Intravital microscopy: Visualizing immunity in context

Immunity

Volumn 21, Issue 3, 2004, Pages 315-329

  Sumen, Cenk ^a,b   Mempel, Thorsten R ^a,b   Mazo, Irina B ^a,b   Von Andrian, Ulrich H ^a,b  

^a CENTER FOR BLOOD RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTIC METHOD; BONE MARROW CELL; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CYTOSKELETON; HUMAN; IMAGING SYSTEM; IMMUNE RESPONSE; LYMPH NODE; MICROSCOPY; NONHUMAN; PHOTON; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION;

ANIMALS; CELL COMMUNICATION; CELL MOVEMENT; DENDRITIC CELLS; DIAGNOSTIC IMAGING; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSCOPY; MICROSCOPY, VIDEO; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES;

EID: 4444328615     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2004.08.006     Document Type: Review

References (147)

1. Abo T., Kawamura T., Watanabe H. Physiological responses of extrathymic T cells in the liver. Immunol. Rev. 174:2000;135-149
2. Allan R.S., Smith C.M., Belz G.T., van Lint A.L., Wakim L.M., Heath W.R., Carbone F.R. Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science. 301:2003;1925-1928
3. Ansel K.M., Cyster J.G. Chemokines in lymphopoiesis and lymphoid organ development. Curr. Opin. Immunol. 13:2001;172-179
4. Atherton A., Born G.V.R. Quantitative investigation of the adhesiveness of circulating polymorphonuclear leucocytes to blood vessel walls. J. Physiol. 222:1972;447-474
5. Baez S. An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy. Microvasc. Res. 5:1973;384-394
6. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J., Pulendran B., Palucka K. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:2000;767-811
7. Bargatze R.F., Jutila M.A., Butcher E.C. Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ. The multistep model confirmed and refined Immunity. 3:1995;99-108
8. Barrett T.A., Bluestone J.A. Development of TCR gamma delta iIELs. Semin. Immunol. 7:1995;299-305
9. Batista F.D., Iber D., Neuberger M.S. B cells acquire antigen from target cells after synapse formation. Nature. 411:2001;489-494
10. Belz G.T., Behrens G.M., Smith C.M., Miller J.F., Jones C., Lejon K., Fathman C.G., Mueller S.N., Shortman K., Carbone F.R., Heath W.R. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J. Exp. Med. 196:2002;1099-1104
11. Berg E.L., McEvoy L.M., Berlin C., Bargatze R.F., Butcher E.C. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature. 366:1993;695-698
12. Berlin-Rufenach C., Otto F., Mathies M., Westermann J., Owen M.J., Hamann A., Hogg N. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1- deficient mice. J. Exp. Med. 189:1999;1467-1478
13. Bonifaz L.C., Bonnyay D.P., Charalambous A., Darguste D.I., Fujii S., Soares H., Brimnes M.K., Moltedo B., Moran T.M., Steinman R.M. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J. Exp. Med. 199:2004;815-824
14. Bousso P., Robey E. Dynamics of CD8(+) T cell priming by dendritic cells in intact lymph nodes. Nat. Immunol. 4:2003;579-585
15. Bousso P., Bhakta N.R., Lewis R.S., Robey E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science. 296:2002;1876-1880
16. Branemark P.-I. Vital Microscopy of Bone Marrow in Rabbit. 1959;Berlingska Boktryckeriet, Lund
17. Butcher E.C. Leukocyte-endothelial cell recognition. three (or more) steps to specificity and diversity Cell. 67:1991;1033-1036
18. Butcher E.C., Picker L.J. Lymphocyte homing and homeostasis. Science. 272:1996;60-66
19. Cahalan M.D., Parker I., Wei S.H., Miller M.J. Two-photon tissue imaging. seeing the immune system in a fresh light Nat. Rev. Immunol. 2:2002;872-880
20. Calvi L.M., Adams G.B., Weibrecht K.W., Weber J.M., Olson D.P., Knight M.C., Martin R.P., Schipani E., Divieti P., Bringhurst F.R., et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 425:2003;841-846
21. Campbell J.J., Hedrick J., Zlotnik A., Siani M.A., Thompson D.A., Butcher E.C. Chemokines and the arrest of lymphoyctes rolling under flow conditions. Science. 279:1998;381-384
22. Carrasco Y.R., Fleire S.J., Cameron T., Dustin M.L., Batista F.D. LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity. 20:2004;589-599
23. Carvalho-Tavares J., Hickey M.J., Hutchison J., Michaud J., Sutcliffe I.T., Kubes P. A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature. Circ. Res. 87:2000;1141-1148
24. Cavanagh L.L., von Andrian U.H. Travellers in many guises. the origins and destinations of dendritic cells Immunol. Cell Biol. 80:2002;448-462
25. Cohnheim J. Lectures on General Pathology. A Handbook for Practitioners and Students:1889;The New Sydenham Society, London
26. Condeelis J., Segall J.E. Intravital imaging of cell movement in tumours. Nat. Rev. Cancer. 3:2003;921-930
27. Davignon D., Martz E., Reynolds T., Kürzinger K., Springer T.A. Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1). Mechanism of blocking of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions J. Immunol. 127:1981;590-595
28. DeMali K.A., Wennerberg K., Burridge K. Integrin signaling to the actin cytoskeleton. Curr. Opin. Cell Biol. 15:2003;572-582
29. den Haan J.M.M., Lehar S.M., Bevan M.J. CD8+ but not CD8- dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 192:2000;1685-1695
30. Denk W., Strickler J.H., Webb W.W. Two-photon laser scanning fluorescence microscopy. Science. 248:1990;73-76
31. Dexter T.M., Allen T.D., Lajtha L.G. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J. Cell. Physiol. 91:1977;335-344
32. Di Rosa F., Santoni A. Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery. Eur. J. Immunol. 32:2002;1873-1880
33. Di Rosa F., Santoni A. Memory T-cell competition for bone marrow seeding. Immunology. 108:2003;296-304
34. Dustin M.L., Springer T.A. T cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature. 341:1989;619-624
35. Dustin M.L., Chan A.C. Signaling takes shape in the immune system. Cell. 103:2000;283-294
36. Dustin M.L., Bromley S.K., Zhengyan K., Peterson D.A., Unanue E.R. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc. Natl. Acad. Sci. USA. 94:1997;3909-3913
37. Ellyard J.I., Avery D.T., Phan T.G., Hare N.J., Hodgkin P.D., Tangye S.G. Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow. Blood. 103:2004;3805-3812
38. Enghofer M., Bojunga J., Usadel K.H., Kusterer K. Intravital measurement of donor lymphocyte adhesion to islet endothelium of recipient animals in diabetes transfer experiments. Exp. Clin. Endocrinol. Diabetes. 103(Suppl 2):1995;99-102
39. Falkvoll K.H., Rofstad E.K., Brustad T., Marton P. A transparent chamber for the dorsal skin fold of athymic mice. Exp. Cell Biol. 52:1984;260-268
40. Faroudi M., Utzny C., Salio M., Cerundolo V., Guiraud M., Muller S., Valitutti S. Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction. manifestation of a dual activation threshold Proc. Natl. Acad. Sci. USA. 100:2003;14145-14150. a
41. Faroudi M., Zaru R., Paulet P., Muller S., Valitutti S. Cutting edge. T lymphocyte activation by repeated immunological synapse formation and intermittent signaling J. Immunol. 171:2003;1128-1132. b
42. Feuerer M., Beckhove P., Bai L., Solomayer E.F., Bastert G., Diel I.J., Pedain C., Oberniedermayr M., Schirrmacher V., Umansky V. Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Nat. Med. 7:2001;452-458. a
43. Feuerer M., Rocha M., Bai L., Umansky V., Solomayer E.F., Bastert G., Diel I.J., Schirrmacher V. Enrichment of memory T cells and other profound immunological changes in the bone marrow from untreated breast cancer patients. Int. J. Cancer. 92:2001;96-105. b
44. Feuerer M., Beckhove P., Garbi N., Mahnke Y., Limmer A., Hommel M., Hammerling G.J., Kyewski B., Hamann A., Umansky V., Schirrmacher V. Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat. Med. 9:2003;1151-1157
45. Foxman E.F., Campbell J.J., Butcher E.C. Multistep navigation and the combinatorial control of leukocyte chemotaxis. J. Cell Biol. 139:1997;1349-1360
46. Fujimori H., Miura S., Koseki S., Hokari R., Komoto S., Hara Y., Hachimura S., Kaminogawa S., Ishii H. Intravital observation of adhesion of lamina propria lymphocytes to microvessels of small intestine in mice. Gastroenterology. 122:2002;734-744
47. Funakoshi N., Onizuka M., Yanagi K., Ohshima N., Tomoyasu M., Sato Y., Yamamoto T., Ishikawa S., Mitsui T. A new model of lung metastasis for intravital studies. Microvasc. Res. 59:2000;361-367
48. Germain R.N., Stefanova I., Dorfman J. Self-recognition and the regulation of CD4+ T cell survival. Adv. Exp. Med. Biol. 512:2002;97-105
49. Giagulli C., Scarpini E., Ottoboni L., Narumiya S., Butcher E.C., Constantin G., Laudanna C. RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines. critical role of LFA-1 affinity triggering in lymphocyte in vivo homing Immunity. 20:2004;25-35
50. Grakoui A., Bromley S.K., Sumen C., Davis M.M., Shaw A.S., Allen P.M., Dustin M.L. The immunological synapse. a molecular machine controlling T cell activation Science. 285:1999;221-227
51. Grayson M.H., Hotchkiss R.S., Karl I.E., Holtzman M.J., Chaplin D.D. Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. Am. J. Physiol. Heart Circ. Physiol. 284:2003;H2213-H2226
52. Gretz J.E., Anderson A.O., Shaw S. Cords, channels, corridors and conduits. critical artichitectural elements facilitating cell interactions in the lymph node cortex Immunol. Rev. 156:1997;11-24
53. Gunzer M., Schafer A., Borgmann S., Grabbe S., Zanker K.S., Brocker E.B., Kampgen E., Friedl P. Antigen presentation in extracellular matrix. interactions of T cells with dendritic cells are dynamic, short lived, and sequential Immunity. 13:2000;323-332
54. Hallek M., Bergsagel P.L., Anderson K.C. Multiple myeloma. increasing evidence for a multistep transformation process Blood. 91:1998;3-21
55. Hendriks H.R., Duijvestijn A.M., Kraal G. Rapid decrease in lymphocyte adherence to high endothelial venules in lymph nodes deprived of afferent lymphatic vessels. Eur. J. Immunol. 17:1987;1691-1695
56. Hermans M.H., Hartsuiker H., Opstelten D. An in situ study of B-lymphocytopoiesis in rat bone marrow. Topographical arrangement of terminal deoxynucleotidyl transferase-positive cells and pre-B cells. J. Immunol. 142:1989;67-73
57. Hideshima T., Richardson P., Anderson K.C. Novel therapeutic approaches for multiple myeloma. Immunol. Rev. 194:2003;164-176
58. Hoffmeister K.M., Felbinger T.W., Falet H., Denis C.V., Bergmeier W., Mayadas T.N., von Andrian U.H., Wagner D.D., Stossel T.P., Hartwig J.H. The clearance mechanism of chilled blood platelets. Cell. 112:2003;87-97
59. Holler P.D., Kranz D.M. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity. 18:2003;255-264
60. Horny H.P., Engst U., Walz R.S., Kaiserling E. In situ immunophenotyping of lymphocytes in human bone marrow. an immunohistochemical study Br. J. Haematol. 71:1989;313-321
61. Huppa J.B., Davis M.M. T-cell-antigen recognition and the immunological synapse. Nat. Rev. Immunol. 3:2003;973-983
62. Huppa J.B., Gleimer M., Sumen C., Davis M.M. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immunol. 4:2003;749-755
63. Itano A.A., Jenkins M.K. Antigen presentation to naive CD4 T cells in the lymph node. Nat. Immunol. 4:2003;733-739
64. Itano A.A., McSorley S.J., Reinhardt R.L., Ehst B.D., Ingulli E., Rudensky A.Y., Jenkins M.K. Distinct Dendritic Cell Populations Sequentially Present a Subcutaneous Antigen to CD4 T Cells and Stimulate Different Aspects of Cell-Mediated Immunity. Immunity. 19:2003;47-57
65. Jain R.K., Munn L.L., Fukumura D. Dissecting tumour pathophysiology using intravital microscopy. Nat. Rev. Cancer. 2:2002;266-276
66. John B., Crispe I.N. Passive and active mechanisms trap activated CD8+ T cells in the liver. J. Immunol. 172:2004;5222-5229
67. Jones S.L., Knaus U.G., Bokoch G.M., Brown E.J. Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils. J. Biol. Chem. 273:1998;10556-10566
68. Jones T.R., Shirasugi N., Adams A.B., Pearson T.C., Larsen C.P. Intravital microscopy identifies selectins that regulate T cell traffic into allografts. J. Clin. Invest. 112:2003;1714-1723
69. Katayama Y., Hidalgo A., Furie B.C., Vestweber D., Furie B., Frenette P.S. PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow. evidence for cooperation between E-selectin ligands and alpha4 integrin Blood. 102:2003;2060-2067
70. Krogsgaard M., Prado N., Adams E.J., He X.L., Chow D.C., Wilson D.B., Garcia K.C., Davis M.M. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol. Cell. 12:2003;1367-1378
71. Kuroda M.J., Schmitz J.E., Seth A., Veazey R.S., Nickerson C.E., Lifton M.A., Dailey P.J., Forman M.A., Racz P., Tenner-Racz K., Letvin N.L. Simian immunodeficiency virus-specific cytotoxic T lymphocytes and cell-associated viral RNA levels in distinct lymphoid compartments of SIVmac-infected rhesus monkeys. Blood. 96:2000;1474-1479
72. Lakkis F.G., Arakelov A., Konieczny B.T., Inoue Y. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat. Med. 6:2000;686-688
73. Lawler C., Suk W.A., Pitt B.R., Croix C.M., Watkins S.C. Multimodal optical imaging. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:2003;L269-L280
74. Lawrence M.B., Berg E.L., Butcher E.C., Springer T.A. Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM-1 in shear flow. Eur. J. Immunol. 25:1995;1025-1031
75. Lawrence M.B., McIntire L.V., Eskin S.G. Effect of flow on polymorphonuclear leukocyte/endothelial cell adhesion. Blood. 70:1987;1284-1290
76. Lee K.H., Holdorf A.D., Dustin M.L., Chan A.C., Allen P.M., Shaw A.S. T cell receptor signaling precedes immunological synapse formation. Science. 295:2002;1539-1542
77. Leunig M., Yuan F., Menger M.D., Boucher Y., Goetz A.E., Messmer K., Jain R.K. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res. 52:1992;6553-6560
78. Lord B.I., Testa N.G., Hendry J.H. The relative spatial distributions of CFUs and CFUc in the normal mouse femur. Blood. 46:1975;65-72
79. Mackay C.R. Chemokines. immunology's high impact factors Nat. Immunol. 2:2001;95-101
80. Maheshwari G., Lauffenburger D.A. Deconstructing (and reconstructing) cell migration. Microsc. Res. Tech. 43:1998;358-368
81. Mandel T.E., Kennedy M.M. The differentiation of murine thymocytes in vivo and in vitro. Immunology. 35:1978;317-331
82. Manz R.A., Thiel A., Radbruch A. Lifetime of plasma cells in the bone marrow. Nature. 388:1997;133-134
83. Marshall D.R., Turner S.J., Belz G.T., Wingo S., Andreansky S., Sangster M.Y., Riberdy J.M., Liu T., Tan M., Doherty P.C. Measuring the diaspora for virus-specific CD8+ T cells. Proc. Natl. Acad. Sci. USA. 98:2001;6313-6318
84. Massberg S., Enders G., Leiderer R., Eisenmenger S., Vestweber D., Krombach F., Messmer K. Platelet-endothelial cell interactions during ischemia/reperfusion. the role of P-selectin Blood. 92:1998;507-515
85. Matloubian M., Lo C.G., Cinamon G., Lesneski M.J., Xu Y., Brinkmann V., Allende M.L., Proia R.L., Cyster J.G. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 427:2004;355-360
86. Mazo I.B., Gutierrez-Ramos J.-C., Frenette P.S., Hynes R.O., Wagner D.D., von Andrian U.H. Hematopoietic progenitor cell rolling in bone marrow microvessels. Parallel contributions by endothelial selectins and VCAM-1 J. Exp. Med. 188:1998;465-474
87. Mazo I.B., Quackenbush E.J., Lowe J.B., von Andrian U.H. Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow. Blood. 99:2002;4182-4191
88. Mazo I.B., von Andrian U.H. Adhesion and homing of blood-borne cells in bone marrow microvessels. J. Leukoc. Biol. 66:1999;25-32
89. McCuskey R.S., McClugage S.G. Jr., Younker W.J. Microscopy of living bone marrow in situ. Blood. 38:1971;87-95
90. Mebius R.E., Streeter P.R., Breve J., Duijvestijn A.M., Kraal G. The influence of afferent lymphatic vessel interruption on vascular addressin expression. J. Cell Biol. 115:1991;85-95
91. Mempel T.R., Henrickson S.E., von Andrian U.H. T cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature. 427:2004;154-159. a
92. Mempel T.R., Scimone M.L., Mora J.R., von Andrian U.H. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr. Opin. Immunol. 16:2004;406-417. b
93. Miller M.J., Wei S.H., Parker I., Cahalan M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science. 296:2002;1869-1873
94. Miller M.J., Wei S.H., Cahalan M.D., Parker I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc. Natl. Acad. Sci. USA. 100:2003;2604-2609
95. Miller M.J., Hejazi A.S., Wei S.H., Cahalan M.D., Parker I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. USA. 101:2004;998-1003
96. Monks C.R.F., Freiberg B.A., Kupfer H., Sciaky N., Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature. 394:1998;82-86
97. Nakagawa K., Miller F.N., Sims D.E., Lentsch A.B., Miyazaki M., Edwards M.J. Mechanisms of interleukin-2-induced hepatic toxicity. Cancer Res. 56:1996;507-510
98. Naramura M., Hu R.J., Gu H. Mice with a fluorescent marker for interleukin 2 gene activation. Immunity. 9:1998;209-216
99. Nilsson S.K., Johnston H.M., Coverdale J.A. Spatial localization of transplanted hemopoietic stem cells. inferences for the localization of stem cell niches Blood. 97:2001;2293-2299
100. O'Connor B.P., Gleeson M.W., Noelle R.J., Erickson L.D. The rise and fall of long-lived humoral immunity. terminal differentiation of plasma cells in health and disease Immunol. Rev. 194:2003;61-76
101. Okada T., Ngo V.N., Ekland E.H., Forster R., Lipp M., Littman D.R., Cyster J.G. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J. Exp. Med. 196:2002;65-75
102. Osmond D.G. Population dynamics of bone marrow B lymphocytes. Immunol. Rev. 93:1986;103-124
103. Palframan R.T., Jung S., Cheng G., Weninger W., Luo Y., Dorf M., Littman D.R., Rollins B.J., Zweerink H., Rot A., von Andrian U.H. Inflammatory chemokine transport and presentation in HEV. A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues J. Exp. Med. 194:2001;1361-1374
104. Pannarale L., Morini S., D'Ubaldo E., Gaudio E., Marinozzi G. SEM corrosion-casts study of the microcirculation of the flat bones in the rat. Anat. Rec. 247:1997;462-471
105. Paramithiotis E., Cooper M.D. Memory B lymphocytes migrate to bone marrow in humans. Proc. Natl. Acad. Sci. USA. 94:1997;208-212
106. Potter M. Neoplastic development in plasma cells. Immunol. Rev. 194:2003;177-195
107. Price P.W., Cerny J. Characterization of CD4+ T cells in mouse bone marrow. I. Increased activated/memory phenotype and altered TCR Vbeta repertoire. Eur. J. Immunol. 29:1999;1051-1056
108. Purbhoo M.A., Irvine D.J., Huppa J.B., Davis M.M. T cell killing does not require the formation of a stable mature immunological synapse. Nat. Immunol. 5:2004;524-530
109. Reus W.F., Robson M.C., Zachary L., Heggers J.P. Acute effects of tobacco smoking on blood flow in the cutaneous micro-circulation. Br. J. Plast. Surg. 37:1984;213-215
110. Rot A., von Andrian U.H. Chemokines in innate and adaptive host defense. basic chemokinese grammar for immune cells Annu. Rev. Immunol. 22:2004;891-928
111. Sallusto F., Lenig D., Forster R., Lipp M., Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 401:1999;708-712
112. Saxton M.J. Single-particle tracking. the distribution of diffusion coefficients Biophys. J. 72:1997;1744-1753
113. Scharffetter-Kochanek K., Lu H., Norman K., van Nood N., Munoz F., Grabbe S., McArthur M., Lorenzo I., Kaplan S., Ley K., et al. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J. Exp. Med. 188:1998;119-131
114. Schirrmacher V., Feuerer M., Fournier P., Ahlert T., Umansky V., Beckhove P. T-cell priming in bone marrow. the potential for long-lasting protective anti-tumor immunity Trends Mol. Med. 9:2003;526-534
115. Schmits R., Kundig T.M., Baker D.M., Shumaker G., Simard J.J., Duncan G., Wakeham A., Shahinian A., van der Heiden A., Bachmann M.F., et al. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med. 183:1996;1415-1426
116. Shinkura R., Matsuda F., Sakiyama T., Tsubata T., Hiai H., Paumen M., Miyawaki S., Honjo T. Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. Int. Immunol. 8:1996;1067-1075
117. Shohet S.B., Bernard M.D., Thevenin J.-M., Sherman I.W., von Andrian U.H. Newer facets of sickle cell disease adhesiveness. Cell. Mol. Biol. Lett. 3:1998;413-422
118. Sikora L., Johansson A.C., Rao S.P., Hughes G.K., Broide D.H., Sriramarao P. A murine model to study leukocyte rolling and intravascular trafficking in lung microvessels. Am. J. Pathol. 162:2003;2019-2028
119. Slifka M., Whitmire J., Ahmed R. Bone marrow contains virus-specific cytotoxic T lymphocytes. Blood. 90:1997;2103-2108
120. Slifka M.K., Antia R., Whitmire J.K., Ahmed R. Humoral immunity due to long-lived plasma cells. Immunity. 8:1998;363-372
121. Sligh J.E. Jr., Ballantyne C.M., Rich S., Hawkins H.K., Smith C.W., Bradley A., Beaudet A.L. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA. 90:1993;8529-8533
122. Smith A.L., Fazekas de St Groth B. Antigen-pulsed CD8alpha+ dendritic cells generate an immune response after subcutaneous injection without homing to the draining lymph node. J. Exp. Med. 189:1999;593-598
123. Springer T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration. the multistep paradigm Cell. 76:1994;301-314
124. Stefanova I., Dorfman J.R., Germain R.N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature. 420:2002;429-434
125. Stein J.V., Rot A., Luo Y., Narasimhaswamy M., Nakano H., Gunn M.D., Matsuzawa A., Quackenbush E.J., Dorf M.E., von Andrian U.H. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J. Exp. Med. 191:2000;61-76
126. Steinman R.M., Hawiger D., Nussenzweig M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:2003;685-711
127. Stoll S., Delon J., Brotz T.M., Germain R.N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science. 296:2002;1873-1876
128. Tang H.L., Cyster J.G. Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells. Science. 284:1999;819-822
129. Tokoyoda K., Egawa T., Sugiyama T., Choi B.I., Nagasawa T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity. 20:2004;707-718
130. Tripp R.A., Topham D.J., Watson S.R., Doherty P.C. Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking. J. Immunol. 158:1997;3716-3720
131. Vajkoczy P., Laschinger M., Engelhardt B. Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J. Clin. Invest. 108:2001;557-565
132. Vajkoczy P., Menger M.D. New model for the study of the microcirculation of islet grafts in hairless and nude mice. Transplant. Proc. 26:1994;687
133. van Stipdonk M.J., Hardenberg G., Bijker M.S., Lemmens E.E., Droin N.M., Green D.R., Schoenberger S.P. Dynamic programming of CD8+ T lymphocyte responses. Nat. Immunol. 4:2003;361-365
134. Veihelmann A., Szczesny G., Nolte D., Krombach F., Refior H.J., Messmer K. A novel model for the study of synovial microcirculation in the mouse knee joint in vivo. Res. Exp. Med. (Berl.). 198:1998;43-54
135. von Andrian U.H. Intravital microscopy of the peripheral lymph node microcirculation in mice. Microcirculation. 3:1996;287-300
136. von Andrian U.H., Mackay C.R. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343:2000;1020-1034
137. von Andrian U.H., Mempel T.R. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 3:2003;867-878
138. von Boehmer H., Aifantis I., Gounari F., Azogui O., Haughn L., Apostolou I., Jaeckel E., Grassi F., Klein L. Thymic selection revisited. how essential is it? Immunol. Rev. 191:2003;62-78
139. Wagner R. Erläuterungstafeln zur Physiologie und Entwicklungsgeschichte. 1839;Leopold Voss, Leipzig
140. Warnock R.A., Askari S., Butcher E.C., von Andrian U.H. Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. J. Exp. Med. 187:1998;205-216
141. Wei S.H., Parker I., Miller M.J., Cahalan M.D. A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol. Rev. 195:2003;136-159
142. Weninger W., Crowley M.A., Manjunath N., von Andrian U.H. Migratory properties of naive, effector, and memory CD8(+) T cells. J. Exp. Med. 194:2001;953-966
143. Werr J., Xie X., Hedqvist P., Ruoslahti E., Lindbom L. beta1 integrins are critically involved in neutrophil locomotion in extravascular tissue In vivo. J. Exp. Med. 187:1998;2091-2096
144. Wolf K., Muller R., Borgmann S., Brocker E.B., Friedl P. Amoeboid shape change and contact guidance. T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases Blood. 102:2003;3262-3269
145. Wright D.E., Wagers A.J., Gulati A.P., Johnson F.L., Weissman I.L. Physiological migration of hematopoietic stem and progenitor cells. Science. 294:2001;1933-1936
146. Yu W., Nagaoka H., Jankovic M., Misulovin Z., Suh H., Rolink A., Melchers F., Meffre E., Nussenzweig M.C. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature. 400:1999;682-687
147. Zhang J., Niu C., Ye L., Huang H., He X., Tong W.G., Ross J., Haug J., Johnson T., Feng J.Q., et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 425:2003;836-841