Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines

Neurochemistry International

Volumn 42, Issue 7, 2003, Pages 591-601

  Muraoka, Osamu ^a   Xu, Bo ^a   Tsurumaki, Tatsuru ^a   Akira, Shizuo ^b   Yamaguchi, Tsuyoshi ^a   Higuchi, Hiroshi ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

JAK1; JAK2; Leptin; NPY; STAT3

Indexed keywords

ISOPROTEIN; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR JAK1; TRANSCRIPTION FACTOR JAK2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL STRAIN; CONTROLLED STUDY; GENE ACTIVATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HORMONE ACTION; HORMONE RESPONSE; MOUSE; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TRANSACTIVATION;

ANIMALS; BASE SEQUENCE; DNA-BINDING PROTEINS; ELECTROPHYSIOLOGY; HUMANS; JANUS KINASE 1; JANUS KINASE 2; LEPTIN; MICE; MOLECULAR SEQUENCE DATA; NEURONS; NEUROPEPTIDE Y; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0037410059     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(02)00160-2     Document Type: Article

References (49)

1. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., Flier J.S. Role of leptin in the neuroendocrine response to fasting. Nature. 382:1996;250-252.
2. Bahary N., Leibel R.L., Joseph L., Friedman J.M. Molecular mapping of the mouse db mutation. Proc. Natl. Acad. Sci. U.S.A. 87:1990;8642-8646.
3. Banks A.S., Davis S.M., Bates S.H., Myers M.G. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275:2000;14563-14572.
4. Baskin D.G., Breininger J.F., Schwartz M.W. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes. 48:1999;828-833.
5. Baumann H., Morella K.K., White D.W., Dembski M., Bailon P.S., Kim H., Lai C.F., Tartaglia L.A. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl. Acad. Sci. U.S.A. 93:1996;8374-8378.
6. Becker S., Groner B., Muller C.W. Three-dimensional structure of the Stat3b homodimer bound to DNA. Nature. 394:1998;145-151.
7. Bjorbaek C., Uotani S., da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272:1997;32686-32695.
8. Bjorbaek C., El-Haschimi K., Frantz J.D., Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J. Biol. Chem. 274:1999;30059-30065.
9. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
10. Carpenter L.R., Farruggella T.J., Symes A., Karow M.L., Yancopoulos G.D., Stahl N. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. Proc. Natl. Acad. Sci. U.S.A. 95:1998;6061-6066.
11. Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., Lakey N.D., Culpepper J., Moore K.J., Duyk G.M., Tepper R.I., Morgenstern J.P. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:1996;491-495.
12. Chen X., Vinkemeier U., Zhao Y., Jeruzalmi D., Darnell J.E., Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell. 93:1998;827-839.
13. Coleman D.L. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 9:1973;294-298.
14. Coleman D.L. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia. 14:1978;141-148.
15. Devos R., Guisez Y., der Hyden J.V., White D.W., Kalai K., Fountoulakis M., Plaetinck G. Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J. Biol. Chem. 272:1997;18304-18310.
16. Dryden S., King P., Pickavance L., Williams G. Divergent effects of intracerebroventricular and peripheral leptin administration on feeding and hypothalamic neuropeptide Y in lean and obese (fa/fa) Zucker rats. Clin. Sci. (Colch). 96:1999;307-312.
17. Elias C.F., Aschkenasi C., Lee C., Kelly J., Ahima R.S., Miller J.S., Saper C.B., Elmquist J.K. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 23:1999;775-786.
18. Fei H., Okano H.J., Li C., Lee G.H., Zhao C., Darnell R., Friedman J.M. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. U.S.A. 94:1997;7001-7005.
19. Ghilardi N., Ziegler S., Wiestner A., Stoffel R., Heim M.H., Skoda R.C. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. U.S.A. 93:1996;6231-6235.
20. Harvey J., McKay N.G., Walker K.S., der Kaay J.V., Downes C.P., Ashford M.L.J. Essential role of phosphoinositide 3-kinase in leptin-induced K(ATP) channel activation in the rat CRI-G1 insulinoma cell line. J. Biol. Chem. 275:2000;4660-4669.
21. Higuchi H., Nakano K., Miki N. Identification of NGF-response element in the rat neuropeptide Y gene and induction of the binding proteins. Biochem. Biophys. Res. Commun. 189:1992;1553-1560.
22. 2+- and cyclic AMP/phorbol 12-myristate 13-acetate-responsive elements. J. Neurochem. 66:1996;1802-1809.
23. Kalra S.P., Dube M.G., Sahu A., Phelps C.P., Kalra P.S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. U.S.A. 88:1991;10931-10935.
24. Lee G.H., Proenca R., Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., Friedman J.M. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:1996;632-635.
25. Leibel R.L., Chung W.K., Chu S.C. Jr. The molecular genetics of rodent single gene obesities. J. Biol. Chem. 272:1997;31937-31940.
26. Li C., Friedman J.M. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc. Natl. Acad. Sci. U.S.A. 96:1999;9677-9682.
27. Magni P., Vettor R., Pagano C., Calcagno A., Martini L., Motta M. Control of the expression of human neuropeptide Y by leptin: in vitro studies. Peptides. 22:2001;415-420.
28. McCowen K.C., Chow J.C., Smith R.J. Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology. 139:1998;4442-4447.
29. Mercer J.G., Hoggard N., Williams L.N., Lawrence C.B., Hannah L.T., Morgan P.J., Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J. Neuroendocrinol. 8:1996;733-735.
30. Minami M., Inoue M., Wei S., Takeda K., Matsumoto M., Kishimoto T., Akira S. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc. Natl. Acad. Sci. U.S.A. 93:1996;3963-3966.
31. Mizushima S., Nagata S. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:1990;5322.
32. 2+/calmodulin-dependent response and up-regulates the gene expression of calcineurin in rat hypothalamus. Life Sci. 63:1998;PL311-PL315.
33. Niwa H., Yamamura K., Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene. 108:1991;193-199.
34. Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., Prunkard D.E., Porte D., Woods S.C., Seeley R.J., Weigle D.S. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 45:1996;531-535.
35. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98:1996;1101-1106.
36. Schwartz M.W., Woods S.C., Porte D., Seeley R.J., Baskin D.G. Central nervous system control of food intake. Nature. 404:2000;661-671.
37. Shimizu-Albergine M., Ippolito D.L., Beavo J.A. Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus. J. Neurosci. 21:2001;1238-1246.
38. Starr R., Willson T.A., Viney E.M., Murray L.J.L., Rayner J.R., Jenkins B.J., Gonda T.J., Alexander W.S., Metcalf D., Nicola N.A., Hilton D.J. A family of cytokine-inducible inhibitors of signaling. Nature. 387:1997;917-921.
39. Spanswick D., Smith M.A., Groppi V.E., Logan S.D., Ashford M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 390:1997;521-525.
40. Stephens T.W., Basinski M., Bristow P.K., Bue-Valleskey J.M., Burgett S.J., Craft L., Hale J., Hoffmann J., Hsiung H.M., Kriauciunas A., MacKellar W., Rosteck P.R., Schoner B., Smith D., Tinsley F.C., Zhang X.-Y., Heiman M. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:1995;530-532.
41. Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272:1997;6093-6096.
42. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Woolf E.A., Monroe C.A., Tepper R.I. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1995;1263-1271.
43. Waelput W., Verhee A., Broekaert D., Eyckerman S., Vandekerckhove J., Beattie J.H., Tavernier J. Identification and expression analysis of leptin-regulated immediate early response and late target genes. Biochem. J. 348(Part 1):2000;55-61.
44. Wang Y., Kuropatwinski K.K., White D.W., Hawley T.S., Hawley R.G., Tartaglia L.A., Baumann H. Leptin receptor action in hepatic cells. J. Biol. Chem. 272:1997;16216-16223.
45. Wilding J.P., Gilbey S.G., Bailey C.J., Batt R.A., Williams G., Ghatei M.A., Bloom S.R. Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology. 132:1993;1939-1944.
46. Yamashita T., Murakami T., Otani S., Kuwajima M., Shima M. Leptin receptor signal transduction: OBRa and OBRb of fa type. Biochem. Biophys. Res. Commun. 246:1998;752-759.
47. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.
48. Zhang Y., Turkson J., Carter-Su C., Smithgall T., Levitzki A., Kraker A., Krolewski J.J., Medveczky P., Jove R. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. J. Biol. Chem. 275:2000;24935-24944.
49. Zong C.S., Chan J., Levy D.E., Horvath C., Sadowski H.B., Wang L.H. Mechanism of STAT3 activation by insulin-like growth factor I receptor. J. Biol. Chem. 275:2000;15099-15105.