Dendritic cells and the control of immunity: Enhancing the efficiency of antigen presentation

Mount Sinai Journal of Medicine

Volumn 68, Issue 3, 2001, Pages 160-166

  Steinman, Ralph M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Adsorptive endocytosis; Antigen presentation; Antigen processing; Costimulators; Cross presentation; Dendritic cells; Immune therapy; T cells

Indexed keywords

ANTIGEN PRESENTATION; ARTICLE; CELLULAR IMMUNITY; DENDRITIC CELL; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; MAJOR HISTOCOMPATIBILITY COMPLEX; METHODOLOGY; T LYMPHOCYTE;

ANTIGEN PRESENTATION; DENDRITIC CELLS; HUMANS; IMMUNITY, CELLULAR; IMMUNOTHERAPY; MAJOR HISTOCOMPATIBILITY COMPLEX; T-LYMPHOCYTES;

EID: 0035347549     PISSN: 00272507     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973; 137:1142-1162.
2. Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J Exp Med 1974; 139:380-397.
3. Inaba K, Nakano K, Muramatsu S. Cellular synergy in the manifestation of accessory cell activity for in vitro antibody response. J Immunol 1981; 127:453-461.
4. Inaba K, Steinman RM, Van Voorhis WC, Muramatsu S. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and man. Proc Natl Acad Sci U SA 1983; 80:6041-6045.
5. Inaba K, Steinman RM. Protein-specific helper T lymphocyte formation initiated by dendritic cells. Science 1985; 229:475-479.
6. Steinman RM, Witmer MD. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci U S A 1978; 75:5132-5136.
7. Steinman RM, Gutchinov B, Witmer MD, Nussenzweig MC. Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med 1983; 157:613-627.
8. Klinkert WEF, Labadie JH, O'Brien JP, et al. Rat dendritic cells function as accessory cells and control the production of a soluble factor required for mitogen responses of T lymphocytes. Proc Natl Acad Sci USA 1978; 77:5414-5418.
9. Romani N, Inaba K, Pure E, et al. A small number of anti-CD3 molecules on dendritic cells stimulate DNA synthesis in mouse T lymphocytes. J Exp Med 1989; 169:1153-1168.
10. Britz JS, Askenase PW, Ptak W, et al. Specialized antigen-presenting cells: Splenic dendritic cells, and peritoneal exudate cells induced by mycobacteria, activate effector T-cells that are resistant to suppression. J Exp Med 1982; 155:1344-1356.
11. Nussenzweig MC, Steinman RM, Gutchinov B, Cohn ZA. Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. J Exp Med 1980; 152:1070-1084.
12. Geijtenbeek TBH, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-585.
13. Inaba K, Witmer-Pack M, Inaba M, et al. The tissue distribution of the B7-2 costimulator in mice: Abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med 1994; 180:1849-1860.
14. Turley SJ, Inaba K, Garrett WS, et al. Transport of peptide-MHC class II complexes in developing dendritic cells. Science 2000; 288:522-527.
15. Ingulli E, Mondino A, Khoruts A, Jenkins MK. In vivo detection of dendritic cell antigen presentation to CD4+ T-cells. J Exp Med 1997; 185:2133-2141.
16. Matsuno K, Ezaki T, Kudo S, Uehara Y. A life stage of particle-laden rat dendritic cells in vivo: Their terminal division, active phagocytosis and translocation from the liver to hepatic lymph. J Exp Med 1996; 183:1865-1878.
17. Inaba K, Steinman RM. Resting and sensitized T lymphocytes exhibit distinct stimulatory [antigen-presenting cell] requirements for growth and lymphokine release. J Exp Med 1984; 160:1717-1735.
18. Inaba K, Metlay JP, Crowley MT, Steinman RM. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T-cells in situ. J Exp Med 1990; 172:631-640.
19. Ludewig B, Ehl S, Karrer U, et al. Dendritic cells efficiently induce protective antiviral immunity. J Virol 1998; 272:3812-3818.
20. Mayordomo JI, Zorina T, Storkus WJ, et al. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nature Med 1995; 1:1297-1302.
21. Ludewig B, Odermatt B, Landmann S, et al. Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J Exp Med 1998; 188:1493-1501.
22. Schuler G, Steinman RM. Dendritic cells as adjuvants for immune-mediated resistance to tumors. J Exp Med 1997; 186:1183-1187.
23. Dhodapkar MV, Bhardwaj N. Active immunization of humans with dendritic cells. J Clin Immunol 2000; 20:167-174.
24. Inaba K, Inaba M, Romani N, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176:1693-1702.
25. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 1992; 360:258-261.
26. Bender A, Sapp M, Schuler G, et al. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Meth 1996; 196:121-135.
27. Romani N, Reider D, Heuer M, et al. Generation of mature dendritic cells from human blood: An improved method with special regard to clinical applicability. J Immunol Meth 1996; 196:137-151.
28. Thurner B, Haendle I, Röder C, et al. Vaccination with Mage3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T-cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med 1999; 190:1669-1678.
29. Dhodapkar M, Steinman RM, Sapp M, et al. Rapid generation of broad T-cell immunity in humans after single injection of mature dendritic cells. J Clin Invest 1999; 104:173-180.
30. Banchereau J, Palucka AK, Dhodapkar M, et al. Immunological and clinical responses to CD34+ hematopoietic progenitor-derived DC in patients with stage IV melanoma. Submitted for publication.
31. Inaba K, Turley S, Iyoda T, et al. The formation of immunogenic MHC class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J Exp Med 2000; 191:927-936.
32. Dhodapkar MV, Steinman RM, Krasovsky J, et al. Antigen specific inhibition of effector T-cell function in humans after injection of immature dendritic cells. J Exp Med 2001; 193:233-238.
33. Josien R, Hi H-L, Ingulli E, et al. TRANCE, a tumor necrosis family member, enhances the longevity and adjuvant properties of dendritic cells in vivo. J Exp Med 2000; 191:495-501.
34. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate antigen in the major histocompatibility class II compartment. Downregulation by cytokines and bacterial products. J Exp Med 1995; 182:389-400.
35. Inaba K, Inaba M, Naito M, Steinman RM. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med 1993; 178:479-488.
36. 5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med 1998; 188:1359-1368.
37. Inaba K, Turley S, Yamaide F, et al. Efficient presentation of phagocytosed cellular fragments on the MHC class II products of dendritic cells. J Exp Med 1998; 188:2163-2173.
38. Mahnke K, Guo M, Lee S, et al. The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via MHCII+, lysosomal compartments. J Cell Biol 2000; 151:673-683.
39. Albert ML, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998; 392:86-89.
40. Regnault A, Lankar D, Lacabanne V, et al. Fcγ receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med 1999; 189:371-380.
41. Rodriguez A, Regnault A, Kleijmeer M, et al. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells. Nature Cell Biol 1999; 1:362-368.
42. Munz C, Bickham KL, Subklewe M, et al. Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1. J Exp Med 2000; 191:1649-1660.
43. Subklewe M, Paludan C, Tsang ML, et al. Dendritic cells cross-present latency gene products from Epstein Barr virus transformed B cells and expand tumor-reactive CD8+ killer T-cells. J Exp Med 2001; 193:405-412.
44. Berard F, Blanco P, Davoust J, et al. Priming of naive CD8 T-cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. J Exp Med 2000; 192:1535-1544.
45. Pierre P, Mellman I. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. Cell 1998; 93:1135-1145.