Vaccination against chlamydial genital tract infection after immunization with dendritic cells pulsed ex vivo with nonviable Chlamydiae

Journal of Experimental Medicine

Volumn 188, Issue 5, 1998, Pages 809-818

  Su, Hua ^a   Messer, Ronald ^a   Whitmire, William ^a   Fischer, Elizabeth ^a   Portis, John C ^a   Caldwell, Harlan D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

CD4+ T cells; Chlamydia; Immunization; Mucosal protective immunity; Pulsed dendritic cells

Indexed keywords

CD4 ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ARTICLE; CHLAMYDIA; CONTROLLED STUDY; GENITAL TRACT INFECTION; HISTOPATHOLOGY; IMMUNE RESPONSE; INFECTION CONTROL; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE; VACCINATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; CYTOKINES; DENDRITIC CELLS; FEMALE; HELA CELLS; HUMANS; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; VACCINES, INACTIVATED; VAGINAL DISEASES;

EID: 0032494186     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.5.809     Document Type: Article

References (53)

1. Schachter, J. 1988. The intracellular life of Chlamydia. Curr. Top. Microbiol. Immunol. 138:109-139.
2. Jones, B.R. 1975. The prevention of blindness from trachoma. Trans. Ophthalmol. Soc. UK. 95:16-33.
3. Brunham, R.C., B. Binns, J. McDowell, and M. Paraskevas. 1986. Chlamydia trachomatis infection in women with ectopic pregnancy. Obstet. Gynecol. 67:722-726.
4. Brunham, R.C., I.W. Maclean, B. Binns, and R.W. Peeling. 1985. Chlamydia trachomatis: its role in tubal infertility. J. Infect. Dis. 152:1275-1282.
5. Chow, J.M., M.L. Yonekura, G.A. Richwald, S. Greenland, R.L. Sweet, and J. Schachter. 1990. The association between Chlamydia trachomatis and ectopic pregnancy. JAMA (J. Am. Med. Assoc.). 263:3164-3167.
6. Jones, R.B., B.R. Ardery, S.L. Hui, and R.E. Cleary. 1982. Correlation between serum antichlamydial antibodies and tubal factor as a cause of infertility. Fertil. Steril. 38:553-558.
7. Barron, A.L., H.J. White, R.G. Rank, B.L. Soloff, and E.B. Moses. 1981. A new animal model for the study of Chlamydia trachomatis genital infections: infection of mice with the agent of mouse pneumonitis. J. Infect. Dis. 143:63-66.
8. Patton, D.L., D.V. Landers, and J. Schachter. 1989. Experimental Chlamydia trachomatis salpingitis in mice: initial studies on the characterization of the leukocyte response to chlamydial infection. J. Infect. Dis. 159:1105-1110.
9. Swenson, C.E., E. Donegan, and J. Schachter. 1983. Chlamydia trachomatis-induced salpingitis in mice. J. Infect. Dis. 148:1101-1107.
10. de la Maza, L.M., S. Pal, A. Khamesipour, and E.M. Peterson. 1994. Intravaginal inoculation of mice with the Chlamydia trachomatis mouse pneumonitis biovar results in infertility. Infect. Immun. 62:2094-2097.
11. Williams, D.M., B.G. Grubbs, E. Pack, K. Kelly, and R.G. Rank. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect. Immun. 65:2876-2882.
12. Morrison, R.P., K. Feilzer, and D.B. Tumas. 1995. Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection. Infect. Immun. 63: 4661-4668.
13. + T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect. Immun. 63:3302-3308.
14. 1 lymphocyte clone. Reg. Immunol. 5:317-324.
15. Perry, L.L., K. Feilzer, and H.D. Caldwell. 1997. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-γ-dependent and -independent pathways. J. Immunol. 158:3344-3352.
16. Cotter, T.W., K.H. Ramsey, G.S. Miranpuri, C.E. Poulsen, and G.I. Byrne. 1997. Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice. Inject. Immun. 65:2145-2152.
17. Su, H., K. Feilzer, H.D. Caldwell, and R.P. Morrison. 1997. Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. Infect. Immun. 65:1993-1999.
18. Johansson, M., M. Ward, and N. Lycke. 1997. B-cell-deficient mice develop complete immune protection against genital tract infection with Chlamydia trachomatis. Immunology. 92: 422-428.
19. Johansson, M., K. Schon, M. Ward, and N. Lycke. 1997. Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response. Infect. Immun. 65:1032-1044.
20. Kelly, K.A., E.A. Robinson, and R.G. Rank. 1996. Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection. Infect. Immun. 64:4976-4983.
21. Pal, S., E.M. Peterson, and L.M. de la Maza. 1996. Intranasal immunization induces long-term protection in mice against a Chlamydia trachomatis genital challenge. Infect. Immun. 64: 5341-5348.
22. Banchereau, J., and R.M. Steinman. 1998. Dendritic cells and the control of immunity. Nature. 392:245-252.
23. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
24. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R.M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte-macrophage colony-stimulating factor. J. Exp. Med. 176:1693-1702.
25. Zitvogel, L., J.I. Mayordomo, T. Tjandrawan, A.B. DeLeo, M.R. Clarke, M.T. Lotze, and W.J. Storkus. 1996. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med. 183:87-97.
26. Mayordomo, J.I., T. Zorina, W.J. Storkus, L. Zitvogel, C. Celluzzi, L.D. Falo, C.J. Melief, S.T. Ildstad, W.M. Kast, A.B. Deleo, and M.T. Lotze. 1995. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat. Med. 1:1297-1302.
27. Gyure, L.A., R. Barfoot, S. Denham, and J.G. Hall. 1987. Immunity to a syngeneic sarcoma induced in rats by dendritic lymph cells exposed to the tumour either in vivo or in vitro. Br. J. Cancer. 55:17-20.
28. Celluzzi, C.M., J.I. Mayordomo, W.J. Storkus, M.T. Lotze, and L.D. Falo, Jr. 1996. Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity. J. Exp. Med. 183:283-287.
29. Celluzzi, C.M., and L.D. Falo, Jr. 1998. Cutting edge: physical interaction between dendritic cells and tumor cells results in an immunogen that induces protective and therapeutic tumor rejection. J. Immunol. 160:3081-3085.
30. Nestle, F.O., S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G., Burg, and D. Schadendorf. 1998. Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells. Nat. Med. 4:328-332.
31. Mayordomo, J.I., T. Zorina, W.J. Storkus, L. Zitvogel, M.D. Garcia-Prats, A.B. DeLeo, and M.T. Lotze. 1997. Bone marrow-derived dendritic cells serve as potent adjuvants for pepride-based antitumor vaccines. Stem Cells. 15:94-103.
32. Caldwell, H.D., J. Kromhout, and J. Schachter. 1981. Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect. Immun. 31: 1161-1176.
33. Svensson, M., B. Stockinger, and M.J. Wick. 1997. Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells. J. Immunol. 158:4229-4236.
34. Inaba, K., M. Inaba, M. Naito, and R.M. Steinman. 1993. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J. Exp. Med. 178:479-488.
35. Ojcius, D.M., Y. Bravo de Alba, J.M. Kanellopoulos, R.A. Hawkins, K.A. Kelly, R.G. Rank, and A. Dautry-Varsat. 1998. Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells. J. Immunol. 160: 1297-1303.
36. H1 cells. Immunol. Today. 14:335-338.
37. + T cells. J. Immunol. 154:5071-5079.
38. Reis e Sousa, C., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, R.N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186:1819-1829.
39. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
40. Mbow, M.L., N. Zeidner, N. Panella, R.G. Titus, and J. Piesman. 1997. Borrelia burgdorferi-pulsed dendritic cells induce a protective immune response against tick-transmitted spirochetes. Infect. Immun. 65:3386-3390.
41. Brossart, P., A.W. Goldrath, E.A. Butz, S. Martin, and M.J. Bevan. 1997. Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL. J. Immunol. 158:3270-3276.
42. Cooper, A.M., A.D. Roberts, E.R. Rhoades, J.E. Callahan, D.M. Getzy, and I.M. Orme. 1995. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology. 84:423-432.
43. Tripp, C.S., M.K. Gately, J. Hakimi, P. Ling, and E.R. Unanue. 1994. Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-γ. J. Immunol. 152:1883-1887.
44. Mattner, F., K. Di Padova, and G. Alber. 1997. Interleukin-12 is indispensable tor protective immunity against Leishmania major. Infect. Immun. 65:4378-4383.
45. Gazzinelli, R.T., M. Wysocka, S. Hayashi, E.Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533-2543.
46. Afonso, L.C.C., T.M. Scharton, L.Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science. 263:235-237.
47. Miller, M.A., M.J. Skeen, and H.K. Ziegler. 1995. Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes. J. Immunol. 155:4817-4828.
48. Miller, M.A., M.J. Skeen, and H.K. Ziegler. 1997. A synthetic peptide administered with IL-12 elicits immunity to Listeria monocytogenes. J. Immunol. 159:3675-3679.
49. Steinman, R.M., M. Pack, and K. Inaba. 1997. Dendritic cells in the T-cell areas of lymphoid organs. Immunol. Rev. 156:25-37.
50. Barratt-Boyes, S.M., S.C. Watkins, and O.J. Finn. 1997. In vivo migration of dendritic cells differentiated in vitro. A chimpanzee model. J. Immunol. 158:4543-4547.
51. Grouard, G., I. Durand, L. Filgueira, J. Banchereau, and Y.-J. Liu. 1996. Dendritic cells capable of stimulating T cells in germinal centres. Nature. 384:364-367.
52. Pal, S., I. Theodor, E.M. Peterson, and L.M. de la Maza. 1997. Immunization with an acellular vaccine consisting of the outer membrane complex of Chlamydia trachomatis induces protection against a genital challenge. Infect. Immun. 65: 3361-3369.
53. + T cell responses associated with control of viremia. Science. 278:1447-1450.