. Acad. Sci. USA 86, 10034-10038.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 10034-10038
    • Murphy, K.M.1    Weaver, C.T.2    Elish, M.3    Allen, P.M.4    Loh, D.Y.5
  • 165
    • 0025064213 scopus 로고
    • Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus
    • Nikolic Zugic, J., and Bevan, M. J. (1990). Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus. Int. Immunol. 2, 135-141.
    • (1990) Int. Immunol. , vol.2 , pp. 135-141
    • Nikolic Zugic, J.1    Bevan, M.J.2
  • 166
    • 0029894534 scopus 로고    scopus 로고
    • Antigen compartmentation and T helper cell tolerance induction
    • Oehen, S., Feng, L., Xia, Y., Surh, C. D., and Hedrick, S. M. (1996). Antigen compartmentation and T helper cell tolerance induction. J. Exp. Med. 183, 2617-2626.
    • (1996) J. Exp. Med. , vol.183 , pp. 2617-2626
    • Oehen, S.1    Feng, L.2    Xia, Y.3    Surh, C.D.4    Hedrick, S.M.5
  • 167
    • 0029584352 scopus 로고
    • Antigen-specific suppressor factor: Missing pieces in the puzzle
    • O'Hara, R. M. (1995). Antigen-specific suppressor factor: Missing pieces in the puzzle. Immunol. Res. 14, 252-262.
    • (1995) Immunol. Res. , vol.14 , pp. 252-262
    • O'Hara, R.M.1
  • 169
    • 0025370870 scopus 로고
    • T cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Ota, K., Matsui, M., Milford, E. L., Mackin, G. A., Weiner, H. L., and Hafler, D. A. (1990). T cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346, 183-187.
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1    Matsui, M.2    Milford, E.L.3    Mackin, G.A.4    Weiner, H.L.5    Hafler, D.A.6
  • 171
    • 0000658958 scopus 로고
    • Immunogenetic consequences of vascular anastomoses between bovine twins
    • Owen, R. D. (1945). Immunogenetic consequences of vascular anastomoses between bovine twins. Science 102, 400-401.
    • (1945) Science , vol.102 , pp. 400-401
    • Owen, R.D.1
  • 173
    • 0029939945 scopus 로고    scopus 로고
    • The role of costimulation and Fas in T cell apoptosis and peripheral tolerance
    • Parijs, L. V., Ibraghimov, A., and Abbas, A. K. (1996). The role of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4, 321-328.
    • (1996) Immunity , vol.4 , pp. 321-328
    • Parijs, L.V.1    Ibraghimov, A.2    Abbas, A.K.3
  • 174
    • 0031424315 scopus 로고    scopus 로고
    • Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification
    • Pelanda, R., Schwers, S., Sonoda, E., Torres, R. M., Nemazee, D., and Rajewsky, K. (1997). Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification. Immunity 7, 765-775.
    • (1997) Immunity , vol.7 , pp. 765-775
    • Pelanda, R.1    Schwers, S.2    Sonoda, E.3    Torres, R.M.4    Nemazee, D.5    Rajewsky, K.6
  • 175
    • 0030966217 scopus 로고    scopus 로고
    • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
    • Perez, V. L., Van Parijs, L., Biuckians, A., Zheng, X. X., Strom, T. B., and Abbas, A. K. (1997). Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417.
    • (1997) Immunity , vol.6 , pp. 411-417
    • Perez, V.L.1    van Parijs, L.2    Biuckians, A.3    Zheng, X.X.4    Strom, T.B.5    Abbas, A.K.6
  • 176
    • 0025155486 scopus 로고
    • Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors
    • Pette, M., Fujita, K., Wilkinson, D., Altmann, D. M., Trowsdale, J., Giegerich, G., Hinkkanen, A., Epplen, J. T., Kappos, L., and Wekerle, H. (1990). Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc. Natl. Acad. Sci. USA 87, 7968-7972.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7968-7972
    • Pette, M.1    Fujita, K.2    Wilkinson, D.3    Altmann, D.M.4    Trowsdale, J.5    Giegerich, G.6    Hinkkanen, A.7    Epplen, J.T.8    Kappos, L.9    Wekerle, H.10
  • 178
    • 0024307348 scopus 로고
    • Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    • Pircher, H., Bürki, K., Lang, R., Hengartner, H., and Zinkernagel, R. M. (1989). Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342, 559-561.
    • (1989) Nature , vol.342 , pp. 559-561
    • Pircher, H.1    Bürki, K.2    Lang, R.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 179
    • 0025761241 scopus 로고
    • Lower receptor avidity required for thymic clonal deletion than for effector T-cell function
    • Pircher, H., Roher, U. H., Moskiphidis, D., Zinkernagel, R. M., and Hengartner, H. (1991). Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature 351, 482-485.
    • (1991) Nature , vol.351 , pp. 482-485
    • Pircher, H.1    Roher, U.H.2    Moskiphidis, D.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 183
    • 0027957577 scopus 로고
    • + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
    • + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179, 709-713.
    • (1994) J. Exp. Med. , vol.179 , pp. 709-713
    • Punt, J.A.1    Osborne, B.A.2    Takahama, Y.3    Sharrow, S.O.4    Singer, A.5
  • 184
    • 0024539445 scopus 로고
    • Resistance to experimental autoimmune encephalomyelitis induced by neonatal tolerization to myelin basic-protein: Clonal elimination vs. Regulation of autoaggressive lymphocytes
    • Qin, Y., Sun, D., Goto, M., Meyermann, R., and Wekerle, H. (1989). Resistance to experimental autoimmune encephalomyelitis induced by neonatal tolerization to myelin basic-protein: Clonal elimination vs. regulation of autoaggressive lymphocytes. Eur. J. Immunol. 19, 373-380.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 373-380
    • Qin, Y.1    Sun, D.2    Goto, M.3    Meyermann, R.4    Wekerle, H.5
  • 186
    • 0024381358 scopus 로고
    • A nondeletional mechanism of thymic self tolerance
    • Ramsdell, F., Lantz, T., and Fowlkes, B. J. (1989). A nondeletional mechanism of thymic self tolerance. Science 246, 1038-1041.
    • (1989) Science , vol.246 , pp. 1038-1041
    • Ramsdell, F.1    Lantz, T.2    Fowlkes, B.J.3
  • 187
    • 0021257136 scopus 로고
    • Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens
    • Ready, A. R., Jenkinson, E. J., Kingston, R., and Owen, J. J. T. (1984). Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens. Nature 310, 231-233.
    • (1984) Nature , vol.310 , pp. 231-233
    • Ready, A.R.1    Jenkinson, E.J.2    Kingston, R.3    Owen, J.J.T.4
  • 188
    • 0028989154 scopus 로고
    • Proliferation is a prerequisite for bacterial superantigen-indueed T cell apoptosis in vivo
    • Renno, T., Hahne, M., and MacDonald, H. R. (1995). Proliferation is a prerequisite for bacterial superantigen-indueed T cell apoptosis in vivo. J. Exp. Med. 181, 2283-2287.
    • (1995) J. Exp. Med. , vol.181 , pp. 2283-2287
    • Renno, T.1    Hahne, M.2    MacDonald, H.R.3
  • 189
    • 0025320109 scopus 로고
    • Clonal deletion an clonal anergy in the thymus induced by cellular elements with different radiation sensitivities
    • Roberts, J. L., Sharrow, S. O., and Singer, A. (1990). Clonal deletion an clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. J. Exp. Med. 171, 935-940.
    • (1990) J. Exp. Med. , vol.171 , pp. 935-940
    • Roberts, J.L.1    Sharrow, S.O.2    Singer, A.3
  • 190
    • 0026633043 scopus 로고
    • The level of CD8 expression can determine the outcome of thymic selection
    • Robey, E. A., Ramsdell, F., Kioussis, D., Sha, W., Loh, D., Axel, R. A., and Fowlkes, B. J. (1991). The level of CD8 expression can determine the outcome of thymic selection. Cell 69, 1089-1096.
    • (1991) Cell , vol.69 , pp. 1089-1096
    • Robey, E.A.1    Ramsdell, F.2    Kioussis, D.3    Sha, W.4    Loh, D.5    Axel, R.A.6    Fowlkes, B.J.7
  • 191
    • 0028957496 scopus 로고
    • Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance
    • Rocha, B., Grandien, A., and Freitas, A. A. (1995). Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181, 993-1003.
    • (1995) J. Exp. Med. , vol.181 , pp. 993-1003
    • Rocha, B.1    Grandien, A.2    Freitas, A.A.3
  • 192
    • 0027532184 scopus 로고
    • Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen
    • Rocha, B., Tanchot, C., and von Boehmer, H. (1993). Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. Exp. Med. 177, 1517-1521.
    • (1993) J. Exp. Med. , vol.177 , pp. 1517-1521
    • Rocha, B.1    Tanchot, C.2    von Boehmer, H.3
  • 193
    • 0025908321 scopus 로고
    • Peripheral selection of the T cell repertoire
    • Rocha, B., and von Boehmer, H. (1991). Peripheral selection of the T cell repertoire. Science 251, 1225-1228.
    • (1991) Science , vol.251 , pp. 1225-1228
    • Rocha, B.1    von Boehmer, H.2
  • 194
    • 0029659057 scopus 로고    scopus 로고
    • Immune deviation: The third dimension of nondeletional T cell tolerance
    • Röcken, M., and Shevach, E. M. (1996). Immune deviation: The third dimension of nondeletional T cell tolerance. Immunol. Rev. 149, 175-194.
    • (1996) Immunol. Rev. , vol.149 , pp. 175-194
    • Röcken, M.1    Shevach, E.M.2
  • 195
    • 0026775464 scopus 로고
    • Infection breaks T-cell tolerance
    • Röcken, M., Urban, J. F., and Shevach, E. M. (1992). Infection breaks T-cell tolerance. Nature 359, 79-82.
    • (1992) Nature , vol.359 , pp. 79-82
    • Röcken, M.1    Urban, J.F.2    Shevach, E.M.3
  • 197
    • 0023223175 scopus 로고
    • T cell priming in vivo: A major role for B cells in presenting antigen to T cells in lymph nodes
    • Ron, Y., and Sprent, J. (1987). T cell priming in vivo: A major role for B cells in presenting antigen to T cells in lymph nodes. J. Immunol. 138, 2848-2856.
    • (1987) J. Immunol. , vol.138 , pp. 2848-2856
    • Ron, Y.1    Sprent, J.2
  • 198
    • 0027536244 scopus 로고
    • B lymphocytes in vivo fail to prime naive T cells in the induction of tolerance to soluble protein antigens
    • Ronchese, F., and Hausmann, B. (1993). B lymphocytes in vivo fail to prime naive T cells in the induction of tolerance to soluble protein antigens. J. Exp. Med. 177, 679-690.
    • (1993) J. Exp. Med. , vol.177 , pp. 679-690
    • Ronchese, F.1    Hausmann, B.2
  • 200
    • 0025762970 scopus 로고
    • Acetylcholine receptor-specific T lymphocyte clones in the normal human immune repertoire: Target epitopes, HLA restriction, and membrane phenotypes
    • Salvetti, M., Jung, S., Chang, S.-F., Will, H., Schalke, B. C. G., and Wekerle, H. (1991). Acetylcholine receptor-specific T lymphocyte clones in the normal human immune repertoire: Target epitopes, HLA restriction, and membrane phenotypes. Ann. Neurol. 29, 508-516.
    • (1991) Ann. Neurol. , vol.29 , pp. 508-516
    • Salvetti, M.1    Jung, S.2    Chang, S.-F.3    Will, H.4    Schalke, B.C.G.5    Wekerle, H.6
  • 201
    • 0027422843 scopus 로고
    • Th2 activated cells prevent experimental autoimmune uveoretinitis, a Th1 dependent autoimmune disease
    • Saoudi, A., Kuhn, J., Huygen, K., de-Kosak, Y., Velu, T., Goldman, M., Druet, P., and Bellon, B. (1993). Th2 activated cells prevent experimental autoimmune uveoretinitis, a Th1 dependent autoimmune disease. Eur. J. Immunol. 23, 3096-3103.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 3096-3103
    • Saoudi, A.1    Kuhn, J.2    Huygen, K.3    de-Kosak, Y.4    Velu, T.5    Goldman, M.6    Druet, P.7    Bellon, B.8
  • 202
    • 0029659056 scopus 로고    scopus 로고
    • The physiological role of regulatory T cells in the prevention of autoimmunity: The function of the thymus in the generation of the regulatory T cell subset
    • Saoudi, A., Seddon, B., Heath, V., Fowell, D., and Mason, D. (1996). The physiological role of regulatory T cells in the prevention of autoimmunity: The function of the thymus in the generation of the regulatory T cell subset. Immunol. Rev. 149, 195-216.
    • (1996) Immunol. Rev. , vol.149 , pp. 195-216
    • Saoudi, A.1    Seddon, B.2    Heath, V.3    Fowell, D.4    Mason, D.5
  • 203
    • 0030779118 scopus 로고    scopus 로고
    • A mechanism for the major histocompatibility complex-linked resistance to autoimmunity
    • Schmidt, D., Verdaguer, J., Averill, N., and Santamaria, P. (1997). A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J. Exp. Med. 186, 1059-1075.
    • (1997) J. Exp. Med. , vol.186 , pp. 1059-1075
    • Schmidt, D.1    Verdaguer, J.2    Averill, N.3    Santamaria, P.4
  • 205
    • 0025872395 scopus 로고
    • Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction
    • Schönrich, G., Kalinke, U., Momburg, F., Malissen, M., Hämmerling, G. J., and Arnold, B. (1991). Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65, 293-304.
    • (1991) Cell , vol.65 , pp. 293-304
    • Schönrich, G.1    Kalinke, U.2    Momburg, F.3    Malissen, M.4    Hämmerling, G.J.5    Arnold, B.6
  • 207
    • 0025339511 scopus 로고
    • A cell culture model for T lymphocyte clonal anergy
    • Schwartz, R. H. (1990). A cell culture model for T lymphocyte clonal anergy. Science 248, 1349-1355.
    • (1990) Science , vol.248 , pp. 1349-1355
    • Schwartz, R.H.1
  • 208
  • 212
    • 0023785318 scopus 로고
    • Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
    • Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russell, J. H., and Loh, D. Y. (1988). Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335, 271-274.
    • (1988) Nature , vol.335 , pp. 271-274
    • Sha, W.C.1    Nelson, C.A.2    Newberry, R.D.3    Kranz, D.M.4    Russell, J.H.5    Loh, D.Y.6
  • 214
    • 0026531128 scopus 로고
    • Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice
    • Sidman, C. L., Marshall, J. D., and Von Boehmer, H. (1992). Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice. Eur. J. Immunol. 22, 499-504.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 499-504
    • Sidman, C.L.1    Marshall, J.D.2    von Boehmer, H.3
  • 215
  • 216
    • 0030796631 scopus 로고    scopus 로고
    • Pancreatic gene expression in rare cells of thymic medulla: Evidence for functional contribution to T cell tolerance
    • Smith, K. M., Olson, D. C., Hirose, R., and Hanahan, D. (1997). Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. Int. Immunol. 9, 1355-1364.
    • (1997) Int. Immunol. , vol.9 , pp. 1355-1364
    • Smith, K.M.1    Olson, D.C.2    Hirose, R.3    Hanahan, D.4
  • 217
    • 0025864107 scopus 로고
    • Acetylcholine receptor-reactive T lymphocytes from healthy subjects and myasthenia gravis patients
    • Sommer, N., Harcourt, G. C., Willcox, N., Beeson, D., and Newsom-Davis, J. (1991). Acetylcholine receptor-reactive T lymphocytes from healthy subjects and myasthenia gravis patients. Neurology 41, 1270-1276.
    • (1991) Neurology , vol.41 , pp. 1270-1276
    • Sommer, N.1    Harcourt, G.C.2    Willcox, N.3    Beeson, D.4    Newsom-Davis, J.5
  • 219
    • 0016823587 scopus 로고
    • Association of immunity and tolerance to host H-2 determinants in irradiated F1 hybrid mice reconstituted with bone marrow from one parental strain
    • Sprent, J., von Boehmer, H., and Nabholz, M. (1975). Association of immunity and tolerance to host H-2 determinants in irradiated F1 hybrid mice reconstituted with bone marrow from one parental strain. J. Exp. Med. 142, 321-331.
    • (1975) J. Exp. Med. , vol.142 , pp. 321-331
    • Sprent, J.1    von Boehmer, H.2    Nabholz, M.3
  • 220
    • 0014047736 scopus 로고
    • Developmental aspects of immunity
    • Sterzl, J., and Silverstein, A. M. (1967). Developmental aspects of immunity. Adv. Immunol. 6, 337-459.
    • (1967) Adv. Immunol. , vol.6 , pp. 337-459
    • Sterzl, J.1    Silverstein, A.M.2
  • 221
    • 0029862687 scopus 로고    scopus 로고
    • B cells solicit their own help from T cells
    • Stockinger, B., Zal, T., Zal, A., and Gray, D. (1996). B cells solicit their own help from T cells. J. Exp. Med. 183, 891-899.
    • (1996) J. Exp. Med. , vol.183 , pp. 891-899
    • Stockinger, B.1    Zal, T.2    Zal, A.3    Gray, D.4
  • 222
    • 0026634939 scopus 로고
    • T cells bearing the CD44hi "memory" phenotype display characteristics of activated cells in G1 stage of cell cycle
    • Stout, R. D., and Suttles, J. (1992). T cells bearing the CD44hi "memory" phenotype display characteristics of activated cells in G1 stage of cell cycle. Cell. Immunol. 141, 433-443.
    • (1992) Cell. Immunol. , vol.141 , pp. 433-443
    • Stout, R.D.1    Suttles, J.2
  • 223
    • 0031569520 scopus 로고    scopus 로고
    • Immune deviation in relation to ocular immune privilege
    • Streilein, J. W., Ksander, B. R., and Taylor, A. W. (1997). Immune deviation in relation to ocular immune privilege. J. Immunol. 158, 3557-3560.
    • (1997) J. Immunol. , vol.158 , pp. 3557-3560
    • Streilein, J.W.1    Ksander, B.R.2    Taylor, A.W.3
  • 224
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • Surh, C. D., and Sprent, J. (1994). T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372, 100-103.
    • (1994) Nature , vol.372 , pp. 100-103
    • Surh, C.D.1    Sprent, J.2
  • 226
    • 0028104782 scopus 로고
    • High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins
    • Sykulev, Y., Brunmark, A., Tsomides, T. J., Kageyama, S., Jackson, M., Peterson, P. A., and Eisen, H. N. (1994). High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA 91, 11487-11491.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11487-11491
    • Sykulev, Y.1    Brunmark, A.2    Tsomides, T.J.3    Kageyama, S.4    Jackson, M.5    Peterson, P.A.6    Eisen, H.N.7
  • 227
    • 0030200829 scopus 로고    scopus 로고
    • The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice
    • Sytwu, H. K., Liblau, R. S., and McDevitt, H. O. (1996). The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity 5, 17-30.
    • (1996) Immunity , vol.5 , pp. 17-30
    • Sytwu, H.K.1    Liblau, R.S.2    McDevitt, H.O.3
  • 228
    • 0028845691 scopus 로고
    • T cell awareness of paternal alloantigens during pregnancy
    • Tafuri, A., Alferink, J., Moller, P., Hammerling, G. J., and Arnold, B. (1995). T cell awareness of paternal alloantigens during pregnancy. Science 270, 630-633.
    • (1995) Science , vol.270 , pp. 630-633
    • Tafuri, A.1    Alferink, J.2    Moller, P.3    Hämmerling, G.J.4    Arnold, B.5
  • 230
    • 0027368190 scopus 로고
    • In vitro negative selection of ab T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells
    • Tanaka, Y., Mamalaki, C., Stockinger, B., and Kioussis, D. (1993). In vitro negative selection of ab T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells. Eur. J. Immunol. 23, 2614-2621.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2614-2621
    • Tanaka, Y.1    Mamalaki, C.2    Stockinger, B.3    Kioussis, D.4
  • 231
    • 0030779119 scopus 로고    scopus 로고
    • Peripheral selection of T cell repertoires: The role of continuous thymus output
    • Tanchot, C., and Rocha, B. (1997). Peripheral selection of T cell repertoires: The role of continuous thymus output. J. Exp. Med. 186, 1099-1106.
    • (1997) J. Exp. Med. , vol.186 , pp. 1099-1106
    • Tanchot, C.1    Rocha, B.2
  • 233
    • 0024505883 scopus 로고
    • Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of GD8 molecules
    • Teh, H., Kishi, H., Scott, B., and von Boehmer, H. (1989). Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of GD8 molecules. J. Exp. Med. 169, 795-806.
    • (1989) J. Exp. Med. , vol.169 , pp. 795-806
    • Teh, H.1    Kishi, H.2    Scott, B.3    von Boehmer, H.4
  • 234
    • 0030694234 scopus 로고    scopus 로고
    • The emerging role of CTLA-4 as an immune attenuator
    • Thompson, C. B., and Allison, J. P. (1997). The emerging role of CTLA-4 as an immune attenuator. Immunity 7, 445-450.
    • (1997) Immunity , vol.7 , pp. 445-450
    • Thompson, C.B.1    Allison, J.P.2
  • 235
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs, S. L., Russell, D. M., and Nemazee, D. (1993). Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020.
    • (1993) J. Exp. Med. , vol.177 , pp. 1009-1020
    • Tiegs, S.L.1    Russell, D.M.2    Nemazee, D.3
  • 237
    • 0030719389 scopus 로고    scopus 로고
    • A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes
    • Turner, M., Mee, J., Walters, A. E., Quinn, M. E., Mellor, A. L., Zamoyska, R., and Tybulewicz, V. L. J. (1997). A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity 7, 451-460.
    • (1997) Immunity , vol.7 , pp. 451-460
    • Turner, M.1    Mee, J.2    Walters, A.E.3    Quinn, M.E.4    Mellor, A.L.5    Zamoyska, R.6    Tybulewicz, V.L.J.7
  • 239
    • 0028409106 scopus 로고
    • Intracellular signals that mediate thymic negative selection
    • Vasquez, N. J., Kane, L. P., and Hedrick, S. M. (1994). Intracellular signals that mediate thymic negative selection. Immunity 1, 45-56.
    • (1994) Immunity , vol.1 , pp. 45-56
    • Vasquez, N.J.1    Kane, L.P.2    Hedrick, S.M.3
  • 240
    • 0028918793 scopus 로고
    • Lipopolysaccharide interferes with the induction of peripheral T cell death
    • Vella, A. T., McCormack, J. E., Linsley, P. S., Kappler, J. W., and Marrack, P. (1995). Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2, 261-270.
    • (1995) Immunity , vol.2 , pp. 261-270
    • Vella, A.T.1    McCormack, J.E.2    Linsley, P.S.3    Kappler, J.W.4    Marrack, P.5
  • 242
    • 0031568068 scopus 로고    scopus 로고
    • Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen
    • Volkmann, A., Zal, T., and Stockinger, B. (1997). Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen. J. Immunol. 158, 693-706.
    • (1997) J. Immunol. , vol.158 , pp. 693-706
    • Volkmann, A.1    Zal, T.2    Stockinger, B.3
  • 243
    • 0021688652 scopus 로고
    • Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymic epithelial cells
    • von Boehmer, H., and Schubiger, H. K. (1984). Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymic epithelial cells. Eur. J. Immunol. 14, 1048-1052.
    • (1984) Eur. J. Immunol. , vol.14 , pp. 1048-1052
    • von Boehmer, H.1    Schubiger, H.K.2
  • 244
    • 0030066656 scopus 로고    scopus 로고
    • CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance
    • Walunas, T. L., Sperling, A. I., Khattri, R., Thompson, C. B., and Bluestone, J. A. (1996). CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J. Immunol. 156, 1006-1013.
    • (1996) J. Immunol. , vol.156 , pp. 1006-1013
    • Walunas, T.L.1    Sperling, A.I.2    Khattri, R.3    Thompson, C.B.4    Bluestone, J.A.5
  • 245
    • 0028223194 scopus 로고
    • Sepsis-induced apoptosis of the thymocytes in mice
    • Wang, S. D., Huang, K. J., Lin, Y. S., and Lei, H. Y. (1994). Sepsis-induced apoptosis of the thymocytes in mice.J. Immunol. 152, 5014-5021.
    • (1994) J. Immunol. , vol.152 , pp. 5014-5021
    • Wang, S.D.1    Huang, K.J.2    Lin, Y.S.3    Lei, H.Y.4
  • 246
    • 0028902304 scopus 로고
    • Role of the thymus in the generation of skin-homing alpha beta and gamma delta virgin T cells
    • Washington, E. A., Kimpton, W. G., Holder, J. E., and Cahill, R. N. (1995). Role of the thymus in the generation of skin-homing alpha beta and gamma delta virgin T cells. Eur. J. Immunol. 25, 723-727.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 723-727
    • Washington, E.A.1    Kimpton, W.G.2    Holder, J.E.3    Cahill, R.N.4
  • 248
    • 0025602793 scopus 로고
    • Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
    • Webb, S., Morris, C., and Sprent, J. (1990). Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity. Cell 63, 1249-1256.
    • (1990) Cell , vol.63 , pp. 1249-1256
    • Webb, S.1    Morris, C.2    Sprent, J.3
  • 249
    • 0030443713 scopus 로고    scopus 로고
    • The immune response to islets in experimental diabetes and insulin-dependent diabetes mellitus
    • Wegmann, D. R. (1996). The immune response to islets in experimental diabetes and insulin-dependent diabetes mellitus. Curr. Opin. Immunol. 8, 860-864.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 860-864
    • Wegmann, D.R.1
  • 250
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • Weiner, H. L. (1997). Oral tolerance: Immune mechanisms and treatment of autoimmune diseases. Immunol. Today 18, 335-343.
    • (1997) Immunol. Today , vol.18 , pp. 335-343
    • Weiner, H.L.1
  • 251
    • 0027940262 scopus 로고
    • Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen
    • Zal, T., Volkmann, A., and Stockinger, B. (1994). Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J. Exp. Med. 180, 2089-2099.
    • (1994) J. Exp. Med. , vol.180 , pp. 2089-2099
    • Zal, T.1    Volkmann, A.2    Stockinger, B.3
  • 252
    • 0029810903 scopus 로고    scopus 로고
    • Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function
    • Zal, T., Weiss, S., Mellor, A., and Stockinger, B. (1996). Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA 93, 9102-9107.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9102-9107
    • Zal, T.1    Weiss, S.2    Mellor, A.3    Stockinger, B.4
  • 254
    • 0029914914 scopus 로고    scopus 로고
    • Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
    • Zhou, T., Cheng, J., Yang, P., Wang, Z., Liu, C., Su, X., Bluethmann, H., and Mountz, J. D. (1996). Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells. J. Exp. Med. 183, 1879-1892.
    • (1996) J. Exp. Med. , vol.183 , pp. 1879-1892
    • Zhou, T.1    Cheng, J.2    Yang, P.3    Wang, Z.4    Liu, C.5    Su, X.6    Bluethmann, H.7    Mountz, J.D.8
  • 255
    • 0018170714 scopus 로고
    • Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus
    • Zinkernagel, R. M., Callahan, G. N., Klein, J., and Dennert, G. (1979). Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. Nature 271, 251-253.
    • (1979) Nature , vol.271 , pp. 251-253
    • Zinkernagel, R.M.1    Callahan, G.N.2    Klein, J.3    Dennert, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.