Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation

Peptides

Volumn 23, Issue 6, 2002, Pages 1087-1091

  Naveilhan, Philippe ^a,b   Svensson, Lennart ^c   Nyström, Susanne ^c   Ekstrand, A Jonas ^c   Ernfors, Patrik ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b INSERM   (France)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Mice; Obesity; Y2 receptor knock out

Indexed keywords

NEUROPEPTIDE Y2 RECEPTOR; CHOLESTEROL; LEPTIN; LIPID; LIPOPROTEIN; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HOMEOSTASIS; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; BODY WEIGHT; CROSS BREEDING; FEMALE; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; TEMPERATURE; TIME; TRANSGENIC MOUSE;

ANIMAL; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; CROSSES, GENETIC; FEMALE; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; LEPTIN; LIPIDS; LIPOPROTEINS; MICE; MICE, INBRED BALB C; MICE, OBESE; MICE, TRANSGENIC; NEUROPEPTIDE Y; RECEPTORS, NEUROPEPTIDE Y; SUPPORT, NON-U.S. GOV'T; TEMPERATURE; TIME FACTORS; ANIMALS;

EID: 0035996844     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(02)00042-6     Document Type: Article

References (19)

1. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
2. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
3. Leptin and the regulation of body weight in mammals
4. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: Comparison of wild-type, Y1 receptor-deficient and Y5 receptor-deficient mice
5. Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol levels
6. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice
7. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
8. Role of the Y5 neuropeptide Y receptor in feeding and obesity
9. Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
10. Complementary and overlapping expression of Y1, Y2 and Y5 receptors in the developing and adult mouse nervous system
11. Characterization of plasma lipids in genetically obese mice: The mutants obese, fat, tubby, and lethal yellow
12. A population study of the plasma neuropeptide Y: Correlations with components of the metabolic syndrome
13. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
14. The role of neuropeptide Y in the antiobesity action of the obese gene product
15. The body-mass index of twins who have reared apart
16. Neurohormonal determinants of sex differences in the hypothalamic regulation of feeding behavior and body weight in the rat
17. Sex differences in the activational effects of gonadal hormones on food intake and body weight
18. Sex hormones and the selective estrogen receptor modulator tamoxifen modulate weekly body weights and food intake in adolescent and adult rats
19. Oleoyl-estrone does not alter hypothalamic neuropeptide Y in Zucker lean and obese rats