Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

Nature Immunology

Volumn 5, Issue 12, 2004, Pages 1235-1242

  Hugues, Stéphanie ^a   Fetler, Luc ^b   Bonifaz, Laura ^c,e   Helft, Julie ^d   Amblard, François ^b   Amigorena, Sebastian ^a  

^a INSERM   (France)

^b CNRS   (France)

^c ROCKEFELLER UNIVERSITY   (United States)

^d INSTITUT CURIE   (France)

^e INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; IMMUNITY; IMMUNOLOGICAL TOLERANCE; LYMPH NODE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL MOTION; CLASSIFICATION; CYTOLOGY; IMMUNOLOGY; TIME;

ANIMALS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL MOVEMENT; DENDRITIC CELLS; IMMUNE TOLERANCE; LYMPH NODES; T-LYMPHOCYTES; TIME FACTORS;

EID: 16544383331     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1134     Document Type: Article

References (18)

1. Steinman, R.M., Hawiger, D. & Nussenzweig, M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685-711 (2003).
2. + T cell tolerance. J. Exp. Med. 196, 1627-1638 (2002).
3. + T cell tolerance. Immunity 18, 713-720 (2003).
4. Bajenoff, M., Granjeaud, S. & Guerder, S. The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation. J. Exp. Med. 198, 715-24 (2003).
5. Stoll, S., Delon, J., Brotz, T.M. & Germain, R.N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873-1876 (2002).
6. Miller, M.J., Hejazi, A.S., Wei, S.H., Cahalan, M.D. & Parker, I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. USA 101, 998-1003 (2004).
7. Miller, M.J., Wei, S.H., Cahalan, M.D. & Parker, I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc. Natl. Acad. Sci. USA 100, 2604-2609 (2003).
8. Miller, M.J., Wei, S.H., Parker, I. & Cahalan, M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296, 1869-1873 (2002).
9. Mempel, T.R., Henrickson, S.E. & Von Andrian, U.H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154-159 (2004).
10. + T cell priming by dendritic cells in intact lymph nodes. Nat. Immunol. 4, 579-585 (2003).
11. Gunzer, M. et al. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13, 323-332 (2000).
12. Benvenuti, F. et al. Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes. J. Immunol. 172, 292-301 (2004).
13. Bonifaz, L.C. et al. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J. Exp. Med. 199, 815-824 (2004).
14. van Stipdonk, M.J., Lemmens, E.E. & Schoenberger, S.P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2, 423-429 (2001).
15. Gett, A.V., Sallusto, F., Lanzavecchia, A. & Geginat, J. T cell fitness determined by signal strength. Nat. Immunol. 4, 355-360 (2003).
16. Hugues, S. et al. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Immunity 16, 169-181 (2002).
17. + T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J. Exp. Med. 194, 707-717 (2001).
18. Coscoy, S. et al. Molecular analysis of microscopic ezrin dynamics by two-photon FRAP. Proc. Natl. Acad. Sci. USA 99, 12813-12818 (2002).