Frontline: Induction of apoptosis and modulation of c-FLIPL and p53 in immature dendritic cells infected with herpes simplex virus

European Journal of Immunology

Volumn 34, Issue 4, 2004, Pages 941-951

  Müller, Dagmar B ^a   Raftery, Martin J ^a   Kather, Angela ^a   Giese, Thomas ^b   Schönrich, Günther ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Apoptosis; c FLIP; Dendritic cell; Herpes simplex virus; Immune evasion

Indexed keywords

ACICLOVIR; CASPASE 8; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; LIGAND; PROTEIN BCL 2; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; APOPTOSIS REGULATORY PROTEIN; CARRIER PROTEIN; CASP8 PROTEIN, HUMAN; CASPASE; CFLAR PROTEIN, HUMAN; MEMBRANE PROTEIN; MESSENGER RNA; SIGNAL PEPTIDE; TNFSF10 PROTEIN, HUMAN;

ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; ENDOTHELIUM CELL; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IMMUNOMODULATION; IMMUNOREGULATION; INFECTION SENSITIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; UMBILICAL VEIN; UPREGULATION; ANIMAL; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CARRIER PROTEINS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CASPASES; DENDRITIC CELLS; FLOW CYTOMETRY; HERPES SIMPLEX; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE GLYCOPROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIMPLEXVIRUS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 3843133166     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324509     Document Type: Article

References (43)

1. Roizman, B. and Pellett, P. E., The family Herpesviridae: a brief introduction. In Knipe, D. M. and Howley, P. M. (Eds.) Fields Virology. Lippincott Williams & Wilkins, Philadelphia 2001, pp 2381-2397.
2. Koelle, D. M. and Corey, L., Recent progress in herpes simplex virus immunobiology and vaccine research. Clin. Microbiol. Rev. 2003. 16: 96-113.
3. Alcami, A. and Koszinowski, U. H., Viral mechanisms of immune evasion. Immunol. Today 2000. 21: 447-455.
4. Raftery, M. J., Behrens, C. K., Müller, A., Krammer, P. H., Walczak, H. and Schönrich, G., Herpes simplex virus type 1 infection of activated cytotoxic T cells: induction of fratricide as a mechanism of viral immune evasion. J. Exp. Med. 1999. 190: 1103-1113.
5. Leopardi, R., van Sand, C. and Roizman, B., The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus. Proc. Natl. Acad. Sci. USA 1997. 94: 7891-7896.
6. Jerome, K. R., Chen, Z., Lang, R., Torres, M. R., Hofmeister, J., Smith, S., Fox, R., Froelich, C. J. and Corey, L., HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas. J. Immunol. 2001. 167: 3928-3935.
7. Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
8. Lanzavecchia, A. and Sallusto, F., Regulation of T cell immunity by dendritic cells. Cell 2001. 106: 263-266.
9. Guermonprez, P., Valladeau, J., Zitvogel, L., Thery, C. and Amigorena, S., Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 2002. 20: 621-667.
10. Coffin, R. S., Thomas, S. K., Thomas, N. S., Lilley, C. E., Pizzey, A. R., Griffiths, C. H., Gibb, B. J., Wagstaff, M. J., Inges, S. J., Binks, M. H., Chain, B. M., Thrasher, A. J., Rutault, K. and Latchman, D. S., Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry. Gene Ther. 1998. 5: 718-722.
11. Salio, M., Cella, M., Suter, M. and Lanzavecchia, A., Inhibition of dendritic cell maturation by herpes simplex virus. Eur. J. Immunol. 1999. 29: 3245-3253.
12. Kruse, M., Rosorius, O., Kratzer, F., Stelz, G., Kuhnt, C., Schuler, G., Hauber, J. and Steinkasserer, A., Mature dendritic cells infected with herpes simplex virus type 1 exhibited inhibited T-cell stimulatory capacity. J. Virol. 2000. 74: 7127-7136.
13. Mikloska, Z., Bosnjak, L. and Cunningham, A. L., Immature monocyte-derived dendritic cells are productively infected with herpes simplex virus type 1. J. Virol. 2001. 75: 5958-5964.
14. Pollara, G., Speidel, K., Samady, L., Rajpopat, M., McGrath, Y., Ledermann, J., Coffin, R. S., Katz, D. R. and Chain, B., Herpes simplex virus infection of dendritic cells: balance among activation, inhibition, and immunity. J. Infect. Dis. 2003. 187: 165-178.
15. Samady, L., Costigliola, E., MacCormac, L., McGrath, Y., Cleverley, S., Lilley, C. E., Smith, J., Latchman, D. S., Chain, B. and Coffin, R. S., Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs(-) HSV vectors for dendritic cell-mediated immunotherapy. J. Virol. 2003. 77: 3768-3776.
16. Benedict, C. A., Banks, T. A. and Ware, C. F., Death and survival: viral regulation of TNF sigaling pathways. Curr. Opin. Immunol. 2003. 15: 59-65.
17. Thome, M. and Tschopp, J., Regulation of lymphocyte proliferation and death by FLIP. Nat. Rev. Immunol. 2001. 1: 50-58.
18. Krueger, A., Baumann, S., Krammer, P. H. and Kirchhoff, S., FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol. Cell Biol. 2001. 21: 8247-8254.
19. Ashany, D., Savir, A., Bhardwaj, N. and Elkon, K. B., Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway. J. Immunol. 1999. 163: 5303-5311.
20. Leverkus, M., Walczak, H., McLellan, A., Fries, H. W., Terbeck, G., Brocker, E. B. and Kampgen, E., Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis. Blood 2000. 96: 2628-2631.
21. Rescigno, M., Piguet, V., Valzasina, B., Lens, S., Zubler, R., French, L., Kindler, V., Tschopp, J. and Ricciardi-Castagnoli, P., Fas engagement induces the maturation of dendritic cells (DC), the release of interleukin (IL)-1 beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses. J. Exp. Med. 2000. 192: 1661-1668.
22. Willems, F., Amraoui, Z., Vanderheyde, N., Verhasselt, V., Aksoy, E., Scaffidi, C., Peter, M. E., Krammer, P. H. and Goldman, M., Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide. Blood 2002. 95: 3478-3482.
23. Nicolo, C., Tamassini, B., Rippo, M. R. and Testi, R., UVB-induced apoptosis of human dendritic cells: contribution by caspase-dependent and caspase-independent pathways. Blood 2001. 97: 1803-1808.
24. Jones, C. A., Fernandez, M., Herc, K., Bosnjak, L., Miranda-Saksena, M., Boadle, R. A. and Cunningham, A., Herpes simplex virus type 2 induces rapid cell death and functional impairment of murine dendritic cells in vitro. J. Virol. 2003. 77: 11139-11149.
25. Kuida, K., Zheng, T. S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P. and Flavell, R. A., Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 1996. 384: 368-372.
26. Vidalain, P. O., Azocar, O., Lamouille, B., Astier, A., Rabourdin-Combe, C. and Servet-Delprat, C., Measles virus induces functional TRAIL production by human dendritic cells. J. Virol. 2000. 74: 556-559.
27. Raftery, M. J., Schwab, M., Eibert, S., Samstag, Y., Walczak, H. and Schönrich, G., Targeting of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy. Immunity 2001. 15: 997-1009.
28. Washburn, B., Weigand, M. A., Grosse-Wilde, A., Janke, M., Stahl, H., Rieser, E., Sprick, M. R., Schirrmacher, V. and Walczak, H., TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus. J. Immunol. 2003. 170: 1814-1821.
29. Fanger, N. A., Maliszewski, C. R., Schooley, K. and Griffith, T. S., Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J. Exp. Med. 1999. 190: 1155-1164.
30. Santini, S. M., Lapenta, C., Logozzi, M., Parlato, S., Spada, M., Di Pucchio, T. and Belardelli, F., Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J. Exp. Med. 2000. 191: 1777-1788.
31. Rivera-Walsh, I., Waterfield, M., Xiao, G., Fong, A. and Sun, S. C., NF-kappaB signaling pathway governs TRAIL gene expression and human T cell leukemia virus-I Tax-induced T cell death. J. Biol. Chem. 2001. 276: 40385-40388.
32. Chinnaiyan, A. M., O'Rourke, K., Yu, G. L., Lyons, R. H., Garg, M., Duan, D. R., Xing, L., Gentz, R., Ni, J. and Dixit, V. M., Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996. 274: 990-992.
33. Perlman, H., Pagliari, L. J., Georganas, C., Mano, T., Walsh, K. and Pope, R. M., FLICE-inhibitory protein expression during macrophage differentiation confers resistance to Fas-mediated apoptosis. J. Exp. Med. 1999. 190: 1679-1688.
34. Takaoka, A., Hayakawa, S., Yanai, H., Stoiber, D., Negishi, H., Kikuchi, H., Sasaki, S., Imai, K., Shibue, T., Honda, K. and Taniguchi, T., Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 2003. 424: 516-523.
35. Chipuk, J. E., Maurer, U., Green, D. R. and Schuler, M., Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell 2003. 4: 371-381.
36. Milhara, M., Erster, S., Zaika, A., Petrenko, O., Chittenden, T., Pancoska, P. and Moll, U. M., p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 2003. 11: 577-590.
37. Kreuz, S., Siegmund, D., Scheurich, P. and Wajant, H., NF-kappaB inducers up-regulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol. Cell. Biol. 2001. 21: 3964-3973.
38. Micheau, O., Lens, S., Gaide, O., Alevizopoulos, K. and Tschopp, J., NF-kappaB signals induce the expression of c-FLIP. Mol. Cell. Biol. 2001. 21: 5299-5305.
39. Fukazawa, T., Fujiwara, T., Uno, F., Teraishi, F., Kadowaki, Y., Itoshima, T., Takata, Y., Kagawa, S., Roth, J. A., Tschopp, J. and Tanaka, N., Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. Oncogene 2001. 20: 5225-5231.
40. Fulda, S., Meyer, E. and Debatin, K. M., Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. Cancer Res. 2000. 60: 3947-3956.
41. Jaffe, E. A., Nachman, R. L., Becker, C. G. and Minick, C. R., Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 1973. 52: 2745-2756.
42. Vermes, I., Haanen, C., Steffens-Nakken, H. and Reutelingsperger, C., A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J. Immunol. Methods 1995. 184: 39-51.
43. Scaffidi, C., Schmitz, I., Krammer, P. H. and Peter, M. E., The role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol. Chem. 1999. 274: 1541-1548.