Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells

Journal of Experimental Medicine

Volumn 195, Issue 3, 2002, Pages 343-351

  Ferlazzo, Guido ^a,e   Tsang, Ming L ^b   Moretta, Lorenzo ^c,d   Melioli, Giovanni ^a   Steinman, Ralph M ^b   Münz, Christian ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b ROCKEFELLER UNIVERSITY   (United States)

^c G GASLINI INSTITUTE   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Dendritic cells; Immune regulation; Natural killer cells; NCR; NKp30

Indexed keywords

CELL RECEPTOR; CYTOKINE; GAMMA INTERFERON; HLA A ANTIGEN; HLA ANTIBODY; HLA B ANTIGEN; HLA C ANTIGEN; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NKP30 RECEPTOR; NKP44 RECEPTOR; NKP46 RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLYSIS; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOREGULATION; NATURAL KILLER CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 0037017387     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011149     Document Type: Article

References (58)

1. Dendritic cells and the control of immunity
2. The cell biology of antigen presentation in dendritic cells
3. Immunobiology of dendritic cells
4. Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism
5. In search of the 'missing self: MHC molecules and NK cell recognition
6. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: The NK gene complex
7. NK cell receptors
8. HLA class I specific inhibitory receptors
9. Natural killer cell receptors specific for MHC class I molecules
10. A human NK and K cell subset shares with cytotoxic T cells expression of the antigen recognized by antibody OKT8
11. Functional and biochemical analysis of CD16 antigen on natural killer cells and granulocytes
12. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
13. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis
14. p46, a novel natural killer cell-specific surface molecule that mediates cell activation
15. On guard-activating NK cell receptors
16. Activating receptors And coreceptors involved in human natural killer cell-mediated cytolysis
17. Natural killer cells in antiviral defense: Function and regulation by innate cytokines
18. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions
19. Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line
20. - "nonspecific" killer cells
21. Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
22. Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate antitumor immune responses in vivo
23. Expression of B7-1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity
24. B7-1 enhances natural killer cell-mediated cytotoxicity and inhibits tumor growth of a poorly immunogenic murine carcinoma
25. A reassessment of the role of B7-1 expression in tumor rejection
26. Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1)
27. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
28. + NK cells
29. Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): Cytolytic activity and proliferation of NK cells are differentially regulated by NKSF
30. Interleukin 15: Biology and relevance to human disease
31. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor
32. Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15
33. Enhancement of natural killer cell cytotoxicity by the human herpesvirus-7 via IL-15 induction
34. Spontaneous cell-mediated cytotoxicity in humans: Role of interferon and immunoglobulins
35. Cell-mediated cytotoxicity against virus-infected target cells in humans. II. Interferon induction and activation of natural killer cells
36. Enhanced NK cell activity in mice injected with interferon and interferon inducers
37. Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice
38. Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction
39. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
40. Interferons α and β as immune regulators - A new look
41. Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: Implications for anti-cancer and anti-viral therapy
42. NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection
43. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells
44. Biology of natural killer cells
45. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
46. Natural killing of herpes simplex virus type 1-infected target cells: Normal human responses and influence of antiviral antibody
47. Deficient natural killer cell activity in x-linked lymphoproliferative syndrome
48. Cytotoxic T cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients
49. Viral subversion of the immune system
50. Recognition of autologous dendritic cells by human NK cells
51. Targeting of human dendritic cells by autologous NK cells
52. Interleukin-12-activated natural killer cells recognize B7 costimulatory molecules on tumor cells and autologous dendritic cells
53. HLA class I molecule expression is up-regulated during maturation of dendritic cells, protecting them from natural killer cell-mediated lysis
54. The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity
55. NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46
56. Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression
57. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
58. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells