Infection of dendritic cells by murine cytomegalovirus induces functional paralysis

Nature Immunology

Volumn 2, Issue 11, 2001, Pages 1077-1084

  Andrews, Daniel M ^a   Andoniou, Christopher E ^a   Granucci, Francesca ^b   Ricciardi Castagnoli, Paola ^b   Degli Esposti, Mariapia A ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DENDRITIC CELL; HUMAN IMMUNODEFICIENCY VIRUS; HYPOTHESIS; IMMUNE DEFICIENCY; IMMUNE RESPONSE; MEASLES VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; BETA-GALACTOSIDASE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DENDRITIC CELLS; ENDOCYTOSIS; GENES, REPORTER; IMMUNE TOLERANCE; IMMUNOCOMPROMISED HOST; IMMUNOLOGIC DEFICIENCY SYNDROMES; LAC OPERON; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTE SUBSETS; VIRUS REPLICATION;

EID: 0035164788     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni724     Document Type: Article

References (50)

1. Generalized immunosuppression: How viruses undermine the immune response
2. Cytomegalovirus persistence by evasion from immune control
3. Immune evasion by cytomegalovirus-survival strategies of a highly adapted opportunist
4. Cytomegaloviral control of MHC class I function in the mouse
5. Murine cytomegalovirus infection inhibits IFN γ-induced MHC class II expression on macrophages: The role of type 1 interferon
6. Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10
7. The murine cytomegalovirus chemokine homolog, m131/129, is a determinant of viral pathogenicity
8. Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo
9. Murine cytomegalovirus inhibits interferon γ-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes
10. Cytomegalovirus evasion of natural killer cell responses
11. Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus
12. Biphasic viremia and viral gene expression in leukocytes during acute cytomegalovirus infection of mice
13. Replication of murine cytomegalovirus in differentiated macrophages as a determinant of viral pathogenesis
14. Monocyte-derived dendritic cells are permissive to the complete replicative cycle of human cytomegalovirus
15. Dendritic cells and the control of immunity
16. New insights into the mobilization and phagocytic activity of dendritic cells
17. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo
18. Dendritic cells at the end of the Millennium
19. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures
20. Early events in dendritic cell maturation induced by LPS
21. Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli
22. Bacterial lipopolysaccharide contamination of commercial collagen preparations may mediate dendritic cell maturation in culture
23. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen
24. Identification and characterization of a G protein-coupled receptor homolog encoded by murine cytomegalovirus
25. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
26. Immune suppression by herpesviruses
27. CMV-associated immunosuppression
28. Viral vectors for gene therapy: The art of turning infectious agents into vehicle therapeutics
29. Developmental control of endocytosis in dendritic cells by Cdc42
30. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment - Downregulation by cytokines and bacterial products
31. Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus
32. Transport of peptide-MHC class II complexes in developing dendritic cells
33. How to recognize a foreign submarine
34. Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1)
35. m144, a murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection
36. H2 and non-polarized T cells
37. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy
38. Selective impairment of T lymphocyte activation through the T cell receptor/CD3 complex after cytomegalovirus infection
39. Cytomegalovirus infection of peripheral blood mononuclear cells: Effects on interleukin-1 and -2 production and responsiveness
40. Studies of depressed interleukin-2 production by spleen cells from mice following infection with cytomegalovirus
41. In vivo application of recombinant interleukin-2 in the immunotherapy of established cytomegalovirus infection
42. Murine cytomegalovirus independently inhibit priming of helper and cytotoxic T lymphocytes
43. Mechanisms of immunosuppression in cytomegalovirus mononucleosis. II. Virus-monocyte interactions
44. Role of the monocyte in cytomegalovirus-mediated immunosuppression in vitro
45. Induction of apoptosis of T cells by infecting mice with murine cytomegalovirus
46. The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells
47. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified
48. Interleukin(IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells