Functional properties of leptin receptor isoforms containing the gln→pro extracellular domain mutation of the fatty rat

Endocrinology

Volumn 139, Issue 9, 1998, Pages 3681-3690

  Da Silva, Barbara A ^a   Bjørbæk, Christian ^a   Uotani, Shigeo ^a   Flier, Jeffrey S ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b OCLC Online Computer Library   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; LEPTIN; LEPTIN RECEPTOR; LUCIFERASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL CULTURE; ENZYME ASSAY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE MUTATION; IMMUNOBLOTTING; MAMMAL; MISSENSE MUTATION; MOLECULAR CLONING; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RECEPTOR BINDING; RODENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 0031761827     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.9.6168     Document Type: Article

References (64)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
2. Frederich RC, Hamann A, Anderson S, Lollman B, Lowell BB, Flier JS 1995 Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Med 1:1311-1314
3. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman, JM 1995 Weight reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P 1995 Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
5. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
6. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL 1995 Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96:2065-2075
7. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte Jr D, Woods SC, Seeley RJ, Weigle DS 1996 Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535
8. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, MacKellar W, Rosteck Jr PR, Schoner B, Smith D, Tinsley FC, Zhang XY, Heiman M 1995 The role of neuropeptide Y in the antiobestiy action of the obese gene product. Nature 377:530-532
9. Chen G, Koyama K, Yuan X, Lee Y, Zhou YT, O'Doherty R, Newgard CB, Unger RH 1996 Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA 93:14795-14799
10. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS 1996 Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252
11. Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, Unger RH 1997 Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94:4637-4641
12. Muller G, Ertl J, Gerl M, Preibisch G 1997 Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 272:10585-10593
13. Zachow RJ, Magoffin DA 1997 Direct intraovarian effects of leptin. Endocrinology 138:847-850
14. Mikhail AA, Beck EX, Shafer A, Barut B, Gbur JS, Zupancic TJ, Schweitzer AC, Cioffi JA, Lacaud G, Ouyang B, Keller G, Snodgrass HR 1997 Leptin stimulates fetal and adult erythroid and myeloid development. Blood 89:1507-1512
15. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI 1995 Identification and expression cloning of a leprin receptor. OB-R. Cell 83:1263-1271
16. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM 1996 Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635
17. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC 1996 Defective STAT signaling by the leptin receptors in diabetic mice. Proc Natl Acad Sci USA 93:6231-6235
18. Luoh SM, Di Marco F, Levin N, Armanini M, Xie MH, Nelson C, Bennett GL, Williams M, Spencer SA, Gourney A, de Sauvage FJ 1997 Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin. J Mol Endocrinol 18:77-85
19. Hoggard N, Mercer JG, Rayner DV, Moar K, Trayburn P, Williams LM 1997 Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochem Biophys Res Commun 232:383-387
20. Dyer CJ, Simmons JM, Matteri RL, Keisler DH 1997 Effects of an intravenous injection of NPY on leptin and NPY-Y1 receptor mRNA expression in ovine adipose tissue. Domest Anim Endocrinol 14:119-128
21. Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, Friedman JM 1997 Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA 94:7001-7005
22. Argiles JM 1989 The obese Zucker rat: a choice for fat metabolism. Prog Lipid Res 28:53-66
23. Zucker LM, Zucker TF 1961 Fatty, a new mutation in the rat. J Hered 52:275-278
24. Buchberger P, Schmidt I 1996 Is the onset of obesity in suckling fa/fa rats linked to a potentially larger milk intake? Am J Physiol 271:R472-R476
25. White BD, Martin RJ 1997 Evidence for a central mechanism of obesity in the Zucker rat: role of neuropeptide Y and leptin. Proc Soc Exp Biol Med 214:222-232
26. Chua Jr SC, Chung WK, Wu-Peng XS, Zhang Y, Liu S, Tartaglia L, Leibel RL 1996 Phenotypes of mouse diabetes and rat fatty due to mutations in the ob (leptin) receptor. Science 271:994-996
27. Chen H, Chatlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495
28. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CJ, Hess JF 1996 Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 13:18-19
29. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K 1996 Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 222:19-26
30. Chua Jr SC, White DW, Wu-Peng XS, Liu S, Okada N, Kershaw EE, Chung WK, Power-Kehoe L, Chua M, Tartaglia LA, Leibel RL 1996 Phenotype of fatty due to gln269pro mutation in the leptin receptor (lepr). Diabetes 45:1141-1143
31. Takaya K, Ogawa Y, Hiraoka J, Hosoda K, Yamori Y, Nakao K, Koletsky RJ 1996 Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat Genet 14:130-131
32. Takaya K, Ogawa Y, Isse N, Okazaki T, Satoh N, Masuzaki H, Mori K, Tamura N, Hosoda K, Nakao K 1996 Molecular cloning of rat leptin receptor isoform complementary DNAs - identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem Biophys Res Commun 225:75-83
33. Devos R, Richards JG, Campfield LA, Tartaglia LA, Guisez Y, Van Der Heyden J, Travernier J, Plaetinck G, Burn P 1996 Ob protein binds specifically to the choroid plexus of mice and rats. Proc Natl Acad Sci USA 93:5668-5673
34. Rosenblum CI, Tota M, Cully D, Smith T, Collum R Qureshi S, Hess JF, Phillips MS, Hey PJ, Vongs A, Fong TM, Xu L, Chen HY, Smith RG, Schindler C, Van der Ploeg LHT 1996 Functional STAT 1 and 3 signaling by the leptin receptor (Ob-R); reduced expression of the rat fatty leptin receptor in transfected cells. Endocrinology 137:5178-5181
35. White DW, Wang Y, Chua Jr SC, Morgenstern JP, Leibel RL, Baumann H, Tartaglia LA 1997 Constitutive and impaired signaling of leptin receptors containing the gin→ pro extracellular domain fatty mutation. Proc Natl Acad Sci USA 94:10657-10662
36. Yamashita T, Murakami T, Iida M, Kuwajima M, Shima K 1997 Leptin receptor of Zucker fatty rat performs reduced signal transduction. Diabetes 46:1077-1080
37. Tartaglia LA 1997 The leptin receptor. J Biol Chem 272:6093-6096
38. white DW, Kuropatwinski KK, Devos R, Baumann H, Tartaglia LA 1997 Leptin receptor (Ob-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J Biol Chem 272:4065-4071
39. Ghilardi N, Skoda RC 1997 The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol 11:393-399
40. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, Tartaglia LA 1996 The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93:8374-8378
41. Vaisse C, Halaas JL, Horvath CM, Darnell Jr JE, Stoffel M, Friedman JM 1996 Leptin activation of STAT3 in the hypothalamus of wild-type and ob/ob but not db/db mice. Nat Genet 14:95-97
42. Bjørbæk C, Uotani S, Da Silva B, Flier JS 1997 Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272:32686-32695
43. Murakami T, Yamashita T, Iida M, Kuwajima M, Shima K 1997 A short form of leptin receptor performs signal transduction. Biochem Biophys Res Commun 231:26-29
44. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM 1996 Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311
45. Golden PL, Maccagnan TJ, Pardridge WM 1997 Human blood-brain barrier leptin receptor. J Clin Invest 99:14-18
46. Wu-Peng XS, Chua Jr SC, Okada N, Iiu S, Nicolson M, Leibel RL 1997 Phenotype of the obese Koletsky (f) rat due to tyr763stop mutation in the extracellular domain of the leptin receptor (lepr). Evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Diabetes 46:513-518
47. Bjørbæk C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS 1998 Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1:619-625
48. Cohen DM, Gullans SR, Chin WW 1996 Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent ets motifs. J Biol Chem 271:12903-12908
49. Scatchard G 1949 The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51:660-672
50. Ihle JN 1995 Cytokine receptor signaling. Nature 377:591-594
51. Darnell Jr JE, Kerr IM, Stark GR 1994 Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421
52. Cao XM, Guy GR, Sukhatme VP, Tan YH 1992 Regulation of the egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts. J Biol Chem 267:1345-1349
53. Vincent V, Goffin V, Rozakis-Adcock M, Mornon JP, Kelly PA 1997 Identification of cytoplasmic motifs required for short prolactin receptor internalization. J Biol Chem 272:7062-7068
54. Wiley HS, Cunningham DD 1982 The endocytotic rate constant. J Biol Chem 257:4222-4229
55. Heldin CH, Wasteson A, Westermark B 1982 Interaction of platelet-derived growth factor with its fibroblast receptor. J Biol Chem 257:4216-4221
56. Pas and other db/db mice. J Biol Chem 273:10078-10082
57. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bourneres P, Lebouc Y, Froguel P, Guy-Grand B 1998 A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392:398-401
58. Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF 1996 The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 45:992-994
59. Gotoda T, Manning BS, Goldstone AP, Imrie H, Evans AL, Strosberg AD, McKeigue PM, Scott J, Aitman TJ 1997 Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Genet 6:869-876
60. Matsuoka N, Ogawa Y, Hosoda K, Matsuda J, Masuzaki T, Azuma N, Miyawaki T, Natsui K, Nishimura H, Yoshimasa Y, Nishi S, Thompson DB, Nakao K 1997 Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia 40:1204-1210
61. Seeley RJ, van Dijk G, Campfield LA, Smith FJ, Burn P, Nelligan JA, Bell SM, Baskin DG, Woods SC, Schwartz MW 1996 Intraventricular leptin reduces food intake and body weight of lean rats but not Zucker rats. Horm Metab Res 28:664-668
62. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, Jeanrenaud B 1996 The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Diabetes 45:1446-1450
63. Cumin F, Baum HP, de Gasparo M, Levens N 1997 Removal of endogenous leptin from the circulation by the kidney. Int J Obes Relat Metab Disord 21:495-504
64. Genty N, Paly J, Edery M, Kelly PA, Djiane J, Salesse R 1994 Endocytosis and degradation of prolactin and its receptor in CHO cells stably transfected with prolactin receptor cDNA. Mol Cell Endocrinol 99:221-228