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Volumn 81, Issue 2, 2004, Pages 223-241

Leptin signaling

Author keywords

Feeding; Hypothalamus; Leptin; Neuropeptide; Obesity

Indexed keywords

4 AMINOBUTYRIC ACID; AGOUTI RELATED PROTEIN; GALANIN; GHRELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; LEPTIN; LEPTIN RECEPTOR; MELANIN CONCENTRATING HORMONE; MELATONIN; NEUROPEPTIDE Y; OPIATE PEPTIDE; OREXIN; PROLACTIN; THYROID HORMONE;

EID: 2442670123     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2004.02.014     Document Type: Article
Times cited : (347)

References (220)
  • 2
    • 0033303819 scopus 로고    scopus 로고
    • Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia
    • Ahima R.S., Kelly J., Elmquist J.K., Flier J.S. Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology. 140:1999;4923-4931
    • (1999) Endocrinology , vol.140 , pp. 4923-4931
    • Ahima, R.S.1    Kelly, J.2    Elmquist, J.K.3    Flier, J.S.4
  • 3
    • 0032032575 scopus 로고    scopus 로고
    • Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function
    • Ahima R.S., Prabakaran D., Flier J.S. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J. Clin. Invest. 101:1998;1020-1027
    • (1998) J. Clin. Invest. , vol.101 , pp. 1020-1027
    • Ahima, R.S.1    Prabakaran, D.2    Flier, J.S.3
  • 6
    • 84964125510 scopus 로고
    • Localization of a "feeding center" in the hypothalamus of the rat
    • Anand B.K., Brobeck J.R. Localization of a "feeding center" in the hypothalamus of the rat. Proc. Soc. Exp. Biol. Med. 77:1951;323-324
    • (1951) Proc. Soc. Exp. Biol. Med. , vol.77 , pp. 323-324
    • Anand, B.K.1    Brobeck, J.R.2
  • 8
    • 0036219070 scopus 로고    scopus 로고
    • Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
    • Bahrenberg G., Behrmann I., Barthel A., Hekerman P., Heinrich P.C., Joost H.G., et al. Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Mol. Endocrinol. 16:2002;859-872
    • (2002) Mol. Endocrinol. , vol.16 , pp. 859-872
    • Bahrenberg, G.1    Behrmann, I.2    Barthel, A.3    Hekerman, P.4    Heinrich, P.C.5    Joost, H.G.6
  • 9
    • 0032763709 scopus 로고    scopus 로고
    • Impaired transport of leptin across the blood-brain barrier in obesity
    • Banks W.A., DiPalma C.R., Farrell C.L. Impaired transport of leptin across the blood-brain barrier in obesity. Peptides. 20:1999;1341-1345
    • (1999) Peptides , vol.20 , pp. 1341-1345
    • Banks, W.A.1    Dipalma, C.R.2    Farrell, C.L.3
  • 10
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks W.A., Kastin A.J., Huang W., Jaspan J.B., Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides. 17:1996;305-311
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 13
    • 0030928781 scopus 로고    scopus 로고
    • Insulin stimulates both leptin secretion and production by rat white adipose tissue
    • Barr V.A., Malide D., Zarnowski M.J., Taylor S.I., Cushman S.W. Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology. 138:1997;4463-4472
    • (1997) Endocrinology , vol.138 , pp. 4463-4472
    • Barr, V.A.1    Malide, D.2    Zarnowski, M.J.3    Taylor, S.I.4    Cushman, S.W.5
  • 14
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W., Wang Y., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature. 421:2003;856-859
    • (2003) Nature , vol.421 , pp. 856-859
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3    Schubert, M.4    Tso, A.W.5    Wang, Y.6
  • 15
    • 0033401863 scopus 로고    scopus 로고
    • Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus
    • Bergen H.T., Mizuno T., Taylor J., Mobbs C.V. Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus. Brain Res. 85:1999;198-203
    • (1999) Brain Res. , vol.85 , pp. 198-203
    • Bergen, H.T.1    Mizuno, T.2    Taylor, J.3    Mobbs, C.V.4
  • 17
    • 0033569730 scopus 로고    scopus 로고
    • The role of SOCS-3 in leptin signaling and leptin resistance
    • Bjorbaek C., El-Haschimi K., Frantz J.D., Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J. Biol. Chem. 274:1999;30059-30065
    • (1999) J. Biol. Chem. , vol.274 , pp. 30059-30065
    • Bjorbaek, C.1    El-Haschimi, K.2    Frantz, J.D.3    Flier, J.S.4
  • 18
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell. 1:1998;619-625
    • (1998) Mol. Cell. , vol.1 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 20
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjorbaek C., Uotani S., da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272:1997;32686-32695
    • (1997) J. Biol. Chem. , vol.272 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    Da Silva, B.3    Flier, J.S.4
  • 22
    • 0031769566 scopus 로고    scopus 로고
    • Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion
    • Bornstein S.R., Licinio J., Tauchnitz R., Engelmann L., Negrao A.B., Gold P., et al. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion. J. Clin. Endocrinol. Metab. 83:1998;280-283
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 280-283
    • Bornstein, S.R.1    Licinio, J.2    Tauchnitz, R.3    Engelmann, L.4    Negrao, A.B.5    Gold, P.6
  • 23
    • 0030919919 scopus 로고    scopus 로고
    • Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: Leptin inhibits cortisol release directly
    • Bornstein S.R., Uhlmann K., Haidan A., Ehrhart-Bornstein M., Scherbaum W.A. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly. Diabetes. 46:1997;1235-1238
    • (1997) Diabetes , vol.46 , pp. 1235-1238
    • Bornstein, S.R.1    Uhlmann, K.2    Haidan, A.3    Ehrhart-Bornstein, M.4    Scherbaum, W.A.5
  • 24
    • 0032576536 scopus 로고    scopus 로고
    • Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems
    • Broberger C., De Lecea L., Sutcliffe J.G., Hokfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol. 402:1998;460-474
    • (1998) J. Comp. Neurol. , vol.402 , pp. 460-474
    • Broberger, C.1    De Lecea, L.2    Sutcliffe, J.G.3    Hokfelt, T.4
  • 25
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 26
    • 0035964727 scopus 로고    scopus 로고
    • Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat
    • Canpolat S., Sandal S., Yilmaz B., Yasar A., Kutlu S., Baydas G., et al. Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat. Eur. J. Pharmacol. 428:2001;145-148
    • (2001) Eur. J. Pharmacol. , vol.428 , pp. 145-148
    • Canpolat, S.1    Sandal, S.2    Yilmaz, B.3    Yasar, A.4    Kutlu, S.5    Baydas, G.6
  • 27
    • 0030594830 scopus 로고    scopus 로고
    • Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
    • Caro J.F., Kolaczynski J.W., Nyce M.R., Ohannesian J.P., Opentanova I., Goldman W.H., et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 348:1996;159-161
    • (1996) Lancet , vol.348 , pp. 159-161
    • Caro, J.F.1    Kolaczynski, J.W.2    Nyce, M.R.3    Ohannesian, J.P.4    Opentanova, I.5    Goldman, W.H.6
  • 29
    • 0030727778 scopus 로고    scopus 로고
    • Influence of endogenous leptin tone on the estrous cycle and luteinizing hormone pulsatility in female rats
    • Carro E., Pinilla L., Seoane L.M., Considine R.V., Aguilar E., Casanueva F.F., et al. Influence of endogenous leptin tone on the estrous cycle and luteinizing hormone pulsatility in female rats. Neuroendocrinology. 66:1997;375-377
    • (1997) Neuroendocrinology , vol.66 , pp. 375-377
    • Carro, E.1    Pinilla, L.2    Seoane, L.M.3    Considine, R.V.4    Aguilar, E.5    Casanueva, F.F.6
  • 32
    • 0031763786 scopus 로고    scopus 로고
    • Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: Dexamethasone and estradiol stimulate leptin release in women, but not in men
    • Casabiell X., Pineiro V., Peino R., Lage M., Camina J., Gallego R., et al. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. J. Clin. Endocrinol. Metab. 83:1998;2149-2155
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2149-2155
    • Casabiell, X.1    Pineiro, V.2    Peino, R.3    Lage, M.4    Camina, J.5    Gallego, R.6
  • 33
    • 0031666525 scopus 로고    scopus 로고
    • Serum leptin concentration in women: Effect of age, obesity, and estrogen administration
    • Castracane V.D., Kraemer R.R., Franken M.A., Kraemer G.R., Gimpel T. Serum leptin concentration in women: effect of age, obesity, and estrogen administration. Fertil. Steril. 70:1998;472-477
    • (1998) Fertil. Steril. , vol.70 , pp. 472-477
    • Castracane, V.D.1    Kraemer, R.R.2    Franken, M.A.3    Kraemer, G.R.4    Gimpel, T.5
  • 34
    • 0037651108 scopus 로고    scopus 로고
    • The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
    • Chan J.L., Heist K., DePaoli A.M., Veldhuis J.D., Mantzoros C.S. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J. Clin. Invest. 111:2003;1409-1421
    • (2003) J. Clin. Invest. , vol.111 , pp. 1409-1421
    • Chan, J.L.1    Heist, K.2    Depaoli, A.M.3    Veldhuis, J.D.4    Mantzoros, C.S.5
  • 35
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab F.F., Lim M.E., Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12:1996;318-320
    • (1996) Nat. Genet. , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 36
    • 0031014413 scopus 로고    scopus 로고
    • Early onset of reproductive function in normal female mice treated with leptin
    • Chehab F.F., Mounzih K., Lu R., Lim M.E. Early onset of reproductive function in normal female mice treated with leptin. Science. 275:1997;88-90
    • (1997) Science , vol.275 , pp. 88-90
    • Chehab, F.F.1    Mounzih, K.2    Lu, R.3    Lim, M.E.4
  • 37
    • 0036833472 scopus 로고    scopus 로고
    • Clinical review 153: Lipodystrophy in human immunodeficiency virus-infected patients
    • Chen D., Misra A., Garg A. Clinical review 153: lipodystrophy in human immunodeficiency virus-infected patients. J. Clin. Endocrinol. Metab. 87:2002;4845-4856
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 4845-4856
    • Chen, D.1    Misra, A.2    Garg, A.3
  • 38
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:1996;491-495
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5    Ellis, S.J.6
  • 40
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • Chua S.C. Jr., Chung W.K., Wu-Peng X.S., Zhang Y., Liu S.M., Tartaglia L., et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 271:1996;994-996
    • (1996) Science , vol.271 , pp. 994-996
    • Chua Jr., S.C.1    Chung, W.K.2    Wu-Peng, X.S.3    Zhang, Y.4    Liu, S.M.5    Tartaglia, L.6
  • 41
    • 0031980203 scopus 로고    scopus 로고
    • Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice
    • Chung W.K., Belfi K., Chua M., Wiley J., Mackintosh R., Nicolson M., et al. Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice. Am. J. Physiol. 274:1998;R985-R990
    • (1998) Am. J. Physiol. , vol.274
    • Chung, W.K.1    Belfi, K.2    Chua, M.3    Wiley, J.4    MacKintosh, R.5    Nicolson, M.6
  • 42
    • 0344450708 scopus 로고    scopus 로고
    • A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    • Clement K., Vaisse C., Lahlou N., Cabrol S., Pelloux V., Cassuto D., et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 392:1998;398-401
    • (1998) Nature , vol.392 , pp. 398-401
    • Clement, K.1    Vaisse, C.2    Lahlou, N.3    Cabrol, S.4    Pelloux, V.5    Cassuto, D.6
  • 44
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman D.L. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 9:1973;294-298
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 45
    • 0018139377 scopus 로고
    • Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
    • Coleman D.L. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia. 14:1978;141-148
    • (1978) Diabetologia , vol.14 , pp. 141-148
    • Coleman, D.L.1
  • 46
    • 0036724616 scopus 로고    scopus 로고
    • Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy
    • Colombo C., Cutson J.J., Yamauchi T., Vinson C., Kadowaki T., Gavrilova O., et al. Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. Diabetes. 51(9):Sep. 2002;2727-2733
    • (2002) Diabetes , vol.51 , Issue.9 , pp. 2727-2733
    • Colombo, C.1    Cutson, J.J.2    Yamauchi, T.3    Vinson, C.4    Kadowaki, T.5    Gavrilova, O.6
  • 48
    • 0030914157 scopus 로고    scopus 로고
    • Stimulation of corticotrophin-releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants
    • Costa A., Poma A., Martignoni E., Nappi G., Ur E., Grossman A. Stimulation of corticotrophin-releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants. NeuroReport. 8:1997;1131-1134
    • (1997) NeuroReport , vol.8 , pp. 1131-1134
    • Costa, A.1    Poma, A.2    Martignoni, E.3    Nappi, G.4    Ur, E.5    Grossman, A.6
  • 49
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • Cowley M.A., Smart J.L., Rubinstein M., Cerdan M.G., Diano S., Horvath T.L., et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 411:2001;480-484
    • (2001) Nature , vol.411 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6
  • 50
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley M.A., Smith R.G., Diano S., Tschop M., Pronchuk N., Grove K.L., et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 37:2003;649-661
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3    Tschop, M.4    Pronchuk, N.5    Grove, K.L.6
  • 51
    • 0029763177 scopus 로고    scopus 로고
    • The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals
    • Cusin I., Rohner-Jeanrenaud F., Stricker-Krongrad A., Jeanrenaud B. The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes. 45:1996;1446-1450
    • (1996) Diabetes , vol.45 , pp. 1446-1450
    • Cusin, I.1    Rohner-Jeanrenaud, F.2    Stricker-Krongrad, A.3    Jeanrenaud, B.4
  • 52
    • 0031761827 scopus 로고    scopus 로고
    • Functional properties of leptin receptor isoforms containing the gln→pro extracellular domain mutation of the fatty rat
    • [see comments]
    • da Silva B.A., Bjorbaek C., Uotani S., Flier J.S. Functional properties of leptin receptor isoforms containing the gln→pro extracellular domain mutation of the fatty rat. [see comments] Endocrinology. 139:1998;3681-3690
    • (1998) Endocrinology , vol.139 , pp. 3681-3690
    • Da Silva, B.A.1    Bjorbaek, C.2    Uotani, S.3    Flier, J.S.4
  • 54
    • 0030759490 scopus 로고    scopus 로고
    • Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage
    • Dawson R., Pelleymounter M.A., Millard W.J., Liu S., Eppler B. Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage. Am. J. Physiol. 273:1997;E202-E206
    • (1997) Am. J. Physiol. , vol.273
    • Dawson, R.1    Pelleymounter, M.A.2    Millard, W.J.3    Liu, S.4    Eppler, B.5
  • 56
    • 0032424554 scopus 로고    scopus 로고
    • Thyroid hormones modulate serum leptin levels: Observations in thyrotoxic and hypothyroid women
    • Diekman M.J., Romijn J.A., Endert E., Sauerwein H., Wiersinga W.M. Thyroid hormones modulate serum leptin levels: observations in thyrotoxic and hypothyroid women. Thyroid. 8:1998;1081-1086
    • (1998) Thyroid , vol.8 , pp. 1081-1086
    • Diekman, M.J.1    Romijn, J.A.2    Endert, E.3    Sauerwein, H.4    Wiersinga, W.M.5
  • 57
    • 0030735541 scopus 로고    scopus 로고
    • Isoproterenol and somatostatin decrease plasma leptin in humans: A novel mechanism regulating leptin secretion
    • Donahoo W.T., Jensen D.R., Yost T.J., Eckel R.H. Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion. J. Clin. Endocrinol. Metab. 82:1997;4139-4143
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 4139-4143
    • Donahoo, W.T.1    Jensen, D.R.2    Yost, T.J.3    Eckel, R.H.4
  • 58
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
    • Ducy P., Amling M., Takeda S., Priemel M., Schilling A.F., Beil F.T., et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 100:2000;197-207
    • (2000) Cell , vol.100 , pp. 197-207
    • Ducy, P.1    Amling, M.2    Takeda, S.3    Priemel, M.4    Schilling, A.F.5    Beil, F.T.6
  • 59
    • 0034981838 scopus 로고    scopus 로고
    • Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes
    • Ebihara K., Ogawa Y., Masuzaki H., Shintani M., Miyanaga F., Aizawa-Abe M., et al. Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. Diabetes. 50:2001;1440-1448
    • (2001) Diabetes , vol.50 , pp. 1440-1448
    • Ebihara, K.1    Ogawa, Y.2    Masuzaki, H.3    Shintani, M.4    Miyanaga, F.5    Aizawa-Abe, M.6
  • 60
    • 0031846614 scopus 로고    scopus 로고
    • Chronic administration of OB protein decreases food intake by selectively reducing meal size in female rats
    • Eckel L.A., Langhans W., Kahler A., Campfield L.A., Smith F.J., Geary N. Chronic administration of OB protein decreases food intake by selectively reducing meal size in female rats. Am. J. Physiol. 275:1998;R186-R193
    • (1998) Am. J. Physiol. , vol.275
    • Eckel, L.A.1    Langhans, W.2    Kahler, A.3    Campfield, L.A.4    Smith, F.J.5    Geary, N.6
  • 63
    • 0033931981 scopus 로고    scopus 로고
    • Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
    • El-Haschimi K., Pierroz D.D., Hileman S.M., Bjorbaek C., Flier J.S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 105:2000;1827-1832
    • (2000) J. Clin. Invest. , vol.105 , pp. 1827-1832
    • El-Haschimi, K.1    Pierroz, D.D.2    Hileman, S.M.3    Bjorbaek, C.4    Flier, J.S.5
  • 65
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: Hypothalamic control of food intake and body weight
    • Elmquist J.K., Elias C.F., Saper C.B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 22:1999;221-232
    • (1999) Neuron , vol.22 , pp. 221-232
    • Elmquist, J.K.1    Elias, C.F.2    Saper, C.B.3
  • 66
    • 0033001325 scopus 로고    scopus 로고
    • Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues
    • Emilsson V., Arch J.R., de Groot R.P., Lister C.A., Cawthorne M.A. Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues. FEBS Lett. 455:1999;170-174
    • (1999) FEBS Lett. , vol.455 , pp. 170-174
    • Emilsson, V.1    Arch, J.R.2    De Groot, R.P.3    Lister, C.A.4    Cawthorne, M.A.5
  • 67
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • Erickson J.C., Clegg K.E., Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 381:1996;415-421
    • (1996) Nature , vol.381 , pp. 415-421
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 68
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • Erickson J.C., Hollopeter G., Palmiter R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science. 274:1996;1704-1707
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 70
    • 0032931966 scopus 로고    scopus 로고
    • Effect of the genetic background on the reproduction of leptin-deficient obese mice
    • Ewart-Toland A., Mounzih K., Qiu J., Chehab F.F. Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology. 140:1999;732-738
    • (1999) Endocrinology , vol.140 , pp. 732-738
    • Ewart-Toland, A.1    Mounzih, K.2    Qiu, J.3    Chehab, F.F.4
  • 71
    • 0033983466 scopus 로고    scopus 로고
    • Regulation of lipolysis and leptin biosynthesis in rodent adipose tissue by growth hormone
    • Fain J.N., Bahouth S.W. Regulation of lipolysis and leptin biosynthesis in rodent adipose tissue by growth hormone. Metabolism. 49:2000;239-244
    • (2000) Metabolism , vol.49 , pp. 239-244
    • Fain, J.N.1    Bahouth, S.W.2
  • 73
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi I.S., Matarese G., Lord G.M., Keogh J.M., Lawrence E., Agwu C., et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J. Clin. Invest. 110:2002;1093-1103
    • (2002) J. Clin. Invest. , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1    Matarese, G.2    Lord, G.M.3    Keogh, J.M.4    Lawrence, E.5    Agwu, C.6
  • 74
    • 0017734430 scopus 로고
    • Surgical removal of adipose tissue alters feeding behavior and the development of obesity in rats
    • Faust I.M., Johnson P.R., Hirsch J. Surgical removal of adipose tissue alters feeding behavior and the development of obesity in rats. Science. 197:1977;393-396
    • (1977) Science , vol.197 , pp. 393-396
    • Faust, I.M.1    Johnson, P.R.2    Hirsch, J.3
  • 75
    • 0342858793 scopus 로고    scopus 로고
    • Alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
    • Fekete C., Legradi G., Mihaly E., Huang Q.H., Tatro J.B., Rand W.M., et al. alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J. Neurosci. 20:2000;1550-1558
    • (2000) J. Neurosci. , vol.20 , pp. 1550-1558
    • Fekete, C.1    Legradi, G.2    Mihaly, E.3    Huang, Q.H.4    Tatro, J.B.5    Rand, W.M.6
  • 76
    • 0036773547 scopus 로고    scopus 로고
    • Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; Comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis
    • Fekete C., Sarkar S., Rand W.M., Harney J.W., Emerson C.H., Bianco A.C., et al. Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology. 143:2002;3846-3853
    • (2002) Endocrinology , vol.143 , pp. 3846-3853
    • Fekete, C.1    Sarkar, S.2    Rand, W.M.3    Harney, J.W.4    Emerson, C.H.5    Bianco, A.C.6
  • 77
    • 0037385790 scopus 로고    scopus 로고
    • Adiposity signals and food reward: Expanding the CNS roles of insulin and leptin
    • Figlewicz D.P. Adiposity signals and food reward: expanding the CNS roles of insulin and leptin. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284:2003;R882-R892
    • (2003) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.284
    • Figlewicz, D.P.1
  • 78
    • 0031791294 scopus 로고    scopus 로고
    • In vivo and in vitro evidence for the involvement of tumor necrosis factor-alpha in the induction of leptin by lipopolysaccharide
    • Finck B.N., Kelley K.W., Dantzer R., Johnson R.W. In vivo and in vitro evidence for the involvement of tumor necrosis factor-alpha in the induction of leptin by lipopolysaccharide. Endocrinology. 139:1998;2278-2283
    • (1998) Endocrinology , vol.139 , pp. 2278-2283
    • Finck, B.N.1    Kelley, K.W.2    Dantzer, R.3    Johnson, R.W.4
  • 80
    • 0030745227 scopus 로고    scopus 로고
    • Serum leptin is increased in growth hormone-deficient adults: Relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year
    • Fisker S., Vahl N., Hansen T.B., Jorgensen J.O., Hagen C., Orskov H., et al. Serum leptin is increased in growth hormone-deficient adults: relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year. Metabolism. 46:1997;812-817
    • (1997) Metabolism , vol.46 , pp. 812-817
    • Fisker, S.1    Vahl, N.2    Hansen, T.B.3    Jorgensen, J.O.4    Hagen, C.5    Orskov, H.6
  • 81
    • 0032065645 scopus 로고    scopus 로고
    • Clinical review 94: What's in a name? in search of leptin's physiologic role
    • Flier J.S. Clinical review 94: what's in a name? In search of leptin's physiologic role. J. Clin. Endocrinol. Metab. 83:1998;1407-1413
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 1407-1413
    • Flier, J.S.1
  • 83
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich R.C., Hamann A., Anderson S., Lollmann B., Lowell B.B., Flier J.S. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1:1995;1311-1314
    • (1995) Nat. Med. , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3    Lollmann, B.4    Lowell, B.B.5    Flier, J.S.6
  • 84
    • 0034611675 scopus 로고    scopus 로고
    • Obesity in the new millennium
    • Friedman J.M. Obesity in the new millennium. Nature. 404:2000;632-634
    • (2000) Nature , vol.404 , pp. 632-634
    • Friedman, J.M.1
  • 86
    • 0030964490 scopus 로고    scopus 로고
    • Serum leptin levels in normal children: Relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage
    • Garcia-Mayor R.V., Andrade M.A., Rios M., Lage M., Dieguez C., Casanueva F.F. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J. Clin. Endocrinol. Metab. 82:1997;2849-2855
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 2849-2855
    • Garcia-Mayor, R.V.1    Andrade, M.A.2    Rios, M.3    Lage, M.4    Dieguez, C.5    Casanueva, F.F.6
  • 87
    • 0033964872 scopus 로고    scopus 로고
    • Lipodystrophies
    • Garg A. Lipodystrophies. Am. J. Med. 108:2000;143-152
    • (2000) Am. J. Med. , vol.108 , pp. 143-152
    • Garg, A.1
  • 90
    • 0033308714 scopus 로고    scopus 로고
    • Serum leptin response to the acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency
    • Gill M.S., Toogood A.A., Jones J., Clayton P.E., Shalet S.M. Serum leptin response to the acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency. J. Clin. Endocrinol. Metab. 84:1999;1288-1295
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 1288-1295
    • Gill, M.S.1    Toogood, A.A.2    Jones, J.3    Clayton, P.E.4    Shalet, S.M.5
  • 91
    • 0029811162 scopus 로고    scopus 로고
    • Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus
    • Glaum S.R., Hara M., Bindokas V.P., Lee C.C., Polonsky K.S., Bell G.I., et al. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol. Pharmacol. 50:1996;230-235
    • (1996) Mol. Pharmacol. , vol.50 , pp. 230-235
    • Glaum, S.R.1    Hara, M.2    Bindokas, V.P.3    Lee, C.C.4    Polonsky, K.S.5    Bell, G.I.6
  • 92
    • 0031017561 scopus 로고    scopus 로고
    • Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
    • Golden P.L., Maccagnan T.J., Pardridge W.M. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J. Clin. Invest. 99:1997;14-18
    • (1997) J. Clin. Invest. , vol.99 , pp. 14-18
    • Golden, P.L.1    MacCagnan, T.J.2    Pardridge, W.M.3
  • 93
    • 0030032754 scopus 로고    scopus 로고
    • Genomic structure and promoter analysis of the human obese gene
    • Gong D.W., Bi S., Pratley R.E., Weintraub B.D. Genomic structure and promoter analysis of the human obese gene. J. Biol. Chem. 271:1996;3971-3974
    • (1996) J. Biol. Chem. , vol.271 , pp. 3971-3974
    • Gong, D.W.1    Bi, S.2    Pratley, R.E.3    Weintraub, B.D.4
  • 95
    • 0036162117 scopus 로고    scopus 로고
    • The neuroanatomical axis for control of energy balance
    • Grill H.J., Kaplan J.M. The neuroanatomical axis for control of energy balance. Front. Neuroendocrinol. 23:2002;2-40
    • (2002) Front. Neuroendocrinol. , vol.23 , pp. 2-40
    • Grill, H.J.1    Kaplan, J.M.2
  • 96
    • 0031854256 scopus 로고    scopus 로고
    • Chronic administration of leptin into the lateral ventricle induces sexual maturation in severely food-restricted female rats
    • Gruaz N.M., Lalaoui M., Pierroz D.D., Englaro P., Sizonenko P.C., Blum W.F., et al. Chronic administration of leptin into the lateral ventricle induces sexual maturation in severely food-restricted female rats. J. Neuroendocrinol. 10:1998;627-633
    • (1998) J. Neuroendocrinol. , vol.10 , pp. 627-633
    • Gruaz, N.M.1    Lalaoui, M.2    Pierroz, D.D.3    Englaro, P.4    Sizonenko, P.C.5    Blum, W.F.6
  • 97
    • 0031963436 scopus 로고    scopus 로고
    • Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
    • Hakansson M.L., Brown H., Ghilardi N., Skoda R.C., Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 18:1998;559-572
    • (1998) J. Neurosci. , vol.18 , pp. 559-572
    • Hakansson, M.L.1    Brown, H.2    Ghilardi, N.3    Skoda, R.C.4    Meister, B.5
  • 98
    • 0032424694 scopus 로고    scopus 로고
    • Transcription factor STAT3 in leptin target neurons of the rat hypothalamus
    • Hakansson M.L., Meister B. Transcription factor STAT3 in leptin target neurons of the rat hypothalamus. Neuroendocrinology. 68:1998;420-427
    • (1998) Neuroendocrinology , vol.68 , pp. 420-427
    • Hakansson, M.L.1    Meister, B.2
  • 100
    • 0035172040 scopus 로고    scopus 로고
    • Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling
    • Harris M., Aschkenasi C., Elias C.F., Chandrankunnel A., Nillni E.A., Bjoorbaek C., et al. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J. Clin. Invest. 107:2001;111-120
    • (2001) J. Clin. Invest. , vol.107 , pp. 111-120
    • Harris, M.1    Aschkenasi, C.2    Elias, C.F.3    Chandrankunnel, A.4    Nillni, E.A.5    Bjoorbaek, C.6
  • 101
    • 0025614453 scopus 로고
    • Role of set-point theory in regulation of body weight
    • Harris R.B. Role of set-point theory in regulation of body weight. FASEB J. 4:1990;3310-3318
    • (1990) FASEB J. , vol.4 , pp. 3310-3318
    • Harris, R.B.1
  • 102
    • 0022897953 scopus 로고
    • Dynamics of recovery of body composition after overfeeding, food restriction or starvation of mature female rats
    • Harris R.B., Kasser T.R., Martin R.J. Dynamics of recovery of body composition after overfeeding, food restriction or starvation of mature female rats. J. Nutr. 116:1986;2536-2546
    • (1986) J. Nutr. , vol.116 , pp. 2536-2546
    • Harris, R.B.1    Kasser, T.R.2    Martin, R.J.3
  • 103
    • 0029976373 scopus 로고    scopus 로고
    • Early and late stimulation of ob mRNA expression in meal-fed and overfed rats
    • Harris R.B., Ramsay T.G., Smith S.R., Bruch R.C. Early and late stimulation of ob mRNA expression in meal-fed and overfed rats. J. Clin. Invest. 97:1996;2020-2026
    • (1996) J. Clin. Invest. , vol.97 , pp. 2020-2026
    • Harris, R.B.1    Ramsay, T.G.2    Smith, S.R.3    Bruch, R.C.4
  • 105
    • 0028849084 scopus 로고
    • The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha
    • He Y., Chen H., Quon M.J., Reitman M. The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 270:1995;28887-28891
    • (1995) J. Biol. Chem. , vol.270 , pp. 28887-28891
    • He, Y.1    Chen, H.2    Quon, M.J.3    Reitman, M.4
  • 107
    • 70449255388 scopus 로고
    • The effects of lesions in the hypothalamus in parabiotic rats
    • Hervey G.R. The effects of lesions in the hypothalamus in parabiotic rats. J. Physiol. (Lond.). 145:1959;336-352
    • (1959) J. Physiol. (Lond.) , vol.145 , pp. 336-352
    • Hervey, G.R.1
  • 108
    • 84990756135 scopus 로고
    • Hypothalamic lesions and adiposity in the rat
    • Hetherington A.W., Ranson S.W. Hypothalamic lesions and adiposity in the rat. Anat. Rec. 78:1940;149-172
    • (1940) Anat. Rec. , vol.78 , pp. 149-172
    • Hetherington, A.W.1    Ranson, S.W.2
  • 109
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
    • Heymsfield S.B., Greenberg A.S., Fujioka K., Dixon R.M., Kushner R., Hunt T., et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA. 282:1999;1568-1575
    • (1999) JAMA , vol.282 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3    Dixon, R.M.4    Kushner, R.5    Hunt, T.6
  • 112
    • 0033391940 scopus 로고    scopus 로고
    • Physiological roles of the leptin endocrine system: Differences between mice and humans
    • Himms-Hagen J. Physiological roles of the leptin endocrine system: differences between mice and humans. Crit. Rev. Clin. Lab. Sci. 36:1999;575-655
    • (1999) Crit. Rev. Clin. Lab. Sci. , vol.36 , pp. 575-655
    • Himms-Hagen, J.1
  • 113
    • 0029907970 scopus 로고    scopus 로고
    • Evidence for leptin binding to proteins in serum of rodents and humans: Modulation with obesity
    • Houseknecht K.L., Mantzoros C.S., Kuliawat R., Hadro E., Flier J.S., Kahn B.B. Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes. 45:1996;1638-1643
    • (1996) Diabetes , vol.45 , pp. 1638-1643
    • Houseknecht, K.L.1    Mantzoros, C.S.2    Kuliawat, R.3    Hadro, E.4    Flier, J.S.5    Kahn, B.B.6
  • 114
    • 0037086629 scopus 로고    scopus 로고
    • Leptin affects the electrical activity of neurones in the hypothalamic supraoptic nucleus
    • Honda K., Narita K., Murata T., Higuchi T. Leptin affects the electrical activity of neurones in the hypothalamic supraoptic nucleus. Brain Res. Bull. 57:2002;721-725
    • (2002) Brain Res. Bull. , vol.57 , pp. 721-725
    • Honda, K.1    Narita, K.2    Murata, T.3    Higuchi, T.4
  • 115
    • 0034802108 scopus 로고    scopus 로고
    • Minireview: Ghrelin and the regulation of energy balance - A hypothalamic perspective
    • Horvath T.L., Diano S., Sotonyi P., Heiman M., Tschop M. Minireview: ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology. 142:2001;4163-4169
    • (2001) Endocrinology , vol.142 , pp. 4163-4169
    • Horvath, T.L.1    Diano, S.2    Sotonyi, P.3    Heiman, M.4    Tschop, M.5
  • 116
    • 0031791643 scopus 로고    scopus 로고
    • Effects of leptin on corticotropin-releasing factor (CRF) synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese (ob/ob) mice
    • Huang Q., Rivest R., Richard D. Effects of leptin on corticotropin- releasing factor (CRF) synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese (ob/ob) mice. Endocrinology. 139:1998;1524-1532
    • (1998) Endocrinology , vol.139 , pp. 1524-1532
    • Huang, Q.1    Rivest, R.2    Richard, D.3
  • 118
    • 0028863211 scopus 로고
    • Structural organization and chromosomal assignment of the human obese gene
    • Isse N., Ogawa Y., Tamura N., Masuzaki H., Mori K., Okazaki T., et al. Structural organization and chromosomal assignment of the human obese gene. J. Biol. Chem. 270:1995;27728-27733
    • (1995) J. Biol. Chem. , vol.270 , pp. 27728-27733
    • Isse, N.1    Ogawa, Y.2    Tamura, N.3    Masuzaki, H.4    Mori, K.5    Okazaki, T.6
  • 121
    • 84958689411 scopus 로고
    • The role of depot fat in the hypothalamic control of food intake in the rat
    • Kennedy G.C. The role of depot fat in the hypothalamic control of food intake in the rat. Proc. R. Soc. Med. 140:1953;578-596
    • (1953) Proc. R. Soc. Med. , vol.140 , pp. 578-596
    • Kennedy, G.C.1
  • 123
    • 0033928131 scopus 로고    scopus 로고
    • Physiopathology of prolactin secretion in obesity
    • Kopelman P.G. Physiopathology of prolactin secretion in obesity. Int. J. Obes. Relat. Metab. Disord. 24(Suppl. 2):2000;S104-S108
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , Issue.SUPPL. 2
    • Kopelman, P.G.1
  • 124
    • 0035145908 scopus 로고    scopus 로고
    • Transgenic complementation of leptin-receptor deficiency: I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene
    • Kowalski T.J., Liu S.M., Leibel R.L., Chua S.C. Jr. Transgenic complementation of leptin-receptor deficiency: I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes. 50:2001;425-435
    • (2001) Diabetes , vol.50 , pp. 425-435
    • Kowalski, T.J.1    Liu, S.M.2    Leibel, R.L.3    Chua Jr., S.C.4
  • 125
    • 0031786041 scopus 로고    scopus 로고
    • Short-term changes in serum leptin levels provide a strong metabolic marker for the growth response to growth hormone treatment in children. Swedish Study Group for Growth Hormone Treatment
    • Kristrom B., Carlsson B., Rosberg S., Carlsson L.M., Albertsson-Wikland K. Short-term changes in serum leptin levels provide a strong metabolic marker for the growth response to growth hormone treatment in children. Swedish Study Group for Growth Hormone Treatment. J. Clin. Endocrinol. Metab. 83:1998;2735-2741
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2735-2741
    • Kristrom, B.1    Carlsson, B.2    Rosberg, S.3    Carlsson, L.M.4    Albertsson-Wikland, K.5
  • 126
    • 0029848687 scopus 로고    scopus 로고
    • Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women
    • Larsson H., Ahren B. Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women. J. Clin. Endocrinol. Metab. 81:1996;4428-4432
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 4428-4432
    • Larsson, H.1    Ahren, B.2
  • 127
    • 0031156840 scopus 로고    scopus 로고
    • Serum leptin levels in women with polycystic ovary syndrome: The role of insulin resistance/hyperinsulinemia
    • Laughlin G.A., Morales A.J., Yen S.S. Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia. J. Clin. Endocrinol. Metab. 82:1997;1692-1696
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1692-1696
    • Laughlin, G.A.1    Morales, A.J.2    Yen, S.S.3
  • 128
    • 0031025130 scopus 로고    scopus 로고
    • Hypoleptinemia in women athletes: Absence of a diurnal rhythm with amenorrhea
    • Laughlin G.A., Yen S.S. Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea. J. Clin. Endocrinol. Metab. 82:1997;318-321
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 318-321
    • Laughlin, G.A.1    Yen, S.S.2
  • 130
    • 0035937174 scopus 로고    scopus 로고
    • Liporegulation in diet-induced obesity. the antisteatotic role of hyperleptinemia
    • Lee Y., Wang M.Y., Kakuma T., Wang Z.W., Babcock E., McCorkle K., et al. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J. Biol. Chem. 276:2001;5629-5635
    • (2001) J. Biol. Chem. , vol.276 , pp. 5629-5635
    • Lee, Y.1    Wang, M.Y.2    Kakuma, T.3    Wang, Z.W.4    Babcock, E.5    McCorkle, K.6
  • 131
    • 0031824260 scopus 로고    scopus 로고
    • Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus
    • Legradi G., Emerson C.H., Ahima R.S., Rand W.M., Flier J.S., Lechan R.M. Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus. Neuroendocrinology. 68:1998;89-97
    • (1998) Neuroendocrinology , vol.68 , pp. 89-97
    • Legradi, G.1    Emerson, C.H.2    Ahima, R.S.3    Rand, W.M.4    Flier, J.S.5    Lechan, R.M.6
  • 132
    • 0030786368 scopus 로고    scopus 로고
    • Beta 3-Adrenergic-mediated suppression of leptin gene expression in rats
    • Li H., Matheny M., Scarpace P.J. beta 3-Adrenergic-mediated suppression of leptin gene expression in rats. Am. J. Physiol. 272:1997;E1031-E1036
    • (1997) Am. J. Physiol. , vol.272
    • Li, H.1    Matheny, M.2    Scarpace, P.J.3
  • 133
    • 16944364768 scopus 로고    scopus 로고
    • Human leptin levels are pulsatile and inversely related to pituitary-adrenal function
    • Licinio J., Mantzoros C., Negrao A.B., Cizza G., Wong M.L., Bongiorno P.B., et al. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat. Med. 3:1997;575-579
    • (1997) Nat. Med. , vol.3 , pp. 575-579
    • Licinio, J.1    Mantzoros, C.2    Negrao, A.B.3    Cizza, G.4    Wong, M.L.5    Bongiorno, P.B.6
  • 134
    • 13144293061 scopus 로고    scopus 로고
    • Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women
    • Licinio J., Negrão A.B., Mantzoros C., Kaklamani V., Wong M.L., Bongiorno P.B., et al. Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. Proc. Natl. Acad. Sci. U. S. A. 95:1998;2541-2546
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 2541-2546
    • Licinio, J.1    Negrão, A.B.2    Mantzoros, C.3    Kaklamani, V.4    Wong, M.L.5    Bongiorno, P.B.6
  • 136
    • 0036790386 scopus 로고    scopus 로고
    • Role of leptin in immunology
    • Lord G. Role of leptin in immunology. Nutr. Rev. 60:2002;S35-S38
    • (2002) Nutr. Rev. , vol.60
    • Lord, G.1
  • 137
    • 0029078449 scopus 로고
    • Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes
    • MacDougald O.A., Hwang C.S., Fan H., Lane M.D. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc. Natl. Acad. Sci. U. S. A. 92:1995;9034-9037
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9034-9037
    • MacDougald, O.A.1    Hwang, C.S.2    Fan, H.3    Lane, M.D.4
  • 138
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1:1995;1155-1161
    • (1995) Nat. Med. , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3    Pratley, R.E.4    Lee, G.H.5    Zhang, Y.6
  • 139
    • 0030980198 scopus 로고    scopus 로고
    • A longitudinal assessment of hormonal and physical alterations during normal puberty in boys: V. Rising leptin levels may signal the onset of puberty
    • Mantzoros C.S., Flier J.S., Rogol A.D. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys: V. Rising leptin levels may signal the onset of puberty. J. Clin. Endocrinol. Metab. 82:1997;1066-1070
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1066-1070
    • Mantzoros, C.S.1    Flier, J.S.2    Rogol, A.D.3
  • 142
    • 8544258847 scopus 로고    scopus 로고
    • Glucocorticoid regulation of leptin synthesis and secretion in humans: Elevated plasma leptin levels in Cushing's syndrome
    • Masuzaki H., Ogawa Y., Hosoda K., Miyawaki T., Hanaoka I., Hiraoka J., et al. Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing's syndrome. J. Clin. Endocrinol. Metab. 82:1997;2542-2547
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 2542-2547
    • Masuzaki, H.1    Ogawa, Y.2    Hosoda, K.3    Miyawaki, T.4    Hanaoka, I.5    Hiraoka, J.6
  • 143
    • 0030866843 scopus 로고    scopus 로고
    • Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
    • Masuzaki H., Ogawa Y., Sagawa N., Hosoda K., Matsumoto T., Mise H., et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 3:1997;1029-1033
    • (1997) Nat. Med. , vol.3 , pp. 1029-1033
    • Masuzaki, H.1    Ogawa, Y.2    Sagawa, N.3    Hosoda, K.4    Matsumoto, T.5    Mise, H.6
  • 144
    • 7844225512 scopus 로고    scopus 로고
    • Augmented placental production of leptin in preeclampsia: Possible involvement of placental hypoxia
    • Mise H., Sagawa N., Matsumoto T., Yura S., Nanno H., Itoh H., et al. Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia. J. Clin. Endocrinol. Metab. 83:1998;3225-3229
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 3225-3229
    • Mise, H.1    Sagawa, N.2    Matsumoto, T.3    Yura, S.4    Nanno, H.5    Itoh, H.6
  • 145
    • 0032882951 scopus 로고    scopus 로고
    • Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice
    • Mistry A.M., Swick A., Romsos D.R. Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice. Am. J. Physiol. 277:1999;R742-R747
    • (1999) Am. J. Physiol. , vol.277
    • Mistry, A.M.1    Swick, A.2    Romsos, D.R.3
  • 146
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague C.T., Farooqi I.S., Whitehead J.P., Soos M.A., Rau H., Wareham N.J., et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387:1997;903-908
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3    Soos, M.A.4    Rau, H.5    Wareham, N.J.6
  • 147
    • 0033304752 scopus 로고    scopus 로고
    • Leptin gene expression in the brain and pituitary gland
    • Morash B., Li A., Murphy P.R., Wilkinson M., Ur E. Leptin gene expression in the brain and pituitary gland. Endocrinology. 140:1999;5995-5998
    • (1999) Endocrinology , vol.140 , pp. 5995-5998
    • Morash, B.1    Li, A.2    Murphy, P.R.3    Wilkinson, M.4    Ur, E.5
  • 148
    • 0031724787 scopus 로고    scopus 로고
    • Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state
    • Mounzih K., Qiu J., Ewart-Toland A., Chehab F.F. Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state. Endocrinology. 139:1998;5259-5262
    • (1998) Endocrinology , vol.139 , pp. 5259-5262
    • Mounzih, K.1    Qiu, J.2    Ewart-Toland, A.3    Chehab, F.F.4
  • 149
    • 0028972884 scopus 로고
    • Dexamethasone regulates obese expression in isolated rat adipocytes
    • Murakami T., Iida M., Shima K. Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem. Biophys. Res. Commun. 214:1995;1260-1267
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 1260-1267
    • Murakami, T.1    Iida, M.2    Shima, K.3
  • 150
    • 0037410059 scopus 로고    scopus 로고
    • Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines
    • Muraoka O., Xu B., Tsurumaki T., Akira S., Yamaguchi T., Higuchi H. Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines. Neurochem. Int. 42:2003;591-601
    • (2003) Neurochem. Int. , vol.42 , pp. 591-601
    • Muraoka, O.1    Xu, B.2    Tsurumaki, T.3    Akira, S.4    Yamaguchi, T.5    Higuchi, H.6
  • 151
    • 0031813699 scopus 로고    scopus 로고
    • Evidence for GnRH regulation by leptin: Leptin administration prevents reduced pulsatile LH secretion during fasting
    • Nagatani S., Guthikonda P., Thompson R.C., Tsukamura H., Maeda K.I., Foster D.L. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology. 67:1998;370-376
    • (1998) Neuroendocrinology , vol.67 , pp. 370-376
    • Nagatani, S.1    Guthikonda, P.2    Thompson, R.C.3    Tsukamura, H.4    Maeda, K.I.5    Foster, D.L.6
  • 152
    • 0032861562 scopus 로고    scopus 로고
    • Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
    • Naveilhan P., Hassani H., Canals J.M., Ekstrand A.J., Larefalk A., Chhajlani V., et al. Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat. Med. 5:1999;1188-1193
    • (1999) Nat. Med. , vol.5 , pp. 1188-1193
    • Naveilhan, P.1    Hassani, H.2    Canals, J.M.3    Ekstrand, A.J.4    Larefalk, A.5    Chhajlani, V.6
  • 153
    • 0035996844 scopus 로고    scopus 로고
    • Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation
    • Naveilhan P., Svensson L., Nystrom S., Ekstrand A.J., Ernfors P. Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation. Peptides. 23:2002;1087-1091
    • (2002) Peptides , vol.23 , pp. 1087-1091
    • Naveilhan, P.1    Svensson, L.2    Nystrom, S.3    Ekstrand, A.J.4    Ernfors, P.5
  • 154
    • 0037288941 scopus 로고    scopus 로고
    • Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signaling capabilities
    • Niswender K.D., Schwartz M.W. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front. Neuroendocrinol. 24:2003;1-10
    • (2003) Front. Neuroendocrinol. , vol.24 , pp. 1-10
    • Niswender, K.D.1    Schwartz, M.W.2
  • 155
    • 0036317022 scopus 로고    scopus 로고
    • Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy
    • Oral E.A., Ruiz E., Andewelt A., Sebring N., Wagner A.J., Depaoli A.M., et al. Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy. J. Clin. Endocrinol. Metab. 87:2002;3110-3117
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3110-3117
    • Oral, E.A.1    Ruiz, E.2    Andewelt, A.3    Sebring, N.4    Wagner, A.J.5    Depaoli, A.M.6
  • 157
    • 0037244706 scopus 로고    scopus 로고
    • The inhibition of growth hormone secretion presented in obesity is not mediated by the high leptin levels: A study in human leptin deficiency patients
    • Ozata M., Dieguez C., Casanueva F.F. The inhibition of growth hormone secretion presented in obesity is not mediated by the high leptin levels: a study in human leptin deficiency patients. J. Clin. Endocrinol. Metab. 88:2003;312-316
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 312-316
    • Ozata, M.1    Dieguez, C.2    Casanueva, F.F.3
  • 158
    • 0033304576 scopus 로고    scopus 로고
    • Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
    • Ozata M., Ozdemir I.C., Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J. Clin. Endocrinol. Metab. 84:1999;3686-3695
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3686-3695
    • Ozata, M.1    Ozdemir, I.C.2    Licinio, J.3
  • 160
    • 0022764022 scopus 로고
    • Receptor-mediated peptide transport through the blood-brain barrier
    • Pardridge W.M. Receptor-mediated peptide transport through the blood-brain barrier. Endocr. Rev. 7:1986;314-330
    • (1986) Endocr. Rev. , vol.7 , pp. 314-330
    • Pardridge, W.M.1
  • 162
    • 0036114844 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    • Petersen K.F., Oral E.A., Dufour S., Befroy D., Ariyan C., Yu C., et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J. Clin. Invest. 109:2002;1345-1350
    • (2002) J. Clin. Invest. , vol.109 , pp. 1345-1350
    • Petersen, K.F.1    Oral, E.A.2    Dufour, S.3    Befroy, D.4    Ariyan, C.5    Yu, C.6
  • 163
    • 0031794524 scopus 로고    scopus 로고
    • Leptin and the pituitary-thyroid axis: A comparative study in lean, obese, hypothyroid and hyperthyroid subjects
    • Pinkney J.H., Goodrick S.J., Katz J., Johnson A.B., Lightman S.L., Coppack S.W., et al. Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects. Clin. Endocrinol. (Oxf.). 49:1998;583-588
    • (1998) Clin. Endocrinol. (Oxf.) , vol.49 , pp. 583-588
    • Pinkney, J.H.1    Goodrick, S.J.2    Katz, J.3    Johnson, A.B.4    Lightman, S.L.5    Coppack, S.W.6
  • 164
    • 0030930441 scopus 로고    scopus 로고
    • Circulating leptin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (Macaca mulatta)
    • Plant T.M., Durrant A.R. Circulating leptin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (Macaca mulatta). Endocrinology. 138:1997;4505-4508
    • (1997) Endocrinology , vol.138 , pp. 4505-4508
    • Plant, T.M.1    Durrant, A.R.2
  • 165
    • 0036791462 scopus 로고    scopus 로고
    • Leptin and insulin action in the central nervous system
    • Porte D. Jr., Baskin D.G., Schwartz M.W. Leptin and insulin action in the central nervous system. Nutr. Rev. 60:2002;S20-S29
    • (2002) Nutr. Rev. , vol.60
    • Porte Jr., D.1    Baskin, D.G.2    Schwartz, M.W.3
  • 166
    • 0031734449 scopus 로고    scopus 로고
    • Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland
    • Pralong F.P., Roduit R., Waeber G., Castillo E., Mosimann F., Thorens B., et al. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology. 139:1998;4264-4268
    • (1998) Endocrinology , vol.139 , pp. 4264-4268
    • Pralong, F.P.1    Roduit, R.2    Waeber, G.3    Castillo, E.4    Mosimann, F.5    Thorens, B.6
  • 167
    • 0037388560 scopus 로고    scopus 로고
    • Differential mechanisms and development of leptin resistance in A/J versus C57BL/6J mice during diet-induced obesity
    • Prpic V., Watson P.M., Frampton I.C., Sabol M.A., Jezek G.E., Gettys T.W. Differential mechanisms and development of leptin resistance in A/J versus C57BL/6J mice during diet-induced obesity. Endocrinology. 144:2003;1155-1163
    • (2003) Endocrinology , vol.144 , pp. 1155-1163
    • Prpic, V.1    Watson, P.M.2    Frampton, I.C.3    Sabol, M.A.4    Jezek, G.E.5    Gettys, T.W.6
  • 168
    • 0034914282 scopus 로고    scopus 로고
    • Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes
    • Qiu J., Ogus S., Mounzih K., Ewart-Toland A., Chehab F.F. Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes. Endocrinology. 142:2001;3415-3421
    • (2001) Endocrinology , vol.142 , pp. 3415-3421
    • Qiu, J.1    Ogus, S.2    Mounzih, K.3    Ewart-Toland, A.4    Chehab, F.F.5
  • 169
    • 0032962371 scopus 로고    scopus 로고
    • Daily melatonin administration at middle age suppresses male rat visceral
    • Rasmussen D.D., Boldt B.M., Wilkinson C.W., Yellon S.M., Matsumoto A.M. Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels. Endocrinology. 140:1999;1009-1012
    • (1999) Endocrinology , vol.140 , pp. 1009-1012
    • Rasmussen, D.D.1    Boldt, B.M.2    Wilkinson, C.W.3    Yellon, S.M.4    Matsumoto, A.M.5
  • 170
    • 0033022224 scopus 로고    scopus 로고
    • Truncated human leptin (delta133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport
    • Rau H., Reaves B.J., O'Rahilly S., Whitehead J.P. Truncated human leptin (delta133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport. Endocrinology. 140:1999;1718-1723
    • (1999) Endocrinology , vol.140 , pp. 1718-1723
    • Rau, H.1    Reaves, B.J.2    O'Rahilly, S.3    Whitehead, J.P.4
  • 172
    • 0030040740 scopus 로고    scopus 로고
    • Regulation of ob gene mRNA levels in cultured adipocytes
    • Rentsch J., Chiesi M. Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett. 379:1996;55-59
    • (1996) FEBS Lett. , vol.379 , pp. 55-59
    • Rentsch, J.1    Chiesi, M.2
  • 173
    • 0031713957 scopus 로고    scopus 로고
    • Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids
    • Roemmich J.N., Clark P.A., Berr S.S., Mai V., Mantzoros C.S., Flier J.S., et al. Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Am. J. Physiol. 275:1998;E543-E551
    • (1998) Am. J. Physiol. , vol.275
    • Roemmich, J.N.1    Clark, P.A.2    Berr, S.S.3    Mai, V.4    Mantzoros, C.S.5    Flier, J.S.6
  • 174
    • 0035210714 scopus 로고    scopus 로고
    • Direct modification of somatotrope function by long-term leptin treatment of primary cultured ovine pituitary cells
    • Roh S.G., Nie G.Y., Loneragan K., Gertler A., Chen C. Direct modification of somatotrope function by long-term leptin treatment of primary cultured ovine pituitary cells. Endocrinology. 142:2001;5167-5171
    • (2001) Endocrinology , vol.142 , pp. 5167-5171
    • Roh, S.G.1    Nie, G.Y.2    Loneragan, K.3    Gertler, A.4    Chen, C.5
  • 176
    • 0036093071 scopus 로고    scopus 로고
    • Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones
    • Rosenbaum M., Murphy E.M., Heymsfield S.B., Matthews D.E., Leibel R.L. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J. Clin. Endocrinol. Metab. 87:2002;2391-2394
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 2391-2394
    • Rosenbaum, M.1    Murphy, E.M.2    Heymsfield, S.B.3    Matthews, D.E.4    Leibel, R.L.5
  • 179
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • Saladin R., De Vos P., Guerre-Millo M., Leturque A., Girard J., Staels B., et al. Transient increase in obese gene expression after food intake or insulin administration. Nature. 377:1995;527-529
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3    Leturque, A.4    Girard, J.5    Staels, B.6
  • 180
    • 17344384196 scopus 로고    scopus 로고
    • Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia
    • Sarraf P., Frederich R.C., Turner E.M., Ma G., Jaskowiak N.T., Rivet D. Jr., et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J. Exp. Med. 185:1997;171-175
    • (1997) J. Exp. Med. , vol.185 , pp. 171-175
    • Sarraf, P.1    Frederich, R.C.2    Turner, E.M.3    Ma, G.4    Jaskowiak, N.T.5    Rivet Jr., D.6
  • 181
    • 8044227781 scopus 로고    scopus 로고
    • Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: Evidence for loss of its satiety effect in VMH-lesioned rats
    • Satoh N., Ogawa Y., Katsuura G., Tsuji T., Masuzaki H., Hiraoka J., et al. Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned rats. Endocrinology. 138:1997;947-954
    • (1997) Endocrinology , vol.138 , pp. 947-954
    • Satoh, N.1    Ogawa, Y.2    Katsuura, G.3    Tsuji, T.4    Masuzaki, H.5    Hiraoka, J.6
  • 182
    • 0030885398 scopus 로고    scopus 로고
    • Entrainment of the diurnal rhythm of plasma leptin to meal timing
    • Schoeller D.A., Cella L.K., Sinha M.K., Caro J.F. Entrainment of the diurnal rhythm of plasma leptin to meal timing. J. Clin. Invest. 100:1997;1882-1887
    • (1997) J. Clin. Invest. , vol.100 , pp. 1882-1887
    • Schoeller, D.A.1    Cella, L.K.2    Sinha, M.K.3    Caro, J.F.4
  • 183
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
    • Schwartz M.W., Peskind E., Raskind M., Boyko E.J., Porte D. Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. 2:1996;589-593
    • (1996) Nat. Med. , vol.2 , pp. 589-593
    • Schwartz, M.W.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte Jr., D.5
  • 185
    • 8244232511 scopus 로고    scopus 로고
    • Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients
    • Sharma K., Considine R.V., Michael B., Dunn S.R., Weisberg L.S., Kurnik B.R., et al. Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Kidney Int. 51:1997;1980-1985
    • (1997) Kidney Int. , vol.51 , pp. 1980-1985
    • Sharma, K.1    Considine, R.V.2    Michael, B.3    Dunn, S.R.4    Weisberg, L.S.5    Kurnik, B.R.6
  • 186
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I., Hammer R.E., Ikemoto S., Brown M.S., Goldstein J.L. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature. 401:1999;73-76
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 187
    • 0007524724 scopus 로고    scopus 로고
    • Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting
    • Sinha M.K., Opentanova I., Ohannesian J.P., Kolaczynski J.W., Heiman M.L., Hale J., et al. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J. Clin. Invest. 98:1996;1277-1282
    • (1996) J. Clin. Invest. , vol.98 , pp. 1277-1282
    • Sinha, M.K.1    Opentanova, I.2    Ohannesian, J.P.3    Kolaczynski, J.W.4    Heiman, M.L.5    Hale, J.6
  • 190
    • 0037353788 scopus 로고    scopus 로고
    • Developmental changes in plasma leptin and hypothalamic leptin receptor expression in the rat: Peripubertal changes and the emergence of sex differences
    • Smith J.T., Waddell B.J. Developmental changes in plasma leptin and hypothalamic leptin receptor expression in the rat: peripubertal changes and the emergence of sex differences. J. Endocrinol. 176:2003;313-319
    • (2003) J. Endocrinol. , vol.176 , pp. 313-319
    • Smith, J.T.1    Waddell, B.J.2
  • 191
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • Spanswick D., Smith M.A., Groppi V.E., Logan S.D., Ashford M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 390:1997;521-525
    • (1997) Nature , vol.390 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.5
  • 192
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogonadism and morbid obesity
    • Strobel A., Issad T., Camoin L., Ozata M., Strosberg A.D. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat. Genet. 18:1998;213-215
    • (1998) Nat. Genet. , vol.18 , pp. 213-215
    • Strobel, A.1    Issad, T.2    Camoin, L.3    Ozata, M.4    Strosberg, A.D.5
  • 193
    • 0034453187 scopus 로고    scopus 로고
    • Circulating concentrations of nocturnal leptin, growth hormone, and insulin-like growth factor-I increase before the onset of puberty in agonadal male monkeys: Potential signals for the initiation of puberty
    • Suter K.J., Pohl C.R., Wilson M.E. Circulating concentrations of nocturnal leptin, growth hormone, and insulin-like growth factor-I increase before the onset of puberty in agonadal male monkeys: potential signals for the initiation of puberty. J. Clin. Endocrinol. Metab. 85:2000;808-814
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 808-814
    • Suter, K.J.1    Pohl, C.R.2    Wilson, M.E.3
  • 194
    • 0036875212 scopus 로고    scopus 로고
    • Divergent effects of leptin in mice susceptible or resistant to obesity
    • Takahashi N., Patel H.R., Qi Y., Dushay J., Ahima R.S. Divergent effects of leptin in mice susceptible or resistant to obesity. Horm. Metab. Res. 34:2002;691-697
    • (2002) Horm. Metab. Res. , vol.34 , pp. 691-697
    • Takahashi, N.1    Patel, H.R.2    Qi, Y.3    Dushay, J.4    Ahima, R.S.5
  • 195
    • 0030267744 scopus 로고    scopus 로고
    • Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat
    • Takaya K., Ogawa Y., Hiraoka J., Hosoda K., Yamori Y., Nakao K., et al. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat. Genet. 14:1996;130-131
    • (1996) Nat. Genet. , vol.14 , pp. 130-131
    • Takaya, K.1    Ogawa, Y.2    Hiraoka, J.3    Hosoda, K.4    Yamori, Y.5    Nakao, K.6
  • 196
    • 0036847619 scopus 로고    scopus 로고
    • Leptin regulates bone formation via the sympathetic nervous system
    • Takeda S., Elefteriou F., Levasseur R., Liu X., Zhao L., Parker K.L., et al. Leptin regulates bone formation via the sympathetic nervous system. Cell. 111:2002;305-317
    • (2002) Cell , vol.111 , pp. 305-317
    • Takeda, S.1    Elefteriou, F.2    Levasseur, R.3    Liu, X.4    Zhao, L.5    Parker, K.L.6
  • 197
    • 0031761830 scopus 로고    scopus 로고
    • Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone
    • Tannenbaum G.S., Gurd W., Lapointe M. Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone. Endocrinology. 139:1998;3871-3875
    • (1998) Endocrinology , vol.139 , pp. 3871-3875
    • Tannenbaum, G.S.1    Gurd, W.2    Lapointe, M.3
  • 198
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272:1997;6093-6096
    • (1997) J. Biol. Chem. , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 199
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1995;1263-1271
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3    Deng, N.4    Culpepper, J.5    Devos, R.6
  • 200
    • 0030581666 scopus 로고    scopus 로고
    • Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079
    • Trayhurn P., Duncan J.S., Rayner D.V., Hardie L.J. Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079. Biochem. Biophys. Res. Commun. 228:1996;605-610
    • (1996) Biochem. Biophys. Res. Commun. , vol.228 , pp. 605-610
    • Trayhurn, P.1    Duncan, J.S.2    Rayner, D.V.3    Hardie, L.J.4
  • 201
    • 0033694535 scopus 로고    scopus 로고
    • Lipotoxic diseases of nonadipose tissues in obesity
    • Unger R.H., Orci L. Lipotoxic diseases of nonadipose tissues in obesity. Int. J. Obes. Relat. Metab. Disord. 24(Suppl. 4):2000;S28-S32
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , Issue.SUPPL. 4
    • Unger, R.H.1    Orci, L.2
  • 202
    • 0033008075 scopus 로고    scopus 로고
    • Functional properties of leptin receptor isoforms: Internalization and degradation of leptin and ligand-induced receptor downregulation
    • Uotani S., Bjorbaek C., Tornoe J., Flier J.S. Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes. 48:1999;279-286
    • (1999) Diabetes , vol.48 , pp. 279-286
    • Uotani, S.1    Bjorbaek, C.2    Tornoe, J.3    Flier, J.S.4
  • 206
    • 0032543680 scopus 로고    scopus 로고
    • A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
    • Wang J., Liu R., Hawkins M., Barzilai N., Rossetti L. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature. 393:1998;684-688
    • (1998) Nature , vol.393 , pp. 684-688
    • Wang, J.1    Liu, R.2    Hawkins, M.3    Barzilai, N.4    Rossetti, L.5
  • 207
    • 0037112698 scopus 로고    scopus 로고
    • Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in rats
    • Watanobe H. Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in rats. J. Physiol. 545:2002;255-268
    • (2002) J. Physiol. , vol.545 , pp. 255-268
    • Watanobe, H.1
  • 208
    • 0037101623 scopus 로고    scopus 로고
    • Leptin regulates growth hormone-releasing factor, somatostatin, and alpha-melanocyte-stimulating hormone but not neuropeptide Y release in rat hypothalamus in vivo: Relation with growth hormone secretion
    • Watanobe H., Habu S. Leptin regulates growth hormone-releasing factor, somatostatin, and alpha-melanocyte-stimulating hormone but not neuropeptide Y release in rat hypothalamus in vivo: relation with growth hormone secretion. J. Neurosci. 22:2002;6265-6271
    • (2002) J. Neurosci. , vol.22 , pp. 6265-6271
    • Watanobe, H.1    Habu, S.2
  • 209
    • 0034731556 scopus 로고    scopus 로고
    • Stimulation of prolactin secretion by chronic, but not acute, administration of leptin in the rat
    • Watanobe H., Schioth H.B., Suda T. Stimulation of prolactin secretion by chronic, but not acute, administration of leptin in the rat. Brain Res. 887:2000;426-431
    • (2000) Brain Res. , vol.887 , pp. 426-431
    • Watanobe, H.1    Schioth, H.B.2    Suda, T.3
  • 210
    • 0033575892 scopus 로고    scopus 로고
    • Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats
    • Watanobe H., Suda T., Wikberg J.E., Schioth H.B. Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats. Biochem. Biophys. Res. Commun. 263:1999;162-165
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 162-165
    • Watanobe, H.1    Suda, T.2    Wikberg, J.E.3    Schioth, H.B.4
  • 211
    • 0030928574 scopus 로고    scopus 로고
    • Constitutive and impaired signaling of leptin receptors containing the Gln→Pro extracellular domain fatty mutation
    • White D.W., Wang D., Chua S.C. Jr., Morgenstern J.P., Leibel R.L., Baumann H., et al. Constitutive and impaired signaling of leptin receptors containing the Gln→Pro extracellular domain fatty mutation. Proc. Natl. Acad. Sci. U. S. A. 94:1997;10657-10662
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 10657-10662
    • White, D.W.1    Wang, D.2    Chua Jr., S.C.3    Morgenstern, J.P.4    Leibel, R.L.5    Baumann, H.6
  • 213
    • 0034465880 scopus 로고    scopus 로고
    • Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat
    • Wolden-Hanson T., Mitton D.R., McCants R.L., Yellon S.M., Wilkinson C.W., Matsumoto A.M., et al. Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology. 141:2000;487-497
    • (2000) Endocrinology , vol.141 , pp. 487-497
    • Wolden-Hanson, T.1    Mitton, D.R.2    McCants, R.L.3    Yellon, S.M.4    Wilkinson, C.W.5    Matsumoto, A.M.6
  • 214
    • 0034991928 scopus 로고    scopus 로고
    • Leptin stimulates gonadotropin releasing hormone release from cultured intact hemihypothalami and enzymatically dispersed neurons
    • Woller M., Tessmer S., Neff D., Nguema A.A., Roo B.V., Waechter-Brulla D. Leptin stimulates gonadotropin releasing hormone release from cultured intact hemihypothalami and enzymatically dispersed neurons. Exp. Biol. Med. 226:2001;591-596
    • (2001) Exp. Biol. Med. , vol.226 , pp. 591-596
    • Woller, M.1    Tessmer, S.2    Neff, D.3    Nguema, A.A.4    Roo, B.V.5    Waechter-Brulla, D.6
  • 215
    • 0031046730 scopus 로고    scopus 로고
    • Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): Evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat
    • Wu-Peng X.S., Chua S.C. Jr., Okada N., Liu S.M., Nicolson M., Leibel R.L. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Diabetes. 46:1997;513-518
    • (1997) Diabetes , vol.46 , pp. 513-518
    • Wu-Peng, X.S.1    Chua Jr., S.C.2    Okada, N.3    Liu, S.M.4    Nicolson, M.5    Leibel, R.L.6
  • 216
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7:2001;941-946
    • (2001) Nat. Med. , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3    Terauchi, Y.4    Kubota, N.5    Hara, K.6
  • 219
    • 0031046147 scopus 로고    scopus 로고
    • Direct intraovarian effects of leptin: Impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells
    • Zachow R.J., Magoffin D.A. Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology. 138:1997;847-850
    • (1997) Endocrinology , vol.138 , pp. 847-850
    • Zachow, R.J.1    Magoffin, D.A.2


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