Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells

Journal of Experimental Medicine

Volumn 198, Issue 2, 2003, Pages 235-247

  Yamazaki, Sayuri ^a   Iyoda, Tomonori ^b   Tarbell, Kristin ^a   Olson, Kara ^a   Velinzon, Klara ^a   Inaba, Kayo ^b   Steinman, Ralph M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Anergy; CD25+ CD4+ regulatory T cells; CD86; Dendritic cells; IL 2

Indexed keywords

CD4 ANTIGEN; CD86 ANTIGEN; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CELL ACTIVITY; CELL CONTACT; CELL GROWTH; CLONAL ANERGY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CLONAL ANERGY; DENDRITIC CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES;

EID: 0042512461     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030422     Document Type: Article

References (52)

1. Sakaguchi, S., N. Sakaguchi, J. Shimizu, S. Yamazaki, T. Sakihama, M. Itoh, Y. Kuniyasu, T. Nomura, M. Toda, and T. Takahashi. 2001. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18-32.
2. Shevach, E.M. 2000. Regulatory T cells in autoimnmnity. Annu. Rev. Immunol. 18:423-449.
3. Saoudi, A., B. Seddon, V. Heath, V. Fowell, and D. Mason. 1996. The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset. Immunol. Rev. 149:195-216.
4. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimnmne diseases. J. Immunol. 155:1151-1164.
5. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387-396.
6. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160:1212-1218.
7. + T regulatory cells suppress Helicobacter hepaticus-induced colitis.J. Exp. Med. 196:505-516.
8. + regulatory T cells control Leishmania major persistence and immunity. Nature. 420:502-507.
9. + T cell responses. J. Exp. Med. 196:1585-1592.
10. + T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163:5211-5218.
11. + regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med. 194:823-832.
12. + T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J. Immunol. 169:5401-5404.
13. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193:1311-1318.
14. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969-1980.
15. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
16. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164:183-190.
17. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008-3018.
18. + suppressor T cells in vivo. Nat. Immunol. 3:33-41.
19. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303-310.
20. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295-302.
21. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:135-142.
22. + immunoregulatory T cells. Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity. 16:311-323.
23. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor foxp3. Science. 299:1057-1061.
24. + regulatory T cells. Nat. Immunol. 4:330-336.
25. + T regulatory cells. Nat. Immunol. 4:337-342.
26. + T cell-mediated suppression by dendritic cells. Science. 299:1033-1036.
27. Steinman, R.M., D. Hawiger, and M.C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:685-711.
28. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R.M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693-1702.
29. + dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 195:1289-1302.
30. + T cell tolerance. J. Exp. Med. 196:1627-1638.
31. Wells, A.D., H. Gedmundsdottir, and L.A. Turka. 1997. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction of a proliferative response. J. Clin. Invest. 100:3137-3183.
32. Granucci, F., C. Vizzardelli, N. Pavelka, S. Feau, M. Persico, E. Virzi, M. Rescigno, G. Moro, and P. Ricciardi-Castagnoli. 2001. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat. Immunol. 2:882-888.
33. + immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196:401-406.
34. Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell. 101:455-458.
35. + regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA. 99:8213-8218.
36. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301-306.
37. Apostolou, I., A. Sarukhan, L. Klein, and H. Von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756-763.
38. + immunoregulatory T cells that control autoimmune diabetes. Immunity. 12:431-440.
39. + regulatory T cell function. J. Exp. Med. 196:851-857.
40. + T cells. Proc. Natl. Acad. Sci. USA. 99:8832-8837.
41. Caramalho, I., T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot. 2003. Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197:403-411.
42. Malek, T., A. Yu, V. Vincek, P. Scibelli, and L. Kong. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeca-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17:167.
43. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. Methods. 162:5317-5326.
44. + regulatory T cells in vivo. J. Exp. Med. 198:249-258.
45. + regulatory T cells control Th1 responses to foreign antigens induced by mature DCs in vivo. J. Exp. Med. 198:259-266.
46. + T cells with regulatory properties from human blood. J. Exp. Med. 193:1303-1310.
47. + T helper cells. J. Exp. Med. 196:255-260.
48. + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med. 196:247-253.
49. Steinman, R.M., and M.C. Nussenzweig. 2002. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA. 99:351-358.
50. Huang, F.-P., N. Platt, M. Wykes, J.R. Major, T.J. Powell, C.D. Jenkins, and G.G. MacPherson. 2000. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med. 191:435-442.
51. Liu, K., T. Iyoda, M. Saternus, K. Kimura, K. Inaba, and R.M. Steinman. 2002. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 196:1091-1097.
52. Scheinecker, C., R. McHugh, E.M. Shevach, and R.N. Germain. 2002. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 196:1079-1090.