The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses

Immunity

Volumn 19, Issue 5, 2003, Pages 641-644

  Trinchieri, Giorgio ^a   Pflanz, Stefan ^a   Kastelein, Robert A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN DERIVATIVE; UNCLASSIFIED DRUG;

IMMUNITY; IMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY; T LYMPHOCYTE;

EID: 0345358584     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(03)00296-6     Document Type: Review

References (18)

1. Aggarwal S., Ghilardi N., Xie M.H., de Sauvage F.J., Gurney A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278:2003;1910-1914.
2. Broberg E.K., Setala N., Eralinna J.P., Salmi A.A., Roytta M., Hukkanen V. Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice. J. Interferon Cytokine Res. 22:2002;641-651.
3. Chen Q., Ghilardi N., Wang H., Baker T., Xie M.H., Gurney A., Grewal I.S., de Sauvage F.J. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature. 407:2000;916-920.
4. Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 421:2003;744-748.
5. Fieschi C., Casanova J.L. The role of interleukin-12 in human infectious diseases. only a faint signature Eur. J. Immunol. 33:2003;1461-1464.
6. Hamano S., Himeno K., Ishii K., Yamanaka A., Miyazaki Y., Takeda A., Zhang M., Hisaeda H., Mak T.W., Yoshimura A., Yoshida H. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity. 19:2003;657-667. this issue.
7. Jankovic D., Kullberg M.C., Hieny S., Caspar P., Collazo C.M., Sher A. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity. 16:2002;429-439.
8. Kopp T., Lenz P., Bello-Fernandez C., Kastelein R.A., Kupper T.S., Stingl G. IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice. evidence for enhanced cutaneous immunity J. Immunol. 170:2003;5438-5444.
9. Lelievre E., Plun-Favreau H., Chevalier S., Froger J., Guillet C., Elson G.C., Gauchat J.F., Gascan H. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine. specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component J. Biol. Chem. 276:2001;22476-22484.
10. Mullen A.C., High F.A., Hutchins A.S., Lee H.W., Villarino A.V., Livingston D.M., Kung A.L., Cereb N., Yao T.P., Yang S.Y., Reiner S.L. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science. 292:2001;1907-1910.
11. Nieuwenhuis E.E., Neurath M.F., Corazza N., Iijima H., Trgovcich J., Wirtz S., Glickman J., Bailey D., Yoshida M., Galle P.R., et al. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc. Natl. Acad. Sci. USA. 99:2002;16951-16956.
12. Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 13:2000;715-725.
13. Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168:2002;5699-5708.
14. Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., Hibbert L., Churakova T., Travis M., Vaisberg E., et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity. 16:2002;779-790.
15. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:2003;133-146.
16. Villarino A.V., Hibbert L., Lieberman L., Wilson E., Mak T., Yoshida H., Kastelein R., Saris C., Hunter C.A. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity. 19:2003;645-655. this issue.
17. Yoshida H., Hamano S., Senaldi G., Covey T., Faggioni R., Mu S., Xia M., Wakeham A.C., Nishina H., Potter J., et al. WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity. 15:2001;569-578.
18. Zhang G.X., Gran B., Yu S., Li J., Siglienti I., Chen X., Kamoun M., Rostami A. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice. IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system J. Immunol. 170:2003;2153-2160.