Repetitive injections of dendritic cells matured with tumor necrosis factor α induce antigen-specific protection of mice from autoimmunity

Journal of Experimental Medicine

Volumn 195, Issue 1, 2002, Pages 15-21

  Menges, Mauritius ^a   Rößner, Susanne ^a   Voigtländer, Constanze ^a   Schindler, Heike ^a   Kukutsch, Nicole A ^a   Bogdan, Christian ^a   Erb, Klaus ^b   Schuler, Gerold ^a   Lutz, Manfred B ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Dendritic cells; EAE; IL 10; TNF; Tolerance

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; AUTOIMMUNITY; DENDRITIC CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNE TOLERANCE; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MYELIN-ASSOCIATED GLYCOPROTEIN; PEPTIDE FRAGMENTS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037033427     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011341     Document Type: Article

References (37)

1. Dendritic cells and the control of immunity
2. Dendritic cell regulation of TH1-TH2 development
3. Transcriptional reprogramming of dendritic cells by differentiation stimuli
4. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation
5. Distribution of HLA class II molecules in epidermal Langerhans cells in situ
6. The tissue distribution of the B7-2 co-stimulator in mice: Abundant expression on dendritic cells in situ and during maturation in vitro
7. Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro
8. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation-resistant and prolong allograft survival in vivo
9. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
10. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
11. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation
12. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells
13. Regulatory activity of autocrine IL-10 on dendritic cell functions
14. Adherent dendritic cells expressing high levels of interleukin-10 and low levels of interleukin-12 induce antigen-specific tolerance to experimental autoimmune encephalomyelitis
15. Coupling of peripheral tolerance to endogenous interleukin 10 promotes effective modulation of myelin-activated T cells and ameliorates experimental allergic encephalomyelitis
16. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
17. Interleukin-10-deficient mice develop chronic enterocolitis
18. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
19. Induction of tolerance by IL-10-treated dendritic cells
20. Dendritic cell subtypes in mouse lymphoid organs: Cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes
21. Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes
22. Induction of hapten-specific tolerance by interleukin 10 in vivo
23. Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients
24. CTLA-4 regulates induction of anergy in vivo
25. + immunoregulatory T cells that control autoimmune diabetes
26. Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: Implications for pathogenesis and therapy of autoimmune demyelination
27. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation
28. Regulatory T cells in the control of immune pathology
29. + cells with regulatory properties from human blood
30. Melanosomes in phagocytic vacuoles in Langerhans cells
31. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
32. Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes
33. The induction of tolerance by dendritic cells that have captured apoptotic cells
34. Dendritic cells induce peripheral t cell unresponsiveness under steady state conditions in vivo
35. Migration of Langerhans cells and dermal dendritic cells in skin organ cultures: Augmentation by TNF-alpha and IL-1beta
36. Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells
37. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs