Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy

Diabetes

Volumn 51, Issue 9, 2002, Pages 2727-2733

  Colombo, Carlo ^a   Cutson, Jalme J ^a   Yamauchi, Toshimasa ^b   Vinson, Charles ^c   Kadowaki, Takashi ^b   Gavrilova, Oksana ^a   Reitman, Marc L ^a,d  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADIPOSE TISSUE; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; ENERGY METABOLISM; FOOD INTAKE; INSULIN RESISTANCE; LIPOATROPHIC DIABETES MELLITUS; LIPOATROPHY; METABOLIC ACTIVATION; METABOLIC DISORDER; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEATOSIS; TISSUE TRANSPLANTATION; TRIACYLGLYCEROL BLOOD LEVEL; WHITE ADIPOSE TISSUE;

EID: 0036724616     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.9.2727     Document Type: Article

References (30)

1. Leptin and the regulation of body weight in mammals
2. Lipoatrophy revisited
3. Lipodystrophies
4. Life without white fat: A transgenic mouse
5. Targeted expression of a toxin gene to adipose tissue: Transgenic mice resistant to obesity
6. Troglitazone action is independent of adipose tissue
7. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-lc in adipose tissue: Model for congenital generalized lipodystrophy
8. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
9. Leptin reverses insulin resistance and diabetes meilitus in mice with congenital lipodystrophy
10. Leptin and diabetes in lipoatrophic mice
11. Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes
12. Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) and electrophoretic assays for the mouse obese (Lepob) mutation
13. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
14. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
15. The adipocyte-secreted protein Acrp 30 enhances hepatic insulin action
16. AdipoQ is a novel adipose-specific gene dysregulated in obesity
17. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
18. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
19. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
20. Selective deletion of leptin receptor in neurons leads to obesity
21. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
22. Direct antidiabetic effect of leptin through triglyceride depletion of tissues
23. Liporegulation in diet-induced obesity: The antisteatotic role of hyperleptinemia
24. Regulation of fatty acid homeostasis in cells: Novel role of leptin
25. Cellular mechanisms of insulin resistance
26. Leptin-replacement therapy for lipodystrophy
27. Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
28. WY14,643, a peroxisome proliferator-activated receptor α PPARα agonist improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-I mice
29. Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice
30. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: Implications for the development of adipogenic diabetes mellitus