Lipotoxic diseases of nonadipose tissues in obesity

International Journal of Obesity

Volumn 24, Issue , 2000, Pages S28-S32

  Unger, R H ^a   Orci, L ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Lipoapoptosis; Lipotoxicity; Nonadipose tissues; Obesity

Indexed keywords

CERAMIDE; FATTY ACID; INSULIN; LEPTIN; LEPTIN RECEPTOR; NITRIC OXIDE; TRIACYLGLYCEROL; TROGLITAZONE;

ADIPOCYTE; ADIPOSE TISSUE; APOPTOSIS; CALORIC INTAKE; CONFERENCE PAPER; FATTY ACID METABOLISM; HEART DISEASE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE;

ADIPOCYTES; ANIMALS; APOPTOSIS; CARRIER PROTEINS; FATTY ACIDS; OBESITY; RATS; RATS, ZUCKER; RECEPTORS, CELL SURFACE;

EID: 0033694535     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801498     Document Type: Article

References (17)

1. Neel JV. The ‘thrifty genotype’ in 1998. Nutr Rev 1999; 57(5Pt2): S2-S9.
2. Unger RH. How obesity causes diabetes in Zucker diabetic fatty rats. Trends Endocrinol Metab 1997; 7: 276-282.
3. Campbell PJ, Carlson MG, Nurghan NM. Fat metabolism in human obesity. Am J Physiol 1994; 266: E600-E605.
4. Hamilton JA. Fatty acid transport: difficult or easy? J Lipid Res 1998; 39: 467-481.
5. Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced ß-cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 1998; 95: 2498-2502.
6. Unger RH, Zhou YT, Orci L. Regulation of fatty acid homeo-stasis in cells: novel role of leptin. Proc Natl Acad Sci USA 1999; 96: 2327-2332.
7. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K. Substitution at codon 269 (glutamine β-proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 1996; 224: 597-604.
8. Phillips MS, Liu QY, Hammond HA, Dugan V, Hey PJ, Caskey CT, Hess JF. Leptin receptor missense mutation in the fatty Zucker rat. Nature Genet 1996; 13: 18-19.
9. Higa M, Zhou YT, Ravazzola M, Baetens D, Orci L, Unger RH. Troglitazone prevents mitochondrial alterations, ß-cell destruction and diabetes in obese prediabetic rats. Proc Natl Acad Sci USA 1999; 96: 11513-11518.
10. Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH. Protection against ß-cell lipoapoptosis through leptin-dependent maintenance of Bcl-2 expression. Proc Natl Acad Sci USA 1998; 95: 9558-9561.
11. Shimabukuro M, Ohneda M, Lee YH, Unger RH. Role of nitric oxide in obesity-induced ß-cell disease. J Clin Invest 1997; 100: 290-295.
12. Zhou YT, Shimabukuro M, Wang MY, Lee Y, Higa M, Milburn JL, Newgard CB, Unger RH. Role of peroxisome proliferator-activated receptor a in disease of pancreatic ß-cells. Proc Natl Acad Sci USA 1998; 95: 8898-8903.
13. Zhou YT, Wang ZW, Higa M, Newgard CB, Unger RH. Reversing adipocyte differentiation: implications for treatment of obesity. Proc Natl Acad Sci USA 1999; 96: 2391-2395.
14. Zhou YT, Shimabukuro M, Lee Y, Koyama K, Higa M, Ferguson T, Unger RH. Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes. Diabetes 1998; 47: 1904-1908.
15. Katsuyama K, Shichiri M, Marumo F, Hirata Y. Role of nuclear factor KB activation in cytokine-and sphingomyelinase-stimulated inducible nitric oxide synthase gene expression in vascular smooth muscle cells. Endocrinology 1998; 139: 4506-4512.
16. Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH. Lipoapoptosis in ß-cells of obese prediabetic fa/fa rats: role of serine palmitoyl transferase overexpression. J Biol Chem 1998; 273: 32487-32490.
17. Shimabukuro M, Zhou YT, Lee Y, Unger RH. Troglitazone lowers islet fat and restores ß-cell function of Zucker diabetic fatty rats. J Biol Chem 1998; 273: 3547-3550.