Reorganization of multivesicular bodies regulates MHC class II 11 antigen presentation by dendritic cells

Journal of Cell Biology

Volumn 155, Issue 1, 2001, Pages 53-63

  Kleijmeer, Monique ^a   Ramm, Georg ^a   Schuurhuis, Danita ^b   Griffith, Janice ^a   Rescigno, Maria ^c   Ricciardi Castagnoli, Paola ^c   Rudensky, Alexander Y ^d   Ossendorp, Ferry ^d   Melief, Cornelis J M ^d   Stoorvogel, Willem ^a   Geuze, Hans J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presentation; Dendritic cells; Endosomes; Lysosomes; Major histocompatibility complex

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; CELL MEMBRANE; CELL ORGANELLE; CELL VACUOLE; DENDRITIC CELL; ENDOSOME; INTRACELLULAR TRANSPORT; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM;

ANIMALS; ANTIGEN PRESENTATION; CELLS, CULTURED; DENDRITIC CELLS; ENDOCYTOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS II; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PROTEIN TRANSPORT; TRANSPORT VESICLES; UP-REGULATION;

ANIMALIA;

EID: 0035494424     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200103071     Document Type: Article

References (67)

1. Nonclassical MHC class II molecules
2. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes
3. Dendritic cells and the control of immunity
4. Selective modulation of the major histocompatibility complex class II antigen presentation pathway following B cell receptor ligation and protein kinase C activation
5. Actin microfilaments control the MHC class II antigen presentation pathway in B cells
6. Etudeau microscope electronique de corpuscules d'aspect virusal dans les epithelions mammaires de la souris
7. A shared alloantigenic determinant on la antigens encoded by the 1-A and 1-E subregions: Evidence for 1 region gene duplication
8. Role for intracellular proteases in the processing and transport of class II HLA antigens
9. Invariant chain structure and MHC class II function
10. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes
11. Exosome: From internal vesicle of the multivesicular body to intercellular signalling device
12. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
13. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells
14. A study of complexes of class II invariant chain peptide: Major histocompatibility complex class II molecules using a new complex-specific monoclonal antibody
15. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
16. Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity
17. MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
18. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding
19. The role ofendosomes and lysosomes in MHC class lI functioning
20. Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins
21. Dendritic cells: Unique leukocyte populations which control the primary immune response
22. Vesicle fusion and formation at the surface of pinocytic vacuoles in macrophages
23. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
24. Peptide exchange in MHC molecules
25. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
26. Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments
27. Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo
28. The impact of the nonclassical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules
29. The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif
30. Antigen processing for amateurs and professionals
31. A novel MHC class II epitope expressed in thymic medulla but not cortex
32. Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells
33. Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body
34. Studies on the endoplasmic reticulum. II. Simple dispositions in cells in situ
35. The fine structure of neurons
36. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
37. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments
38. Major histocompatibillty complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes
39. Developmental regulation ofinvariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
40. Developmental regulation of MHC class II transport in mouse dendritic cells
41. Localization and intracellular transport of MHC class II molecules in bone marrow-derived dendritic cells
42. Invariant chain controls H2-M proreolysis in mouse splenocytes and dendritic cells
43. Functional early endosomes are required for maturation of major histocompatibility complex class II molecules in human B lymphoblastoid cells
44. Clathrin-coated lattices and buds on MHC class II compartments do not selectively recruit mature MHC-II
45. B lymphocytes secrete antigen-presenting vesicles
46. Immunogold labeling of uttrathin cryosections: Application in immunology
47. Fc-gamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization
48. Sequential processing of epidermal growth factor in early and late endosomes of rat liver
49. Dendritic cell maturation is required for initiation of the immune response
50. Bacteria-induced neo-biosynthe sis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells
51. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading
52. Rapid-freezing cytochemistry: Preservation of tubular lysosomes and enzyme activity
53. Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules
54. Sequence analysis of peptides bound to MHC class II molecules
55. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
56. An electron microscope study of the rat ovum
57. A novel class of clathrincoated vesicles budding from endosomes
58. Tubular lysosome morphology and distribution within macrophages depend on the integrity of cytoplasmic microtubules
59. Chemokine up-regulation and activated T cell attraction by maturing dendritic cells
60. MHC class II transport from lysosomal compartments to the cell surface is determined by stable peptide binding, but not by the cytosolic domains of the alpha- and beta-chains
61. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73
62. Transport of peptide-MHC class II complexes in developing dendritic cells
63. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM
64. Capture and processing of exogenous antigens for presentation on MHC molecules
65. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures
66. The fine structure of the renal glomerulus of the mouse