Natural killer cells and dendritic cells: Rendezvous in abused tissues

Nature Reviews Immunology

Volumn 2, Issue 12, 2002, Pages 957-964

  Moretta, Alessandro ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; HLA ANTIGEN CLASS 1;

ACUTE GRANULOCYTIC LEUKEMIA; BONE MARROW TRANSPLANTATION; CELL INTERACTION; DENDRITIC CELL; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER CELL; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; ACTIVE IMMUNIZATION; ANIMAL; CELL COMMUNICATION; CELL MOTION; DOWN REGULATION; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM;

ANIMALS; CELL COMMUNICATION; CELL MOVEMENT; DENDRITIC CELLS; DOWN-REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNITY, ACTIVE; IMMUNITY, NATURAL; KILLER CELLS, NATURAL; RECEPTORS, IMMUNOLOGIC;

EID: 0036884423     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri956     Document Type: Review

References (72)

1. Cooper, M. A., Fehniger, T. A. & Caligiuri, M. A. The biology of human natural killer-cell subsets. Trends Immunol. 22, 633-640 (2001).
2. Robertson, M. J. Role of chemokines in the biology of natural killer cells. J. Leukocyte Biol. 71, 173-183 (2002).
3. Moretta, A. et al. Receptors for HLA-class I molecules in human natural killer cells. Annu. Rev. Immunol. 14, 619-648 (1996).
4. Long, E. O. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17, 875-904 (1999). References 3 and 4 focus on the various inhibitory natural killer (NK)-cell receptors that are specific for MHC class I molecules. These receptors allow NK cells to discriminate between immature and mature dendritic cells (DCs).
5. Garrido, F. et al. Implications for immunosurveillance of altered HLA-class I phenotypes in human tumors. Immunol. Today 18, 89-95 (1997).
6. Karre, K., Ljunggren, H. G., Piontek, G. & Kiessling, R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319, 675-678 (1986).
7. Lopez-Botet, M., Llano, M. & Ortega, M. Human cytomegalovirus and natural killer-mediated surveillance of HLA class I expression: a paradigm of host-pathogen adaptation. Immunol. Rev. 181, 193-202 (2001).
8. Vilches, C. & Parham, P. KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu. Rev. Immunol. 20, 217-251 (2002).
9. Wilson, M. J. et al. Plasticity in the organization and sequences of human KIR/ILT gene families. Proc. Natl Acad. Sci. USA 97, 4778-4784 (2000).
10. Uhrberg, M. et al. Human diversity in killer-cell inhibitory receptor genes. Immunity 7, 753-760 (1997).
11. + NK cells by the expression of clonally distributed functional surface molecules. Correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. J. Exp. Med. 172, 1589-1598 (1990).
12. Moretta, A. et al. p58 molecules as putative receptors for MHC class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J. Exp. Med 178, 597-604 (1993).
13. Wagtmann, N. et al. Molecular clones of the p58 NK-cell receptor reveal immunoglobulin related molecules with diversity in both the extra- and intracellular domains. Immunity 2, 439-449 (1995).
14. Colonna, M. & Samaridis, J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 269, 405-408 (1995).
15. D'Andrea, A. et al. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J. Immunol. 155, 2306-2310 (1995).
16. Gumperz, J. E., Litwin, V., Phillips, J. H., Lanier, L. L. & Parham, P. The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. J Exp. Med. 181, 1133-1144 (1995).
17. Vitale, M. et al. Physical and functional independency of p70 and p58 NK-cell receptors for HLA-class I. Their role in the definition of different groups of alloreactive NK-cell clones. Proc Natl Acad. Sci. USA 93, 1453-1457 (1996).
18. Valiante, N. M. et al. Functionally and structurally distinct NK-cell receptors in the peripheral blood of two human donors. Immunity 7, 739-751 (1997).
19. Moretta, A. et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19, 197-223 (2001).
20. Diefenbach, A. & Raulet, D. H. Strategies for target-cell recognition by natural killer cells. Immunol. Rev. 181, 170-184 (2001).
21. Cerwenka, A. & Lanier, L. L. Ligands for natural-killer-cell receptors: redundancy of specificity Immunol. Rev. 181, 158-169 (2001).
22. Cosman, D. et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14, 123-133 (2001). References 19-22 focus on the structure, function and ligand specificity of activating NK-cell receptors, including the various NCR, NKG2D and 2B4 molecules. At least one of these receptors (NKp30) seems to be involved directly in the recognition of DCs by human NK cells.
23. Costello, R. et al. Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia Blood 99, 3661-3667 (2002).
24. Steinman, R. M. & Cohn, Z. A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137, 1142-1162 (1973).
25. Banchereau, J. & Steinman, R. M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998).
26. Banchereau, J. et al. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767-811 (2000).
27. Randolph, G. J., Beaulieu, S., Lebecque, S., Steinman, R. M. & Muller, W. A. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 282, 480-483 (1998).
28. Sallusto, F. & Lanzavecchia, A. Mobilizing dendritic cells for tolerance, priming and chronic inflammation. J. Exp. Med. 189, 611-614 (1999).
29. Sallusto, F., Cella, M., Danieli, C. & Lanzavecchia, A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389-400 (1995).
30. De Baey, A. & Lanzavecchia, A. The role of aquaporins in dendritic-cell macropinocytosis. J. Exp. Med. 191. 743-747 (2000).
31. Reis e Sousa, C. Dendritic cells as sensors of infection. Immunity 14, 495-498 (2001).
32. Cella, M. et al. Maturation, activation and protection of dendritic cells induced by double-stranded RNA. J. Exp. Med. 189, 821-829 (1999).
33. Cella, M., Engering, A., Pinet, V. Pieters, J. & Lanzavecchia, A. Inflammatoy stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388. 782-787 (1997).
34. Saeki, H., Moore, A. M., Brown, M. J. & Hwang, S. T. Secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 162, 2472-2475 (1999).
35. Sallusto, F. et al. Distinct patterns and kinetics of chemokine production regulate dendritic-cell function. Eur. J. Immunol. 29, 1617-1625 (1999).
36. Sallusto, F., Mackay, C. R. & Lanzavecchia, A. The role of chemokine receptors in primary, effector and memory immune responses. Annu. Rev. Immunol. 18, 593-620 (2000).
37. Montoya, M. et al. Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood 99, 3263-3271 (2002).
38. Kalinski, P., Hilkens, C. M., Weirenga, E. A. & Kapsenberg, M. L. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today 20, 561-567 (1999).
39. Fernandez, N. et al. Dendritic cells directly trigger NK-cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nature Med. 5, 405-411 (1999). This is a pioneering study describing the existence of reciprocal control during NK-cell-DC interactions in the mouse system.
40. Fedazzo, G. et al. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J. Exp Med. 195, 343-351 (2002).
41. Piccioli, D., Sbrana, S., Melandri, E. & Valiante, N. M. Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J. Exp. Med 195, 335-341 (2002).
42. Gerosa, F. et al. Reciprocal activating interaction between NK cells and dendritic cells. J. Exp. Med. 195, 327-333 (2002). References 40-42 address, for the first time, the issue of bi-directional cross-talk between NK cells and DCs in humans. It is shown that NK cells can kill DCs through NKp30, that NK cells proliferate in the presence of DCs and that NK cells can promote DC maturation.
43. Wilson, J. L. et al. Targeting of human dendritic cells by autologous NK cells. J. Immunol. 163, 6365-6370 (1999).
44. Spaggiari, G. M. et al. NK-cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46. Eur. J. Immunol. 31, 1656-1665 (2001).
45. Carbone, E. et al. Recognition of autologous dendritic cells by human NK cells. Eur. J. Immunol. 29, 4022-4029 (1999).
46. Zitvogel, L. Dendritic and natural killer cells cooperate in the control/switch of innate immunity. J. Exp. Med. 195, 9-14 (2002).
47. Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P. & Salazar-Mather, T. P. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17, 189-220 (1999). An authoritative review of the NK-cell response to various pathogens in vivo. Also, the migration of NK cells in response to innate cytokines is discussed.
48. Godiska, R. et al. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells and natural killer cells. J. Exp. Med. 185, 1595-1604 (1997).
49. Yoneda, O. et al. Fractalkine-mediated endothelial-cell injury by NK cells. J. Immunol 16, 4055-4062 (2000).
50. + NK and NKT peripheral-blood lymphocytes identified by chemokine receptor expression repertoire. J. Immunol. 166, 6477-6482 (2001). A complete analysis of chemokine-receptor expression by human NK-cell subsets.
51. Gerszten, R. E. et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions Nature 398, 718-723 (1999).
52. Inngjerdingen, M., Damaj, B., Azzam, A. & Maghazachi, A. Expression and regulation of chemokine receptors in human natural killer cells. Blood 97, 367-375 (2001).
53. 3CR1, which mediates both leukocyte migration and adhesion. Cell 91, 521-530 (1997).
54. + cell-derived NK-cell cytotoxicity by DC. Eur. J. Immunol. 166, 1590-1600 (2001).
55. + blood DC enhance NK-cell-mediated cytotoxicity Eur. J. Immunol. 31, 2633-2641 (2001).
56. Granucci, F. et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nature Immunol. 2, 882-888 (2001).
57. Mattei, F., Schiavoni, G., Belardelli, F. & Tough, D. F. IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic-cell activation. J. Immunol. 167, 1179-1187 (2001).
58. + dendritic-cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 196, 1289-1302 (2002). This study provides direct evidence of the cooperation between NK cells and DCs during the process of endocytosis of dying cells.
59. Sauter, B. et al. Consequences of cell death Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191, 423-434 (2000).
60. Gallucci, S., Lolkema, M. & Matzinger, P. Natural adjuvants: endogenous activators of dendritic cells. Nature Med. 5, 1249-1255 (1999).
61. Basu, S., Binder, R., Suto, R., Anderson, K. & Srivastava, P. Necrotic but not apoptotic cell death releases heat-shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway. Int. Immunol. 12, 1539-1546 (2000).
62. Somersan, S. et al. Primary tumor tissue lysates are enriched in heat-shock proteins and induce the maturation of human dendritic cells J. Immunol. 167, 4844-4852 (2001).
63. Albert, M. L., Sauter, B. & Bhardwaj, N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392, 86-89 (1998).
64. + killer T cells. J. Exp. Med. 193, 405-412 (2001).
65. 5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 191, 613-623 (1998).
66. Gorelik, L. & Flavell, R. A. Transforming growth factor-β in T-cell biology. Nature Rev. Immunol. 2, 46-53 (2002).
67. Ferlazzo, G., Semino, C. & Melioli, G. HLA class I molecule expression is up-regulated during maturation of dendritic cells, protecting them from natural killer cell-mediated lysis. Immunol. Lett. 76, 37-41 (2001).
68. Forster, R. et al. CCR7 coordinates the primary immune responses by establishing functional microenvironments in secondary lymphoid organs. Cell 99, 23-33 (1999).
69. Ruggieri, L. et al. Role of NK-cell alloreactivity in HLA-mismatched hematopoietic stem-cell transplantation. Blood 94, 333-339 (1999).
70. Ruggeri, L. et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295, 2097-2100 (2002). In this study, evidence is provided for the ability of KIR-mismatched alloreactive NK cells to prevent graft-versus-host disease by eliminating recipient antigen-presenting cells.
71. Kärre, K. A perfect mismatch. Science 295, 2029-2031 (2002).
72. Velardi, A., Ruggeri, L., Moretta, A. & Moretta, L. NK cells: a lesson from mismatched hematopoietic transplantation. Trends Immunol. 23, 438-444 (2002).