Human dendritic cells very efficiently present a heterologous antigen expressed on the surface of recombinant gram-positive bacteria to CD4+ T lymphocytes

Journal of Immunology

Volumn 163, Issue 6, 1999, Pages 3029-3036

  Corinti, Silvia ^a   Medaglini, Donata ^b   Cavani, Andrea ^a   Rescigno, Maria ^c   Pozzi, Gianni ^b   Ricciardi Castagnoli, Paola ^c   Girolomoni, Giampiero ^a  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; RANTES; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; BACTERIAL MEMBRANE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; NORMAL HUMAN; PRIORITY JOURNAL; STREPTOCOCCUS GORDONII; T LYMPHOCYTE;

ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CHEMOKINES; CLONE CELLS; CYTOKINES; DENDRITIC CELLS; ENDOCYTOSIS; EPITOPES, T-LYMPHOCYTE; HUMANS; PEPTIDE FRAGMENTS; PHAGOCYTOSIS; RECOMBINANT FUSION PROTEINS; STREPTOCOCCUS; TETANUS TOXIN;

EID: 0033568009     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.
2. Young, J. W., and K. Inaba. 1996. Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity. J. Exp. Med. 183:7.
3. Girolomoni, G., and P. Ricciardi-Castagnoli. 1997, Dendritic cells hold promise for immunotherapy. Immunol. Today 18:102.
4. Hsu, F. J., C. Benike, F. Fagnoni, T. M. Liles, D. Czerwinski, B. Taidi, E. G. Engleman, and R. Levy. 1996. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat. Med. 2:52.
5. Nestle, F. O., S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf. 1998. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat. Med. 4:328.
6. Schuler, G., and R. M. Steinman. 1997. Dendritic cells as adjuvants for immunemediated resistance to tumors. J. Exp. Med. 186:1183.
7. Enk, A. H., H. Jonuleit, J. Saloga, and J. Knop. 1997. Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma. Int. J. Cancer 73:309.
8. Winzler, C., P. Rovere, M. Rescigno, F. Granucci, G. Penna, L. Adorini, V. S. Zimmermann, J. Davoust, and P. Ricciardi-Castagnoli. 1997. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J. Exp. Med. 185:317.
9. Henderson, R. A., S. C. Watkins, and J. L. Flynn. 1997. Activation of human dendritic cells following infection with Mycobacterium tuberculosis. J. Immunol. 159:535.
10. Rescigno, M., S. Citterio, C. Thèry, M. Rittig, D. Medaglini, G. Pozzi, S. Amigorena, and P. Ricciardi-Castagnoli. 1998. Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells. Proc. Natl. Acad. Sci. USA 95:5229.
11. Jakob, T., P. S. Walker, A. M. Krieg, M. C. Udey, and J. C. Vogel. 1998. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J. Immunol. 161:3042.
12. Häcker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G. B. Lipford, and H. Wagner. 1998. CpG-DNA specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17:6230.
13. Verjans, G. M. G. M., R. Janssen, F. G. C. M. UytdeHaag, C. E. M. van Doornik, and J. Tommassen. 1995. Intracellular processing and presentation of T cell epitopes, expressed by recombinant Escherichia coli and Salmonella typhimurium, to human T cells. Eur. J. Immunol. 25:405.
14. Pozzi, G., M. R. Oggioni, and D. Medaglini. 1997. Recombinant Streptococcus gordonii as a live vehicle for vaccine antigens. In Gram-Positive Bacteria as Vaccine Vehicles for Mucosal Immunization. G. Pozzi and J. M. Wells, eds. Landes Biosciences, Austin, TX, p. 35.
15. Rüssmann, H., H. Shams, F. Poblete, Y. Fu, J. E. Galán, and R. O. Donis. 1998. Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science 281:565.
16. Sizemore, D., A. Branstrom, and J. Sadoff. 1997. Attenuated bacteria as DNA delivery vehicle for DNA-mediated immunization. Vaccine 15:804.
17. Darij, A., C. A. Guzmán, B. Gerstel, P. Wachholz, K. N. Timmis, J. Wehland, T. Chakraborty, and S. Weiss. 1997. Oral somatic transgene vaccination using attenuated S. typhimurium. Cell 91:765.
18. Dietrich, G., A. Bubert, I. Gentschev, Z. Sokolovic, A. Simm, A. Catic, S. H. E. Kaufmann, J. Hess, A. A. Szalay, and W. Goebel. 1998. Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes. Nat. Biotech. 16:181.
19. Paglia, P., E. Medina, I. Arioli, C. A. Guzmán, and M. P. Colombo. 1998. Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a marine fibrosarcoma. Blood 92:3172.
20. Oggioni, M. R., R. Manganelli, M. Contorni, M. Tommasino, and G. Pozzi. 1995. Immunisation of mice by oral colonisation with live recombinant commensal streptococci. Vaccine 13:775.
21. Medaglini, D., G. Pozzi, T. P. King, and V. A. Fischetti. 1995. Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization. Proc. Natl. Acad. Sci. USA 92:6868.
22. Oggioni, M. R., D. Medaglini, L. Romano, F. Peruzzi, T. Maggi, L. Lozzi, L. Bracci, M. Zazzi, F. Manca, P. E. Valensin, and G. Pozzi. 1999. Antigenicity and immunogenicity of the V3 domain of HIV type 1 glycoprotein 120 expressed on the surface of Streptococcus gordonii. AIDS Res. Hum. Retroviruses 15:451.
23. Di Fabio, S., D. Medaglini, C. M. Rush, F. Corrias, G. L. Panzini, M. Pace, P. Verani, G. Pozzi, and F. Titti. 1998. Vaginal immunization of Cynomolgus monkeys with Streptococcus gordonii expressing HIV-1 and HPV-6 antigens. Vaccine 16:485.
24. Oggioni, M. R., and G. Pozzi. 1996. A host-vector system for heterologous gene expression in Streptococcus gordonii. Gene 169:85.
25. Pozzi, G., M. Contorni, M. R. Oggioni, R. Manganelli, M. Tommasino, F. Cavalieri, and V. A. Fischetti. 1992. Delivery and expression of a heterelogous antigen on the surface of streptococci. Infect. Immun. 60:1902.
26. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179:1109.
27. Reis e Sousa, C., P. D. Stahl, and J. M. Austin. 1993. Phagocytosis of antigens by Langerhans cells in vitro. J. Exp. Med. 178:509.
28. Sallusto, F., M. Cella, C. Danieli, and A. Lanzavecchia. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182:389.
29. Corinti, S., E. Fanales-Belasio, C. Albanesi, A. Cavani, P. Angelisova, and G. Girolomoni. 1999. Crosslinking of membrane CD43 mediates dendritic cell maturation. J. Immunol. 162:6331.
30. De Saint-Vis, B., I. Figier-Vivier, C. Massacrier, C. Gaillard, B. Vanbervliet, S. Aït-Yahia, J. Banchereau, Y.-J. Liu, S. Lebecque, and C. Caux. 1998. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J. Immunol. 160:1666.
31. Filigueira, L., F. O. Nestle, M. Rittig, H. I. Joller, and P. Groscurth. 1996. Human dendritic cells phagocytose and process Borrelia burgdorferi. J. Immunol. 157: 2998.
32. Ojcius, D. M., Y. Bravo de Alba, J. M. Kanellopoulos, R. A. Hawkins, K. A. Kelly, R. G. Rank, and A. Dautry-Varsat. 1998. Internalization of Chlamydia by dendritic cells and stimulation of Chlamidia-specific T cells. J. Immunol. 160:1297.
33. Blank, C., H. Fuchs, K. Rappersberger, M. Röllinghoff, and H. Moll. 1993. Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major. J. Infect. Dis. 167:418.
34. Albert, M. L., B. Sauter, and N. Bhardwaj. 1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86.
35. Svensson, M., B. Stockinger, and M. J. Wick. 1997. Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells. J. Immunol. 158:1997.
36. Inaba, K., S. Turley, F. Yamaide, T. Yyoda, K. Mahnke, M. Inaba, M. Pack, M. Subklewe, B. Sauter, D. Sheff, M. Albert, N. Bhardwaj, I. Mellman, and R. M. Steinman. 1998. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J. Exp. Med. 188:2163.
37. Thurnher, M., R. Ramoner, G. Gastl, C. Radmayr, G. Böck, M. Herold, H. Klocker, and G. Bartsch. 1997. Bacillus Calmette-Guérin mycobacteria stimulate human blood dendritic cells. Int. J. Cancer 70:128.
38. Pierre, P., S. J. Turley, E. Gatti, M. Hull, J. Meltzer, A. Mirza, K. Inaba, R. M. Steinman, and I. Mellman. 1997. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 388:787.
39. Cella, M., A. Engering, V. Pinet, J. Pieters, and A. Lanzavecchia. 1997. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388:782.
40. Foti, M., F. Granucci, D. Aggujaro, W. Luini, S. Minardi, A. Mantovani, S. Sozzani, and P. Ricciardi-Castagnoli. 1999. Upon dendritic cell activation chemokines and chemokine receptors expression are rapidly regulated for recruitment and maintenance of dendritic cells at the inflammatory site. Int. Immunol. 6:979.
41. Sallusto, F., P. Schaerli, P. Loetscher, C. Schaniel, D. Lenig, C. R. Mackay, S. Qin, and A. Lanzavecchia. 1998. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 28:2760.
42. Bonecchi, R., G. Bianchi, P. Panina-Bordignon, D. D'Ambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P. A. Gray, A. Mantovani, and F. Sinigaglia. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 187:129.
43. Sallusto, F., D. Lenig, C. R. Mackay, and A. Lanzavecchia. 1998. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187:875.
44. Gangur, V., F. E. R. Simons, and K. T. Hayglass. 1998. Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-γ over IL-4 responses. FASEB J. 12:705.
45. Hadida, F., V. Vieillard, B. Autran, I. Clark-Lewis, M. Baggiolini, and P. Debré. 1998. HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3. J. Exp. Med. 188:609.
46. Lauber, M. S., B. Roberts, B. Pers, A. Mehling, T. A. Luger, T. Schwarz, and S. Grabbe. 1999. Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage. J. Immunol. 162:168.
47. Ishida, T., T. Oyama, D. P. Carbone, and D. I. Gabrilovich. 1998. Defective function of Langerhans cells in tumor-bearing animals is the result of defective maturation from hemopoietic progenitors. J. Immunol. 161:4842.
48. + progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor. Blood 92:4778.
49. Sozzani, S., P. Allavena, A. Vecchi, and A. Mantovani. 1999. The role of chemokines in the regulation of dendritic cell trafficking. J. Leuokocyte Biol. 66:1.
50. Ludewig, B., B. Odermatt, S. Landmann, H. Hengartner, and R. M. Zinkernagel. 1998. Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J. Exp. Med. 188:1493.